Genomic responses to inflammation in mouse models mimic humans: We concur, apples to oranges comparisons won't do

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 4, 2015, Pages E346-

  Shay, Tal ^a   Lederer, James A ^b   Benoist, Christophe ^c  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS BY BODY ANATOMY; GENE EXPRESSION; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; IMMUNOREGULATION; INBRED MOUSE STRAIN; INFLAMMATION; INFLAMMATORY DISEASE; LETTER; LEUKOCYTE; MOUSE; MOUSE MODEL; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SPECIES COMPARISON; ANIMAL; DISEASE MODEL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC DATABASE;

ANIMALS; DATABASES, GENETIC; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION;

EID: 84921905460     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1416629111     Document Type: Letter

References (5)

1. Takao K, Miyakawa T (2015) Genomic responses in mouse models greatly mimic human inflammatory diseases. Proc Natl Acad Sci USA 112:1167-1172.
2. Seok J, et al.; Inflammation and Host Response to Injury, Large Scale Collaborative Research Program (2013) Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci USA 110(9):3507-3512.
3. Shay T, et al.; ImmGen Consortium (2013) Conservation and divergence in the transcriptional programs of the human and mouse immune systems. Proc Natl Acad Sci USA 110(8):2946-2951.
4. Storey JD, Tibshirani R (2003) Statistical significance for genomewide studies. Proc Natl Acad Sci USA 100(16):9440-9445.
5. Shoda LK, et al. (2005) A comprehensive review of interventions in the NOD mouse and implications for translation. Immunity 23(2):115-126.