Abnormal morphology of myelin and axon pathology in murine models of multiple sclerosis

Neurochemistry International

Volumn 81, Issue , 2015, Pages 16-27

  Bando, Yoshio ^a   Nomura, Taichi ^a   Bochimoto, Hiroki ^a   Murakami, Koichi ^a   Tanaka, Tatsuhide ^a   Watanabe, Tsuyoshi ^a   Yoshida, Shigetaka ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

Axon; Axonal injury; Demyelination; Multiple sclerosis; Myelin

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; CUPRIZONE; MYELIN; OSMIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; CORPUS CALLOSUM; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXPERIMENTAL NEUROLOGIC DISEASE; FEMALE; GOLGI COMPLEX; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUMBAR SPINAL CORD; MITOCHONDRION; MOLECULAR PATHOLOGY; MOUSE; MOUSE MODEL; MULTIPLE SCLEROSIS; NERVE FIBER; NEUROPATHOLOGY; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN STRUCTURE; REMYELINIZATION; SCANNING ELECTRON MICROSCOPY; SHIVERER MOUSE; SMOOTH ENDOPLASMIC RETICULUM; SPINAL CORD NERVE CELL; WHITE MATTER; ANIMAL; AUTOPSY; BRAIN; C57BL MOUSE; DISEASE MODEL; METABOLISM; MYELIN SHEATH; PATHOLOGY; SPINAL CORD; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ANIMALIA; MURINAE; MUS;

ANIMALS; AUTOPSY; AXONS; BRAIN; CUPRIZONE; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; MULTIPLE SCLEROSIS; MYELIN SHEATH; SPINAL CORD;

EID: 84921853739     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2015.01.002     Document Type: Article

References (42)

1. Arnett H.A., Mason J., Marino M., Suzuki K., Matsushima G.K., and Ting J.P. TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination Nat. Neurosci 11 2001 1116 1122
2. Bando Y., Ito S., Nagai Y., Terayama R., Kishibe M., and Jiang Y.P. Implications of protease M/neurosin in myelination during experimental demyelination and remyelination Neurosci. Lett 405 2006 175 180
3. Baumann N., and Pham-Dinh D. Biology of oligodendrocyte and myelin in the mammalian central nervous system Physiol. Rev 81 2001 871 927
4. Blackmore W.F. Observations on oligodendrocyte degeneration, the resolution of status spongiosus and remyelination in cuprizone intoxication in mice J. Neurocyrol 1 1972 413 426
5. Campbell G.R., Ohno N., Turnbull D.M., and Mahad D.J. Mitochondrial changes within axons in multiple sclerosis: an update Curr. Opin. Neurol 25 2012 221 230
6. Craner M., and Fugger L. Axonal injury in reverse Nat. Med 17 2011 423 425
7. Denic A., Johnson A.J., Bieber A.J., Warrington A.E., Rodriguez M., and Pirko I. The relevance of animal models in multiple sclerosis research Pathophysiology 18 2011 21 29
8. Dhib-Jalbut S. Pathologenesis of myelin/oligodendrocyte damage in multiple sclerosis Neurology 68 2007 S13 S21
9. Dutta R., and Trapp B.D. Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis Prog. Neurobiol 93 2011 1 12
10. Dutta R., McDonough J., Yin X., Peterson J., Chang A., and Torres T. Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients Ann. Neurol 59 2006 478 489
11. Edgar J.M., McLaughlin M., Yool D., Zhang S.C., Fowler J.H., and Montague P. Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia J. Cell Biol 166 2004 121 131
12. Greenstein J.I. Current concepts of the cellular and molecular pathophysiology of multiple sclerosis Dev. Neurobiol 67 2007 1248 1265
13. Gudi V., Gingele S., Skripuletz T., and Stangel M. Glial response during cuprizone-induced de- and remyelination in the CNS: lessons learned Front Cell Neurosci 8 2014 73
14. Hafler D.A. Multiple sclerosis J. Clin. Invest 113 2004 788 794
15. Issazadeh S., Abdallah K., Chitnis T., Chandraker A., Wells A.D., and Turka L.A. Role of passive T-cell death in chronic experimental autoimmune encephalomyelitis J. Clin. Invest 105 2000 1109 1116
16. Kiryu-Seo S., Ohno N., Kidd G.J., Komuro H., and Trapp B.D. Demyelination increases axonal stationary mitochondrial size and the speed of axonal mitochondrial transport J. Neurosci 30 2010 6658 6666
17. Krumbholz M., and Meinl E. B cells in MS and NMO: pathogenesis and therapy Semin. Immunopathol 36 2014 339 350
18. Lappe-Siefke C., Goebbels S., Gravel M., Nicksch E., Lee J., and Braun P.E. Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination Nat. Genet 33 2003 366 374
19. Martin R., McFarland H.F., and McFarlin D.E. Immunological aspects of demyelinating diseases Annu. Rev. Immunol 10 1992 153 187
20. Mayo L., Quintana F.J., and Weiner H.L. The innate immune system in demyelinating disease Immunol. Rev 248 2012 170 187
21. Misko A., Jiang S., Wegorzewska I., Milbrandt J., and Baloh R.H. Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex J. Neurosci 30 2010 4232 4240
22. Mix E., Meyer-Rienecker H., Peter Hartung H., and Zettl U.K. Animal models of multiple sclerosis - potentials and limitations Prog. Neurobiol 92 2010 386 404
23. Nikić I., Merkler D., Sorbara C., Brinkoetter M., Kreutzfeldt M., and Bareyre F.M. A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis Nat. Med 17 2011 495 499
24. Nomura T., Bando Y., Bochimoto H., Koga D., Watanabe T., and Yoshida S. Three-dimensional ultra-structures of myelin and the axons in the spinal cord: application of SEM with the osmium maceration method to the central nervous system in two mouse models Neurosci. Res 75 2013 190 197
25. Noseworthy J.H., Lucchinetti C., Rodriguez M., and Weinshenker B.G. Multiple sclerosis N. Engl. J. Med 343 2000 938 952
26. Ohno N., Kidd G.J., Mahad D., Kiryu-Seo S., Avishai A., and Komuro H. Myelination and axonal electrical activity modulate the distribution and motility of mitochondria at CNS nodes of Ranvier J. Neurosci 31 2011 7249 7258
27. Perkins G.A., Sosinsky G.E., Ghassemzadeh S., Perez A., Jones Y., and Ellisman M.H. Electron tomographic analysis of cytoskeletal cross-bridges in the paranodal region of the node of Ranvier in peripheral nerves J. Struct. Biol 161 3 2008 469 480
28. Ramírez O.A., and Couve A. The endoplasmic reticulum and protein trafficking in dendrites and axons Trends Cell Biol 21 4 2011 219 227
29. Sano, Y., 1995. Neuroscience-Morphological Basis. I Neuron and Glia 136.
30. Sato N., Seiwa C., Uruse M., Yamamoto M., Tanaka K., and Kawakita T. Administration of chinpi, a component of the herbal medicine ninjin-youei-to, reverses age-induced demyelination Evid. Based Complement. Alternat. Med 2011 2011 617438
31. Schirmer L., Merkler D., König F.B., Brück W., and Stadelmann C. Neuroaxonal regeneration is more pronounced in early multiple sclerosis than in traumatic brain injury lesions Brain Pathol 23 2013 2 12
32. Sharp W.W., Fang Y.H., Han M., Zhang H.J., Hong Z., and Banathy A. Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission FASEB J. 28 2014 316 326
33. Stadelmann C., Wegner C., and Brück W. Inflammation, demyelination, and degeneration - recent insights from MS pathology Biochim. Biophys. Acta 1812 2011 275 282
34. Stirling D.P., and Stys P.K. Mechanisms of axonal injury: internodal nanocomplexes and calcium deregulation Trends Mol. Med 16 2010 160 170
35. Stirling D.P., Cummins K., Wayne Chen S.R., and Stys P. Axoplasmic reticulum Ca(2+) release causes secondary degeneration of spinal axons Ann. Neurol 75 2014 220 229
36. Tanaka T., Murakami K., Bando Y., and Yoshida S. Minocycline reduces remyelination by suppressing ciliary neurotrophic factor expression after cuprizone-induced demyelination J. Neurochem 127 2013 259 270
37. Terayama R., Bando Y., Murakami K., Kato K., Kishibe M., and Yoshida S. Neuropsin promotes oligodendrocyte death, demyelination and axonal degeneration after spinal cord injury Neuroscience 148 2007 175 187
38. Trapp B.D., and Stys P.K. Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis Lancet Neurol 8 2009 280 291
39. Tse H.Y., Li J., Zhao X., Chen F., Ho P.P., and Shaw M.K. Lessons learned from studies of natural resistance in murine experimental autoimmune encephalomyelitis Curr. Trends Immunol 13 2012 1 12
40. Watanabe T., Sakai Y., Koga D., Bochimoto H., Hira Y., and Hosaka M. A unique ball-shaped Golgi apparatus in the rat pituitary gonadotrope: its functional implications in relation to the arrangement of the microtubule network J. Histochem. Cytochem 60 2012 588 602
41. Yin X., Crawford T.O., Griffin J.W., Tu P.-H., Lee V.M.Y., and Li C. Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons J. Neurosci 18 1998 1953 1962
42. Zhang C.L., Ho P.L., Kintner D.B., Sun D., and Chiu S.Y. Activity-dependent regulation of mitochondrial motility by calcium and Na/K-ATPase at nodes of Ranvier of myelinated nerves J. Neurosci 30 2010 3555 3566