The effect of sildenafil and udenafil on testicular damage following ischemia-reperfusion injury in rats

Journal of Urology

Volumn 192, Issue 4, 2014, Pages 1272-1277

  Özgür, Berat Cem ^a   Telli, Onur ^a   Yuceturk, Cem Nedim ^a   Sarici, Haşmet ^a   Ozer, Elif ^a   Surer, Hatice ^a   Kilinc, Aytun Sadan ^a   Hucumenoglu, Sema ^a   Eroglu, Muzaffer ^a  

^a Ankara Research and Training Hospital   (Turkey)

Author keywords

reperfusion injury; sildenafil; spermatic cord torsion; testis; udenafil

Indexed keywords

MALONALDEHYDE; NITRITE; SILDENAFIL; THIOL DERIVATIVE; UDENAFIL; PHOSPHODIESTERASE V INHIBITOR; PIPERAZINE DERIVATIVE; PURINE DERIVATIVE; PYRIMIDINE DERIVATIVE; SULFONAMIDE; SULFONE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING; CONTROLLED STUDY; EDEMA; HISTOPATHOLOGY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; TESTIS INJURY; TESTIS TORSION; TISSUE LEVEL; ANIMAL; COMPARATIVE STUDY; COMPLICATION; DISEASE MODEL; DRUG COMBINATION; DRUG EFFECTS; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; TESTICULAR DISEASES; TESTIS;

ANIMALS; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; INJECTIONS, INTRAPERITONEAL; MALE; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PURINES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SULFONAMIDES; SULFONES; TESTICULAR DISEASES; TESTIS;

EID: 84921952594     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2014.04.011     Document Type: Article

References (28)

1. A.H. Salmasi, A. Beheshtian, and S. Payabvash Effect of morphine on ischemia-reperfusion injury: experimental study in testicular torsion rat model Urology 66 2005 1338
2. Y.T. Wong, R. Ruan, and F.E.H. Tay Relationship between levels of oxidative DNA damage, lipid peroxidation and mitochondrial membrane potential in young and old F344 rats Free Radic Res 40 2006 393
3. L. Tian, Q. Cai, and H. Wei Alterations of antioxidant enzymes and oxidative damage to macromolecules in different organs of rats during aging Free Radic Biol Med 24 1998 1477
4. W. Wasowicz, J. Neve, and A. Peretz Optimized steps in fluorometric determination of thiobarbituric acid-reactive substance in serum: importance of extraction pH and influence of sample preservation and storage Clin Chem 39 1993 2522
5. J. Sedlak, and R.H. Lindsay Estimation of total, protein bound, and non-protein sulfhydryl groups in tissue with Ellman's reagent Anal Biochem 25 1968 192
6. A.K. Smarason, K.G. Allman, and D. Young Elevated levels of serum nitrate, a stable end product of nitric oxide, in women with pre-eclampsia Br J Obstet Gynaecol 104 1997 538
7. M.J. Cosentino, M. Nishida, and R. Rabinowitz Histological changes occurring in the contralateral testes of prepubertal rats subjected to various durations of unilateral spermatic cord torsion J Urol 133 1985 906
8. J.B. Anderson, and R.C.N. Williamson The fate of human testis following unilateral torsion of the spermatic cord Br J Urol 58 1986 698
9. G. Bartsch, S. Frank, and H. Marberger Testicular torsion: late results with special regard to fertility and endocrine function J Urol 124 1980 375
10. D. Wilhelm Filho, M.A. Torres, and A.L. Bordin Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury Mol Aspects Med 25 2004 199
11. H. Ardehali, and B. O'Rourke Mitochondrial K (ATP) channels in cell survival and death J Mol Cell Cardiol 39 2005 7
12. B. Erol, H. Tokgoz, and V. Hanci Vardenafil reduces testicular damage following ischemia/reperfusion injury in rats Kaohsiung J Med Sci 25 2009 374
13. D.L. Carden, and D.N. Granger Pathophysiology of ischaemia-reperfusion injury J Pathol 190 2000 255
14. H. Yasa, N. Yakut, and B. Emrecan Protective effects of levosimendan and iloprost on lung injury induced by limb ischemia-reperfusion: a rabbit model J Surg Res 147 2008 138
15. H. Okutan, C. Savas, and N. Delibas The antioxidant effect of melatonin in lung injury after aortic occlusion-reperfusion Interact Cardiovasc Thorac Surg 3 2004 519
16. S.B. Guimarães, O.S. Kimura, and P.R. Vasconcelos Dimethylsulfoxide attenuates ischemia-reperfusion injury in rat testis Acta Cir Bras 25 2010 357
17. S. Somuncu, M. Cakmak, and S. Erdogan Protective effects of trapidil in ischemia reperfusion injury due to testicular torsion and detorsion: an experimental study Int J Urol 13 2006 601
18. F.N. Salloum, R.A. Ockaili, and M. Wittkamp Vardenafil: a novel type 5 phosphodiesterase inhibitor reduces myocardial infarct size following ischemia/reperfusion injury via opening of mitochondrial K(ATP) channels in rabbits J Mol Cell Cardiol 40 2006 405
19. T.M. Kolettis, K. Kontaras, and I. Spartinos Dose-dependent effects of sildenafil on post-ischaemic left ventricular function in the rat isolated heart J Pharm Pharmacol 62 2010 346
20. U. Koltuksuz, M.K. Irmak, and A. Karaman Testicular nitric oxide levels after unilateral testicular torsion/detorsion in rats pretreated with caffeic acid phenethyl ester Urol Res 28 2000 360
21. H.M. Prillaman, and T.T. Turner Rescue of testicular function after acute experimental torsion J Urol 157 1997 340
22. E.F. du Toit, E. Rossouw, and R. Salie Effect of sildenafil on reperfusion function, infarct size, and cyclic nucleotide levels in the isolated rat heart model Cardiovasc Drugs Ther 19 2005 23
23. H. YIldIz, A.S. Durmus, and H. Şimşek Dose-dependent protective effect of sildenafil citrate on testicular injury after torsion/detorsion in rats Andrologia 44 suppl. 2012 300
24. C. Zhao, S. Kim, and D. Yang Efficacy and safety of once daily dosing of udenafil in the treatment of erectile dysfunction: results of a multicenter, randomized, double-blind, placebo-controlled trial Eur Urol 60 2011 380
25. M.O. Istanbulluoglu, M. Zor, and A. Celik Effects of vardenafil on testicular torsion/detorsion damage: an experimental study in pigs Urol Int 86 2011 228
26. J.G. Mogilner, M. Lurie, and A.G. Coran Effect of diclofenac on germ cell apoptosis following testicular ischemia-reperfusion injury in a rat Pediatr Surg Int 22 2006 99
27. F. Andiran, D.H. Okur, and A. Kilinc Do experimentally induced ipsilateral testicular torsion, vas deferens obstruction, intra-abdominal testis or venous obstruction damage the contralateral testis through a common mechanism? BJU Int 85 2000 330
28. A. Unsal, E. Devrim, and C. Guven Propofol attenuates reperfusion injury after testicular torsion and detorsion World J Urol 22 2004 461