Multidimensional mass spectrometry-based shotgun lipidomics

Methods in Molecular Biology

Volumn 1198, Issue , 2014, Pages 203-220

  Wang, Miao ^a   Han, Xianlin ^a  

^a NONE

Author keywords

Direct infusion; Intrasource separation; Lipidome; Mass spectrometry; Shotgun lipidomics

Indexed keywords

LIPID; LIPIDOME;

ARTICLE; ELECTROSPRAY MASS SPECTROMETRY; HYDROPHOBICITY; IONIZATION; LIPID ANALYSIS; LIPIDOMICS; MASS SPECTROMETRY; MOLECULE; NOISE; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DETERMINATION; ANIMAL; HUMAN; ISOLATION AND PURIFICATION; LIPID METABOLISM; METABOLOMICS; PROCEDURES;

ANIMALS; HUMANS; LIPID METABOLISM; LIPIDS; MASS SPECTROMETRY; METABOLOMICS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84921837979     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-1258-2_13     Document Type: Article

References (34)

1. Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AH Jr, Murphy RC, Raetz CR, Russell DW, Seyama Y, Shaw W, Shimizu T, Spener F, van Meer G, VanNieuwenhze MS, White SH, Witztum JL, Dennis EA (2005) A comprehensive classification system for lipids. J Lipid Res 46:839–861
2. Han X, Gross RW (2003) Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics. J Lipid Res 44: 1071–1079
3. Shevchenko A, Simons K (2010) Lipidomics: coming to grips with lipid diversity. Nat Rev Mol Cell Biol 11:593–598
4. Han X, Gross RW (2005) Shotgun lipidomics: Electrospray ionization mass spectrometric analysis and quantitation of the cellular lipidomes directly from crude extracts of biological samples. Mass Spectrom Rev 24:367–412
5. Han X, Gross RW (2005) Shotgun lipidomics: multi-dimensional mass spectrometric analysis of cellular lipidomes. Expert Rev Proteomics 2:253–264
6. Han X, Yang K, Gross RW (2012) Multidimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses. Mass Spectrom Rev 31:134–178
7. Sun G, Yang K, Zhao Z, Guan S, Han X, Gross RW (2008) Matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of cellular glycerophospholipids enabled by multiplexed solvent dependent analyte- matrix interactions. Anal Chem 80:7576–7585
8. Kiebish MA, Bell R, Yang K, Phan T, Zhao Z, Ames W, Seyfried TN, Gross RW, Chuang JH, Han X (2010) Dynamic simulation of cardiolipin remodeling: greasing the wheels for an interpretative approach to lipidomics. J Lipid Res 51:2153–2170
9. Yang K, Han X (2011) Accurate Quantification of Lipid Species by Electrospray Ionization Mass Spectrometry–Meets a Key Challenge in Lipidomics. Metabolites 1:21–40
10. Jiang X, Cheng H, Yang K, Gross RW, Han X (2007) Alkaline methanolysis of lipid extracts extends shotgun lipidomics analyses to the low abundance regime of cellular sphingolipids. Anal Biochem 371:135–145
11. Yang K, Zhao Z, Gross RW, Han X (2007) Shotgun lipidomics identifies a paired rule for the presence of isomeric ether phospholipid molecular species. PLoS ONE 2:e1368
12. Han X, Yang K, Cheng H, Fikes KN, Gross RW (2005) Shotgun lipidomics of phosphoethanolamine- containing lipids in biological samples after one-step in situ derivatization. J Lipid Res 46:1548–1560
13. Wang M, Fang H, Han X (2012) Shotgun lipidomics analysis of 4-hydroxyalkenal species directly from lipid extracts after one-step in situ derivatization. Anal Chem 84:4580–4586
14. Han X, Yang J, Cheng H, Ye H, Gross RW (2004) Towards fingerprinting cellular lipidomes directly from biological samples by twodimensional electrospray ionization mass spectrometry. Anal Biochem 330:317–331
15. Han X, Gross RW (1994) Electrospray ionization mass spectroscopic analysis of human erythrocyte plasma membrane phospholipids. Proc Natl Acad Sci U S A 91:10635–10639
16. Koivusalo M, Haimi P, Heikinheimo L, Kostiainen R, Somerharju P (2001) Quantitative determination of phospholipid compositions by ESI-MS: effects of acyl chain length, unsaturation, and lipid concentration on instrument response. J Lipid Res 42:663–672
17. DeLong CJ, Baker PRS, Samuel M, Cui Z, Thomas MJ (2001) Molecular species composition of rat liver phospholipids by ESI-MS/ MS: the effect of chromatography. J Lipid Res 42:1959–1968
18. Yang K, Cheng H, Gross RW, Han X (2009) Automated lipid identification and quantification by multi-dimensional mass spectrometrybased shotgun lipidomics. Anal Chem 81: 4356–4368
19. Han X, Yang K, Gross RW (2008) Microfluidicsbased electrospray ionization enhances intrasource separation of lipid classes and extends identification of individual molecular species through multi-dimensional mass spectrometry: Development of an automated high throughput platform for shotgun lipidomics. Rapid Commun Mass Spectrom 22:2115–2124
20. Yang K, Fang X, Gross RW, Han X (2011) A practical approach for determination of mass spectral baselines. J Am Soc Mass Spectrom 22:2090–2099
21. Han X, Gross RW (2001) Quantitative analysis and molecular species fingerprinting of triacylglyceride molecular species directly from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry. Anal Biochem 295:88–100
22. Christie WW, Han X (2010) Lipid Analysis: Isolation, Separation, Identification and Lipidomic Analysis, 4th edn. The Oily Press, Bridgwater, England
23. Han X, Yang K, Yang J, Cheng H, Gross RW (2006) Shotgun lipidomics of cardiolipin molecular species in lipid extracts of biological samples. J Lipid Res 47:864–879
24. Vance DE, Vance JE (2008) Biochemistry of Lipids, Lipoproteins and Membranes, 5th edn. Elsevier Science B.V, Amsterdam
25. Yang K, Zhao Z, Gross RW, Han X (2009) Systematic analysis of choline-containing phospholipids using multi-dimensional mass spectrometry- based shotgun lipidomics. J Chromatogr B 877:2924–2936
26. Han X (2002) Characterization and direct quantitation of ceramide molecular species from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry. Anal Biochem 302:199–212
27. Han X, Cheng H (2005) Characterization and direct quantitation of cerebroside molecular species from lipid extracts by shotgun lipidomics. J Lipid Res 46:163–175
28. Hsu FF, Turk J (2001) Structural determination of glycosphingolipids as lithiated adducts by electrospray ionization mass spectrometry using low-energy collisional-activated dissociation on a triple stage quadrupole instrument. J Am Soc Mass Spectrom 12:61–79
29. Hsu F-F, Bohrer A, Turk J (1998) Electrospray ionization tandem mass spectrometric analysis of sulfatide. Determination of fragmentation patterns and characterization of molecular species expressed in brain and in pancreatic islets. Biochim Biophys Acta 1392:202–216
30. Jiang X, Han X (2006) Characterization and direct quantitation of sphingoid base-1- phosphates from lipid extracts: A shotgun lipidomics approach. J Lipid Res 47:1865–1873
31. Jiang X, Yang K, Han X (2009) Direct quantitation of psychosine from alkaline-treated lipid extracts with a semi-synthetic internal standard. J Lipid Res 50:162–172
32. Cheng H, Jiang X, Han X (2007) Alterations in lipid homeostasis of mouse dorsal root ganglia induced by apolipoprotein E deficiency: A shotgun lipidomics study. J Neurochem 101: 57–76
33. Su X, Han X, Mancuso DJ, Abendschein DR, Gross RW (2005) Accumulation of longchain acylcarnitine and 3-hydroxy acylcarnitine molecular species in diabetic myocardium: identification of alterations in mitochondrial fatty acid processing in diabetic myocardium by shotgun lipidomics. Biochemistry 44:5234–5245
34. Kalderon B, Sheena V, Shachrur S, Hertz R, Bar-Tana J (2002) Modulation by nutrients and drugs of liver acyl-CoAs analyzed by mass spectrometry. J Lipid Res 43:1125–1132