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Volumn 180, Issue 8, 2014, Pages 847-852

The explanatory role of stroke as a mediator of the mortality risk difference between older adults who initiate first-versus second-generation antipsychotic drugs

Author keywords

Aged; Antipsychotic drugs; Cerebrovascular disease; Death; Mediation analysis; Mortality risk; Pharmacoepidemiology; Stroke

Indexed keywords

FIRST GENERATION ANTIPSYCHOTIC DRUG; NEUROLEPTIC AGENT; SECOND GENERATION ANTIPSYCHOTIC DRUG; UNCLASSIFIED DRUG;

EID: 84921767497     PISSN: 00029262     EISSN: 14766256     Source Type: Journal    
DOI: 10.1093/aje/kwu210     Document Type: Article
Times cited : (15)

References (37)
  • 1
    • 41649103102 scopus 로고    scopus 로고
    • American Psychiatric Association practice guideline for the treatment of patients with Alzheimer's disease and other dementias. Second edition
    • Rabins PV, Blacker D, Rovner BW, et al. American Psychiatric Association practice guideline for the treatment of patients with Alzheimer's disease and other dementias. Second edition. Am J Psychiatry. 2007;164(12 suppl):5-56.
    • (2007) Am J Psychiatry. , vol.164 , Issue.12 , pp. 5-56
    • Rabins, P.V.1    Blacker, D.2    Rovner, B.W.3
  • 2
    • 80053215800 scopus 로고    scopus 로고
    • Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: A systematic review and meta-analysis
    • Maher AR, Maglione M, Bagley S, et al. Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis. JAMA. 2011;306(12):1359-1369.
    • (2011) JAMA , vol.306 , Issue.12 , pp. 1359-1369
    • Maher, A.R.1    Maglione, M.2    Bagley, S.3
  • 4
    • 26844538114 scopus 로고    scopus 로고
    • Risk of death with atypical antipsychotic drug treatment for dementia: Metaanalysis of randomized placebo-controlled trials
    • Schneider LS, Dagerman KS, Insel P. Risk of death with atypical antipsychotic drug treatment for dementia: metaanalysis of randomized placebo-controlled trials. JAMA. 2005;294(15):1934-1943.
    • (2005) JAMA , vol.294 , Issue.15 , pp. 1934-1943
    • Schneider, L.S.1    Dagerman, K.S.2    Insel, P.3
  • 5
    • 77955606293 scopus 로고    scopus 로고
    • Antipsychotics and the risk of death in the elderly: An instrumental variable analysis using two preference based instruments
    • Pratt N, Roughead EE, Ryan P, et al. Antipsychotics and the risk of death in the elderly: an instrumental variable analysis using two preference based instruments. Pharmacoepidemiol Drug Saf. 2010;19(7):699-707.
    • (2010) Pharmacoepidemiol Drug Saf. , vol.19 , Issue.7 , pp. 699-707
    • Pratt, N.1    Roughead, E.E.2    Ryan, P.3
  • 6
    • 33947264305 scopus 로고    scopus 로고
    • Risk of death associated with the use of conventional versus atypical antipsychotic drugs among elderly patients
    • Schneeweiss S, Setoguchi S, Brookhart A, et al. Risk of death associated with the use of conventional versus atypical antipsychotic drugs among elderly patients. CMAJ. 2007;176(5):627-632.
    • (2007) CMAJ , vol.176 , Issue.5 , pp. 627-632
    • Schneeweiss, S.1    Setoguchi, S.2    Brookhart, A.3
  • 7
    • 84858419468 scopus 로고    scopus 로고
    • Differential risk of death in older residents in nursing homes prescribed specific antipsychotic drugs: Population based cohort study
    • Huybrechts KF, Gerhard T, Crystal S, et al. Differential risk of death in older residents in nursing homes prescribed specific antipsychotic drugs: population based cohort study. BMJ. 2012;344:e977.
    • (2012) BMJ , vol.344 , pp. e977
    • Huybrechts, K.F.1    Gerhard, T.2    Crystal, S.3
  • 8
    • 84891827755 scopus 로고    scopus 로고
    • Risk of death associated with the use of conventional vs. Atypical antipsychotic medications: Evaluating the use of the Emilia-Romagna Region database for pharmacoepidemiological studies
    • Sikirica S, Marino M, Gagne JJ, et al. Risk of death associated with the use of conventional vs. atypical antipsychotic medications: evaluating the use of the Emilia-Romagna Region database for pharmacoepidemiological studies. J Clin Pharm Ther. 2014;39(1):38-44.
    • (2014) J Clin Pharm Ther. , vol.39 , Issue.1 , pp. 38-44
    • Sikirica, S.1    Marino, M.2    Gagne, J.J.3
  • 9
    • 70350664784 scopus 로고    scopus 로고
    • London, United Kingdom: European Medicines Agency;, Published November 20, 2008. Accessed November 18, 2013
    • European Medicines Agency. CHMP Assessment on Conventional Antipsychotics. London, United Kingdom: European Medicines Agency; 2008. http://www.ema.europa. eu/docs/en-GB/document-library/Report/2010/01/WC500054057.pdf. Published November 20, 2008. Accessed November 18, 2013.
    • (2008) CHMP Assessment on Conventional Antipsychotics
    • European Medicines Agency1
  • 10
    • 0036436448 scopus 로고    scopus 로고
    • Risperidone (Risperdal): Increased rate of cerebrovascular events in dementia trials
    • Wooltorton E. Risperidone (Risperdal): increased rate of cerebrovascular events in dementia trials. CMAJ. 2002;167(11):1269-1270.
    • (2002) CMAJ , vol.167 , Issue.11 , pp. 1269-1270
    • Wooltorton, E.1
  • 11
    • 2342628427 scopus 로고    scopus 로고
    • Olanzapine (Zyprexa): Increased incidence of cerebrovascular events in dementia trials
    • Wooltorton E. Olanzapine (Zyprexa): increased incidence of cerebrovascular events in dementia trials. CMAJ. 2004;170(9):1395.
    • (2004) CMAJ , vol.170 , Issue.9 , pp. 1395
    • Wooltorton, E.1
  • 12
    • 28544448856 scopus 로고    scopus 로고
    • Treatment of late-life disordered behavior, agitation, and psychosis
    • Salzman C, ed, 4th ed. Philadelphia, PA: Lippincott Williams & Wilkins
    • Jeste DV, Sable JA, Salzman C. Treatment of late-life disordered behavior, agitation, and psychosis. In: Salzman C, ed. Clinical Geriatric Psychopharmacology. 4th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2005:129-170.
    • (2005) Clinical Geriatric Psychopharmacology , pp. 129-170
    • Jeste, D.V.1    Sable, J.A.2    Salzman, C.3
  • 13
    • 84873716475 scopus 로고    scopus 로고
    • Association of stroke with the receptor-binding profiles of antipsychotics-a case-crossover study
    • Wu CS, Wang SC, Gau SS, et al. Association of stroke with the receptor-binding profiles of antipsychotics-a case-crossover study. Biol Psychiatry. 2013;73(5):414-421.
    • (2013) Biol Psychiatry , vol.73 , Issue.5 , pp. 414-421
    • Wu, C.S.1    Wang, S.C.2    Gau, S.S.3
  • 14
    • 79960426655 scopus 로고    scopus 로고
    • Risk of cerebrovascular accident associated with use of antipsychotics: Populationbased case-control study
    • Laredo L, Vargas E, Blasco AJ, et al. Risk of cerebrovascular accident associated with use of antipsychotics: populationbased case-control study. J Am Geriatr Soc. 2011;59(7):1182-1187.
    • (2011) J Am Geriatr Soc. , vol.59 , Issue.7 , pp. 1182-1187
    • Laredo, L.1    Vargas, E.2    Blasco, A.J.3
  • 15
    • 70449375212 scopus 로고    scopus 로고
    • Risk of cerebrovascular events in elderly users of antipsychotics
    • Kleijer BC, van Marum RJ, Egberts AC, et al. Risk of cerebrovascular events in elderly users of antipsychotics. J Psychopharmacol. 2009;23(8):909-914.
    • (2009) J Psychopharmacol. , vol.23 , Issue.8 , pp. 909-914
    • Kleijer, B.C.1    Van Marum, R.J.2    Egberts, A.C.3
  • 16
    • 37749013455 scopus 로고    scopus 로고
    • Risk of stroke with typical and atypical anti-psychotics: A retrospective cohort study including unexposed subjects
    • Sacchetti E, Trifirò G, Caputi A, et al. Risk of stroke with typical and atypical anti-psychotics: a retrospective cohort study including unexposed subjects. J Psychopharmacol. 2008;22(1):39-46.
    • (2008) J Psychopharmacol. , vol.22 , Issue.1 , pp. 39-46
    • Sacchetti, E.1    Trifirò, G.2    Caputi, A.3
  • 17
    • 39649084693 scopus 로고    scopus 로고
    • Ventricular arrhythmias and cerebrovascular events in the elderly using conventional and atypical antipsychotic medications
    • Wang PS, Schneeweiss S, Setoguchi S, et al. Ventricular arrhythmias and cerebrovascular events in the elderly using conventional and atypical antipsychotic medications. J Clin Psychopharmacol. 2007;27(6):707-710.
    • (2007) J Clin Psychopharmacol. , vol.27 , Issue.6 , pp. 707-710
    • Wang, P.S.1    Schneeweiss, S.2    Setoguchi, S.3
  • 18
    • 33748936850 scopus 로고    scopus 로고
    • Outcomes of antipsychotic drug use in community-dwelling elders with dementia
    • Kolanowski A, Fick D, Waller JL, et al. Outcomes of antipsychotic drug use in community-dwelling elders with dementia. Arch Psychiatr Nurs. 2006;20(5):217-225.
    • (2006) Arch Psychiatr Nurs. , vol.20 , Issue.5 , pp. 217-225
    • Kolanowski, A.1    Fick, D.2    Waller, J.L.3
  • 19
    • 28744446448 scopus 로고    scopus 로고
    • Risperidone treatment in elderly patients with dementia: Relative risk of cerebrovascular events versus other antipsychotics
    • Finkel S, Kozma C, Long S, et al. Risperidone treatment in elderly patients with dementia: relative risk of cerebrovascular events versus other antipsychotics. Int Psychogeriatr. 2005;17(4):617-629.
    • (2005) Int Psychogeriatr. , vol.17 , Issue.4 , pp. 617-629
    • Finkel, S.1    Kozma, C.2    Long, S.3
  • 20
    • 84858343138 scopus 로고    scopus 로고
    • Comparative safety of antipsychotic medications in nursing home residents
    • Huybrechts KF, Schneeweiss S, Gerhard T, et al. Comparative safety of antipsychotic medications in nursing home residents. J Am Geriatr Soc. 2012;60(3):420-429.
    • (2012) J Am Geriatr Soc. , vol.60 , Issue.3 , pp. 420-429
    • Huybrechts, K.F.1    Schneeweiss, S.2    Gerhard, T.3
  • 21
    • 25444456717 scopus 로고    scopus 로고
    • Second-generation antipsychotics and risk of cerebrovascular accidents in the elderly
    • Percudani M, Barbui C, Fortino I, et al. Second-generation antipsychotics and risk of cerebrovascular accidents in the elderly. J Clin Psychopharmacol. 2005;25(5):468-470.
    • (2005) J Clin Psychopharmacol. , vol.25 , Issue.5 , pp. 468-470
    • Percudani, M.1    Barbui, C.2    Fortino, I.3
  • 22
    • 20044375721 scopus 로고    scopus 로고
    • Atypical antipsychotic drugs and risk of ischaemic stroke: Population based retrospective cohort study
    • Gill SS, Rochon PA, Herrmann N, et al. Atypical antipsychotic drugs and risk of ischaemic stroke: population based retrospective cohort study. BMJ. 2005;330(7489):445.
    • (2005) BMJ , vol.330 , Issue.7489 , pp. 445
    • Gill, S.S.1    Rochon, P.A.2    Herrmann, N.3
  • 23
    • 26644452304 scopus 로고    scopus 로고
    • Cerebrovascular events among elderly nursing home patients treated with conventional or atypical antipsychotics
    • Liperoti R, Gambassi G, Lapane KL, et al. Cerebrovascular events among elderly nursing home patients treated with conventional or atypical antipsychotics. J Clin Psychiatry. 2005;66(9):1090-1096.
    • (2005) J Clin Psychiatry , vol.66 , Issue.9 , pp. 1090-1096
    • Liperoti, R.1    Gambassi, G.2    Lapane, K.L.3
  • 24
    • 2942618528 scopus 로고    scopus 로고
    • Atypical antipsychotics and risk of cerebrovascular accidents
    • Herrmann N, Mamdani M, Lanctôt KL. Atypical antipsychotics and risk of cerebrovascular accidents. Am J Psychiatry. 2004;161(6):1113-1115.
    • (2004) Am J Psychiatry , vol.161 , Issue.6 , pp. 1113-1115
    • Herrmann, N.1    Mamdani, M.2    Lanctôt, K.L.3
  • 25
    • 77953957726 scopus 로고    scopus 로고
    • Conceptual issues concerning mediation, interventions and composition
    • Vanderweele TJ, Vansteelandt S. Conceptual issues concerning mediation, interventions and composition. Stat Interface. 2009;2(4):457-468.
    • (2009) Stat Interface , vol.2 , Issue.4 , pp. 457-468
    • Vanderweele, T.J.1    Vansteelandt, S.2
  • 26
    • 84879516417 scopus 로고    scopus 로고
    • Mediation analysis allowing for exposure-mediator interactions and causal interpretation: Theoretical assumptions and implementation with SAS and SPSS macros
    • Valeri L, Vanderweele TJ. Mediation analysis allowing for exposure-mediator interactions and causal interpretation: theoretical assumptions and implementation with SAS and SPSS macros. Psychol Methods. 2013;18(2):137-150.
    • (2013) Psychol Methods , vol.18 , Issue.2 , pp. 137-150
    • Valeri, L.1    Vanderweele, T.J.2
  • 27
    • 84942328794 scopus 로고    scopus 로고
    • Pharmaceutical assistance contract for the elderly
    • Harrisburg, PA: Commonwealth of Pennsylvania;, Accessed July 1, 2013
    • Commonwealth of Pennsylvania. Pharmaceutical Assistance Contract for the Elderly. 6 Pa Code § 22.21. Harrisburg, PA: Commonwealth of Pennsylvania; 2013. http://www.pacode. com/secure/data/006/006toc.html. Accessed July 1, 2013.
    • (2013) Pa Code , vol.6 , pp. 2221
    • Commonwealth of Pennsylvania1
  • 29
    • 84856025109 scopus 로고    scopus 로고
    • A systematic review of validated methods for identifying cerebrovascular accident or transient ischemic attack using administrative data
    • Andrade SE, Harrold LR, Tjia J, et al. A systematic review of validated methods for identifying cerebrovascular accident or transient ischemic attack using administrative data. Pharmacoepidemiol Drug Saf. 2012;21(suppl 1):100-128.
    • (2012) Pharmacoepidemiol Drug Saf. , vol.21 , pp. 100-128
    • Andrade, S.E.1    Harrold, L.R.2    Tjia, J.3
  • 30
    • 79952117042 scopus 로고    scopus 로고
    • Odds ratios for mediation analysis for a dichotomous outcome
    • Vanderweele TJ, Vansteelandt S. Odds ratios for mediation analysis for a dichotomous outcome. Am J Epidemiol. 2010;172(12):1339-1348.
    • (2010) Am J Epidemiol. , vol.172 , Issue.12 , pp. 1339-1348
    • Vanderweele, T.J.1    Vansteelandt, S.2
  • 31
    • 59149087852 scopus 로고    scopus 로고
    • Assessing residual confounding of the association between antipsychotic medications and risk of death using survey data
    • Schneeweiss S, Setoguchi S, Brookhart MA, et al. Assessing residual confounding of the association between antipsychotic medications and risk of death using survey data. CNS Drugs. 2009;23(2):171-180.
    • (2009) CNS Drugs. , vol.23 , Issue.2 , pp. 171-180
    • Schneeweiss, S.1    Setoguchi, S.2    Brookhart, M.A.3
  • 32
    • 77949530870 scopus 로고    scopus 로고
    • Antipsychotics and risk of cerebrovascular events in treatment of behavioural and psychological symptoms of dementia in Hong Kong: A hospital-based, retrospective, cohort study
    • Chan MC, Chong CS, Wu AY, et al. Antipsychotics and risk of cerebrovascular events in treatment of behavioural and psychological symptoms of dementia in Hong Kong: a hospital-based, retrospective, cohort study. Int J Geriatr Psychiatry. 2010;25(4):362-370.
    • (2010) Int J Geriatr Psychiatry , vol.25 , Issue.4 , pp. 362-370
    • Chan, M.C.1    Chong, C.S.2    Wu, A.Y.3
  • 33
    • 84861936838 scopus 로고    scopus 로고
    • Choice of observational study design impacts on measurement of antipsychotic risks in the elderly: A systematic review
    • Pratt N, Roughead EE, Salter A, et al. Choice of observational study design impacts on measurement of antipsychotic risks in the elderly: a systematic review. BMC Med Res Methodol. 2012;12:72.
    • (2012) BMC Med Res Methodol. , vol.12 , pp. 72
    • Pratt, N.1    Roughead, E.E.2    Salter, A.3
  • 34
    • 84871657661 scopus 로고    scopus 로고
    • Analytic results on the bias due to nondifferential misclassification of a binary mediator
    • Ogburn EL, VanderWeele TJ. Analytic results on the bias due to nondifferential misclassification of a binary mediator. Am J Epidemiol. 2012;176(6):555-561.
    • (2012) Am J Epidemiol. , vol.176 , Issue.6 , pp. 555-561
    • Ogburn, E.L.1    VanderWeele, T.J.2
  • 35
    • 80052666172 scopus 로고    scopus 로고
    • Confounding of indirect effects: A sensitivity analysis exploring the range of bias due to a cause common to both the mediator and the outcome
    • Hafeman DM. Confounding of indirect effects: a sensitivity analysis exploring the range of bias due to a cause common to both the mediator and the outcome. Am J Epidemiol. 2011;174(6):710-717.
    • (2011) Am J Epidemiol. , vol.174 , Issue.6 , pp. 710-717
    • Hafeman, D.M.1
  • 36
    • 84902951460 scopus 로고    scopus 로고
    • Sensitivity analysis for direct and indirect effects in the presence of exposure-induced mediator-outcome confounders
    • VanderWeele TJ, Chiba Y. Sensitivity analysis for direct and indirect effects in the presence of exposure-induced mediator-outcome confounders. Epidemiol Biostat Public Health. 2014;11(2):e9027.
    • (2014) Epidemiol Biostat Public Health , vol.11 , Issue.2 , pp. e9027
    • VanderWeele, T.J.1    Chiba, Y.2
  • 37
    • 0142157169 scopus 로고    scopus 로고
    • Evaluating medication effects outside of clinical trials: New-user designs
    • Ray WA. Evaluating medication effects outside of clinical trials: new-user designs. Am J Epidemiol. 2003;158(9):915-920.
    • (2003) Am J Epidemiol. , vol.158 , Issue.9 , pp. 915-920
    • Ray, W.A.1


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