Elevated early follicular progesterone levels and in vitro fertilization outcomes: A prospective intervention study and meta-analysis

Fertility and Sterility

Volumn 102, Issue 2, 2014, Pages

  Hamdine, Ouijdane ^a   Macklon, Nick S ^a,b   Eijkemans, Marinus J C ^a   Laven, Joop S E ^c   Cohlen, Bernard J ^d   Verhoeff, Arie ^e   Van Dop, Peter A ^f   Bernardus, Rob E ^g   Lambalk, Cornelis B ^h,i   Oosterhuis, Gerrit J E ^j   Holleboom, Caspar A G ^k   Van Den Dool Maasland, Grada C ^l   Verburg, Harjo J ^m   Van Der Heijden, Petrus F M ⁿ   Blankhart, Adrienne ^o   Fauser, Bart C J M ^a   Broekmans, Frank J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d ISALA HOSPITAL   (Netherlands)

^e Maasstad Hospital Rotterdam   (Netherlands)

^f CATHARINA HOSPITAL   (Netherlands)

^g TERGOOI HOSPITAL   (Netherlands)

^h VU UNIVERSITY MEDICAL CENTER   (Netherlands)

ⁱ GHENT UNIVERSITY HOSPITAL   (Belgium)

^j MEDISCH SPECTRUM TWENTE   (Netherlands)

^k MEDICAL CENTER HAAGLANDEN   (Netherlands)

^l ALBERT SCHWEITZER HOSPITAL   (Netherlands)

^m LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

ⁿ Leiden University Medical Centre ^*  (Netherlands)

^o ST ANTONIUS HOSPITAL   (Netherlands)

more..

Author keywords

Clinical outcome; GnRH antagonist; IVF; progesterone levels

Indexed keywords

ESTRADIOL; GONADORELIN ANTAGONIST; PROGESTERONE; RECOMBINANT CHORIONIC GONADOTROPIN; RECOMBINANT FOLLITROPIN;

ADULT; ARTICLE; CONTROLLED STUDY; EMBRYO TRANSFER; FEMALE; FEMALE SUBFERTILITY; FERTILIZATION IN VITRO; HUMAN; INTRACYTOPLASMIC SPERM INJECTION; INTRAUTERINE INSEMINATION; LUTEAL PHASE; MAJOR CLINICAL STUDY; META ANALYSIS (TOPIC); MULTICENTER STUDY; ONGOING PREGNANCY RATE; OOCYTE RETRIEVAL; OUTCOME ASSESSMENT; OVARIAN STIMULATION; OVARY FUNCTION; PREGNANCY RATE; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; STIMULATION; SYSTEMATIC REVIEW (TOPIC); TIME TO TREATMENT; TREATMENT OUTCOME;

CLINICAL OUTCOME; GNRH ANTAGONIST; IVF; PROGESTERONE LEVELS;

ADULT; BIOLOGICAL MARKERS; FEMALE; FERTILITY AGENTS, FEMALE; FERTILIZATION IN VITRO; FOLLICLE STIMULATING HORMONE; GONADOTROPIN-RELEASING HORMONE; HORMONE ANTAGONISTS; HUMANS; INFERTILITY; NETHERLANDS; OVARIAN FOLLICLE; OVULATION INDUCTION; PREGNANCY; PREGNANCY RATE; PROGESTERONE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RECOMBINANT PROTEINS; SPERM INJECTIONS, INTRACYTOPLASMIC; TIME FACTORS; TREATMENT OUTCOME; UP-REGULATION;

EID: 84905447835     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2014.05.002     Document Type: Article

References (19)

1. J.A. McCracken, E.E. Custer, and J.C. Lamsa Luteolysis: a neuroendocrine-mediated event Physiol Rev 79 1999 263 323
2. L. Devoto, A. Fuentes, P. Kohen, P. Cespedes, A. Palomino, and R. Pommer et al. The human corpus luteum: life cycle and function in natural cycles Fertil Steril 92 2009 1067 1079
3. N.G. Beckers, N.S. Macklon, M.J. Eijkemans, and B.C. Fauser Women with regular menstrual cycles and a poor response to ovarian hyperstimulation for in vitro fertilization exhibit follicular phase characteristics suggestive of ovarian aging Fertil Steril 78 2002 291 297
4. E.M. Kolibianakis, K. Zikopoulos, J. Smitz, M. Camus, H. Tournaye, and A.C. Van Steirteghem et al. Elevated progesterone at initiation of stimulation is associated with a lower ongoing pregnancy rate after IVF using GnRH antagonists Hum Reprod 19 2004 1525 1529
5. J.E. Mersereau, M.L. Evans, D.H. Moore, J.H. Liu, M.A. Thomas, and R.W. Rebar et al. Luteal phase estrogen is decreased in regularly menstruating older women compared with a reference population of younger women Menopause 15 2008 482 486
6. P. van Zonneveld, G.J. Scheffer, F.J. Broekmans, M.A. Blankenstein, F.H. de Jong, and C.W. Looman et al. Do cycle disturbances explain the age-related decline of female fertility? Cycle characteristics of women aged over 40 years compared with a reference population of young women Hum Reprod 18 2003 495 501
7. J.C. Huang, K.V. Jackson, M.D. Hornstein, and E.S. Ginsburg The effect of elevated serum progesterone during ovulation induction in in vitro fertilization-embryo transfer J Assist Reprod Genet 13 1996 617 624
8. J.A. Sims, H.J. Seltman, and S.J. Muasher Early follicular rise of serum progesterone concentration in response to a flare-up effect of gonadotrophin-releasing hormone agonist impairs follicular recruitment for in-vitro fertilization Hum Reprod 9 1994 235 240
9. Y. Tang, F. Gong, G. Lin, and G. Lu Early follicular progesterone concentrations and in vitro fertilization pregnancy outcomes Fertil Steril 87 2007 991 994
10. C. Blockeel, M. Baumgarten, M. De Vos, G. Verheyen, and P. Devroey Administration of GnRH antagonists in case of elevated progesterone at initiation of the cycle: a prospective cohort study Curr Pharm Biotechnol 12 2011 423 428
11. O. Hamdine, F.J. Broekmans, M.J. Eijkemans, C.B. Lambalk, B.C. Fauser, and J.S. Laven et al. Early initiation of gonadotropin-releasing hormone antagonist treatment results in a more stable endocrine milieu during the mid- and late-follicular phases: a randomized controlled trial comparing gonadotropin-releasing hormone antagonist initiation on cycle day 2 or 6 Fertil Steril 100 2013 867 874
12. O. Hamdine, N.S. Macklon, M.J. Eijkemans, J.S. Laven, B.J. Cohlen, and A. Verhoeff et al. Comparison of early versus late initiation of GnRH antagonist co-treatment for controlled ovarian stimulation in IVF: a randomized controlled trial Hum Reprod 28 2013 3227 3235
13. C. Keck, J. Neulen, S. Breig-Lauel, and M. Breckwoldt Elevated serum progesterone concentrations during the early follicular phase of the menstrual cycle: clinical significance and therapeutic implications Gynecol Endocrinol 13 1999 161 165
14. The American Society for Reproductive Medicine The clinical relevance of luteal phase deficiency: a committee opinion Fertil Steril 98 2012 1112 1117
15. M.V. Sauer, R.J. Paulson, and R.A. Lobo Pregnancy after age 50: application of oocyte donation to women after natural menopause Lancet 341 1993 321 323
16. C. De Geyter, M. De Geyter, P.R. Huber, E. Nieschlag, and W. Holzgreve Progesterone serum levels during the follicular phase of the menstrual cycle originate from the crosstalk between the ovaries and the adrenal cortex Hum Reprod 17 2002 933 939
17. T. Eldar-Geva, E.J. Margalioth, B. Brooks, N. Algur, E. Zylber-Haran, and Y.Z. Diamant The origin of serum progesterone during the follicular phase of menotropin-stimulated cycles Hum Reprod 13 1998 9 14
18. S. Judd, A. Terry, M. Petrucco, and G. White The source of pulsatile secretion of progesterone during the human follicular phase J Clin Endocrinol Metab 74 1992 299 305
19. E.M. Kolibianakis, C. Albano, M. Camus, H. Tournaye, A.C. Van Steirteghem, and P. Devroey Prolongation of the follicular phase in in vitro fertilization results in a lower ongoing pregnancy rate in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonists Fertil Steril 82 2004 102 107