Risk of cerebrovascular events in elderly users of antipsychotics

Journal of Psychopharmacology

Volumn 23, Issue 8, 2009, Pages 909-914

  Kleijer, B C ^a   Van Marum, R J ^b   Egberts, A C G ^c   Jansen, P A F ^b   Knol, W ^d   Heerdink, E R ^c  

^a Gerimedicapraktijk   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

^d Tergooiziekenhuizen ^*  (Netherlands)

Author keywords

Antipsychotic; Cerebrovascular events; Elderly

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANTIARRHYTHMIC AGENT; ANTIDIABETIC AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CARDIAC GLYCOSIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; FIBRINOLYTIC AGENT; NEUROLEPTIC AGENT; VASODILATOR AGENT;

ADVERSE OUTCOME; AGED; ARTICLE; BRAIN HEMORRHAGE; BRAIN INFARCTION; CARDIOVASCULAR RISK; CASE CONTROL STUDY; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR DISEASE; COHORT ANALYSIS; COMMUNITY SAMPLE; CONTROLLED STUDY; DRUG EXPOSURE; FEMALE; HUMAN; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; OCCLUSIVE CEREBROVASCULAR DISEASE; PHARMACY; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; STROKE; SUBDURAL HEMATOMA; TRANSIENT ISCHEMIC ATTACK; TREATMENT DURATION;

AGED; ANTIPSYCHOTIC AGENTS; CEREBROVASCULAR DISORDERS; FEMALE; HUMANS; MALE; RISK;

EID: 70449375212     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881108093583     Document Type: Article

References (24)

1. Food and Drug Administration (2005) FDA public healt advisory: deaths with antipsychotics in elderly patients with behavioral disturbances. http://www.fda.gov/cder/drug/advisory/antipsychotics.htm (accessed 13.02.08).
2. Finkel, S., Kozma, C., Long, S., Greenspan, A., Mahmoud, R., Baser, O., et al. (2005) Risperidone treatment in elderly patients with dementia: relative risk of cerebrovascular events versus other antipsychotics. Int Psychogeriatr 17: 617-629.
3. Gill, SS, Rochon, PA, Herrmann, N., Lee, PE, Sykora, K., Gunraj, N., et al. (2005) Atypical antipsychotic drugs and risk of ischaemic stroke: population based retrospective cohort study. BMJ 330: 445-451.
4. Gill, SS, Bronskill, SE, Normand, SL, Anderson, GM, Sykora, K., Lam, K., et al. (2007) Antipsychotic drug use and mortality in older adults with dementia. Ann Intern Med 146: 775-786. (Pubitemid 351650498)
5. Haupt, M., Cruz-Jentoft, A., Jeste, D. (2006) Mortality in elderly dementia patients treated with risperidone. J Clin Psychopharmacol 26: 566-570.
6. Herings, R. (1993) PHARMO: a record linkage system for post marketing surveillance of prescription drugs in the Netherlands. Utrecht: Thesis Utrecht University, pp. 232.
7. Herrmann, N., Mamdani, M., Lanctot, KL (2004) Atypical antipsychotics and risk of cerebrovascular accidents. Am J Psychiatry 161: 1113-1115.
8. http://www.pharmo.nl. Available from http://www.pharmo.nl. Last checked 1-2-2008.
9. Kales, HC, Valenstein, M., Kim, HM, McCarthy, JF, Ganoczy, D., Cunningham, F., et al. (2007) Mortality risk in patients with dementia treated with antipsychotics versus other psychiatric medications. Am J Psychiatry 164: 1568-1576.
10. Kuehn, BM (2005) FDA warns antipsychotic drugs may be risky for elderly. JAMA 293: 2462.
11. Layton, D., Harris, S., Wilton, LV, Shakir, SA (2005) Comparison of incidence rates of cerebrovascular accidents and transient ischaemic attacks in observational cohort studies of patients prescribed risperidone, quetiapine or olanzapine in general practice in England including patients with dementia. J Psychopharmacol 19: 473-482.
12. Liperoti, R., Gambassi, G., Lapane, KL, Chiang, C., Pedone, C., Mor, V., et al. (2005) Cerebrovascular events among elderly nursing home patients treated with conventional or atypical antipsychotics. J Clin Psychiatry 66: 1090-1096.
13. Nasrallah, HA, White, T., Nasrallah, AT (2004) Lower mortality in geriatric patients receiving risperidone and olanzapine versus haloperidol: preliminary analysis of retrospective data. Am J Geriatr Psychiatry 12: 437-439.
14. Percudani, M., Barbui, C., Fortino, I., Tansella, M., Petrovich, L. (2005) Second-generation antipsychotics and risk of cerebrovascular accidents in the elderly. J Clin Psychopharmacol 25: 468-470. (Pubitemid 41368370)
15. Raivio, MM, Laurila, JV, Strandberg, TE, Tilvis, RS, Pitkala, KH (2007) Neither atypical nor conventional antipsychotics increase mortality or hospital admissions among elderly patients with dementia: a two-year prospective study. Am J Geriatr Psychiatry 15: 416-424.
16. Richelson, E. (1999) Receptor pharmacology of neuroleptics: relation to clinical effects. J Clin Psychiatry 60 (Suppl 10). 5-14.
17. Richelson, E., Souder, T. (2000) Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci 68: 29-39.
18. Schneeweiss, S., Setoguchi, S., Brookhart, A., Dormuth, C., Wang, PS (2007) Risk of death associated with the use of conventional versus atypical antipsychotic drugs among elderly patients. CMAJ 176: 627-632.
19. Schneider, LS, Dagerman, K., Insel, PS (2006) Efficacy and adverse effects of atypical antipsychotics for dementia: meta-analysis of randomized, placebo-controlled trials. Am J Geriatr Psychiatry 14: 191-210.
20. Schneider, LS, Dagerman, KS, Insel, P. (2005) Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA 294: 1934-1943. Stampfer, MJ (2006) Cardiovascular disease and alzheimers disease: common links. J Intern Med 260: 211-223.
21. Suh, GH, Shah, A. (2005) Effect of antipsychotics on mortality in elderly patients with dementia: a 1-year prospective study in a nursing home. Int Psychogeriatr 17: 429-441.
22. Wang, PS, Schneeweiss, S., Avorn, J., Fischer, MA, Mogun, H., Solomon, DH, et al. (2005) Risk of death in elderly users of conventional vs atypical antipsychotic medications. N Engl J Med 353: 2335-2341.
23. Wooltorton, E. (2004) Olanzapine (Zyprexa). increased incidence of cerebrovascular events in dementia trials. CMAJ 170: 1395.
24. Wooltorton, E. (2002) Risperidone (Risperdal). increased rate of cerebrovascular events in dementia trials. CMAJ 167: 1269-1270.