Oxytocin promotes protective behavior in depressed mothers: A pilot study with the enthusiastic stranger paradigm

Depression and Anxiety

Volumn 32, Issue 2, 2015, Pages 76-81

  Mah, Beth L ^a,b   Bakermans Kranenburg, Marian J ^c   Van Ijzendoorn, Marinus H ^c   Smith, Roger ^a  

^a HUNTER MEDICAL RESEARCH INSTITUTE   (Australia)

^b Parent and Infant Mental Health Service   (Australia)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

depression; maternal behaviour; oxytocin; postpartum

Indexed keywords

OXYTOCIN; PLACEBO; OXYTOCIC AGENT;

ADULT; ARTICLE; CHILD CARE; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; MATERNAL BEHAVIOR; PILOT STUDY; PRIORITY JOURNAL; PROGENY; PUERPERAL DEPRESSION; RANDOMIZED CONTROLLED TRIAL; CHILD PARENT RELATION; DRUG EFFECTS; PHYSIOLOGY; PSYCHOLOGY;

ADULT; DEPRESSION, POSTPARTUM; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MATERNAL BEHAVIOR; OXYTOCICS; OXYTOCIN; PARENTING; PILOT PROJECTS;

EID: 84921916149     PISSN: 10914269     EISSN: 15206394     Source Type: Journal    
DOI: 10.1002/da.22245     Document Type: Article

References (40)

1. Carter CS,. Neuroendocrine perspectives on social attachment and love. Psychoneuroendocrinology 1998; 23 (8): 779-818.
2. Bos PA, Panksepp J, Bluthé R-M, et al. Acute effects of steroid hormones and neuropeptides on human social-emotional behavior: a review of single administration studies. Front Neuroendocrinol 2012; 33 (1): 17-35.
3. Feldman R, Gordon I, Schneiderman I, et al. Natural variations in maternal and paternal care are associated with systemic changes in oxytocin following parent-infant contact. Psychoneuroendocrinology 2010; I35 (8): 1133-1141.
4. Galbaly M, Lewis AJ, van IJzendoorn MH, Permezel M,. The role of oxytocin in mother-infant relations: a systemic review of human studies. Harvard Rev Psychiatry 2011; 19 (1): 1-14.
5. Bosch OJ, Meddle SL, Beiderbeck DI, et al. Brain oxytocin correlates with maternal aggression: link to anxiety. J Neurosci 2005; 25 (29): 6807-6815.
6. Kotch JB, Browne DC, Dufort V, et al. Predicting child maltreatment in the first 4 years of life from characteristics assessed in the neonatal period. Child AbuseNegl 1999; 23 (4): 305-319.
7. Rosenblatt J, Factor E, Mayer A,. Relationship between maternal aggression and maternal care in the rat. Aggress Behav 1994; 20: 243-255.
8. Hrdy S,. Mother Nature: Natural Selection and the Female of the Species. London: Chatto and Windus; 1999.
9. Deschamps S, Woodside B, Walker CD,. Pups presence eliminates the stress hyporesponsiveness of early lactating females to a psychological stress representing a threat to the pups. Journal of Neuroendocrinology 2003; 15: 486-497.
10. Kiel EJ, Buss KA,. Associations among context-specific maternal protective behavior, toddler fearful temperament, and maternal accuracy and goals. Soc Dev 2012; 21 (4): 742-760.
11. Stein D, Williamson DE, Birmaher B, et al. Parent-child bonding and family functioning in depressed children and children at high risk and low risk for future depression. J Am Acad Child Adolesc Psychiatry 2000; 39 (11): 1387-1395.
12. Oshino S, Suzuki A, Ishii G, Otani K,. Influences of parental rearing on the personality traits of healthy Japanese. Compr Psychiatry 2007; 48 (5): 465-469.
13. Kiel EJ, Buss KA,. Prospective relations among fearful temperament, protective parenting, and social withdrawal: the role of maternal accuracy in a moderated mediation framework. J Abnorm Child Psychol 2011; 39 (7): 953-966.
14. van Leengoed E, Kerker E, Swanson H,. Inhibition of post-partum maternal behaviour in the rat by infecting an oxytocin antagonist into the cerebral ventricles. J Endocrinol 1987; 112 (2): 275-282.
15. Nephew BC, Bridges RS, Lovelock DF, Byrnes EM,. Enhanced maternal aggression and associated changes in neuropeptide gene expression in multiparous rats. Behav Neurosci 2009; 123 (5): 949-957.
16. Feldman R, Weller A, Zagoory-Sharon O, Levine A,. Evidence for a neuroendocrinological foundation of human affiliation: plasma oxytocin levels across pregnancy and the postpartum period predict mother-infant bonding. Psychol Sci 2007; 18 (11): 965-970.
17. Naber F, van IJzendoorn MH, Deschamps P, et al. Intranasal oxytocin increases fathers' observed responsiveness during play with their children: a double-blind within-subject experiment. Psychoneuroendocrinology 2010; 35 (10): 1583-1586.
18. Riem MME, van IJzendoorn MH, Tops M, et al. No laughing matter: Intranasal oxytocin administration changes functional brain connectivity during exposure to infant laughter. Neuropsychopharmacology 2012; 37 (5): 1257-1266.
19. Purba JS, Hoogendijk WJG, Hofman MA, Swaab DF,. Increased number of vasopressin and oxytocin expressing neurons in the paraventricular nucleus of the hypothalamus in depression. Archf Gen Psychiatry 1996; 53 (2): 137-143.
20. Meynen G, Unmehopa UA, Hofman MA, et al. Hypothalamic oxytocin mRNA expression and melancholic depression. Mol Psychiatry 2007; 12 (2): 118-119.
21. Gordon I, Zagoory-Sharon O, Schneiderman I, et al. Oxytocin and cortisol in romantically unattached young adults: associations with bonding and psychological distress. Dev Psychobiol 2008; 50 (7): 728.
22. Skrundz M, Bolten M, Nast L, et al. Plasma oxytocin concentration during pregnancy is associated with development of postpartum depression. Neuropsychopharmacology 2011; 36 (9): 1886-1893.
23. Mah BL, van IJzendoorn MH, Smith R, Bakermans-Kranenburg MJ,. Oxytocin in postnatally depressed mothers: Its influence on mood and expressed emotion. Prog Neuropsychopharmacol Biol Psychiatry 2013; 40 (Supplement(C)): 267-272.
24. Cox JL, Holden JM, Sagovsky R,. Detection of postnatal depression: development of the 10-item Edinburgh Postnatal Depression Scale. Br J Psychiatry 1987; 15: 782-786.
25. Huffmeijer R, Alink LRA, Tops M, et al. Salivary levels of oxytocin remain elevated for more than two hours after intranasal oxytocin administration. Neuroendocrinol Lett 2012; 33: 21-25.
26. van IJzendoorn MH, Bhandari R, van der Veen R, et al. Elevated salivary levels of oxytocin persist more than 7 h after intranasal administration. Front Neurosci 2012; 6 (174): 1-6.
27. Out D, Pieper S, Bakermans-Kranenburg MJ, et al. Intended sensitive and harsh caregiving responses to infant crying: the role of cry pitch and perceived urgency in an adult twin sample. Child Abuse Negl 2010; 34: 863-873.
28. Benton AL, Hamsher KS,. Multilingual aphasia examination manual. Iowa City, IA: University of Iowa; 1976.
29. Tabachnick BG, Fidell LS,. Using multivariate statistics. 5th ed. Boston, MA: Pearsons Education, Inc.; 2007.
30. Brazelton TB, Nugent JK,. Neonatal Behavioral Assessment Scale. 3rd ed. Clinics in Developmental Medicine No. 137, ed. M.C.O. Bax. London: Cambridge University Press; 1995.
31. Woody EZ, Szechtman H,. A biological security motivation system for potential threats: are there implications for policy-making? Front Human Neurosci 2013; 9 (7).
32. Pedersen CA,. Biological aspects of social bonding and the roots of human violence. Ann N Y Acad Sci 2004; 1036: 106-127.
33. O'Hara MW, Swain AM,. Rates and risk of postpartum depression-a meta-analysis. Int Rev Psychiatry 1996; 8 (1): 37.
34. Bakermans-Kranenburg MJ, van IJzendoorn MH,. Sniffing around oxytocin: review and meta-analyses of trials in healthy and clinical groups with implications for pharmacotherapy. Transl Psychiatry 2013; 3: e258.
35. Bartz J, Simeon D, Hamilton H, et al. Oxytocin can hinder trust and cooperation in borderline personality disorder. Soc Cogn Affect Neurosci 2011; 6 (5): 556-563.
36. Bakermans-Kranenburg MJ, Van IJzendoorn MH, Riem ME, et al. Oxytocin decreases handgrip force in reaction to infant crying in females without harsh parenting experiences. Soc Cogn Affect Neurosci 2012; 7 (8): 951-957.
37. van IJzendoorn MH, Huffmeijer R, Alink LRA, et al. The impact of oxytocin administration on charitable donating is moderated by experiences of parental love-withdrawal. Front Psychol 2011; 2 (258): 1-8.
38. Ammermann RT, Putman FW, Chard KM, et al. PTSD in depressed mothers in home visitation. Psychol Trauma 2012; 4 (2): 186-195.
39. De Dreu CKW, Greer LL, Handgraaf SS, et al. The neuropeptide oxytocin regulates parochial altruism in intergroup conflict among humans. Science 2010; 328: 1408-1411.
40. Australian Bureau of Statistics. Australian demographic statistics. Canberra; 2010.