Oxidative stress by monosodium urate crystals promotes renal cell apoptosis through mitochondrial caspase-dependent pathway in human embryonic kidney 293 cells: Mechanism for urate-induced nephropathy

Apoptosis

Volumn 20, Issue 1, 2015, Pages 38-49

  Choe, Jung Yoon ^a   Park, Ki Yeun ^a   Kim, Seong Kyu ^a  

^a Catholic University of Daegu   (South Korea)

Author keywords

Apoptosis; Ascorbic acid; Interleukin 1 ; Monosodium urate; Reactive oxygen species

Indexed keywords

ASCORBIC ACID; CASPASE; CASPASE 3; CASPASE 9; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 18; INTERLEUKIN 1BETA; LIPOCORTIN 5; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; URATE; APOPTOSIS REGULATORY PROTEIN; URIC ACID;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CRYSTAL; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; GENETIC TRANSFECTION; HEK293 CELL LINE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; KIDNEY CELL; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; URIC ACID NEPHROPATHY; DRUG EFFECTS; KIDNEY; METABOLISM; NEPHRITIS; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASES; CYCLOOXYGENASE 2; HEK293 CELLS; HUMANS; KIDNEY; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; NEPHRITIS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; URIC ACID;

EID: 84922076845     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-014-1057-1     Document Type: Article

References (30)

1. Talbott JH, Terplan KL (1960) The kidney in gout. Medicine (Baltimore) 39:405-467
2. Nickeleit V, Mihatsch MJ (1997) Uric acid nephropathy and end-stage renal disease-review of a non-disease. Nephrol Dial Transplant 12:1832-1838
3. Mazzali M, Kanellis J, Han L, Feng L, Xia YY, Chen Q, Kang DH, Gordon KL, Watanabe S, Nakagawa T, Lan HY, Johnson RJ (2002) Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. Am J Physiol Renal Physiol 282:F991-F997
4. Emmerson BT, Cross M, Osborne JM, Axelsen RA (1990) Reaction of MDCK cells to crystals of monosodium urate monohydrate crystals and uric acid. Kidney Int 37:36-43
5. Umekawa T, Chegini N, Khan SR (2003) Increased expression of monocyte chemoattractant protein-1 (MCP-1) by renal epithelial cells in culture on exposure to calcium oxalate, phosphate and uric acid crystals. Nephrol Dial Transplant 18:664-669
6. Lhotta K, Gruber J, Sgonc R, Fend F, Konig P (1998) Apoptosis of tubular epithelial cells in familial juvenile gouty nephropathy. Nephron 79:340-344
7. Huang WC, Hsu CY, Hu HH, Chou KJ, Lee PT, Chen CL, Chang TY, Fang HC, Chen CL (2008) Lack of direct apoptotic effect of uric acid on renal epithelial cells. Acta Nephrologica 22:91-96
8. Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440:237-241
9. Martinon F (2010) Mechanisms of uric acid crystal-mediated autoinflammation. Immunol Rev 233:218-232
10. Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Mol Cell 10:417-426
11. Zhou R, Yazdi AS, Menu P, Tschopp J (2011) A role for mitochondria in NLRP3 inflammasome activation. Nature 469:221-225
12. Haddad JJ (2004) Redox and oxidant-mediated regulation of apoptosis signaling pathways: immuno-pharmaco-redox conception of oxidative siege versus cell death commitment. Int Immunopharmacol 4:475-493
13. Choe JY, Jung HY, Park KY, Kim SK (2014) Enhanced p62 expression through impaired proteasomal degradation is involved in caspase-1 activation in monosodium urate crystal-induced interleukin-1β expression. Rheumatology (Oxford) 53:1043-1053
14. Iseki K, Ikemiya Y, Inoue T, Iseki C, Kinjo K, Takishita S (2004) Significance of hyperuricemia as a risk factor for developing ESRD in a screened cohort. Am J Kidney Dis 44:642-650
15. Brochner-Mortensen K (1941) 100 gouty patients. Acta Media Scand 106:81-107
16. Park SJ, Jeong KS (2004) Cell-type-specific activation of mitogen-activated protein kinases in PAN-induced progressive renal disease in rats. Biochem Biophys Res Commun 323:1-8
17. Peng Y, Kwok KH, Yang PH, Ng SS, Liu J, Wong OG, He ML, Kung HF, Lin MC (2005) Ascorbic acid inhibits ROS production, NF-kappa B activation and prevents ethanol-induced growth retardation and microencephaly. Neuropharmacology 48:426-434
18. Schultz DR, Harrington WJ Jr (2003) Apoptosis: programmed cell death at a molecular level. Semin Arthritis Rheum 32:345-369
19. Malemud CJ, Sun Y, Pearlman E, Ginley NM, Awadallah A, Wisler BA, Dennis JE (2012) Monosodium urate and tumor necrosis factor-α increase apoptosis in human chondrocyte cultures. Rheumatology (Sunnyvale) 2:113
20. Bordoni V, De Cal M, Rassu M, Cazzavillan S, Segala C, Bonello M, Ranishta R, Andrikos E, Yavuz A, Salvatori G, Galloni E, Bolgan I, Bellomo R, Levin N, Ronco C (2005) Protective effect of urate oxidase on uric acid induced-monocyte apoptosis. Curr Drug Discov Technol 2:29-36
21. Yu MA, Sánchez-Lozada LG, Johnson RJ, Kang DH (2010) Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction. J Hypertens 28:1234-1242
22. Akahoshi T, Nagaoka T, Namai R, Sekiyama N, Kondo H (1997) Prevention of neutrophil apoptosis by monosodium urate crystals. Rheumatol Int 16:231-235
23. Tudan C, Fong D, Duronio V, Burt HM, Jackson JK (2000) The inhibition of spontaneous and tumor necrosis factor-alpha induced neutrophil apoptosis by crystals of calcium pyrophosphate dihydrate and monosodium urate monohydrate. J Rheumatol 27:2463-2472
24. Han HJ, Lim MJ, Lee YJ, Lee JH, Yang IS, Taub M (2007) Uric acid inhibits renal proximal tubule cell proliferation via at least two signaling pathways involving PKC, MAPK, cPLA2, and NF-κB. Am J Physiol Renal Physiol 292:F373-F381
25. Schelling JR, Cleveland RP (1999) Involvement of Fas-dependent apoptosis in renal tubular epithelial cell deletion in chronic renal failure. Kidney Int 56:1313-1316
26. Park CH, Noh JS, Okamoto T, Park JC, Yokozawa T (2012) Evaluation of Effects of Chinese prescription Kangen-karyu on diabetes-induced alterations such as oxidative stress and apoptosis in the liver of type 2 diabetic db/db mice. Evid Based Complement Altern Med 2012:143489
27. Vane JR, Mitchell JA, Appleton I, Tomlinson A, Bishop-Bailey D, Croxtall J, Willoughby DA (1994) Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proc Natl Acad Sci 91:2046-2050
28. Simon HU, Haj-Yehia A, Levi-Schaffer F (2000) Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 5:415-418
29. Kuwano K, Hara N (2000) Signal transduction pathways of apoptosis and inflammation induced by the tumor necrosis factor receptor family. Am J Respir Cell Mol Biol 22:147-149
30. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326-1331