Enhanced Maternal Aggression and Associated Changes in Neuropeptide Gene Expression in Multiparous Rats

Behavioral Neuroscience

Volumn 123, Issue 5, 2009, Pages 949-957

  Nephew, Benjamin C ^a   Bridges, Robert S ^a   Lovelock, Dennis F ^a   Byrnes, Elizabeth M ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

corticotrophin releasing hormone; offspring protection; oxytocin; paraventricular nucleus; vasopressin

Indexed keywords

ARGIPRESSIN; ARGIPRESSIN RECEPTOR; CORTICOTROPIN RELEASING FACTOR; MESSENGER RNA; NEUROPEPTIDE; OXYTOCIN; OXYTOCIN RECEPTOR; VASOPRESSIN V1A RECEPTOR;

AGGRESSION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HOMEOSTASIS; MALE; MATERNAL BEHAVIOR; MULTIPARA; NERVE CELL PLASTICITY; NEUROMODULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIMIPARA; PROTEIN FUNCTION; PUERPERIUM; RAT; REPRODUCTION;

AGGRESSION; AMYGDALA; ANALYSIS OF VARIANCE; ANIMALS; ARGININE VASOPRESSIN; CORTICOSTERONE; CORTICOTROPIN-RELEASING HORMONE; FEMALE; GENE EXPRESSION; HYPOTHALAMUS; LACTATION; MATERNAL BEHAVIOR; OXYTOCIN; PARITY; PREGNANCY; RATS; RECEPTORS, OXYTOCIN; RECEPTORS, VASOPRESSIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEPTAL NUCLEI; STRESS, PHYSIOLOGICAL;

EID: 70350107584     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/a0016734     Document Type: Article

References (29)

1. Bosch O.J., Meddle S.L., Beiderbeck D.I., Douglas A.J., and Neumann I.D. Brain oxytocin correlates with maternal aggression: Link to anxiety. Journal of Neuroscience 25 (2005) 6807-6815
2. Champagne F., Diorio J., Sharma S., and Meaney M.J. Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors. Proceedings of the National Academy of Sciences of the USA 98 (2001) 12736-12741
3. Consiglio A.R., Borsoi A., Pereira G.A.M., and Lucion A.B. Effects of oxytocin microinjected into the central amygdaloid nucleus and bed nucleus of stria terminalis on maternal aggressive behavior in rats. Physiology & Behavior 85 (2005) 354-362
4. D'Anna K.L., and Gammie S.C. Activation of corticotropin-releasing factor receptor 2 in lateral septum negatively regulates maternal defense. Behavioral Neuroscience 123 (2009) 356-368
5. Dwyer C.M. Individual variation in the expression of maternal behaviour: A review of the neuroendocrine mechanisms in the sheep. Journal of Neuroendocrinology 20 (2008) 526-534
6. Erskine M.S., Barfield R.J., and Goldman B.D. Postpartum aggression in rats: II. Dependence on maternal sensitivity to young and effects of experience with pregnancy and parturition. Journal of Comparative and Physiological Psychology 94 (1980) 495-505
7. Ferriera A., and Hansen S. Sensory control of maternal aggression in Rattus norvegicus. Journal of Comparative Psychology 100 (1986) 173-177
8. Flannelly K.J., and Flannelly L. Opponents' size influences maternal aggression. Psychological Reports 57 (1985) 883-886
9. Flannelly K.J., and Flannelly L. Time course of postpartum aggression in rats (Rattus norvegicus). Journal of Comparative Psychology 101 (1987) 101-103
10. Gammie S.C., Hasen N.S., Stevenson S.A., Bale T.L., and D'Anna K.L. Elevated stress sensitivity in corticotropin-releasing factor receptor 2 deficient mice decreases maternal, but not intermale aggression. Behavioural Brain Research 160 (2005) 169-177
11. Gammie S.C., Negron A., Newman S.M., and Rhodes J.S. Corticotropin-releasing factor inhibits maternal aggression in mice. Behavioral Neuroscience 118 (2004) 105-114
12. Gammie S.C., and Nelson R.J. cFOS and pCREB activation and maternal aggression in mice. Brain Research 898 (2001) 232-241
13. Giovenardi M., Padoin M.J., Cadore L.P., and Lucion A.B. Hypothalamic paraventricular nucleus, oxytocin, and maternal aggression in rats. Annals of the New York Academy of Sciences 807 (1997) 606-609
14. Giovenardi M., Padoin M.J., Cadore L.P., and Lucion A.B. Hypothalamic paraventricular nucleus modulates maternal aggression in rats: Effects of ibotenic acid lesion and oxytocin antisense. Physiology & Behavior 63 (1998) 351-359
15. Hasen N.S., and Gammie S.C. Differential fos activation in virgin and lactating mice in response to an intruder. Physiology & Behavior 84 (2005) 681-695
16. Ingram C.D., and Moos F. Oxytocin-containing pathway to the bed nuclei of the stria terminalis of the lactating rat brain: Immunocytochemical and in vitro electrophysiological evidence. Neuroscience 47 (1992) 439-452
17. Lalmansingh A.S., and Uht R.M. Estradiol regulates corticotropin-releasing hormone gene (CRH) expression in a rapid and phasic manner that parallels estrogen receptor-alpha and -beta recruitment to a 3′, 5′-cyclic adenosine 5′-monophosphate regulatory region of the proximal CRH promoter. Endocrinology 149 (2008) 346-357
18. Lambert R.C., Moos F.C., Ingram C.D., Wakerley J.B., Kremarik P., Guerne Y., and Richard P. Electrical activity of neurons in the ventrolateral septum and bed nuclei of the stria terminalis in suckled rats: Statistical analysis gives evidence for sensitivity to oxytocin and for relation to the milk-ejection reflex. Neuroscience 54 (1993) 361-376
19. Lonstein J.S., and Gammie S.C. Sensory, hormonal, and neural controls of maternal aggression in laboratory rodents. Neuroscience and Biobehavioral Reviews 26 (2002) 869-888
20. Lubin D.A., Elliot J.C., Black M.C., and Johns J.M. An oxytocin antagonist infused into the central nucleus of the amygdala increases maternal aggressive behavior. Behavioral Neuroscience 117 (2003) 195-201
21. Mayer A.D., Reisbick S., Siegel H.I., and Rosenblatt J.S. Maternal aggression in rats: Changes over pregnancy and lactation in a Sprague-Dawley strain. Aggressive Behavior 13 (1987) 29-43
22. Mayer A.D., and Rosenblatt J.S. Hormonal factors influence the onset of maternal aggression in laboratory rats. Hormones and Behavior 21 (1987) 253-267
23. Moos F., Poulain D.A., Rodriguez F., Guerne Y., Vincent J.D., and Richard P. Release of oxytocin within the supraoptic nucleus during the milk ejection reflex in rats. Experimental Brain Research 76 (1989) 593-602
24. Nephew B.C., and Bridges R.S. Central actions of arginine vasopressin and a V1a receptor antagonist on maternal aggression, maternal behavior, and grooming in lactating rats. Pharmacology Biochemistry and Behavior 91 (2008) 77-83
25. Nephew B.C., Byrnes E.M., and Bridges R.S. Vasopressin enhanced offspring protection in multiparous rats. Neuropharmacology (2009) in press
26. Ragnauth A.K., Devidze N., Moy V., Finley K., Goodwillie A., Kow L.M., et al. Female oxytocin gene-knockout mice, in a semi-natural environment, display exaggerated aggressive behavior. Genes, Brain, and Behavior 4 (2005) 229-239
27. Stern J.M., and Kolunie J.M. Trigeminal lesions and maternal behavior in Norway rats: Effects of cutaneous rostral snout denervation on maintenance of nurturance and maternal aggression. Behavioral Neuroscience 105 (1991) 984-997
28. Stern J.M., and Kolunie J.M. Maternal aggression of rats is impaired by cutaneous anesthesia of the ventral trunk, but not by nipple removal. Physiology & Behavior 54 (1993) 861-868
29. Svare B., and Gandelman R. A longitudinal analysis of maternal aggression in Rockland-Swiss albino mice. Developmental Psychobiology 9 (1976) 437-446