A polygenic risk score for breast cancer in women receiving tamoxifen or raloxifene on NSABP P-1 and P-2

Breast Cancer Research and Treatment

Volumn 149, Issue 2, 2015, Pages 517-523

  Vachon, Celine M ^a   Schaid, Daniel J ^a   Ingle, James N ^a   Wickerham, D Lawrence ^b,c   Kubo, Michiaki ^d   Mushiroda, Taisei ^d   Goetz, Matthew P ^a   Carlson, Erin E ^a   Paik, Soonmyung ^b   Wolmark, Norman ^b   Nakamura, Yusuke ^e   Wang, Liewei ^f   Weinshilboum, Richard ^f   Couch, Fergus J ^a  

^a MAYO CLINIC   (United States)

^b ALLEGHENY GENERAL HOSPITAL   (United States)

^c NSABP Foundation Inc   (United States)

^d Institute of Physical and Chemical Research   (Japan)

^e UNIVERSITY OF CHICAGO   (United States)

^f MAYO GRADUATE SCHOOL   (United States)

Author keywords

Mammographic density; Polygenic risk score; SERMs; Single nucleotide polymorphisms (SNPs)

Indexed keywords

RALOXIFENE; TAMOXIFEN; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; ESTROGEN RECEPTOR; SELECTIVE ESTROGEN RECEPTOR MODULATOR;

ADULT; ARTICLE; BREAST CANCER; CANCER PREVENTION; CASE CONTROL STUDY; CONTROLLED STUDY; FAMILY HISTORY; FEMALE; GENETIC VARIABILITY; GENOTYPE; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; POLYGENIC RISK SCORE; QUANTITATIVE ANALYSIS; RISK FACTOR; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; AGED; BREAST NEOPLASMS; GENETIC PREDISPOSITION; METABOLISM; MIDDLE AGED; ODDS RATIO; PATHOLOGY; PROGNOSIS; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; RALOXIFENE HYDROCHLORIDE; RECEPTORS, ESTROGEN; RISK FACTORS; SELECTIVE ESTROGEN RECEPTOR MODULATORS; TAMOXIFEN;

EID: 84921924002     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-014-3175-4     Document Type: Article

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