Defining the "sweet spot" for administered luteinizing hormone-to-follicle-stimulating hormone gonadotropin ratios during ovarian stimulation to protect against a clinically significant late follicular increase in progesterone: An analysis of 10,280 first in vitro fertilization cycles

Fertility and Sterility

Volumn 102, Issue 5, 2014, Pages 1312-1317

  Werner, Marie D ^a,b   Forman, Eric J ^a,b   Hong, Kathleen H ^a   Franasiak, Jason M ^a   Molinaro, Thomas A ^a,b   Scott, Richard T ^a,b  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b REPRODUCTIVE MEDICINE ASSOCIATES OF NEW JERSEY   (United States)

Author keywords

Exogenous FSH; Exogenous LH; Gonadotropins; Late follicular increase in progesterone; Stimulation

Indexed keywords

CHORIONIC GONADOTROPIN; FOLLITROPIN; HUMAN MENOPAUSAL GONADOTROPIN; LUTEINIZING HORMONE; PROGESTERONE; RECOMBINANT FOLLITROPIN; RECOMBINANT LUTEINIZING HORMONE; BIOLOGICAL MARKER;

ADULT; ARTICLE; COHORT ANALYSIS; CONTROLLED OVARY HYPERSTIMULATION; FEMALE; FERTILIZATION IN VITRO; HORMONE ACTION; HUMAN; HUMAN CELL; LOW DRUG DOSE; LUTEINIZING HORMONE BLOOD LEVEL; LUTEINIZING HORMONE RELEASE; MAJOR CLINICAL STUDY; METAPHASE; OOCYTE; OOCYTE MATURATION; OUTCOME ASSESSMENT; OVARIAN RESERVE; OVARY HYPERSTIMULATION; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; RETROSPECTIVE STUDY; RISK ASSESSMENT; TREATMENT RESPONSE; BLOOD; DOSE RESPONSE; DRUG ADMINISTRATION; DRUG EFFECTS; FOLLICULAR PHASE; INFERTILITY, FEMALE; OVARY; OVULATION INDUCTION; PATHOLOGY; PREGNANCY; PREGNANCY OUTCOME; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; TREATMENT OUTCOME;

ADULT; BIOLOGICAL MARKERS; COHORT STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; FERTILIZATION IN VITRO; FOLLICLE STIMULATING HORMONE; FOLLICULAR PHASE; HUMANS; INFERTILITY, FEMALE; LUTEINIZING HORMONE; OVARY; OVULATION INDUCTION; PREGNANCY; PREGNANCY OUTCOME; PROGESTERONE; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; TREATMENT OUTCOME;

EID: 84922143961     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2014.07.766     Document Type: Article

References (19)

1. Bosch E, Labarta E, Crespo J, Simón C, Remohí J, Jenkins J, et al. Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles. Hum Reprod 2010;25:2092-100.
2. Fanchin R, Righini C, Olivennes F, Ferreira AL, de Ziegler D, Frydman R. Consequences of premature progesterone elevation on the outcome of in vitro fertilization: insights into a controversy. Fertil Steril 1997;68:799-805.
3. Shulman A, Ghetler Y, Beyth Y, Ben-Nun I. The significance of an early (premature) rise of plasma progesterone in in vitro fertilization cycles induced by a "long protocol" of gonadotropin releasing hormone analogue and human menopausal gonadotropins. J Assist Reprod Genet 1996;13:207-11.
4. Silverberg KM, Burns WN, Olive DL, Riehl RM, Schenken RS. Serum progesterone levels predict success of in vitro fertilization/embryo transfer in patients stimulated with leuprolide acetate and human menopausal gonadotropins. J Clin Endocrinol Metab 1991;73:797-803.
5. Silverberg KM, Martin M, Olive DL, Burns WN, Schenken RS. Elevated serum progesterone levels on the day of human chorionic gonadotropin administration in in vitro fertilization cycles do not adversely affect embryo quality. Fertil Steril 1994;61:508-13.
6. Hofmann GE, Khoury J, Johnson CA, Thie J, Scott RT Jr. Premature luteinization during controlled ovarian hyperstimulation for in vitro fertilizationembryo transfer has no impact on pregnancy outcome. Fertil Steril 1996;66:980-6.
7. Ubaldi F, Camus M, Smitz J, Bennink HC, van Steirteghem A, Devroey P. Premature luteinization in in vitro fertilization cycles using gonadotropinreleasing hormone agonist (GnRH-a) and recombinant follicle-stimulating hormone (FSH) and GnRH-a and urinary FSH. Fertil Steril 1996;66:275-80.
8. Andersen AN, Devroey P, Arce JC. Clinical outcomefollowing stimulation with highly purified hMG or recombinant FSH in patients undergoing IVF: a randomized assessor-blind controlled trial. Hum Reprod 2006;21:3217-27.
9. Smitz J, Andersen AN, Devroey P, Arce JC, MERIT Group. Endocrine profile in serum and follicular fluid differs after ovarian stimulation with HP-hMG or recombinant FSH in IVF patients. Hum Reprod 2007;22:676-87.
10. Shoham Z, Howles CM, Zalel Y, Weissman A, Insler V. Induction of follicular growth and production of a normal hormonal milieu in spite of using a constant low dose of luteinizing hormone in women with hypogonadotrophic hypogonadism. Hum Reprod 1994;9:431-6.
11. Martins WP, Vieira AD, Figueiredo JB, Nastri CO. FSH replaced by low-dose hCG in the late follicular phase versus continued FSH for assisted reproductive techniques. Cochrane Database Syst Rev 2013:CD010042.
12. Sullivan MW, Stewart-Akers A, Krasnow JS, Berga SL, Zeleznik AJ. Ovarian responses in women to recombinant follicle-stimulating hormone and luteinizing hormone (LH): a role for LH in the final stages of follicular maturation. J Clin Endocrinol Metab 1999;84:228-32.
13. Hamdine O, Macklon NS, Eijkemans MJC, Laven JSE, Cohlen BJ, Verhoeff A, et al. Elevated early follicular progesterone levels and in vitro fertilization outcomes: a prospective intervention study and meta-analysis. Fertil Steril 2014;102:448-54.e1.
14. Fanchin R, de Ziegler D, Taieb J, Hazout A, Frydman R. Premature elevation of plasma progesterone alters pregnancy rates of in vitro fertilization and embryo transfer. Fertil Steril 1993;59:1090-4.
15. Fanchin R, Hourvitz A, Olivennes F, Taieb J, Hazout A, Frydman R. Premature progesterone elevation spares blastulation but not pregnancy rates in in vitro fertilization with coculture. Fertil Steril 1997;68:648-52.
16. Harada T, Yoshida S, Katagiri C, Takao N, Ikenari T, Toda T, et al. Reduced implantation rate associated with a subtle rise in serum progesterone concentration during the follicular phase of cycles stimulated with a combination of a gonadotrophin-releasing hormone agonist and gonadotrophin. Hum Reprod 1995;10:1060-4.
17. Kyrou D, Kolibianakis EM, Fatemi HM, Tarlatzis BC, Tournaye H, Devroey P. Is earlier administration of human chorionic gonadotropin (hCG) associated with the probability of pregnancy in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone (GnRH) antagonists? A prospective randomized trial. Fertil Steril 2011;96:1112-5.
18. Fleming R. Progesterone elevation on the day of hCG: methodological issues. Hum Reprod Update 2008;14:391-2.
19. Bosch E, Vidal C, Labarta E, Simon C, Remohi J, Pellicer A. Highly purified hMG versus recombinant FSH in ovarian hyperstimulation with GnRH antagonists- a randomized study. Hum Reprod 2008;23:2346-51.