Impact of Glycation on Antibody Clearance

AAPS Journal

Volumn 17, Issue 1, 2015, Pages 237-244

  Yang, Jane ^a   Primack, Ronya ^b   Frohn, Mike ^c   Wang, Wei ^b   Luan, Peng ^b   Retter, Marc W ^b   Flynn, Gregory C ^a  

^a Product Attribute Sciences   (United States)

^b AMGEN INC   (United States)

^c Departments of Medicinal Chemistry   (United States)

Author keywords

mannose receptor; mass spectrometry; pharmacokinetics; surface plasmon resonance

Indexed keywords

2 IMINO 2 METHOXYETHYL 1 THIOMANNOSIDE; IGG MONOCLONAL ANTIBODY; MANNOSE; MANNOSE RECEPTOR; MANNOSIDE; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; IMMUNOGLOBULIN G; LECTIN; MANNOSE BINDING LECTIN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DERIVATIZATION; DRUG CLEARANCE; MALE; MEAN RESIDENCE TIME; MOUSE; NONHUMAN; PROTEIN GLYCOSYLATION; SURFACE PLASMON RESONANCE; ANIMAL; CHEMISTRY; GLYCOSYLATION; METABOLISM;

ANIMALS; ANTIBODIES, MONOCLONAL; GLYCOSYLATION; IMMUNOGLOBULIN G; LECTINS, C-TYPE; MALE; MANNOSE; MANNOSE-BINDING LECTINS; MICE; RECEPTORS, CELL SURFACE; SURFACE PLASMON RESONANCE;

EID: 84922103487     PISSN: None     EISSN: 15507416     Source Type: Journal    
DOI: 10.1208/s12248-014-9694-4     Document Type: Article

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