Cohort study: Mendelian randomisation meta-analysis sheds doubt on protective associations between 'moderate' alcohol consumption and coronary heart disease

Evidence-Based Medicine

Volumn 20, Issue 1, 2015, Pages 38-

  Chikritzhs, Tanya N ^a   Naimi, Timothy S ^b   Stockwell, Tim R ^c   Liang, Wenbin ^a  

^a CURTIN UNIVERSITY   (Australia)

^b BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF VICTORIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE;

ALCOHOL CONSUMPTION; ARTICLE; GENETIC VARIABILITY; GENOTYPE; INTENTION TO TREAT ANALYSIS; ISCHEMIC HEART DISEASE; MENDELIAN RANDOMIZATION ANALYSIS; META ANALYSIS (TOPIC); OBSERVATIONAL STUDY; RISK FACTOR; CORONARY DISEASE; DRINKING BEHAVIOR; FEMALE; GENETICS; HUMAN; MALE; SINGLE NUCLEOTIDE POLYMORPHISM; STROKE;

ALCOHOL DEHYDROGENASE; ALCOHOL DRINKING; CORONARY DISEASE; FEMALE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; STROKE;

EID: 84922069458     PISSN: 13565524     EISSN: 14736810     Source Type: Journal    
DOI: 10.1136/ebmed-2014-110086     Document Type: Article

References (4)

1. Holmes M, Dale C, Zuccolo L, et al. Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data. BMJ 2014;349:g4164.
2. Voight B, Peloso G, Orho-Melander M, et al. Plasma HDL cholesterol and risk of myocardial infarction: a Mendelian randomisation study. Lancet 2012;380:572-80.
3. Davey Smith G, Harbord R, Ebrahim S. Fibrinogen, C-reactive protein and coronary heart disease: does Mendelian randomization suggest the associations are non-causal? QJM 2004;97:163-6.
4. Liang W, Chikritzhs T. Observational research on alcohol use and chronic disease outcomes, new approaches to counter biases. Scienti ficWorldJournal 2013. http://dx.doi.org/10.1155/2013/860915