Is frozen embryo transfer cycle associated with a significantly lower incidence of ectopic pregnancy? An analysis of more than 30,000 cycles

Fertility and Sterility

Volumn 102, Issue 5, 2014, Pages 1345-1349

  Huang, Bo ^a   Hu, Dan ^a   Qian, Kun ^a   Ai, Jihui ^a   Li, Yufeng ^a   Jin, Lei ^a   Zhu, Guijin ^a   Zhang, Hanwang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Ectopic pregnancy; Embryo cryopreservation; Fresh cycle; Frozen thawed ET; Ovarian stimulation

Indexed keywords

CHORIONIC GONADOTROPIN; ESTRADIOL; ESTRADIOL VALERATE; GONADORELIN AGONIST; LUTEINIZING HORMONE; PROGESTERONE; RECOMBINANT CHORIONIC GONADOTROPIN; RECOMBINANT FOLLITROPIN; TRIPTORELIN;

ARTICLE; BLASTOCYST; COHORT ANALYSIS; CONTROLLED STUDY; CRYOPRESERVATION; ECTOPIC PREGNANCY; EMBRYO; EMBRYO CELL; EMBRYO TRANSFER; ENDOMETRIAL THICKNESS; ESTRADIOL BLOOD LEVEL; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; FREEZE THAWING; FROZEN THAWED EMBRYO TRANSFER; GESTATIONAL SAC; HUMAN; HUMAN CELL; INCIDENCE; INTRACYTOPLASMIC SPERM INJECTION; MAJOR CLINICAL STUDY; OOCYTE RETRIEVAL; OUTCOME ASSESSMENT; PREGNANCY RATE; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; RETROSPECTIVE STUDY; SPERM QUALITY; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; TRANSVAGINAL ECHOGRAPHY; ADULT; ANIMAL EMBRYO; CHINA; INFERTILITY; MIDDLE AGED; OVULATION INDUCTION; PREGNANCY; PREGNANCY OUTCOME; PREGNANCY, ECTOPIC; RISK ASSESSMENT; STATISTICS AND NUMERICAL DATA; TREATMENT OUTCOME; YOUNG ADULT;

ADULT; CHINA; CRYOPRESERVATION; EMBRYO TRANSFER; EMBRYO, MAMMALIAN; FEMALE; FERTILIZATION IN VITRO; HUMANS; INCIDENCE; INFERTILITY; MIDDLE AGED; OVULATION INDUCTION; PREGNANCY; PREGNANCY OUTCOME; PREGNANCY, ECTOPIC; RETROSPECTIVE STUDIES; RISK ASSESSMENT; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84922012092     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2014.07.1245     Document Type: Article

References (30)

1. Walker JJ. Ectopic pregnancy. Clin Obstet Gynecol 2007;50:89-99.
2. Varma R, Gupta J. Tubal ectopic pregnancy. Clin Evid (Online) 2009;2009:1406.
3. Bouyer J, Coste J, Shojaei T, Pouly JL, Fernandez H, Gerbaud L, et al. Risk factors for ectopic pregnancy: a comprehensive analysis based on a large case-control, population-based study in France. Am J Epidemiol 2003;157:185-94.
4. Shaw JL, Dey SK, Critchley HO, Horne AW. Current knowledge of the aetiology of human tubal ectopic pregnancy. Hum Reprod Update 2010;16:432-44.
5. Steptoe PC, Edwards RG. Reimplantation of a human embryo with subsequent tubal pregnancy. Lancet 1976;1:880-2.
6. Revel A, Ophir I, Koler M, Achache H, Prus D. Changing etiology of tubal pregnancy following IVF. Hum Reprod 2008;23:1372-6.
7. Pisarska MD, Carson SA, Buster JE. Ectopic pregnancy. Lancet 1998;351:1115-20.
8. Farquhar CM. Ectopic pregnancy. Lancet 2005;366:583-91.
9. Marcus SF, Brinsden PR. Analysis of the incidence and risk factors associated with ectopic pregnancy following in-vitro fertilization and embryo transfer. Hum Reprod 1995;10:199-203.
10. Clayton HB, Schieve LA, Peterson HB, Jamieson DJ, Reynolds MA, Wright VC. Ectopic pregnancy risk with assisted reproductive technology procedures. Obstet Gynecol 2006;107:595-604.
11. Killick SR. Ultrasound and the receptivity of the endometrium. Reprod Biomed Online 2007;15:63-7.
12. Lesny P, Killick SR. The junctional zone of the uterus and its contractions. BJOG 2004;111:1182-9.
13. Paltieli Y, Eibschitz I, Ziskind G, Ohel G, Silbermann M, Weichselbaum A. High progesterone levels and ciliary dysfunction - a possible cause of ectopic pregnancy. J Assist Reprod Genet 2000;17:103-6.
14. Shapiro BS, Daneshmand ST, De Leon L, Garner FC, Aguirre M, Hudson C. Frozen-thawed embryo transfer is associated with a significantly reduced incidence of ectopic pregnancy. Fertil Steril 2012;98:1490-4.
15. Ishihara O, Kuwahara A, Saitoh H. Frozen-thawed blastocyst transfer reduces ectopic pregnancy risk: an analysis of single embryo transfer cycles in Japan. Fertil Steril 2011;95:1966-9.
16. Decleer W, Osmanagaoglu K, Meganck G, Devroey P. Slightly lower incidence of ectopic pregnancies in frozen embryo transfer cycles versus fresh in vitro fertilization-embryo transfer cycles: a retrospective cohort study. Fertil Steril 2014;101:162-5.
17. Huang B, Li Z, Zhu L, Hu D, Liu Q, Zhu G, et al. Progesterone elevation on the day of HCG administration may affect rescue ICSI. Reprod Biomed Online 2014;29:88-93.
18. World Health Organization. Laboratory manual for the examination and processing of human semen. 5th ed. Geneva: WHO; 2010.
19. Zhu L, Xi Q, Zhang H, Li Y, Ai J, Jin L. Blastocyst culture and cryopreservation to optimize clinical outcomes of warming cycles. Reprod Biomed Online 2013;27:154-60.
20. Barnhart K, van Mello NM, Bourne T, Kirk E, Van Calster B, Bottomley C, et al. Pregnancy of unknown location: a consensus statement of nomenclature, definitions, and outcome. Fertil Steril 2011;95:857-66.
21. Strandell A, Thorburn J, Hamberger L. Risk factors for ectopic pregnancy in assisted reproduction. Fertil Steril 1999;71:282-6.
22. Lyons RA, Saridogan E, Djahanbakhch O. The reproductive significance of human fallopian tube cilia. Hum Reprod Update 2006;12:363-72.
23. Wanggren K, Stavreus-Evers A, Olsson C, Andersson E, Gemzell-Danielsson K. Regulation of muscular contractions in the human Fallopian tube through prostaglandins and progestagens. Hum Reprod 2008;23:2359-68.
24. Wanggren K, Lalitkumar PG, Stavreus-Evers A, Stabi B, Gemzell-Danielsson K. Prostaglandin E2 and F2α receptors in the human fallopian tube before and after mifepristone treatment. Mol Hum Reprod 2006;12:577-85.
25. Lavy G, Diamond MP, DeCherney AH. Ectopic pregnancy: its relationship to tubal reconstructive surgery. Fertil Steril 1987;47:543-56.
26. Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfer in normal responders. Fertil Steril 2011;96:344-8.
27. Mikolajczyk M, Skrzypczak J. Endometrial receptivity - can it be diagnosed and controlled? And why does it matter? Ginekol Pol 2014;85:149-53.
28. von Grothusen C, Lalitkumar S, Rao Boggavarapu N, Gemzell-Danielsson K, Lalitkumar PG. Recent advances in understanding endometrial receptivity: molecular basis and clinical applications. Am J Reprod Immunol 2014;72:148-57.
29. Bermejo A, Iglesias C, Ruiz-AlonsoM, Blesa D, Simon C, Pellicer A, et al. The impact of using the combined oral contraceptive pill for cycle scheduling on gene expression related to endometrial receptivity. Hum Reprod 2014;29:1271-8.
30. Jun SH, Milki AA. Ectopic pregnancy rates with frozen compared with fresh blastocyst transfer. Fertil Steril 2007;88:629-31.