What do we mean by multimorbidity? An analysis of the literature on multimorbidity measures, associated factors, and impact on health services organization

Revue d'Epidemiologie et de Sante Publique

Volumn 62, Issue 5, 2014, Pages 305-314

  Lefevre T ^a,b   d'Ivernois, J F ^b   De Andrade, V ^b   Crozet, C ^b   Lombrail, P ^b   Gagnayre, R ^b  

^a HÔPITAL JEAN VERDIER   (France)

^b UNIVERSITÉ PARIS 13   (France)

Author keywords

Comorbidity; Multimorbidity; Multiple chronic conditions

Indexed keywords

AGE; ARTICLE; ECONOMICS; FUNCTIONAL ASSESSMENT; GENDER; HEALTH CARE NEED; HEALTH CARE ORGANIZATION; HEALTH SERVICE; HUMAN; LITERATURE; MORBIDITY; MULTIMORBIDITY; PREVALENCE; RISK FACTOR; SOCIOECONOMICS; SYSTEMATIC REVIEW; COMORBIDITY; NOMENCLATURE;

COMORBIDITY; HUMANS; TERMINOLOGY AS TOPIC;

EID: 84921847497     PISSN: 03987620     EISSN: 17730627     Source Type: Journal    
DOI: 10.1016/j.respe.2014.09.002     Document Type: Article

References (64)

1. Murray C.J.L., Vos T., Lozano R., Naghavi M., Flaxman A.D., Michaud C., et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012, 380:2197-2223.
2. Yang G., Wang Y., Zeng Y., Gao G.F., Liang X., Zhou M., et al. Rapid health transition in China, 1990-2010: findings from the Global Burden of Disease Study 2010. Lancet 2013, 381:1987-2015.
3. Bloom D., Cafiero E., Jané-Llopis E., Abrahams-Gessel S., Bloom L., Fathima S. The Global Economic Burden of Noncommunicable Diseases 2011, World Economic Forum, Geneva, Switzerland, [World Economic Forum].
4. Chisholm D., Abegunde D., Mendis S., Alwan A., Evans D., Tan Torres Edejer T. Scaling up action noncommunicable diseases: How much will it cost? 2011, World Health Organization, Geneva.
5. Hughes L.D., McMurdo M.E.T., Guthrie B. Guidelines for people not for diseases: the challenges of applying UK clinical guidelines to people with multimorbidity. Age Ageing 2013, 42:62-69.
6. Barnett K., Mercer S.W., Norbury M., Watt G., Wyke S., Guthrie B. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet 2012, 380:37-43.
7. Sampalli T., Fox R.A., Dickson R., Fox J. Proposed model of integrated care to improve health outcomes for individuals with multimorbidities. Patient Prefer Adherence 2012, 6:757-764.
8. D' Ivernois J.-F., Gagnayre R. Éducation thérapeutique chez les patients pluripathologiques Propositions pour la conception de nouveaux programmes d'ETP. Education Thérapeutique du Patient - Therapeutic Patient Education 2012, 5:201-204.
9. Feinstein A.R. The pre-therapeutic classification of co-morbidity in chronic disease. Journal of Chronic Diseases 1970, 23:455-468.
10. Van der Akker M., Buntinx F., Knottnerus A. Comorbidity or multimorbidity what's in a name? A review of literature. Eur J Gen Pract 1996, 2:65-70.
11. Vogeli C., Shields A.E., Lee T.A., Gibson T.B., Marder W.D., Weiss K.B., et al. Multiple chronic conditions: prevalence, health consequences, and implications for quality, care management, and costs. J Gen Intern Med 2007, 22(Suppl. 3):391-395.
12. Huntley A.L., Johnson R., Purdy S., Valderas J.M., Salisbury C. Measures of multimorbidity and morbidity burden for use in primary care and community settings: a systematic review and guide. Ann Fam Med 2012, 10:134-141.
13. Diederichs C., Berger K., Bartels D.B. The measurement of multiple chronic diseases-A systematic review on existing multimorbidity indices. J Gerontol A Biol Sci Med Sci 2011, 66:301-311.
14. Le Reste J.Y., Nabbe P., Manceau B., Lygidakis C., Doerr C., Lingner H., et al. The European General Practice Research Network presents a comprehensive definition of multimorbidity in family medicine and long-term care, following a systematic review of relevant literature. J Am Med Dir Assoc 2013, 14:319-325.
15. Steiner C.A., Friedman B. Hospital utilization, costs, and mortality for adults with multiple chronic conditions, nationwide inpatient sample, 2009. Prev Chronic Dis 2013, 10.
16. Salisbury C., Johnson L., Purdy S., Valderas J.M., Montgomery A.A. Epidemiology and impact of multimorbidity in primary care: a retrospective cohort study. Br J Gen Pract 2011, 61:12-21.
17. Byles J.E., D'Este C., Parkinson L., O'Connell R., Treloar C. Single index of multimorbidity did not predict multiple outcomes. J Clin Epidemiol 2005, 58:997-1005.
18. García-Olmos L., Salvador C.H., Alberquilla Á., Lora D., Carmona M., García-Sagredo P., et al. Comorbidity patterns in patients with chronic diseases in general practice. PLoS ONE 2012, 7:e32141.
19. Gijsen R., Hoeymans N., Schellevis F.G., Ruwaard D., Satariano W.A., van den Bos G.A. Causes and consequences of comorbidity: a review. J Clin Epidemiol 2001, 54:661-674.
20. Van den Akker M., Buntinx F., Roos S., Knottnerus J.A. Problems in determining occurrence rates of multimorbidity. J Clin Epidemiol 2001, 54:675-679.
21. Bayliss E.A., Ellis J.L., Steiner J.F. Seniors' self-reported multimorbidity captured biopsychosocial factors not incorporated into two other data-based morbidity measures. J Clin Epidemiol 2009, 62:550-557.e1.
22. Fortin M., Stewart M., Poitras M.-E., Almirall J., Maddocks H. A systematic review of prevalence studies on multimorbidity: toward a more uniform methodology. Ann Fam Med 2012, 10:142-151.
23. Bayliss E.A., Ellis J.L., Steiner J.F., Main D.S. Initial validation of an instrument to identify barriers to self-management for persons with co-morbidities. Chronic Illn 2005, 1:315-320.
24. Lehnert T., Heider D., Leicht H., Heinrich S., Corrieri S., Luppa M., et al. Review: health care utilization and costs of elderly persons with multiple chronic conditions. Med Care Res Rev 2011, 68:387-420.
25. Kirchberger I., Meisinger C., Heier M., Zimmermann A.-K., Thorand B., Autenrieth C.S., et al. Patterns of multimorbidity in the aged population. Results from the KORA-Age study. PLoS ONE 2012, 7:e30556.
26. Bayliss E.A., Edwards A.E., Steiner J.F., Main D.S. Processes of care desired by elderly patients with multimorbidities. Fam Pract 2008, 25:287-293.
27. Langan J., Mercer S.W., Smith D.J. Multimorbidity and mental health: can psychiatry rise to the challenge?. Br J Psychiatry 2013, 202:391-393.
28. Markowitz S.M., Gonzalez J.S., Wilkinson J.L., Safren S.A. A review of treating depression in diabetes: emerging findings. Psychosomatics 2011, 52:1-18.
29. Piette J.D., Richardson C., Valenstein M. Addressing the needs of patients with multiple chronic illnesses: the case of diabetes and depression. Am J Manag Care 2004, 10(2 Pt 2):152-162.
30. Roy-Byrne P.P., Davidson K.W., Kessler R.C., Asmundson G.J.G., Goodwin R.D., Kubzansky L., et al. Anxiety disorders and comorbid medical illness. Gen Hosp Psychiatry 2008, 30:208-225.
31. Quinones A.R., Liang J., Bennett J.M., Xu X., Ye W. How does the trajectory of multimorbidity vary across black, white, and Mexican Americans in middle and old age?. J Gerontol B Psychol Sci Soc Sci 2011, 66B:739-749.
32. Marengoni A., von Strauss E., Rizzuto D., Winblad B., Fratiglioni L. The impact of chronic multimorbidity and disability on functional decline and survival in elderly persons. A community-based, longitudinal study. J Intern Med 2009, 265:288-295.
33. Fortin M., Lapointe L., Hudon C., Vanasse A., Ntetu A.L., Maltais D. Multimorbidity and quality of life in primary care: a systematic review. Health Qual Life Outcomes 2004, 2:51.
34. Higashi T., Wenger N.S., Adams J.L., Fung C., Roland M., McGlynn E.A., et al. Relationship between number of medical conditions and quality of care. N Engl J Med 2007, 356:2496-2504.
35. Bae S., Rosenthal M.B. Patients with multiple chronic conditions do not receive lower quality of preventive care. J Gen Intern Med 2008, 23:1933-1939.
36. Brilleman S.L., Salisbury C. Comparing measures of multimorbidity to predict outcomes in primary care: a cross sectional study. Fam Pract 2013, 30:172-178.
37. Schäffer I. Does multimorbidity influence the occurrence rates of chronic conditions? A claims data based comparison of expected and observed prevalence rates. PLoS ONE 2012, 7:e45390.
38. Laux G., Kuehlein T., Rosemann T., Szecsenyi J. Co- and multimorbidity patterns in primary care based on episodes of care: results from the German CONTENT project. BMC Health Serv Res 2008, 8:14.
39. Weber G.M., Mandl K.D., Kohane I.S. Finding the missing link for biomedical data. JAMA 2014, 311:2479-2480.
40. Lappenschaar M., Hommersom A., Lucas P.J., Lagro J., Visscher S., Korevaar J.C., et al. Multilevel temporal Bayesian networks can model longitudinal change in multimorbidity. J Clin Epidemiol 2013, 66:1405-1416.
41. Tinetti M.E.F.T. DEsigning health care for the most common chronic condition-multimorbidity. JAMA 2012, 307:2493-2494.
42. Boyd C.M.D.J. Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: Implications for pay for performance. JAMA 2005, 294:716-724.
43. Goldberger J.J. Personalized medicine vs guideline-based medicine. JAMA 2013, 309:2559.
44. Fortin M., Dionne J., Pinho G., Gignac J., Almirall J., Lapointe L. Randomized controlled trials: do they have external validity for patients with multiple comorbidities?. Ann Fam Med 2006, 4:104-108.
45. Bogner H.R., de Vries H.F. Integration of depression and hypertension treatment: a pilot, randomized controlled trial. Ann Fam Med 2008, 6:295-301.
46. Krska J., Cromarty J.A., Arris F., Jamieson D., Hansford D., Duffus P.R., et al. Pharmacist-led medication review in patients over 65: a randomized, controlled trial in primary care. Age Ageing 2001, 30:205-211.
47. Sommers L.S., Marton K.I., Barbaccia J.C., Randolph J. Physician, nurse, and social worker collbration in primary care for chronically ill seniors. Arch Intern Med 2000, 160:1825-1833.
48. Gitlin L.N., Hauck W.W., Dennis M.P., Winter L., Hodgson N., Schinfeld S. Long-term effect on mortality of a home intervention that reduces functional difficulties in older adults: results from a randomized trial. J Am Geriatrics Soc 2009, 57:476-481.
49. Hochhalter A.K., Song J., Rush J., Sklar L., Stevens A. Making the most of your healthcare intervention for older adults with multiple chronic illnesses. Patient Educ Couns 2010, 81:207-213.
50. Smith S.M., Soubhi H., Fortin M., Hudon C., O'Dowd T. Managing patients with multimorbidity: systematic review of interventions in primary care and community settings. BMJ 2012, 345:e5205.
51. Gravelle H., Dusheiko M., Sheaff R., Sargent P., Boaden R., Pickard S., et al. Impact of case management (Evercare) on frail elderly patients: controlled before and after analysis of quantitative outcome data. BMJ 2007, 334:31.
52. Boult C., Wieland G.D. Comprehensive primary care for older patients with multiple chronic conditions: "nobody rushes you through". JAMA 2010, 304:1936-1943.
53. Béland F., Bergman H., Lebel P., Clarfield A.M., Tousignant P., Contandriopoulos A.-P., et al. A system of integrated care for older persons with disabilities in Canada: results from a randomized controlled trial. J Gerontol A Biol Sci Med Sci 2006, 61:367-373.
54. Melis R.J.F., van Eijken M.I.J., Teerenstra S., van Achterberg T., Parker S.G., Borm G.F., et al. A randomized study of a multidisciplinary program to intervene on geriatric syndromes in vulnerable older people who live at home (Dutch EASYcare Study). J Gerontol A Biol Sci Med Sci 2008, 63:283-290.
55. De Bruin S.R., Versnel N., Lemmens L.C., Molema C.C.M., Schellevis F.G., Nijpels G., et al. Comprehensive care programs for patients with multiple chronic conditions: a systematic literature review. Health Policy 2012, 107:108-145.
56. Bayliss E.A., Steiner J.F., Fernald D.H., Crane L.A., Main D.S. Descriptions of barriers to self-care by persons with comorbid chronic diseases. Ann Fam Med 2003, 1:15-21.
57. Bower P., Macdonald W., Harkness E., Gask L., Kendrick T., Valderas J.M., et al. Multimorbidity, service organization and clinical decision making in primary care: a qualitative study. Fam Pract 2011, 28:579-587.
58. Thille P., Ward N., Russell G. Self-management support in primary care: Enactments, disruptions, and conversational consequences. Soc Sci Med 2014, 108C:97-105.
59. Morris R.L., Sanders C., Kennedy A.P., Rogers A. Shifting priorities in multimorbidity: a longitudinal qualitative study of patient's prioritization of multiple conditions. Chronic Illn 2011, 7:147-161.
60. Van den Akker M., Buntinx F., Metsemakers J.F., Roos S., Knottnerus J.A. Multimorbidity in general practice: prevalence, incidence, and determinants of co-occurring chronic and recurrent diseases. J Clin Epidemiol 1998, 51:367-375.
61. Britt H.C., Harrison C.M., Miller G.C., Knox S.A. Prevalence and patterns of multimorbidity in Australia. Med J Aust 2008, 189:72-77.
62. Westert G.P., Satariano W.A., Schellevis F.G., van den Bos G.A. Patterns of comorbidity and the use of health services in the Dutch population. Eur J Public Health 2001, 11:365-372.
63. Prados-Torres A., Poblador-Plou B., Calderón-Larrañaga A., Gimeno-Feliu L.A., González-Rubio F., Poncel-Falcó A., et al. Multimorbidity patterns in primary care: interactions among chronic diseases using factor analysis. PLoS ONE 2012, 7:e32190.
64. Ashman J.J., Beresovsky V. Multiple chronic conditions among US adults who visited physician offices: data from the national Ambulatory Medical Care Survey, 2009. Prev Chronic Dis 2013, 10.