Side effects of analgesia may significantly reduce quality of life in symptomatic multiple myeloma: a cross-sectional prevalence study

Supportive Care in Cancer

Volumn 23, Issue 3, 2015, Pages 671-678

  Sloot, Sarah ^a,b   Boland, Jason ^c   Snowden, John A ^d   Ezaydi, Yousef ^d   Foster, Andrea ^d   Gethin, Alison ^e   Green, Tracy ^e   Chopra, Louise ^d   Verhagen, Stans ^f   Vissers, Kris ^f   Engels, Yvonne ^f   Ahmedzai, Sam H ^e  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF HULL   (United Kingdom)

^d SHEFFIELD TEACHING HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^e UNIVERSITY OF SHEFFIELD   (United Kingdom)

^f RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Analgesics; Multiple myeloma; Opioid; Quality of life; Side effects

Indexed keywords

ACETYLSALICYLIC ACID; ANALGESIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; BUPRENORPHINE; CODEINE; CORTICOSTEROID; DIAMORPHINE; DICLOFENAC; DIHYDROCODEINE; FENTANYL; GABAPENTIN; KETAMINE; METHADONE; MORPHINE; OPIATE; OXYCODONE; PARACETAMOL; PREGABALIN; TRAMADOL; NARCOTIC ANALGESIC AGENT;

ADVERSE DRUG REACTION; AGED; ANALGESIA; ARTICLE; BACKACHE; BONE PAIN; CANCER PAIN; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL ASSESSMENT TOOL; CONSTIPATION; CROSS-SECTIONAL STUDY; DIZZINESS; DROWSINESS; DRUG ERUPTION; FATIGUE; FEMALE; FLATULENCE; HALLUCINATION; HEALTH; HEARTBURN; HOSPITAL; HOT FLUSH; HUMAN; INDIGESTION; INFLUENZA; JAW OSTEONECROSIS; MALE; MULTIPLE MYELOMA; NAUSEA; NEUROPATHIC PAIN; PAIN; PREVALENCE; PRIORITY JOURNAL; PRURITUS; QUALITY OF LIFE; RASH; RECALL; SELF CONCEPT; SEMI STRUCTURED INTERVIEW; SWEATING; VOMITING; XEROSTOMIA; ADVERSE EFFECTS; COMPLICATION; MIDDLE AGED; QUESTIONNAIRE;

AGED; ANALGESIA; ANALGESICS, OPIOID; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; MULTIPLE MYELOMA; PAIN; PAIN MANAGEMENT; PREVALENCE; QUALITY OF LIFE; SURVEYS AND QUESTIONNAIRES;

EID: 84922219820     PISSN: 09414355     EISSN: 14337339     Source Type: Journal    
DOI: 10.1007/s00520-014-2358-1     Document Type: Article

References (27)

1. Bird JM, Owen RG, D'Sa S et al (2011) Guidelines for the diagnosis and management of multiple myeloma 2011. Br J Haematol 154:32–75
2. Niscola P, Scaramucci L, Romani C et al (2010) Pain management in multiple myeloma. Expert Rev Anticancer Ther 10:415–425
3. Snowden JA, Ahmedzai SH, Ashcroft J et al (2011) Guidelines for supportive care in multiple myeloma 2011. Br J Haematol 154:76–103
4. Mhaskar R, Redzepovic J, Wheatley K, Clark OA, Miladinovic B, Glasmacher A, Kumar A, Djulbegovic B (2010) Bisphosphonates in multiple myeloma. Cochrane Database Syst Rev 5:CD003188. doi:10.1002/14651858.CD003188
5. Mendoza TR, Koyyalagunta D, Burton AW et al (2012) Changes in pain and other symptoms in patients with painful multiple myeloma-related vertebral fracture treated with kyphoplasty or vertebroplasty. J Pain: Off J Am Pain Soc 13:564–570
6. Wedin R (2001) Surgical treatment for pathologic fracture. Acta Orthop Scand Suppl 72(2p):1–29
7. Cartoni C, Brunetti GA, Federico V et al (2012) Controlled-release oxycodone for the treatment of bortezomib-induced neuropathic pain in patients with multiple myeloma. Support Care Cancer: Off J Multinatl Assoc Support Care Cancer 20:2621–2626
8. Ahmedzai SH (2001) Window of opportunity for pain control in the terminally ill. Lancet 357:1304–1305
9. Weiss SC, Emanuel LL, Fairclough DL, Emanuel EJ (2001) Understanding the experience of pain in terminally ill patients. Lancet 357:1311–1315
10. Villars P, Dodd M, West C et al (2007) Differences in the prevalence and severity of side effects based on type of analgesic prescription in patients with chronic cancer pain. J Pain Symptom Manag 33:67–77
11. Aaronson NK, Ahmedzai S, Bergman B et al (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85:365–376
12. http://groups.eortc.be/qol/eortc-qlq-c30 European Organsiation for Research and Treatment of Cancer – Quality of Life Department. (Accessed March 29th, 2014)
13. Dickman A (2012) Drugs in palliative care, 2nd edn. Oxford University Press. http://ukcatalogue.oup.com/product/9780199660391.do
14. Osoba D (2002) A taxonomy of the uses of health-related quality-of-life instruments in cancer care and the clinical meaningfulness of the results. Med Care 40:54–55
15. Boland E, Eiser C, Ezaydi Y, Greenfield DM, Ahmedzai SH, Snowden JA (2013) Living with advanced but stable multiple myeloma: a study of the symptom burden and cumulative effects of disease and intensive (hematopoietic stem cell transplant-based) treatment on health-related quality of life. J Pain Symptom Manag 46:671–680
16. Glare P, Walsh D, Sheehan D (2006) The adverse effects of morphine: a prospective survey of common symptoms during repeated dosing for chronic cancer pain. Am J Hosp Palliat Care 23:229–235
17. Gulbrandsen N, Wisloff F, Brinch L et al (2001) Health-related quality of life in multiple myeloma patients receiving high-dose chemotherapy with autologous blood stem-cell support. Med Oncol 18:65–77
18. Uyl-de Groot CA, Buijt I, Gloudemans IJ, Ossenkoppele GJ, Berg HP, Huijgens PC (2005) Health related quality of life in patients with multiple myeloma undergoing a double transplantation. Eur J Haematol 74:136–143
19. Tassinari D, Sartori S, Tamburini E et al (2008) Adverse effects of transdermal opiates treating moderate-severe cancer pain in comparison to long-acting morphine: a meta-analysis and systematic review of the literature. J Palliat Med 11:492–501
20. Clark AJ, Ahmedzai SH, Allan LG et al (2004) Efficacy and safety of transdermal fentanyl and sustained-release oral morphine in patients with cancer and chronic non-cancer pain. Curr Med Res Opin 20:1419–1428
21. Hjalte F, Berggren AC, Bergendahl H, Hjortsberg C (2010) The direct and indirect costs of opioid-induced constipation. J Pain Symptom Manag 40:696–703
22. Ahmedzai SH, Boland J. (2010) Constipation in people prescribed opioids. Clin Evid. PMC2907601
23. Ahmedzai SH, Nauck F, Bar-Sela G, Bosse B, Leyendecker P, Hopp M (2012) A randomized, double-blind, active-controlled, double-dummy, parallel-group study to determine the safety and efficacy of oxycodone/naloxone prolonged-release tablets in patients with moderate/severe, chronic cancer pain. Palliat Med 26:50–60
24. Zhang M, Holman CD, Price SD, Sanfilippo FM, Preen DB, Bulsara MK (2009) Comorbidity and repeat admission to hospital for adverse drug reactions in older adults: Retrospective cohort study. BMJ 338:a2752
25. Gregorian RS Jr, Gasik A, Kwong WJ, Voeller S, Kavanagh S (2010) Importance of side effects in opioid treatment: a trade-off analysis with patients and physicians. J Pain: Off J Am Pain Soc 11:1095–1108
26. Schmier JK, Palmer CS, Flood EM, Gourlay G (2002) Utility assessments of opioid treatment for chronic pain. Pain Med 3:218–230
27. Glintborg B, Poulsen HE, Dalhoff KP (2008) The use of nationwide on-line prescription records improves the drug history in hospitalized patients. Br J Clin Pharmacol 65:265–269