Calcifediol versus vitamin D3 effects on gait speed and trunk sway in young postmenopausal women: a double-blind randomized controlled trial

Osteoporosis International

Volumn 26, Issue 1, 2015, Pages 373-381

  Meyer, O ^a   Dawson Hughes, B ^b   Sidelnikov, E ^a   Egli, A ^a   Grob, D ^c   Staehelin, H B ^d   Theiler, G ^a   Kressig, R W ^d   Simmen, H P ^a   Theiler, R ^e   Bischoff Ferrari, H A ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b TUFTS UNIVERSITY   (United States)

^c Stadtspital Waid   (Switzerland)

^d UNIVERSITY OF BASEL   (Switzerland)

^e TRIEMLI HOSPITAL   (Switzerland)

Author keywords

25(OH)D; Gait speed; Postmenopausal women; RCT; Trunk sway; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; CALCIFEDIOL; CALCITRIOL; COLECALCIFEROL; 25-HYDROXYVITAMIN D; PARATHYROID HORMONE; VITAMIN D;

ADULT; ANTHROPOMETRIC PARAMETERS; ARTICLE; BODY EQUILIBRIUM; BODY MASS; BODY SWAY TEST BATTERY; CALCIUM BLOOD LEVEL; CLINICAL ASSESSMENT; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; GAIT; GAIT SPEED; GALVANIC VESTIBULAR TEST; HUMAN; NORMAL HUMAN; PHYSIOTHERAPIST; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STANDING; SURFACE PROPERTY; TIME TO TREATMENT; TREATMENT DURATION; TRUNK; TRUNK SWAY; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; WALKING SPEED; AGED; ANALOGS AND DERIVATIVES; BLOOD; COMPARATIVE STUDY; DIET SUPPLEMENTATION; DRUG EFFECTS; MIDDLE AGED; PHYSIOLOGY; PROPRIOCEPTION;

AGED; CALCIFEDIOL; CALCITRIOL; CHOLECALCIFEROL; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; GAIT; HUMANS; MIDDLE AGED; PARATHYROID HORMONE; POSTMENOPAUSE; PROPRIOCEPTION; TORSO; VITAMIN D;

EID: 84922073380     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-014-2949-1     Document Type: Article

References (36)

1. Cummings, SR, Studenski S and Ferrucci L (2014) A diagnosis of dismobility-giving mobility clinical visibility: a mobility working group recommendation. JAMA
2. Vermeulen J et al (2011) Predicting ADL disability in community-dwelling elderly people using physical frailty indicators: a systematic review. BMC Geriatr 11:33
3. Cawthon PM et al (2009) Do muscle mass, muscle density, strength, and physical function similarly influence risk of hospitalization in older adults? J Am Geriatr Soc 57(8):1411–9
4. Studenski S et al (2011) Gait speed and survival in older adults. JAMA 305(1):50–8
5. Wicherts IS et al (2007) Vitamin D status predicts physical performance and its decline in older persons. J Clin Endocrinol Metab 6:6
6. Bischoff-Ferrari HA et al (2004) Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > =60 y. Am J Clin Nutr 80(3):752–8
7. Toffanello ED et al (2012) Vitamin D and physical performance in elderly subjects: the Pro.V.A study. PLoS One 7(4):e34950
8. Annweiler C et al (2010) Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: the EPIDOS study. J Bone Miner Res 25(8):1858–66
9. Houston DK et al (2007) Association between vitamin D status and physical performance: the InCHIANTI study. J Gerontol A Biol Sci Med Sci 62(4):440–6
10. Dam TT, von Muhlen D, Barrett-Connor EL (2009) Sex-specific association of serum vitamin D levels with physical function in older adults. Osteoporos Int 20(5):751–60
11. Muir SW, Montero-Odasso M (2011) Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis. J Am Geriatr Soc 59(12):2291–300
12. Latham NK et al (2003) A randomized, controlled trial of quadriceps resistance exercise and vitamin D in frail older people: the frailty interventions trial in elderly subjects (FITNESS). J Am Geriatr Soc 51(3):291–9
13. Gallagher JC (2004) The effects of calcitriol on falls and fractures and physical performance tests. J Steroid Biochem Mol Biol 89–90(1–5):497–501
14. Bunout D et al (2006) Effects of vitamin D supplementation and exercise training on physical performance in Chilean vitamin D deficient elderly subjects. Exp Gerontol 41(8):746–52
15. Dhesi JK et al (2004) Vitamin D supplementation improves neuromuscular function in older people who fall. Age Ageing 33(6):589–95
16. Pfeifer M et al (2009) Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int 20(2):315–22
17. Bischoff-Ferrari HA et al (2004) Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res 19(2):265–9
18. Ceglia L et al (2010) Multi-step immunofluorescent analysis of vitamin D receptor loci and myosin heavy chain isoforms in human skeletal muscle. J Mol Histol 41(2–3):137–42
19. Wang Y, Becklund BR, DeLuca HF (2010) Identification of a highly specific and versatile vitamin D receptor antibody. Arch Biochem Biophys 494(2):166–77
20. Sorensen OH et al (1979) Myopathy in bone loss of ageing: improvement by treatment with 1 alpha-hydroxycholecalciferol and calcium. Clin Sci (Colch) 56(2):157–61
21. Ceglia L, et al (2013) A randomized study on the effect of vitamin D3 supplementation on skeletal muscle morphology and vitamin D receptor concentration in older women. J Clin Endocrinol Metab
22. Endo I et al (2003) Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology 144(12):5138–44
23. Bouillon R, Bischoff-Ferrari H, Willett W (2008) Vitamin D and health: perspectives from mice and man. J Bone Miner Res 23(7):974–9
24. Al-Shoha A et al (2009) Osteomalacia with bone marrow fibrosis due to severe vitamin D deficiency after a gastrointestinal bypass operation for severe obesity. Endocr Pract 15(6):528–33
25. Schott GD, Wills MR (1976) Muscle weakness in osteomalacia. Lancet 1(7960):626–9
26. Jetter A, et al (2013) Pharmacokinetics of oral vitamin D3 and calcifediol. Bone
27. Cashman KD et al (2012) Relative effectiveness of oral 25-hydroxyvitamin D3 and vitamin D3 in raising wintertime serum 25-hydroxyvitamin D in older adults. Am J Clin Nutr 95(6):1350–6
28. Bischoff-Ferrari HA et al (2012) Oral supplementation with 25(OH)D3 versus vitamin D3: effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity. J Bone Miner Res 27(1):160–9
29. Jetter A et al (2014) Pharmacokinetics of oral vitamin D(3) and calcifediol. Bone 59:14–9
30. de Hoon EW et al (2003) Quantitative assessment of the stops walking while talking test in the elderly. Arch Phys Med Rehabil 84(6):838–42
31. Allum JH, Carpenter MG (2005) A speedy solution for balance and gait analysis: angular velocity measured at the centre of body mass. Curr Opin Neurol 18(1):15–21
32. Schmidt-Gayk H et al (2004) Performance evaluation of automated assays for beta-CrossLaps, N-MID-Osteocalcin and intact parathyroid hormone (BIOROSE Multicenter Study). Clin Chem Lab Med 42(1):90–5
33. Houston DK et al (2012) 25-hydroxyvitamin D status and change in physical performance and strength in older adults: the health, aging, and body composition study. Am J Epidemiol 176(11):1025–34
34. Bischoff-Ferrari HA et al (2006) Is fall prevention by vitamin D mediated by a change in postural or dynamic balance? Osteoporos Int 17(5):656–63
35. Sambrook PN et al (2004) Serum parathyroid hormone predicts time to fall independent of vitamin D status in a frail elderly population. J Clin Endocrinol Metab 89(4):1572–6
36. Morris GS et al (2012) Greater than age-predicted functional deficits in older patients with primary hyperparathyroidism. Endocr Pract 18(4):450–5