Resveratrol affects histone 3 lysine 27 methylation of vessels and blood biomarkers in DOCA salt-induced hypertension

Molecular Biology Reports

Volumn 42, Issue 1, 2015, Pages 35-42

  Han, Sevtap ^a   Uludag, Mecit Orhan ^a   Usanmaz, Suzan Emel ^b   Ayaloglu Butun, Fatma ^c   Akcali, Kamil Can ^b   Demirel Yilmaz, Emine ^b  

^a GAZI UNIVERSITY   (Turkey)

^b ANKARA UNIVERSITY   (Turkey)

^c BILKENT UNIVERSITY   (Turkey)

Author keywords

Biomarker; Endothelium; Epigenetic modification; Hypertension; Resveratrol

Indexed keywords

HISTONE 3 LYSINE 27; HISTONE H3; HYDROGEN SULFIDE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; RESVERATROL; UNCLASSIFIED DRUG; ANTIOXIDANT; ARGININE; BIOLOGICAL MARKER; DEOXYCORTICOSTERONE ACETATE; HISTONE; LYSINE; N,N-DIMETHYLARGININE; NITRITE; STILBENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DEOXYCORTICOSTERONE-SALT INDUCED HYPERTENSION; HISTONE METHYLATION; MALE; NONHUMAN; RAT; RENAL ARTERY; THORACIC AORTA; VASCULAR ENDOTHELIUM; VASODILATATION; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD; BLOOD PRESSURE; BLOOD VESSEL; CHEMICALLY INDUCED; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; HYPERTENSION; KIDNEY ARTERY; METABOLISM; METHYLATION; PATHOLOGY; PATHOPHYSIOLOGY; SYSTOLE; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; ARGININE; BIOMARKERS; BLOOD PRESSURE; BLOOD VESSELS; DESOXYCORTICOSTERONE ACETATE; ENDOTHELIUM, VASCULAR; FLUORESCENT ANTIBODY TECHNIQUE; HISTONES; HYDROGEN SULFIDE; HYPERTENSION; LYSINE; MALE; METHYLATION; NITRITES; RATS, WISTAR; RENAL ARTERY; STILBENES; SYSTOLE; VASODILATION;

EID: 84922073125     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-014-3737-x     Document Type: Article

References (32)

1. Coffman TM (2011) Under pressure: the search for the essential mechanisms of hypertension. Nat Med 17(11):1402–1409
2. Tang EH, Vanhoutte PM (2010) Endothelial dysfunction: a strategic target in the treatment of hypertension? Pflugers Arch 459(6):995–1004
3. Schulz E, Gori T, Münzel T (2011) Oxidative stress and endothelial dysfunction in hypertension. Hypertens Res 34(6):665–673
4. Rush JW, Quadrilatero J, Levy AS, Ford RJ (2007) Chronic resveratrol enhances endothelium-dependent relaxation but does not alter eNOS levels in aorta of spontaneously hypertensive rats. Exp Biol Med 232(6):814–822
5. Bhatt SR, Lokhandwala MF, Banday AA (2011) Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats. Eur J Pharmacol 667(1–3):258–264
6. Rimbaud S, Ruiz M, Piquereau J, Mateo P, Fortin D, Veksler V et al (2011) Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure. PLoS ONE 6(10):e26391
7. Petrovski G, Gurusamy N, Das DK (2011) Resveratrol in cardiovascular health and disease. Ann NY Acad Sci 1215:22–33
8. Cowley AW Jr, Nadeau JH, Baccarelli A, Berecek K, Fornage M, Gibbons GH et al (2012) Report of the national heart, lung, and blood institute working group on epigenetics and hypertension. Hypertension 59(5):899–905
9. Navarro-Gonzalvez J, Garcia-Benayas C, Arenas J (1998) Semiautomated measurement of nitrate in biological fluids. Clin Chem 44(3):679–681
10. Usanmaz SE, Demirel Yilmaz E (2008) A microplate based spectrophotometric method for the determination of the total antioxidant capacity of human plasma: modified cupric reducing ability assay. Fundam Clin Pharmacol 22(67–67 Suppl):2
11. Zhang H, Moochhala SM, Bhatia M (2008) Endogenous hydrogen sulfide regulates inflammatory response by activating the ERK pathway in polymicrobial sepsis. J Immunol 181:4320–4331
12. Buluc M, Demirel-Yılmaz E (2002) Possible mechanism for depression of smooth muscle tone by resveratrol. In: Varro A, Vegh A (eds) Advances in Recent Cardiovascular Research. Monduzzi Editore, Bologna, pp 55–59
13. Buluc M, Demirel-Yilmaz E (2006) Resveratrol decreases calcium sensitivity of vascular smooth muscle and enhances cytosolic calcium increase in endothelium. Vascul Pharmacol 44(4):231–237
14. Buluc M, Ayaz M, Turan B, Demirel-Yilmaz E (2007) Resveratrol-induced depression of the mechanical and electrical activities of the rat heart is reversed by glyburide: evidence for possible K(ATP) channels activation. Arch Pharm Res 30(5):603–607
15. Lind L, Granstam SO, Millgård J (2000) Endothelium-dependent vasodilation in hypertension: a review. Blood Press 9(1):4–15
16. Soylemez S, Sepici A, Akar F (2009) Resveratrol supplementation gender independently improves endothelial reactivity and suppresses superoxide production in healthy rats. Cardiovasc Drugs Ther 23(6):449–458
17. Montecucco F, Pende A, Quercioli A, Mach F (2011) Inflammation in the pathophysiology of essential hypertension. J Nephrol 24(1):23–34
18. Landmesser U, Dikalov S, Price SR, McCann L, Fukai T, Holland SM et al (2003) Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest 111(8):1201–1209
19. Martin C, Cameron J, McGrath B (2008) Mechanical and circulating biomarkers in isolated clinic hypertension. Clin Exp Pharmacol Physiol 35(4):402–408
20. Liu Z, Song Y, Zhang X, Liu Z, Zhang W, Mao W, Wang W, Cui W, Zhang X, Jia X, Li N, Han C, Liu C (2005) Effects of trans-resveratrol on hypertension-induced cardiac hypertrophy using the partially nephrectomized rat model. Clin Exp Pharmacol Physiol 32(12):1049–1054
21. Chander V, Chopra K (2006) Possible role of nitric oxide in the protective effect of resveratrol in 5/6th nephrectomized rats. J Surg Res 133(2):129–135
22. Li J, Zhou Z, Jiang DJ, Li D, Tan B, Liu H et al (2007) Reduction of NO- and EDHF-mediated vasodilatation in hypertension: role of asymmetric dimethylarginine. Clin Exp Hypertens 29(7):489–501
23. Borde P, Mohan M, Kasture S (2011) Effect of myricetin on deoxycorticosterone acetate (DOCA)-salt-hypertensive rats. Nat Prod Res 25(16):1549–1559
24. Castro MM, Rizzi E, Ceron CS, Guimaraes DA, Rodrigues GJ, Bendhack LM, Gerlach RF, Tanus-Santos JE (2012) Doxycycline ameliorates 2 K-1C hypertension-induced vascular dysfunction in rats by attenuating oxidative stress and improving nitric oxide bioavailability. Nitric Oxide 26(3):162–168
25. Gómez-Guzmán M, Jiménez R, Sánchez M, Zarzuelo MJ, Galindo P, Quintela AM et al (2012) Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension. Free Radic Biol Med 52(1):70–79
26. Mizutani K, Ikeda K, Nishikata T, Yamori Y (2000) Phytoestrogens attenuate oxidative DNA damage in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats. J Hypertens 18(12):1833–1840
27. Yan H, Du J, Tang C (2004) The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats. Biochem Biophys Res Commun 313(1):22–27
28. Houtkooper RH, Pirinen E, Auwerx J (2012) Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol 13(4):225–238
29. Arrowsmith CH, Bountra C, Fish PV, Lee K, Schapira M (2012) Epigenetic protein families: a new frontier for drug discovery. Nat Rev Drug Discov 11(5):384–400
30. Wu LP, Wang X, Li L, Zhao Y, Lu S, Yu Y et al (2008) Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter. Mol Cell Biol 28(10):3219–3235
31. Qian W, Miki D, Zhang H, Liu Y, Zhang X, Tang K et al (2012) A histone acetyltransferase regulates active DNA demethylation in Arabidopsis. Science 336(6087):1445–1448
32. Justin N, De Marco V, Aasland R, Gamblin SJ (2010) Reading, writing and editing methylated lysines on histone tails: new insights from recent structural studies. Curr Opin Struct Biol 20(6):730–738