-
1
-
-
84872900275
-
Genetic determinants of cardiometabolic risk: A proposed model for phenotype association and interaction
-
Blackett, P. R., and D. K. Sanghera . 2013 . Genetic determinants of cardiometabolic risk: a proposed model for phenotype association and interaction. J. Clin. Lipidol. 7 : 65-81 .
-
(2013)
J. Clin. Lipidol.
, vol.7
, pp. 65-81
-
-
Blackett, P.R.1
Sanghera, D.K.2
-
2
-
-
0036738444
-
Regulation of hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and cholesterol 7alpha-hydroxylase mRNAs in human liver
-
Rudling, M., B. Angelin, L. Stahle, E. Reihner, S. Sahlin, H. Olivecrona, I. Bjorkhem, and C. Einarsson . 2002 . Regulation of hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and cholesterol 7alpha-hydroxylase mRNAs in human liver. J. Clin. Endocrinol. Metab. 87 : 4307-4313 .
-
(2002)
J. Clin. Endocrinol. Metab.
, vol.87
, pp. 4307-4313
-
-
Rudling, M.1
Angelin, B.2
Stahle, L.3
Reihner, E.4
Sahlin, S.5
Olivecrona, H.6
Bjorkhem, I.7
Einarsson, C.8
-
3
-
-
0036864411
-
Sterol regulatory element-binding proteins: Transcriptional activators of lipid synthesis
-
Horton, J. D. 2002 . Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis. Biochem. Soc. Trans. 30 : 1091-1095 .
-
(2002)
Biochem. Soc. Trans.
, vol.30
, pp. 1091-1095
-
-
Horton, J.D.1
-
4
-
-
84860383419
-
The biology and therapeutic targeting of the proprotein convertases
-
Seidah, N. G., and A. Prat . 2012 . The biology and therapeutic targeting of the proprotein convertases. Nat. Rev. Drug Discov. 11 : 367-383 .
-
(2012)
Nat. Rev. Drug Discov.
, vol.11
, pp. 367-383
-
-
Seidah, N.G.1
Prat, A.2
-
5
-
-
84875460859
-
Low density lipoprotein binds to proprotein convertase subtilisin/ kexin type-9 (PCSK9) in human plasma and inhibits PCSK9-mediated low density lipoprotein receptor degradation
-
Kosenko, T., M. Golder, G. Leblond, W. Weng, and T. A. Lagace . 2013 . Low density lipoprotein binds to proprotein convertase subtilisin/ kexin type-9 (PCSK9) in human plasma and inhibits PCSK9-mediated low density lipoprotein receptor degradation. J. Biol. Chem. 288 : 8279-8288 .
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 8279-8288
-
-
Kosenko, T.1
Golder, M.2
Leblond, G.3
Weng, W.4
Lagace, T.A.5
-
6
-
-
40949136906
-
PCSK9: An enigmatic protease
-
Lopez, D. 2008 . PCSK9: an enigmatic protease. Biochim. Biophys. Acta . 1781 : 184-191 .
-
(2008)
Biochim. Biophys. Acta
, vol.1781
, pp. 184-191
-
-
Lopez, D.1
-
7
-
-
78649755606
-
Serum PCSK9 is associated with multiple metabolic factors in a large Han Chinese population
-
Cui, Q., X. Ju, T. Yang, M. Zhang, W. Tang, Q. Chen, Y. Hu, J. V. Haas, J. S. Troutt, R. T. Pickard, et al . 2010 . Serum PCSK9 is associated with multiple metabolic factors in a large Han Chinese population. Atherosclerosis . 213 : 632-636 .
-
(2010)
Atherosclerosis
, vol.213
, pp. 632-636
-
-
Cui, Q.1
Ju, X.2
Yang, T.3
Zhang, M.4
Tang, W.5
Chen, Q.6
Hu, Y.7
Haas, J.V.8
Troutt, J.S.9
Pickard, R.T.10
-
8
-
-
67650263873
-
Genetic and metabolic determinants of plasma PCSK9 levels
-
Lakoski, S. G., T. A. Lagace, J. C. Cohen, J. D. Horton, and H. H. Hobbs . 2009 . Genetic and metabolic determinants of plasma PCSK9 levels. J. Clin. Endocrinol. Metab. 94 : 2537-2543 .
-
(2009)
J. Clin. Endocrinol. Metab.
, vol.94
, pp. 2537-2543
-
-
Lakoski, S.G.1
Lagace, T.A.2
Cohen, J.C.3
Horton, J.D.4
Hobbs, H.H.5
-
9
-
-
33645103550
-
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
-
Cohen, J. C., E. Boerwinkle, T. H. Mosley, Jr ., and H. H. Hobbs . 2006 . Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N. Engl. J. Med. 354 : 1264-1272 .
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 1264-1272
-
-
Cohen, J.C.1
Boerwinkle, E.2
Mosley, T.H.3
Hobbs, H.H.4
-
10
-
-
0037603589
-
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
-
Abifadel, M., M. Varret, J. P. Rabes, D. Allard, K. Ouguerram, M. Devillers, C. Cruaud, S. Benjannet, L. Wickham, D. Erlich, et al . 2003 . Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat. Genet. 34 : 154-156 .
-
(2003)
Nat. Genet.
, vol.34
, pp. 154-156
-
-
Abifadel, M.1
Varret, M.2
Rabes, J.P.3
Allard, D.4
Ouguerram, K.5
Devillers, M.6
Cruaud, C.7
Benjannet, S.8
Wickham, L.9
Erlich, D.10
-
11
-
-
84861528559
-
Common and low-frequency genetic variants in the PCSK9 locus influence circulating PCSK9 levels
-
Chernogubova, E., R. Strawbridge, H. Mahdessian, A. Malarstig, S. Krapivner, B. Gigante, M. L. Hellenius, U. de Faire, A. Franco-Cereceda, A. C. Syvanen, et al . 2012 . Common and low-frequency genetic variants in the PCSK9 locus infl uence circulating PCSK9 levels. Arterioscler. Thromb. Vasc. Biol. 32 : 1526-1534 .
-
(2012)
Arterioscler. Thromb. Vasc. Biol.
, vol.32
, pp. 1526-1534
-
-
Chernogubova, E.1
Strawbridge, R.2
Mahdessian, H.3
Malarstig, A.4
Krapivner, S.5
Gigante, B.6
Hellenius, M.L.7
De Faire, U.8
Franco-Cereceda, A.9
Syvanen, A.C.10
-
12
-
-
84866924889
-
Loss- and gain-of-function PCSK9 variants: Cleavage specifi city, dominant negative effects, and low density lipoprotein receptor (LDLR) degradation
-
Benjannet, S., J. Hamelin, M. Chretien, and N. G. Seidah . 2012 . Loss- and gain-of-function PCSK9 variants: cleavage specifi city, dominant negative effects, and low density lipoprotein receptor (LDLR) degradation. J. Biol. Chem. 287 : 33745-33755 .
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 33745-33755
-
-
Benjannet, S.1
Hamelin, J.2
Chretien, M.3
Seidah, N.G.4
-
13
-
-
67649842300
-
Importance of proprotein convertase subtilisin/kexin type 9 in the hormonal and dietary regulation of rat liver low-density lipoprotein receptors
-
Persson, L., C. Galman, B. Angelin, and M. Rudling . 2009 . Importance of proprotein convertase subtilisin/kexin type 9 in the hormonal and dietary regulation of rat liver low-density lipoprotein receptors. Endocrinology . 150 : 1140-1146 .
-
(2009)
Endocrinology
, vol.150
, pp. 1140-1146
-
-
Persson, L.1
Galman, C.2
Angelin, B.3
Rudling, M.4
-
14
-
-
84857652540
-
Endogenous estrogens lower plasma PCSK9 and LDL cholesterol but not Lp(a) or bile acid synthesis in women
-
Persson, L., P. Henriksson, E. Westerlund, O. Hovatta, B. Angelin, and M. Rudling . 2012 . Endogenous estrogens lower plasma PCSK9 and LDL cholesterol but not Lp(a) or bile acid synthesis in women. Arterioscler. Thromb. Vasc. Biol. 32 : 810-814 .
-
(2012)
Arterioscler. Thromb. Vasc. Biol.
, vol.32
, pp. 810-814
-
-
Persson, L.1
Henriksson, P.2
Westerlund, E.3
Hovatta, O.4
Angelin, B.5
Rudling, M.6
-
15
-
-
26444501044
-
Pituitary control of cholesterol metabolism in normal and LDL receptor knock-out mice: Effects of hypophysectomy and growth hormone treatment
-
Matasconi, M., P. Parini, B. Angelin, and M. Rudling . 2005 . Pituitary control of cholesterol metabolism in normal and LDL receptor knock-out mice: effects of hypophysectomy and growth hormone treatment. Biochim. Biophys. Acta . 1736 : 221-227 .
-
(2005)
Biochim. Biophys. Acta
, vol.1736
, pp. 221-227
-
-
Matasconi, M.1
Parini, P.2
Angelin, B.3
Rudling, M.4
-
16
-
-
33646547336
-
Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c
-
Costet, P., B. Cariou, G. Lambert, F. Lalanne, B. Lardeux, A. L. Jarnoux, A. Grefhorst, B. Staels, and M. Krempf . 2006 . Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c. J. Biol. Chem. 281 : 6211-6218 .
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 6211-6218
-
-
Costet, P.1
Cariou, B.2
Lambert, G.3
Lalanne, F.4
Lardeux, B.5
Jarnoux, A.L.6
Grefhorst, A.7
Staels, B.8
Krempf, M.9
-
17
-
-
84912002789
-
Thyroid hormone reduces PCSK9 and stimulates bile acid synthesis in humans
-
Bonde, Y., O. Breuer, D. Lutjohann, S. Sjoberg, B. Angelin, and M. Rudling . 2014 . Thyroid hormone reduces PCSK9 and stimulates bile acid synthesis in humans. J. Lipid Res. 55 : 2408-2415 .
-
(2014)
J. Lipid Res.
, vol.55
, pp. 2408-2415
-
-
Bonde, Y.1
Breuer, O.2
Lutjohann, D.3
Sjoberg, S.4
Angelin, B.5
Rudling, M.6
-
18
-
-
0022404596
-
Kinetic mechanisms determining variability in low density lipoprotein levels and rise with age
-
Grundy, S. M., G. L. Vega, and D. W. Bilheimer . 1985 . Kinetic mechanisms determining variability in low density lipoprotein levels and rise with age. Arteriosclerosis . 5 : 623-630 .
-
(1985)
Arteriosclerosis
, vol.5
, pp. 623-630
-
-
Grundy, S.M.1
Vega, G.L.2
Bilheimer, D.W.3
-
19
-
-
0026029119
-
Influence of age on the metabolism of plasma low density lipoproteins in healthy males
-
Ericsson, S., M. Eriksson, S. Vitols, K. Einarsson, L. Berglund, and B. Angelin . 1991 . Infl uence of age on the metabolism of plasma low density lipoproteins in healthy males. J. Clin. Invest. 87 : 591-596 .
-
(1991)
J. Clin. Invest.
, vol.87
, pp. 591-596
-
-
Ericsson, S.1
Eriksson, M.2
Vitols, S.3
Einarsson, K.4
Berglund, L.5
Angelin, B.6
-
20
-
-
0037084311
-
Risk factors for coronary heart disease: Implications of gender
-
Roeters van Lennep, J. E., H. T. Westerveld, D. W. Erkelens, and E. E. van der Wall . 2002 . Risk factors for coronary heart disease: implications of gender. Cardiovasc. Res. 53 : 538-549 .
-
(2002)
Cardiovasc. Res.
, vol.53
, pp. 538-549
-
-
Roeters Van Lennep, J.E.1
Westerveld, H.T.2
Erkelens, D.W.3
Van Der Wall, E.E.4
-
21
-
-
81855201805
-
Pronounced variation in bile acid synthesis in humans is related to gender, hypertriglyceridaemia and circulating levels of fibroblast growth factor 19
-
Gälman, C., B. Angelin, and M. Rudling . 2011 . Pronounced variation in bile acid synthesis in humans is related to gender, hypertriglyceridaemia and circulating levels of fi broblast growth factor 19. J. Intern. Med. 270 : 580-588 .
-
(2011)
J. Intern. Med.
, vol.270
, pp. 580-588
-
-
Gälman, C.1
Angelin, B.2
Rudling, M.3
-
22
-
-
0015348189
-
Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
-
Friedewald, W. T., R. I. Levy, and D. S. Fredrickson . 1972 . Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18 : 499-502 .
-
(1972)
Clin. Chem.
, vol.18
, pp. 499-502
-
-
Friedewald, W.T.1
Levy, R.I.2
Fredrickson, D.S.3
-
23
-
-
78650265739
-
Isometric knee-extension and knee-flexion torque production during early follicular and postovulatory phases in recreationally active women
-
Montgomery, M. M., and S. J. Shultz . 2010 . Isometric knee-extension and knee-fl exion torque production during early follicular and postovulatory phases in recreationally active women. J. Athl. Train. 45 : 586-593 .
-
(2010)
J. Athl. Train.
, vol.45
, pp. 586-593
-
-
Montgomery, M.M.1
Shultz, S.J.2
-
24
-
-
77956606535
-
A longitudinal study of serum lipoproteins in relation to endogenous reproductive hormones during the menstrual cycle: Fi ndings from the BioCycle study
-
Mumford, S. L., E. F. Schisterman, A. M. Siega-Riz, R. W. Browne, A. J. Gaskins, M. Trevisan, A. Z. Steiner, J. L. Daniels, C. Zhang, N. J. Perkins, et al . 2010 . A longitudinal study of serum lipoproteins in relation to endogenous reproductive hormones during the menstrual cycle: fi ndings from the BioCycle study. J. Clin. Endocrinol. Metab. 95 : E80-E85 .
-
(2010)
J. Clin. Endocrinol. Metab.
, vol.95
, pp. E80-E85
-
-
Mumford, S.L.1
Schisterman, E.F.2
Siega-Riz, A.M.3
Browne, R.W.4
Gaskins, A.J.5
Trevisan, M.6
Steiner, A.Z.7
Daniels, J.L.8
Zhang, C.9
Perkins, N.J.10
-
25
-
-
0018880759
-
Lipid metabolic studies in oophorectomized women: Effects induced by two different estrogens on serum lipids and lipoproteins
-
Silfverstolpe, G., A. Gustafson, G. Samsioe, and A. Svanborg . 1980 . Lipid metabolic studies in oophorectomized women: effects induced by two different estrogens on serum lipids and lipoproteins. Gynecol. Obstet. Invest. 11 : 161-169 .
-
(1980)
Gynecol. Obstet. Invest.
, vol.11
, pp. 161-169
-
-
Silfverstolpe, G.1
Gustafson, A.2
Samsioe, G.3
Svanborg, A.4
-
26
-
-
78650309921
-
Lipid lowering with thyroid hormone and thyromimetics
-
Angelin, B., and M. Rudling . 2010 . Lipid lowering with thyroid hormone and thyromimetics. Curr. Opin. Lipidol. 21 : 499-506 .
-
(2010)
Curr. Opin. Lipidol.
, vol.21
, pp. 499-506
-
-
Angelin, B.1
Rudling, M.2
-
27
-
-
0026729287
-
Importance of growth hormone for the induction of hepatic low density lipoprotein receptors
-
Rudling, M., G. Norstedt, H. Olivecrona, E. Reihner, J. A. Gustafsson, and B. Angelin . 1992 . Importance of growth hormone for the induction of hepatic low density lipoprotein receptors. Proc. Natl. Acad. Sci. USA . 89 : 6983-6987 .
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 6983-6987
-
-
Rudling, M.1
Norstedt, G.2
Olivecrona, H.3
Reihner, E.4
Gustafsson, J.A.5
Angelin, B.6
-
28
-
-
84871942788
-
Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets
-
Cariou, B., C. Langhi, M. Le Bras, M. Bortolotti, K. A. Le, F. Theytaz, C. Le May, B. Guyomarc'h-Delasalle, Y. Zair, R. Kreis, et al . 2013 . Plasma PCSK9 concentrations during an oral fat load and after short term high-fat, high-fat high-protein and high-fructose diets. Nutr. Metab. (Lond) . 10 : 4 .
-
(2013)
Nutr. Metab. (Lond)
, vol.10
, pp. 4
-
-
Cariou, B.1
Langhi, C.2
Le Bras, M.3
Bortolotti, M.4
Le, K.A.5
Theytaz, F.6
Le May, C.7
Guyomarc'H-Delasalle, B.8
Zair, Y.9
Kreis, R.10
-
29
-
-
84887606397
-
Plasma proprotein convertase subtilisin kexin type 9 levels are related to markers of cholesterol synthesis in familial combined hyperlipidemia
-
Brouwers, M. C., R. J. Konrad, T. M. van Himbergen, A. Isaacs, S. Otokozawa, J. S. Troutt, E. J. Schaefer, M. M. van Greevenbroek, A. F. Stalenhoef, and J. de Graaf . 2013 . Plasma proprotein convertase subtilisin kexin type 9 levels are related to markers of cholesterol synthesis in familial combined hyperlipidemia. Nutr. Metab. Cardiovasc. Dis. . 23 : 1115-1121 .
-
(2013)
Nutr. Metab. Cardiovasc. Dis.
, vol.23
, pp. 1115-1121
-
-
Brouwers, M.C.1
Konrad, R.J.2
Van Himbergen, T.M.3
Isaacs, A.4
Otokozawa, S.5
Troutt, J.S.6
Schaefer, E.J.7
Van Greevenbroek, M.M.8
Stalenhoef, A.F.9
De Graaf, J.10
-
30
-
-
78650419609
-
Circulating proprotein convertase subtilisin kexin type 9 has a diurnal rhythm synchronous with cholesterol synthesis and is reduced by fasting in humans
-
Persson, L., G. Cao, L. Stahle, B. G. Sjoberg, J. S. Troutt, R. J. Konrad, C. Galman, H. Wallen, M. Eriksson, I. Hafstrom, et al . 2010 . Circulating proprotein convertase subtilisin kexin type 9 has a diurnal rhythm synchronous with cholesterol synthesis and is reduced by fasting in humans. Arterioscler. Thromb. Vasc. Biol. 30 : 2666-2672 .
-
(2010)
Arterioscler. Thromb. Vasc. Biol.
, vol.30
, pp. 2666-2672
-
-
Persson, L.1
Cao, G.2
Stahle, L.3
Sjoberg, B.G.4
Troutt, J.S.5
Konrad, R.J.6
Galman, C.7
Wallen, H.8
Eriksson, M.9
Hafstrom, I.10
-
31
-
-
78149300891
-
Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans
-
Browning, J. D., and J. D. Horton . 2010 . Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans. J. Lipid Res. 51 : 3359-3363 .
-
(2010)
J. Lipid Res.
, vol.51
, pp. 3359-3363
-
-
Browning, J.D.1
Horton, J.D.2
-
32
-
-
34247496218
-
Bile acids and lipoprotein metabolism: Effects of cholestyramine and chenodeoxycholic acid on human hepatic mRNA expression
-
Nilsson, L. M., A. Abrahamsson, S. Sahlin, U. Gustafsson, B. Angelin, P. Parini, and C. Einarsson . 2007 . Bile acids and lipoprotein metabolism: effects of cholestyramine and chenodeoxycholic acid on human hepatic mRNA expression. Biochem. Biophys. Res. Commun. 357 : 707-711 .
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.357
, pp. 707-711
-
-
Nilsson, L.M.1
Abrahamsson, A.2
Sahlin, S.3
Gustafsson, U.4
Angelin, B.5
Parini, P.6
Einarsson, C.7
-
33
-
-
84881259052
-
Bile acid and sterol metabolism with combined HMG-CoA reductase and PCSK9 suppression
-
Parker, R. A., R. Garcia, C. S. Ryan, X. Liu, P. Shipkova, V. Livanov, P. Patel, and S. P. Ho . 2013 . Bile acid and sterol metabolism with combined HMG-CoA reductase and PCSK9 suppression. J. Lipid Res. 54 : 2400-2409 .
-
(2013)
J. Lipid Res.
, vol.54
, pp. 2400-2409
-
-
Parker, R.A.1
Garcia, R.2
Ryan, C.S.3
Liu, X.4
Shipkova, P.5
Livanov, V.6
Patel, P.7
Ho, S.P.8
|