Comparative in vitro and in vivo pharmacological investigation of platinum(IV) complexes as novel anticancer drug candidates for oral application

Journal of Biological Inorganic Chemistry

Volumn 20, Issue 1, 2015, Pages 89-99

  Theiner, Sarah ^a   Varbanov, Hristo P ^a   Galanski, Markus ^a   Egger, Alexander E ^c   Berger, Walter ^a,b   Heffeter, Petra ^a,b   Keppler, Bernhard K ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c ADSI Austrian Drug Screening Institute GmbH   (Austria)

Author keywords

Anticancer activity; ICP MS; Oral administration; Platinum(IV) complexes

Indexed keywords

ANTINEOPLASTIC METAL COMPLEX; DIAMMINE(CYCLOBUTANE 1,1 DICARBOXYLATO)BIS[(4 CYCLOPENTYLAMINO) 4 OXOBUTANOATO]PLATINUM COMPLEX; DICHLORIDOBIS[(4 ETHOXY) 4 OXOBUTANOATO]BIS(ETHYLAMINE)PLATINUM COMPLEX; SATRAPLATIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DIAMMINE(CYCLOBUTANE-1,1-DICARBOXYLATO)BIS((4-CYCLOPENTYLAMINO)-4-OXOBUTANOATO)PLATINUM(IV); DICHLORIDOBIS((4-ETHOXY)-4-OXOBUTANOATO)BIS(ETHYLAMINE)PLATINUM(IV); PLATINUM COMPLEX;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER SURVIVAL; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG METABOLISM; DRUG STRUCTURE; DRUG TISSUE LEVEL; FEMALE; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA; LIPOPHILICITY; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SINGLE DRUG DOSE; TUMOR VOLUME; ANIMAL; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; DBA MOUSE; DRUG EFFECTS; DRUG SCREENING; IC50; ORAL DRUG ADMINISTRATION; TISSUE DISTRIBUTION; TUMOR CELL LINE;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; INHIBITORY CONCENTRATION 50; LEUKEMIA; MALE; MICE, INBRED BALB C; MICE, INBRED DBA; NEOPLASM TRANSPLANTATION; ORGANOPLATINUM COMPOUNDS; TISSUE DISTRIBUTION; TUMOR BURDEN;

EID: 84922102876     PISSN: 09498257     EISSN: 14321327     Source Type: Journal    
DOI: 10.1007/s00775-014-1214-6     Document Type: Article

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