7-Nitroindazole Attenuates 6-Hydroxydopamine-Induced Spatial Learning Deficits and Dopamine Neuron Loss in a Presymptomatic Animal Model of Parkinson's Disease

Experimental and Clinical Psychopharmacology

Volumn 16, Issue 2, 2008, Pages 178-189

  Haik, Kristi L ^a,b   Shear, Deborah A ^b,c   Hargrove, Chad ^a   Patton, Jared ^a   Mazei Robison, Michelle ^b,d   Sandstrom, Michael I ^e   Dunbar, Gary L ^b  

^a NORTHERN KENTUCKY UNIVERSITY   (United States)

^b Field Neurosciences Laboratory for Restorative Neurology   (United States)

^c WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e CENTRAL MICHIGAN UNIVERSITY   (United States)

Author keywords

dopamine immunohistochemistry; NADPH diaphorase staining; Parkinson's disease; spatial learning; water T maze

Indexed keywords

7 NITROINDAZOLE; FREE RADICAL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; OXIDOPAMINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CLINICAL FEATURE; COGNITIVE DEFECT; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOPAMINERGIC NERVE CELL; DRUG MECHANISM; EARLY DIAGNOSIS; EARLY INTERVENTION; IMMUNOHISTOCHEMISTRY; LEARNING DISORDER; MALE; MAZE TEST; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PROPHYLAXIS; RAT; SENSORIMOTOR CORTEX; SUBSTANTIA NIGRA; TASK PERFORMANCE;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; DOPAMINE; INDAZOLES; LEARNING DISORDERS; MALE; MAZE LEARNING; NADP; NEURONS; NEUROPROTECTIVE AGENTS; OXIDOPAMINE; PARKINSON DISEASE; PSYCHOMOTOR PERFORMANCE; RATS; RATS, SPRAGUE-DAWLEY; SPATIAL BEHAVIOR; SUBSTANTIA NIGRA;

EID: 43549116644     PISSN: 10641297     EISSN: None     Source Type: Journal    
DOI: 10.1037/1064-1297.16.2.178     Document Type: Article

References (112)