Cardiac myostatin upregulation occurs immediately after myocardial ischemia and is involved in skeletal muscle activation of atrophy

Biochemical and Biophysical Research Communications

Volumn 457, Issue 1, 2015, Pages 106-111

  Castillero, Estibaliz ^a   Akashi, Hirokazu ^b   Wang, Catherine ^a   Najjar, Marc ^a   Ji, Ruiping ^a   Kennel, Peter J ^a   Sweeney, H Lee ^c   Schulze, Paul C ^a   George, Isaac ^a  

^a Division of Cardiothoracic Surgery New York Presbyterian Hospital College of Physicians and Surgeons of Columbia University ^*  (United States)

^b JUNTENDO UNIVERSITY   (Japan)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cardiac cachexia; Grow factors; Heart failure; Ischemia; Myostatin

Indexed keywords

ATROGIN 1; MITOGEN ACTIVATED PROTEIN KINASE P38; MUSCLE RING FINGER 1 PROTEIN; MYOSTATIN; PROTEASOME; PROTEIN KINASE B; UBIQUITIN; BIOLOGICAL MARKER; FBXO32 PROTEIN, MOUSE; MSTN PROTEIN, MOUSE; MUSCLE PROTEIN; SMAD PROTEIN; TRIM63 PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE;

ACUTE HEART INFARCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; HEART INJURY; MALE; MOUSE; MUSCLE ATROPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; UPREGULATION; ANIMAL; BLOOD; C57BL MOUSE; HEART MUSCLE; HEART MUSCLE ISCHEMIA; METABOLISM; PATHOLOGY; TIME;

MUS;

ANIMALS; BIOLOGICAL MARKERS; MALE; MICE, INBRED C57BL; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUSCULAR ATROPHY; MYOCARDIAL ISCHEMIA; MYOCARDIUM; MYOSTATIN; SIGNAL TRANSDUCTION; SKP CULLIN F-BOX PROTEIN LIGASES; SMAD PROTEINS; TIME FACTORS; UBIQUITIN-PROTEIN LIGASES; UP-REGULATION;

EID: 84921783568     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.12.057     Document Type: Article

References (26)

1. A.C. McPherron, A.M. Lawler, S.J. Lee, Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member, Nature 387 (1997) 83-90.
2. M. Sharma, R. Kambadur, K.G. Matthews, et al., Myostatin, a transforming growth factor-beta superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct, J. Cell. Physiol. 180 (1999) 1-9.
3. K.G. Shyu, M.J. Lu, B.W. Wang, et al., Myostatin expression in ventricular myocardium in a rat model of volume-overload heart failure, Eur. J. Clin. Invest. 36 (2006) 713-719.
4. K. Lenk, R. Schur, A. Linke, et al., Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in a chronic heart failure model, Eur. J. Heart Fail. 11 (2009) 342-348.
5. I. George, L.T. Bish, G. Kamalakkannan, et al., Myostatin activation in patients with advanced heart failure and after mechanical unloading, Eur. J. Heart Fail. 12 (2010) 444-453.
6. L.T. Bish, I. George, S. Maybaum, et al., Myostatin is elevated in congenital heart disease and after mechanical unloading, PLoS One 6 (2011) e23818.
7. N. Biesemann, L. Mendler, A. Wietelmann, et al., Myostatin regulates energy homeostasis in the heart and prevents heart failure, Circulation Res. 115 (2014) 296-310.
8. M.F. Jackson, D. Luong, D.D. Vang, et al., The aging myostatin null phenotype: reduced adiposity, cardiac hypertrophy, enhanced cardiac stress response, and sexual dimorphism, J. Endocrinol. 213 (2012) 263-275.
9. B.D. Rodgers, J.P. Interlichia, D.K. Garikipati, et al., Myostatin represses physiological hypertrophy of the heart and excitation-contraction coupling, J. Physiol. 587 (2009) 4873-4886.
10. K.G. Shyu, W.H. Ko, W.S. Yang, et al., Insulin-like growth factor-1 mediates stretch-induced upregulation of myostatin expression in neonatal rat cardiomyocytes, Cardiovasc. Res. 68 (2005) 405-414.
11. M.R. Morissette, S.A. Cook, S. Foo, et al., Myostatin regulates cardiomyocyte growth through modulation of Akt signaling, Circulation Res. 99 (2006) 15-24.
12. J. Heineke, M. Auger-Messier, J. Xu, et al., Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure, Circulation 121 (2010) 419-425.
13. K. Lenk, R. Schur, A. Linke, et al., Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in a chronic heart failure model, Eur. J. Heart Fail. 11 (2009) 342-348.
14. Z. Aversa, A. Bonetto, F. Penna, et al., Changes in myostatin signaling in non-weight-losing cancer patients, Ann. Surg. Oncol. 19 (2012) 1350-1356.
15. N.F. Gonzalez-Cadavid, W.E. Taylor, K. Yarasheski, et al., Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting, Proc. Natl. Acad. Sci. USA 95 (1998) 14938-14943.
16. P.J. Plant, D. Brooks, M. Faughnan, et al., Cellular markers of muscle atrophy in chronic obstructive pulmonary disease, Am. J. Respir. Cell Mol. Biol. 42 (2010) 461-471.
17. I.J. Smith, Z. Aversa, N. Alamdari, et al., Sepsis downregulates myostatin mRNA levels without altering myostatin protein levels in skeletal muscle, J. Cell. Biochem. 111 (2010) 1059-1073.
18. E. Castillero, A.I. Martín, M. López-Menduiña, et al., IGF-I system, atrogenes and myogenic regulatory factors in arthritis induced muscle wasting, Mol. Cell. Endocrinol. 309 (2009) 8-16.
19. A.R. Lima, P.F. Martinez, K. Okoshi, et al., Myostatin and follistatin expression in skeletal muscles of rats with chronic heart failure, Int. J. Exp. Pathol. 91 (2010) 54-62.
20. C. McFarlane, E. Plummer, M. Thomas, et al., Myostatin induces cachexia by activating the ubiquitin proteolytic system through an NF-kappaB-independent, FoxO1-dependent mechanism, J. Cell. Physiol. 209 (2006) 501-514.
21. M. Kato, S. Putta, M. Wang, et al., TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN, Nat. Cell. Biol. 11 (2009) 881-889.
22. J.L. Chen, K.L. Walton, C.E. Winbanks, et al., Elevated expression of activins promotes muscle wasting and cachexia, FASEB J. 28 (2014) 1711-1723.
23. F.S. Loffredo, M.L. Steinhauser, S.M. Jay, et al., Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy, Cell 153 (2013) 828-839.
24. T.A. Souza, X. Chen, Y. Guo, et al., Proteomic identification and functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators, Mol. Endocrinol. 22 (2008) 2689-2702.
25. B.W. Wang, H. Chang, P. Kuan, et al., Angiotensin II activates myostatin expression in cultured rat neonatal cardiomyocytes via p38 MAP kinase and myocyte enhance factor 2 pathway, J. Endocrinol. 197 (2008) 85-93.
26. S.D. Anker, P. Ponikowski, S. Varney, et al., Wasting as independent risk factor for mortality in chronic heart failure, Lancet 349 (1997) 1050-1053.