Defining acute ischemic stroke tissue pathophysiology with whole brain CT perfusion

Journal of Neuroradiology

Volumn 41, Issue 5, 2014, Pages 307-315

  Bivard, A ^a   Levi, C ^b   Krishnamurthy, V ^b   Hislop Jambrich, J ^c   Salazar, P ^d   Jackson, B ^d   Davis, S ^a   Parsons, M ^b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF NEWCASTLE   (Australia)

^c Toshiba Medical System Corporations   (Japan)

^d Vital Images   (United States)

Author keywords

Acute stroke; Ischemic core; Penumbra; Perfusion CT

Indexed keywords

ADULT; AGED; ARTICLE; BRAIN BLOOD FLOW; BRAIN BLOOD VOLUME; BRAIN ISCHEMIA; BRAIN PERFUSION; COMPUTED TOMOGRAPHY SCANNER; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIFFUSION WEIGHTED IMAGING; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MATHEMATICAL MODEL; MEAN TRANSIT TIME; NUCLEAR MAGNETIC RESONANCE SCANNER; PATHOPHYSIOLOGY; PERFUSION WEIGHTED IMAGING; PHASE 2 CLINICAL TRIAL; REPERFUSION; RETROSPECTIVE STUDY; TIME TO PEAK; BLOOD FLOW VELOCITY; BRAIN ANGIOGRAPHY; BRAIN CIRCULATION; COMPLICATION; COMPUTER ASSISTED DIAGNOSIS; FEMALE; MALE; MIDDLE AGED; PATHOLOGY; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; STROKE; VALIDATION STUDY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BLOOD FLOW VELOCITY; BRAIN ISCHEMIA; CEREBRAL ANGIOGRAPHY; CEREBROVASCULAR CIRCULATION; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MALE; MIDDLE AGED; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; STROKE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84922056276     PISSN: 01509861     EISSN: 17730406     Source Type: Journal    
DOI: 10.1016/j.neurad.2013.11.006     Document Type: Article

References (26)

1. Adams H.P., del Zoppo G., Alberts M.J., Bhatt D.L., Brass L., Furlan A., et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Stroke 2007, 38(5):1655-1711.
2. Yaghi S., Bianchi N., Amole A., Hinduja A. ASPECTS is a predictor of favorable CT perfusion in acute ischemic stroke. J Neuroradiol 2013, pii: S0150-9861.
3. Fustier A., Naggara O., Tisserand M., Touzé E., Mellerio C., Edjlali M., et al. Total mismatch in anterior circulation stroke patients before thrombolysis. J Neuroradiol 2013, 40(3):158-163.
4. Bivard A., Spratt N., Levi C.R., Parsons M.W. Acute stroke thrombolysis: time to dispense with the clock and move to tissue-based decision making?. Expert Rev Cardiovasc Ther 2011, 9:451-461.
5. Tarpley J., Franc D., Tansy A.P., Liebeskind D.S. Use of perfusion imaging and other imaging techniques to assess risks/benefits of acute stroke interventions. Curr Atheroscler Rep 2013, 15(7):336.
6. Baird A.E., Benfield A., Schlaug G., Siewert B., Lövblad K.O., Edelman R.R., et al. Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging. Ann Neurol 1997, 41(5):581-589.
7. Lövblad K.O., Baird A.E., Schlaug G., Benfield A., Siewert B., Voetsch B., et al. Ischemic lesion volumes in acute stroke by diffusion-weighted magnetic resonance imaging correlate with clinical outcome. Ann Neurol 1997, 42(2):164-170.
8. Thierfelder K.M., Sommer W.H., Baumann A.B., Klotz E., Meinel F.G., Strobl F.F., et al. Whole-brain CT perfusion: reliability and reproducibility of volumetric perfusion deficit assessment in patients with acute ischemic stroke. Neuroradiol 2013, 55(7):827-835.
9. Bivard A., McElduff P., Spratt N., Levi C., Parsons M. Defining the extent of irreversible brain ischemia using perfusion computed tomography. Cerebrovasc Dis 2011, 31(3):238-245.
10. Bouts M.J., Tiebosch I.A., van der Toorn A., Viergever M.A., Wu O., Dijkhuizen R.M. Early identification of potentially salvageable tissue with MRI-based predictive algorithms after experimental ischemic stroke. J Cereb Blood Flow Metab 2013, 33(7):1075-1082.
11. Lövblad K.O., Altrichter S., Viallon M., Sztajzel R., Delavelle J., Vargas M.I., et al. Neuro-imaging of cerebral ischemic stroke. J Neuroradiol 2008, 35(4):197-209.
12. Parsons M.W., Miteff F., Bateman G.A., Spratt N., Loiselle A., Attia J., et al. Acute ischemic stroke: imaging-guided tenecteplase treatment in an extended time window. Neurology 2009, 72(10):915-921.
13. Parsons M.W., Pepper E.M., Bateman G.A., Wang Y., Levi C.R. Identification of the penumbra and infarct core on hyperacute noncontrast and perfusion CT. Neurology 2007, 68(10):730-736.
14. Lettau M., Laible M. 3-T high-b-value diffusion-weighted MR imaging in hyperacute ischemic stroke. J Neuroradiol 2013, 40(3):149-157.
15. Wintermark M., Flanders A.E., Velthuis B., Meuli R., van Leeuwen M., Goldsher D., et al. Perfusion-CT assessment of infarct core and penumbra: receiver operating characteristic curve analysis in 130patients suspected of acute hemispheric stroke. Stroke 2006, 37:979-985.
16. Miteff F., Levi C.R., Bateman G.A., Spratt N., McElduff P., Parsons M.W. The independent predictive utility of computed tomography angiographic collateral status in acute ischaemic stroke. Brain 2009, 132(8):2231-2238.
17. Campbell B.C., Christensen S., Levi C.R., Desmond P.M., Donnan G.A., Davis S.M., et al. Cerebral blood flow is the optimal CT perfusion parameter for assessing infarct core. Stroke 2011, 42(12):3435-3440.
18. Bivard A., Levi C., Spratt N., Parsons M. Perfusion CT in acute stroke: a comprehensive analysis of infarct and penumbra. Radiology 2013, 267(2):543-550.
19. Besbroek J.M., Niesten J.M., Dankbaar J.W., Biessels G.J., Velthuis B.K., Reitsma J.B., et al. Diagnostic accuracy of CT perfusion imaging for detecting acute ischemic stroke: a systematic review and meta-analysis. Cerebrovasc Dis 2013, 35:493-501.
20. Kidwell C.S., Saver J.L., Mattiello J., Starkman S., Vinuela F., Duckwiler G. Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging. Ann Neurol 2000, 47:462-469.
21. Chalela J.A., Ezzeddine M.A., Calabrese T.M., Latour L.L., Baird A.E., Luby Diffusion and perfusion changes two hours after intravenous RT-PA therapy: a preliminary report. Stroke 2002, 33:356-357.
22. Inoue M., Mlynash M., Straka M., Kemp S., Jovin T.G., Tipirneni A., et al. Clinical outcomes strongly associated with the degree of reperfusion achieved in target mismatch patients: pooled data from the diffusion and perfusion imaging evaluation for understanding stroke evolution studies. Stroke 2013, 44(7):1885-1890.
23. Eilaghi A., Brooks J., d'Esterre C., Zhang L., Swartz R.H., Lee T.Y., et al. Reperfusion is a stronger predictor of good clinical outcome than recanalization in ischemic stroke. Radiology 2013, 269(1):240-248.
24. Knoepfli A.S., Sekoranja L., Bonvin C., Delavelle J., Kulcsar Z., Rüfenacht D., et al. Evaluation of perfusion CT and TIBI grade in acute stroke for predicting thrombolysis benefit and clinical outcome. J Neuroradiol 2009, 36(3):131-137.
25. Bivard A., Spratt N., Levi C., Parsons M. Perfusion computer tomography: imaging and clinical validation in acute ischaemic stroke. Brain 2011, 134:3408-3416.
26. Hakimelahi R., Yoo A.J., He J., Schwamm L.H., Lev M.H., Schaefer P.W., et al. Rapid identification of a major diffusion/perfusion mismatch in distal internal carotid artery or middle cerebral artery ischemic stroke. BMC Neurol 2012, 12:132.