-
1
-
-
79960096827
-
Normalization of the vasculature for treatment of cancer and other diseases
-
Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D et al. Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev 2011; 91: 1071-1121.
-
(2011)
Physiol Rev
, vol.91
, pp. 1071-1121
-
-
Goel, S.1
Duda, D.G.2
Xu, L.3
Munn, L.L.4
Boucher, Y.5
Fukumura, D.6
-
3
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971; 285: 1182-1186.
-
(1971)
N Engl J Med
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
4
-
-
34248173883
-
Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (folfox4) for previously treated metastatic colorectal cancer: Results from the eastern cooperative oncology group study e3200
-
Giantonio BJ, Catalano PJ, Meropol NJ, O'Dwyer PJ, Mitchell EP, Alberts SR et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 2007; 25: 1539-1544.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1539-1544
-
-
Giantonio, B.J.1
Catalano, P.J.2
Meropol, N.J.3
O'Dwyer, P.J.4
Mitchell, E.P.5
Alberts, S.R.6
-
5
-
-
42949149159
-
Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase iii study
-
Saltz LB, Clarke S, Diaz-Rubio E, Scheithauer W, Figer A, Wong R et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol 2008; 26: 2013-2019.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2013-2019
-
-
Saltz, L.B.1
Clarke, S.2
Diaz-Rubio, E.3
Scheithauer, W.4
Figer, A.5
Wong, R.6
-
6
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335-2342.
-
(2004)
N Engl J Med
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
Cartwright, T.4
Hainsworth, J.5
Heim, W.6
-
7
-
-
84885184379
-
Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer
-
Budinska E, Popovici V, Tejpar S, D'Ario G, Lapique N, Sikora KO et al. Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer. J Pathol 2013; 231: 63-76.
-
(2013)
J Pathol
, vol.231
, pp. 63-76
-
-
Budinska, E.1
Popovici, V.2
Tejpar, S.3
D'Ario, G.4
Lapique, N.5
Sikora, K.O.6
-
8
-
-
84885768801
-
Protein kinase inhibitors in metastatic colorectal cancer. Let's pick patients, tumors, and kinase inhibitors to piece the puzzle together!
-
Stintzing S, Lenz HJ. Protein kinase inhibitors in metastatic colorectal cancer. Let's pick patients, tumors, and kinase inhibitors to piece the puzzle together! Expert Opin Pharmacother 2013; 14: 2203-2220.
-
(2013)
Expert Opin Pharmacother
, vol.14
, pp. 2203-2220
-
-
Stintzing, S.1
Lenz, H.J.2
-
9
-
-
36148947536
-
Genetic and epigenetic alterations of ras signalling pathway in colorectal neoplasia: Analysis based on tumour clinicopathological features
-
Harada K, Hiraoka S, Kato J, Horii J, Fujita H, Sakaguchi K et al. Genetic and epigenetic alterations of Ras signalling pathway in colorectal neoplasia: analysis based on tumour clinicopathological features. Br J Cancer 2007; 97: 1425-1431.
-
(2007)
Br J Cancer
, vol.97
, pp. 1425-1431
-
-
Harada, K.1
Hiraoka, S.2
Kato, J.3
Horii, J.4
Fujita, H.5
Sakaguchi, K.6
-
10
-
-
84863922124
-
Comprehensive molecular characterization of human colon and rectal cancer
-
Cancer Genome Atlas Network
-
CancerGenomeAtlasNetwork. Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012; 487: 330-337.
-
(2012)
Nature
, vol.487
, pp. 330-337
-
-
-
11
-
-
84884722908
-
Primary tumor location and bevacizumab effectiveness in patients with metastatic colorectal cancer
-
Boisen MK, Johansen JS, Dehlendorff C, Larsen JS, Osterlind K, Hansen J et al. Primary tumor location and bevacizumab effectiveness in patients with metastatic colorectal cancer. Ann Oncol 2013; 24: 2554-2559.
-
(2013)
Ann Oncol
, vol.24
, pp. 2554-2559
-
-
Boisen, M.K.1
Johansen, J.S.2
Dehlendorff, C.3
Larsen, J.S.4
Osterlind, K.5
Hansen, J.6
-
12
-
-
84875998274
-
Markers of response for the antiangiogenic agent bevacizumab
-
Lambrechts D, Lenz HJ, de Haas S, Carmeliet P, Scherer SJ. Markers of response for the antiangiogenic agent bevacizumab. J Clin Oncol 2013; 31: 1219-1230.
-
(2013)
J Clin Oncol
, vol.31
, pp. 1219-1230
-
-
Lambrechts, D.1
Lenz, H.J.2
De Haas, S.3
Carmeliet, P.4
Scherer, S.J.5
-
13
-
-
27644557532
-
The role of pericytes in blood-vessel formation and maintenance
-
Bergers G, Song S. The role of pericytes in blood-vessel formation and maintenance. Neuro-oncology 2005; 7: 452-464.
-
(2005)
Neuro-oncology
, vol.7
, pp. 452-464
-
-
Bergers, G.1
Song, S.2
-
14
-
-
57649135172
-
A role for vegf as a negative regulator of pericyte function and vessel maturation
-
Greenberg JI, Shields DJ, Barillas SG, Acevedo LM, Murphy E, Huang J et al. A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature 2008; 456: 809-813.
-
(2008)
Nature
, vol.456
, pp. 809-813
-
-
Greenberg, J.I.1
Shields, D.J.2
Barillas, S.G.3
Acevedo, L.M.4
Murphy, E.5
Huang, J.6
-
15
-
-
0037815292
-
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
-
Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A et al. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol 2003; 161: 1163-1177.
-
(2003)
J Cell Biol
, vol.161
, pp. 1163-1177
-
-
Gerhardt, H.1
Golding, M.2
Fruttiger, M.3
Ruhrberg, C.4
Lundkvist, A.5
Abramsson, A.6
-
16
-
-
0035081259
-
Regulation of ras signaling specificity by protein kinase c
-
Rusanescu G, Gotoh T, Tian X, Feig LA. Regulation of Ras signaling specificity by protein kinase C. Mol Cell Biol 2001; 21: 2650-2658.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 2650-2658
-
-
Rusanescu, G.1
Gotoh, T.2
Tian, X.3
Feig, L.A.4
-
17
-
-
84867496141
-
RALBP1/rlip76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization
-
Lee S, Wurtzel JG, Singhal SS, Awasthi S, Goldfinger LE. RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization. Cancer Res 2012; 72: 5165-5173.
-
(2012)
Cancer Res
, vol.72
, pp. 5165-5173
-
-
Lee, S.1
Wurtzel, J.G.2
Singhal, S.S.3
Awasthi, S.4
Goldfinger, L.E.5
-
18
-
-
12844255716
-
Regulator of g-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization
-
Berger M, Bergers G, Arnold B, Hammerling GJ, Ganss R. Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization. Blood 2005; 105: 1094-1101.
-
(2005)
Blood
, vol.105
, pp. 1094-1101
-
-
Berger, M.1
Bergers, G.2
Arnold, B.3
Hammerling, G.J.4
Ganss, R.5
-
19
-
-
79953039953
-
Combinational therapy of interferon-alpha and chemotherapy normalizes tumor vasculature by regulating pericytes including the novel marker rgs5 in melanoma
-
Liu P, Zhang C, Chen J, Zhang R, Ren J, Huang Y et al. Combinational therapy of interferon-alpha and chemotherapy normalizes tumor vasculature by regulating pericytes including the novel marker RGS5 in melanoma. J Immunother 2011; 34: 320-326.
-
(2011)
J Immunother
, vol.34
, pp. 320-326
-
-
Liu, P.1
Zhang, C.2
Chen, J.3
Zhang, R.4
Ren, J.5
Huang, Y.6
-
20
-
-
84875998274
-
Markers of response for the antiangiogenic agent bevacizumab
-
Lambrechts D, Lenz HJ, de Haas S, Carmeliet P, Scherer SJ. Markers of response for the antiangiogenic agent bevacizumab. J Clin Oncol 2013; 31: 1219-1230.
-
(2013)
J Clin Oncol
, vol.31
, pp. 1219-1230
-
-
Lambrechts, D.1
Lenz, H.J.2
De Haas, S.3
Carmeliet, P.4
Scherer, S.J.5
-
21
-
-
80051710027
-
Bevacizumab pharmacogenetics in tumor treatment: Still looking for the right pieces of the puzzle
-
Bocci G, Loupakis F. Bevacizumab pharmacogenetics in tumor treatment: still looking for the right pieces of the puzzle. Pharmacogenomics 2011; 12: 1077-1080.
-
(2011)
Pharmacogenomics
, vol.12
, pp. 1077-1080
-
-
Bocci, G.1
Loupakis, F.2
-
22
-
-
79954562171
-
Molecular predictors of response to antiangiogenesis therapies
-
Gerger A, LaBonte M, Lenz HJ. Molecular predictors of response to antiangiogenesis therapies. Cancer J 2011; 17: 134-141.
-
(2011)
Cancer J
, vol.17
, pp. 134-141
-
-
Gerger, A.1
Labonte, M.2
Lenz, H.J.3
-
23
-
-
84858221706
-
Ensembl 2012
-
Flicek P, Amode MR, Barrell D, Beal K, Brent S, Carvalho-Silva D et al. Ensembl 2012. Nucleic Acids Res 2012; 40: D84-D90.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. D84-D90
-
-
Flicek, P.1
Amode, M.R.2
Barrell, D.3
Beal, K.4
Brent, S.5
Carvalho-Silva, D.6
-
24
-
-
67849101182
-
SNPinfo: Integrating gwas and candidate gene information into functional snp selection for genetic association studies
-
Xu Z, Taylor JA. SNPinfo: integrating GWAS and candidate gene information into functional SNP selection for genetic association studies. Nucleic Acids Res 2009; 37: W600-W605.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. W600-W605
-
-
Xu, Z.1
Taylor, J.A.2
-
25
-
-
38549158538
-
F-snp: Computationally predicted functional snps for disease association studies
-
Lee PH, Shatkay H. F-SNP: computationally predicted functional SNPs for disease association studies. Nucleic Acids Res 2008; 36: D820-D824.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. D820-D824
-
-
Lee, P.H.1
Shatkay, H.2
-
26
-
-
84897409111
-
Association of common gene variants in the wnt/beta-catenin pathway with colon cancer recurrence
-
Paez D, Gerger A, Zhang W, Yang D, Labonte MJ, Benhanim L et al. Association of common gene variants in the WNT/beta-catenin pathway with colon cancer recurrence. Pharmacogenom J 2013; 14: 142-150.
-
(2013)
Pharmacogenom J
, vol.14
, pp. 142-150
-
-
Paez, D.1
Gerger, A.2
Zhang, W.3
Yang, D.4
Labonte, M.J.5
Benhanim, L.6
-
27
-
-
59449091688
-
Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of k-ras in metastatic colorectal cancer patients treated with single-agent cetuximab
-
Lurje G, Nagashima F, Zhang W, Yang D, Chang HM, Gordon MA et al. Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab. Clin Cancer Res 2008; 14: 7884-7895.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7884-7895
-
-
Lurje, G.1
Nagashima, F.2
Zhang, W.3
Yang, D.4
Chang, H.M.5
Gordon, M.A.6
-
28
-
-
36749079336
-
So many correlated tests, so little time! rapid adjustment of p values for multiple correlated tests
-
Conneely KN, Boehnke M. So many correlated tests, so little time! Rapid adjustment of P values for multiple correlated tests. Am Jl Hum Genet 2007; 81: 1158-1168.
-
(2007)
Am Jl Hum Genet
, vol.81
, pp. 1158-1168
-
-
Conneely, K.N.1
Boehnke, M.2
-
30
-
-
11844254414
-
Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
-
Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005; 307: 58-62.
-
(2005)
Science
, vol.307
, pp. 58-62
-
-
Jain, R.K.1
-
31
-
-
84865712382
-
Annotation of functional variation in personal genomes using regulomedb
-
Boyle AP, Hong EL, Hariharan M, Cheng Y, Schaub MA, Kasowski M et al. Annotation of functional variation in personal genomes using RegulomeDB. Genome Res 2012; 22: 1790-1797.
-
(2012)
Genome Res
, vol.22
, pp. 1790-1797
-
-
Boyle, A.P.1
Hong, E.L.2
Hariharan, M.3
Cheng, Y.4
Schaub, M.A.5
Kasowski, M.6
-
32
-
-
55449112450
-
High-resolution mapping of expression-qtls yields insight into human gene regulation
-
Veyrieras JB, Kudaravalli S, Kim SY, Dermitzakis ET, Gilad Y, Stephens M et al. High-resolution mapping of expression-QTLs yields insight into human gene regulation. PLoS Genet 2008; 4: e1000214.
-
(2008)
PLoS Genet
, vol.4
-
-
Veyrieras, J.B.1
Kudaravalli, S.2
Kim, S.Y.3
Dermitzakis, E.T.4
Gilad, Y.5
Stephens, M.6
-
33
-
-
69949176863
-
Common regulatory variation impacts gene expression in a cell type-dependent manner
-
Dimas AS, Deutsch S, Stranger BE, Montgomery SB, Borel C, Attar-Cohen H et al. Common regulatory variation impacts gene expression in a cell type-dependent manner. Science 2009; 325: 1246-1250.
-
(2009)
Science
, vol.325
, pp. 1246-1250
-
-
Dimas, A.S.1
Deutsch, S.2
Stranger, B.E.3
Montgomery, S.B.4
Borel, C.5
Attar-Cohen, H.6
-
34
-
-
43749112760
-
Vascular normalization in rgs5-deficient tumours promotes immune destruction
-
Hamzah J, Jugold M, Kiessling F, Rigby P, Manzur M, Marti HH et al. Vascular normalization in Rgs5-deficient tumours promotes immune destruction. Nature 2008; 453: 410-414.
-
(2008)
Nature
, vol.453
, pp. 410-414
-
-
Hamzah, J.1
Jugold, M.2
Kiessling, F.3
Rigby, P.4
Manzur, M.5
Marti, H.H.6
-
35
-
-
84867868500
-
Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements
-
Barrett LW, Fletcher S, Wilton SD. Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements. Cell Mol Life Sci 2012; 69: 3613-3634.
-
(2012)
Cell Mol Life Sci
, vol.69
, pp. 3613-3634
-
-
Barrett, L.W.1
Fletcher, S.2
Wilton, S.D.3
-
36
-
-
33645109501
-
The effect of rgs12 on pdgfbeta receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells
-
Sambi BS, Hains MD, Waters CM, Connell MC, Willard FS, Kimple AJ et al. The effect of RGS12 on PDGFbeta receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells. Cell Signal 2006; 18: 971-981.
-
(2006)
Cell Signal
, vol.18
, pp. 971-981
-
-
Sambi, B.S.1
Hains, M.D.2
Waters, C.M.3
Connell, M.C.4
Willard, F.S.5
Kimple, A.J.6
-
37
-
-
84879803703
-
Prospective validation of candidate snps of vegf/vegfr pathway in metastatic colorectal cancer patients treated with first-line folfiri plus bevacizumab
-
Loupakis F, Cremolini C, Yang D, Salvatore L, Zhang W, Wakatsuki T et al. Prospective validation of candidate SNPs of VEGF/VEGFR pathway in metastatic colorectal cancer patients treated with First-Line FOLFIRI plus bevacizumab. PLoS One 2013; 8: e66774.
-
(2013)
PLoS One
, vol.8
-
-
Loupakis, F.1
Cremolini, C.2
Yang, D.3
Salvatore, L.4
Zhang, W.5
Wakatsuki, T.6
|