Chaperonin containing TCP1, subunit 8 (CCT8) is upregulated in hepatocellular carcinoma and promotes HCC proliferation

APMIS

Volumn 122, Issue 11, 2014, Pages 1070-1079

  Huang, Xiaodong ^a   Wang, Xingxiu ^a   Cheng, Chun ^a   Cai, Jing ^a   He, Song ^a   Wang, Hua ^a   Liu, Fang ^a   Zhu, Changlai ^a   Ding, Zongmei ^a   Huang, Xianting ^a   Zhang, Tianyi ^a   Zhang, Yixin ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

Chaperonin containing TCP1; Hepatocellular carcinoma; Ki 67; Prognosis; Subunit 8 (CCT8)

Indexed keywords

CHAPERONIN CONTAINING TCP1; CHAPERONIN CONTAINING TCP1 SUBUNIT 8; CYCLINE; KI 67 ANTIGEN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER GRADING; CANCER PROGNOSIS; CANCER STAGING; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IMMUNOCHEMISTRY; IMMUNOHISTOCHEMISTRY; LIVER BIOPSY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MOLECULAR PATHOLOGY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; TUMOR VOLUME; UPREGULATION; GENETICS; LIVER TUMOR; PATHOLOGY; PROGNOSIS; TUMOR CELL LINE;

CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; CHAPERONIN CONTAINING TCP-1; FEMALE; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; S PHASE; UP-REGULATION;

EID: 84922058973     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/apm.12258     Document Type: Article

References (40)

1. Thomas MB, Zhu AX. Hepatocellular carcinoma: the need for progress. J Clin Oncol 2005;23:2892-9.
2. Giannelli G, Antonaci S. Novel concepts in hepatocellular carcinoma: from molecular research to clinical practice. J Clin Gastroenterol 2006;40:842-6.
3. Murray CJ, Lopez AD. Mortality by cause for eight regions of the world: global burden of disease Study. Lancet 1997;349:1269-76.
4. Sherman M. Hepatocellular carcinoma: epidemiology, risk factors, and screening. Semin Liver Dis 2005;25:143-54.
5. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011;61:69-90.
6. Chen JG, Zhang SW, Chen WQ. Analysis of liver cancer mortality in the national retrospective sampling survey of death causes in China, 2004-2005. Zhonghua Yu Fang Yi Xue Za Zhi 2010;44:383-9.
7. Wang H, Wu K, Sun Y, Li Y, Wu M, Qiao Q, et al. STC2 is upregulated in hepatocellular carcinoma and promotes cell proliferation and migration in vitro. BMB Rep 2012;45:629-34.
8. Duffy A, Greten T. Developing better treatments in hepatocellular carcinoma. Expert Rev Gastroenterol Hepatol 2010;4:551-60.
9. Cheung KF, Zhao J, Hao Y, Li X, Lowe AW, Cheng AS, et al. CITED2 is a novel direct effector of peroxisome proliferator-activated receptor gamma in suppressing hepatocellular carcinoma cell growth. Cancer 2013;119:1217-26.
10. Lau WY, Lai EC. Hepatocellular carcinoma: current management and recent advances. Hepatobiliary Pancreat Dis Int 2008;7:237-57.
11. Ke Q, Ji J, Cheng C, Zhang Y, Lu M, Wang Y, et al. Expression and prognostic role of Spy1 as a novel cell cycle protein in hepatocellular carcinoma. Exp Mol Pathol 2009;87:167-72.
12. Kubota H, Hynes G, Willison K. The chaperonin containing t-complex polypeptide 1 (TCP-1). Multisubunit machinery assisting in protein folding and assembly in the eukaryotic cytosol. Eur J Biochem 1995;230:3-16.
13. Liou AK, Willison KR. Elucidation of the subunit orientation in CCT (chaperonin containing TCP1) from the subunit composition of CCT micro-complexes. EMBO J 1997;16:4311-6.
14. Brackley KI, Grantham J. Activities of the chaperonin containing TCP-1 (CCT): implications for cell cycle progression and cytoskeletal organisation. Cell Stress Chaperones 2009;14:23-31.
15. Lin YF, Tsai WP, Liu HG, Liang PH. Intracellular beta-tubulin/chaperonin containing TCP1-beta complex serves as a novel chemotherapeutic target against drug-resistant tumors. Cancer Res 2009;69:6879-88.
16. Tian G, Vainberg IE, Tap WD, Lewis SA, Cowan NJ. Specificity in chaperonin-mediated protein folding. Nature 1995;375:250-3.
17. Frydman J, Hartl FU. Principles of chaperone-assisted protein folding: differences between in vitro and in vivo mechanisms. Science 1996;272:1497-502.
18. Farr GW, Scharl EC, Schumacher RJ, Sondek S, Horwich AL. Chaperonin-mediated folding in the eukaryotic cytosol proceeds through rounds of release of native and nonnative forms. Cell 1997;89:927-37.
19. Thulasiraman V, Yang CF, Frydman J. In vivo newly translated polypeptides are sequestered in a protected folding environment. EMBO J 1999;18:85-95.
20. Won KA, Schumacher RJ, Farr GW, Horwich AL, Reed SI. Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT. Mol Cell Biol 1998;18:7584-9.
21. Guenther MG, Yu J, Kao GD, Yen TJ, Lazar MA. Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. Genes Dev 2002;16:3130-5.
22. Siegers K, Bolter B, Schwarz JP, Bottcher UM, Guha S, Hartl FU. TRiC/CCT cooperates with different upstream chaperones in the folding of distinct protein classes. EMBO J 2003;22:5230-40.
23. Srikakulam R, Winkelmann DA. Myosin II folding is mediated by a molecular chaperonin. J Biol Chem 1999;274:27265-73.
24. Feldman DE, Thulasiraman V, Ferreyra RG, Frydman J. Formation of the VHL-elongin BC tumor suppressor complex is mediated by the chaperonin TRiC. Mol Cell 1999;4:1051-61.
25. Gebauer M, Melki R, Gehring U. The chaperone cofactor Hop/p60 interacts with the cytosolic chaperonin-containing TCP-1 and affects its nucleotide exchange and protein folding activities. J Biol Chem 1998;273:29475-80.
26. Yokota S, Yanagi H, Yura T, Kubota H. Cytosolic chaperonin is up-regulated during cell growth. Preferential expression and binding to tubulin at G(1)/S transition through early S phase. J Biol Chem 1999;274:37070-8.
27. Yokota S, Yamamoto Y, Shimizu K, Momoi H, Kamikawa T, Yamaoka Y, et al. Increased expression of cytosolic chaperonin CCT in human hepatocellular and colonic carcinoma. Cell Stress Chaperones 2001;6:345-50.
28. Grantham J, Brackley KI, Willison KR. Substantial CCT activity is required for cell cycle progression and cytoskeletal organization in mammalian cells. Exp Cell Res 2006;312:2309-24.
29. Shaw PG, Chaerkady R, Wang T, Vasilatos S, Huang Y, Van Houten B, et al. Integrated proteomic and metabolic analysis of breast cancer progression. PLoS ONE 2013;8:e76220.
30. Seiden-Long IM, Brown KR, Shih W, Wigle DA, Radulovich N, Jurisica I, et al. Transcriptional targets of hepatocyte growth factor signaling and Ki-ras oncogene activation in colorectal cancer. Oncogene 2006;25:91-102.
31. Lu M, Ma J, Xue W, Cheng C, Wang Y, Zhao Y, et al. The expression and prognosis of FOXO3a and Skp2 in human hepatocellular carcinoma. Pathol Oncol Res 2009;15:679-87.
32. Deng Q, Wang Q, Zong WY, Zheng DL, Wen YX, Wang KS, et al. E2F8 contributes to human hepatocellular carcinoma via regulating cell proliferation. Cancer Res 2010;70:782-91.
33. Woelfle U, Cloos J, Sauter G, Riethdorf L, Janicke F, van Diest P, et al. Molecular signature associated with bone marrow micrometastasis in human breast cancer. Cancer Res 2003;63:5679-84.
34. Coghlin C, Carpenter B, Dundas SR, Lawrie LC, Telfer C, Murray GI. Characterization and over-expression of chaperonin t-complex proteins in colorectal cancer. J Pathol 2006;210:351-7.
35. Simonetti RG, Camma C, Fiorello F, Politi F, D'Amico G, Pagliaro L. Hepatocellular carcinoma. A worldwide problem and the major risk factors. Dig Dis Sci 1991;36:962-72.
36. Grazi GL, Ercolani G, Pierangeli F, Del Gaudio M, Cescon M, Cavallari A, et al. Improved results of liver resection for hepatocellular carcinoma on cirrhosis give the procedure added value. Ann Surg 2001;234:71-8.
37. Kubota H, Hynes G, Willison K. The eighth Cct gene, Cctq, encoding the theta subunit of the cytosolic chaperonin containing TCP-1. Gene 1995;154:231-6.
38. Willison KR, Hynes G, Davies P, Goldsborough A, Lewis VA. Expression of three t-complex genes, Tcp-1, D17Leh117c3, and D17Leh66, in purified murine spermatogenic cell populations. Genet Res 1990;56:193-201.
39. Kubota H, Willison K, Ashworth A, Nozaki M, Miyamoto H, Yamamoto H, et al. Structure and expression of the gene encoding mouse t-complex polypeptide (Tcp-1). Gene 1992;120:207-15.
40. Camasses A, Bogdanova A, Shevchenko A, Zachariae W. The CCT chaperonin promotes activation of the anaphase-promoting complex through the generation of functional Cdc20. Mol Cell 2003;12:87-100.