The potential use of salivary nitrite as a marker of NO status in humans

Nitric Oxide - Biology and Chemistry

Volumn 45, Issue , 2015, Pages 4-6

  Bryan, Nathan S ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MOUTHWASH; NITRATE; NITRATE REDUCTASE; NITRIC OXIDE; NITRITE; NITROUS ACID; BIOLOGICAL MARKER;

ARTICLE; BLOOD PRESSURE; HUMAN; PRIORITY JOURNAL; SALIVA LEVEL; VEGETABLE; CARDIOVASCULAR DISEASE; CHEMISTRY; METABOLISM; PHYSIOLOGY; SALIVA;

BIOMARKERS; CARDIOVASCULAR DISEASES; HUMANS; METABOLIC NETWORKS AND PATHWAYS; NITRIC OXIDE; NITRITES; SALIVA;

EID: 84921880026     PISSN: 10898603     EISSN: 10898611     Source Type: Journal    
DOI: 10.1016/j.niox.2014.12.011     Document Type: Letter

References (23)

1. B. Spiegelhalder, G. Eisenbrand, R. Preussmann, Influence of dietary nitrate on nitrite content of human saliva: possible relevance to in vivo formation of N-nitroso compounds, Food Cosmet. Toxicol. 14 (6) (1976) 545-548.
2. J.O. Lundberg, M. Govoni, Inorganic nitrate is a possible source for systemic generation of nitric oxide, Free Radic. Biol. Med. 37 (3) (2004) 395-400.
3. M. Govoni, et al., The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash, Nitric Oxide 19 (4) (2008) 333-337.
4. C. Duncan, et al., Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate, Nat. Med. 1 (6) (1995) 546-551.
5. J.W.B. Moir (Ed.), Nitrogen Cycling in Bacteria: Molecular Analysis, Caister Academic Press, Norfolk, UK, 2011.
6. J.O. Lundberg, et al., Intragastric nitric oxide production in humans: measurements in expelled air, Gut 35 (11) (1994) 1543-1546.
7. N. Benjamin, et al., Stomach NO synthesis, Nature 368 (6471) (1994) 502.
8. B. Gago, et al., Red wine-dependent reduction of nitrite to nitric oxide in the stomach, Free Radic. Biol. Med. 43 (9) (2007) 1233-1242.
9. T. Rassaf, et al., Evidence for in vivo transport of bioactive nitric oxide in human plasma, J. Clin. Invest. 109 (9) (2002) 1241-1248.
10. J.W. Elrod, et al., Nitric oxide promotes distant organ protection: evidence for an endocrine role of nitric oxide, Proc. Natl. Acad. Sci. U.S.A. 105 (32) (2008) 11430-11435.
11. E.R. Hyde, et al., Metagenomic analysis of nitrate-reducing bacteria in the oral cavity: implications for nitric oxide homeostasis, PLoS ONE 9 (3) (2014) e88645.
12. N.S. Bryan, J. Loscalzo (Eds.), Nitrite and Nitrate in Human Health and Disease, Nutrition and Health, A. Bendich (Ed.), Humana Press, New York, 2011.
13. J.O. Lundberg, et al., Nitrate and nitrite in biology, nutrition and therapeutics, Nat. Chem. Biol. 5 (12) (2009) 865-869.
14. N.S. Bryan, et al., Dietary nitrite restores NO homeostasis and is cardioprotective in endothelial nitric oxide synthase-deficient mice, Free Radic. Biol. Med. 45 (4) (2008) 468-474.
15. M. Carlstrom, et al., Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice, Proc. Natl. Acad. Sci. U.S.A. 107 (41) (2010) 17716-17720.
16. N.S. Bryan, et al., Nitrite is a signalingmolecule and regulator of gene expression in mammalian tissues, Nat. Chem. Biol. 1 (5) (2005) 290-297.
17. V. Kapil, et al., Physiological role for nitrate-reducing oral bacteria in blood pressure control, Free Radic. Biol. Med. 55 (2013) 93-100.
18. N.S. Bryan, Cardioprotective actions of nitrite therapy and dietary considerations, Front. Biosci. 14 (2009) 4793-4808.
19. L. Qin, et al., Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane, Proc. Natl. Acad. Sci. U.S.A. 109 (33) (2012) 13434-13439.
20. T. Pfaffe, et al., Diagnostic potential of saliva: current state and future applications, Clin. Chem. 57 (5) (2011) 675-687.
21. A.J. Webb, et al., Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite, Hypertension 51 (3) (2008) 784-790.
22. V. Kapil, et al., Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO, Hypertension 56 (2) (2010) 274-281.
23. N.S. Bryan, et al., Acute effects of hemodialysis on nitrite and nitrate: potential cardiovascular implications in dialysis patients, Free Radic. Biol. Med. 58 (2013) 46-51.