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Volumn 239, Issue 10, 2014, Pages 1352-1359

Cardiac sympathetic afferent reflex response to intermedin microinjection into paraventricular nucleus is mediated by nitric oxide and γ-amino butyric acid in hypertensive rats

Author keywords

Cardiac sympathetic afferent reflex; Hypertension; Intermedin; Nitric oxide; Paraventricular nucleus; amino butyric acid

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL) PYRIDAZINIUM BROMIDE; 3 AMINOPROPYL(DIETHOXYMETHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; CAPSAICIN; CGRP8-37; INTERMEDIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG; ADRENOMEDULLIN; INTERMEDIN PROTEIN, RAT; NEUROPEPTIDE;

EID: 84921765081     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370214533882     Document Type: Article
Times cited : (4)

References (49)
  • 2
    • 1342346545 scopus 로고    scopus 로고
    • Intermedin is a calcitonin/ calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes
    • Roh J, Chang CL, Bhalla A, Klein C, Hsu SY. Intermedin is a calcitonin/ calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes. J Biol Chem 2004;279:7264-74
    • (2004) J Biol Chem , vol.279 , pp. 7264-7274
    • Roh, J.1    Chang, C.L.2    Bhalla, A.3    Klein, C.4    Hsu, S.Y.5
  • 3
    • 33646811808 scopus 로고    scopus 로고
    • Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus, heart and kidney
    • Takahashi K, Kikuchi K, Maruyama Y, Urabe T, Nakajima K, Sasano H, Imai Y, Murakami O, Totsune K. Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus, heart and kidney. Peptides 2006;27:1383-9
    • (2006) Peptides , vol.27 , pp. 1383-1389
    • Takahashi, K.1    Kikuchi, K.2    Maruyama, Y.3    Urabe, T.4    Nakajima, K.5    Sasano, H.6    Imai, Y.7    Murakami, O.8    Totsune, K.9
  • 5
    • 15544384843 scopus 로고    scopus 로고
    • Intermedin/adrenomedullin-2 acts within central nervous system to elevate blood pressure and inhibit food and water intake
    • Taylor MM, Bagley SL, Samson WK. Intermedin/adrenomedullin-2 acts within central nervous system to elevate blood pressure and inhibit food and water intake. Am J Physiol Regul Integr Comp Physiol 2005;288:R919-27
    • (2005) Am J Physiol Regul Integr Comp Physiol , vol.288 , pp. R919-R927
    • Taylor, M.M.1    Bagley, S.L.2    Samson, W.K.3
  • 6
    • 70350302608 scopus 로고    scopus 로고
    • Mechanisms involved in the regional haemodynamic effects of intermedin (adrenomedullin 2) compared with adrenomedullin in conscious rats
    • Jolly L, March JE, Kemp PA, Bennett T, Gardiner SM. Mechanisms involved in the regional haemodynamic effects of intermedin (adrenomedullin 2) compared with adrenomedullin in conscious rats. Br J Pharmacol 2009;157:1502-13
    • (2009) Br J Pharmacol , vol.157 , pp. 1502-1513
    • Jolly, L.1    March, J.E.2    Kemp, P.A.3    Bennett, T.4    Gardiner, S.M.5
  • 8
    • 38549162093 scopus 로고    scopus 로고
    • Should we target the sympathetic nervous system in the treatment of obesity-associated hypertension?
    • Biaggioni I. Should we target the sympathetic nervous system in the treatment of obesity-associated hypertension? Hypertension 2008;51:168-71
    • (2008) Hypertension , vol.51 , pp. 168-171
    • Biaggioni, I.1
  • 9
    • 79953728174 scopus 로고    scopus 로고
    • c-Src in paraventricular nucleus modulates sympathetic activity and cardiac sympathetic afferent reflex in renovascular hypertensive rats
    • Han Y, Yuan N, Zhang SJ, Gao J, Shi Z, Zhou YB, Gao XY, Zhu GQ. c-Src in paraventricular nucleus modulates sympathetic activity and cardiac sympathetic afferent reflex in renovascular hypertensive rats. Pflugers Arch 2011;461:437-46
    • (2011) Pflugers Arch , vol.461 , pp. 437-446
    • Han, Y.1    Yuan, N.2    Zhang, S.J.3    Gao, J.4    Shi, Z.5    Zhou, Y.B.6    Gao, X.Y.7    Zhu, G.Q.8
  • 10
    • 33847060915 scopus 로고    scopus 로고
    • The effect of gender on the sympathetic nerve hyperactivity of essential hypertension
    • Hogarth AJ, Mackintosh AF, Mary DA. The effect of gender on the sympathetic nerve hyperactivity of essential hypertension. J Hum Hypertens 2007;21:239-45
    • (2007) J Hum Hypertens , vol.21 , pp. 239-245
    • Hogarth, A.J.1    McKintosh, A.F.2    Mary, D.A.3
  • 11
    • 84875220925 scopus 로고    scopus 로고
    • Angiotensin-(1-7) in the rostral ventrolateral medulla modulates enhanced cardiac sympathetic afferent reflex and sympathetic activation in renovascular hypertensive rats
    • Li P, Sun HJ, Cui BP, Zhou YB, Han Y. Angiotensin-(1-7) in the rostral ventrolateral medulla modulates enhanced cardiac sympathetic afferent reflex and sympathetic activation in renovascular hypertensive rats. Hypertension 2013;61:820-7
    • (2013) Hypertension , vol.61 , pp. 820-827
    • Li, P.1    Sun, H.J.2    Cui, B.P.3    Zhou, Y.B.4    Han, Y.5
  • 12
    • 84861312897 scopus 로고    scopus 로고
    • Sympathetic activation and baroreflex function during intradialytic hypertensive episodes
    • Rubinger D, Backenroth R, Sapoznikov D. Sympathetic activation and baroreflex function during intradialytic hypertensive episodes. PLoS One 2012;7:e36943
    • (2012) PLoS One , vol.7
    • Rubinger, D.1    Backenroth, R.2    Sapoznikov, D.3
  • 13
    • 0032751208 scopus 로고    scopus 로고
    • Sympathetic activation in the pathogenesis of hypertension and progression of organ damage
    • Mancia G, Grassi G, Giannattasio C, Seravalle G. Sympathetic activation in the pathogenesis of hypertension and progression of organ damage. Hypertension 1999;34:724-8
    • (1999) Hypertension , vol.34 , pp. 724-728
    • Mancia, G.1    Grassi, G.2    Giannattasio, C.3    Seravalle, G.4
  • 15
    • 0033176442 scopus 로고    scopus 로고
    • The sympathetic nervous system in the pathogenesis of hypertension
    • Rahn KH, Barenbrock M, Hausberg M. The sympathetic nervous system in the pathogenesis of hypertension. J Hypertens Suppl 1999;17:S11-4
    • (1999) J Hypertens Suppl , vol.17 , pp. S11-S14
    • Rahn, K.H.1    Barenbrock, M.2    Hausberg, M.3
  • 17
    • 77951170020 scopus 로고    scopus 로고
    • Therapeutic strategies for targeting excessive central sympathetic activation in human hypertension
    • Fisher JP, Fadel PJ. Therapeutic strategies for targeting excessive central sympathetic activation in human hypertension. Exp Physiol 2010;95:572-80
    • (2010) Exp Physiol , vol.95 , pp. 572-580
    • Fisher, J.P.1    Fadel, P.J.2
  • 18
    • 77951187765 scopus 로고    scopus 로고
    • The 'neuroadrenergic hypothesis' in hypertension: Current evidence
    • Grassi G, Seravalle G, Quarti-Trevano F. The 'neuroadrenergic hypothesis' in hypertension: current evidence. Exp Physiol 2010;95:581-6
    • (2010) Exp Physiol , vol.95 , pp. 581-586
    • Grassi, G.1    Seravalle, G.2    Quarti-Trevano, F.3
  • 19
    • 0036153114 scopus 로고    scopus 로고
    • Emerging excitatory role of cardiovascular sympathetic afferents in pathophysiological conditions
    • Malliani A, Montano N. Emerging excitatory role of cardiovascular sympathetic afferents in pathophysiological conditions. Hypertension 2002;39:63-8
    • (2002) Hypertension , vol.39 , pp. 63-68
    • Malliani, A.1    Montano, N.2
  • 20
    • 67650901470 scopus 로고    scopus 로고
    • Enhanced cardiac sympathetic afferent reflex involved in sympathetic overactivity in renovascular hypertensive rats
    • Zhu GQ, Xu Y, Zhou LM, Li YH, Fan LM, Wang W, Gao XY, Chen Q. Enhanced cardiac sympathetic afferent reflex involved in sympathetic overactivity in renovascular hypertensive rats. Exp Physiol 2009;94:785-94
    • (2009) Exp Physiol , vol.94 , pp. 785-794
    • Zhu, G.Q.1    Xu, Y.2    Zhou, L.M.3    Li, Y.H.4    Fan, L.M.5    Wang, W.6    Gao, X.Y.7    Chen, Q.8
  • 21
    • 84873454911 scopus 로고    scopus 로고
    • SOD1 gene transfer into paraventricular nucleus attenuates hypertension and sympathetic activity in spontaneously hypertensive rats
    • Yuan N, Zhang F, Zhang LL, Gao J, Zhou YB, Han Y, Zhu GQ. SOD1 gene transfer into paraventricular nucleus attenuates hypertension and sympathetic activity in spontaneously hypertensive rats. Pflugers Arch 2013;465:261-70
    • (2013) Pflugers Arch , vol.465 , pp. 261-270
    • Yuan, N.1    Zhang, F.2    Zhang, L.L.3    Gao, J.4    Zhou, Y.B.5    Han, Y.6    Zhu, G.Q.7
  • 22
    • 84868355106 scopus 로고    scopus 로고
    • Angiotensin-(1-7) in paraventricular nucleus modulates sympathetic activity and cardiac sympathetic afferent reflex in renovascular hypertensive rats
    • Han Y, Sun HJ, Li P, Gao Q, Zhou YB, Zhang F, Gao XY, Zhu GQ. Angiotensin-(1-7) in paraventricular nucleus modulates sympathetic activity and cardiac sympathetic afferent reflex in renovascular hypertensive rats. PLoS One 2012;7:e48966
    • (2012) PLoS One , vol.7
    • Han, Y.1    Sun, H.J.2    Li, P.3    Gao, Q.4    Zhou, Y.B.5    Zhang, F.6    Gao, X.Y.7    Zhu, G.Q.8
  • 23
    • 43549084766 scopus 로고    scopus 로고
    • Paraventricular nucleus is involved in the central pathway of cardiac sympathetic afferent reflex in rats
    • Zhong MK, Duan YC, Chen AD, Xu B, Gao XY, De W, Zhu GQ. Paraventricular nucleus is involved in the central pathway of cardiac sympathetic afferent reflex in rats. Exp Physiol 2008;93:746-53
    • (2008) Exp Physiol , vol.93 , pp. 746-753
    • Zhong, M.K.1    Duan, Y.C.2    Chen, A.D.3    Xu, B.4    Gao, X.Y.5    De, W.6    Zhu, G.Q.7
  • 27
    • 84870570574 scopus 로고    scopus 로고
    • Reduction of nitric oxidemediated γ-amino butyric acid release in rostral ventrolateral medulla is involved in superoxide-induced sympathoexcitation of hypertensive rats
    • Shinohara K, Hirooka Y, Kishi T, Sunagawa K. Reduction of nitric oxidemediated γ-amino butyric acid release in rostral ventrolateral medulla is involved in superoxide-induced sympathoexcitation of hypertensive rats. Circ J 2012;76:2814-21
    • (2012) Circ J , vol.76 , pp. 2814-2821
    • Shinohara, K.1    Hirooka, Y.2    Kishi, T.3    Sunagawa, K.4
  • 29
    • 47649098554 scopus 로고    scopus 로고
    • Intermedin/adrenomedullin-2 (IMD/AM2) relaxes rat main pulmonary arterial rings via cGMPdependent pathway: Role of nitric oxide and large conductance calciumactivated potassium channels (BK(Ca))
    • Kandilci HB, Gumusel B, Lippton H. Intermedin/adrenomedullin-2 (IMD/AM2) relaxes rat main pulmonary arterial rings via cGMPdependent pathway: role of nitric oxide and large conductance calciumactivated potassium channels (BK(Ca)). Peptides 2008;29:1321-28
    • (2008) Peptides , vol.29 , pp. 1321-1328
    • Kandilci, H.B.1    Gumusel, B.2    Lippton, H.3
  • 31
    • 0141893612 scopus 로고    scopus 로고
    • Sympathoexcitation by pvninjected bicuculline requires activation of excitatory amino acid receptors
    • Chen QH, Haywood JR, Toney GM. Sympathoexcitation by pvninjected bicuculline requires activation of excitatory amino acid receptors. Hypertension 2003;42:725-31
    • (2003) Hypertension , vol.42 , pp. 725-731
    • Chen, Q.H.1    Haywood, J.R.2    Toney, G.M.3
  • 32
    • 0025799693 scopus 로고
    • Cardiovascular responses to bicuculline in the paraventricular nucleus of the rat
    • Martin DS, Segura T, Haywood JR. Cardiovascular responses to bicuculline in the paraventricular nucleus of the rat. Hypertension 1991;18:48-55
    • (1991) Hypertension , vol.18 , pp. 48-55
    • Martin, D.S.1    Segura, T.2    Haywood, J.R.3
  • 33
    • 45349091519 scopus 로고    scopus 로고
    • Regulation of cardiac sympathetic afferent reflex by GABA(A) and GABA(B) receptors in paraventricular nucleus in rats
    • Zhong MK, Shi Z, Zhou LM, Gao J, Liao ZH,WangW, Gao XY, Zhu GQ. Regulation of cardiac sympathetic afferent reflex by GABA(A) and GABA(B) receptors in paraventricular nucleus in rats. Eur J Neurosci 2008;27:3226-32
    • (2008) Eur J Neurosci , vol.27 , pp. 3226-3232
    • Zhong, M.K.1    Shi, Z.2    Zhou, L.M.3    Gao, J.4    Liao, Z.H.5    Wang, W.6    Gao, X.Y.7    Zhu, G.Q.8
  • 34
    • 1842785718 scopus 로고    scopus 로고
    • Decrease in arterial pressure induced by adrenomedullin in the hypothalamic paraventricular nucleus is mediated by nitric oxide and GABA
    • Xu Y, Krukoff TL. Decrease in arterial pressure induced by adrenomedullin in the hypothalamic paraventricular nucleus is mediated by nitric oxide and GABA. Regul Pept 2004;119:21-30
    • (2004) Regul Pept , vol.119 , pp. 21-30
    • Xu, Y.1    Krukoff, T.L.2
  • 35
    • 78751489443 scopus 로고    scopus 로고
    • AT1 receptors in paraventricular nucleus contribute to sympathetic activation and enhanced cardiac sympathetic afferent reflex in renovascular hypertensive rats
    • Chen AD, Zhang SJ, Yuan N, Xu Y, De W, Gao XY, Zhu GQ. AT1 receptors in paraventricular nucleus contribute to sympathetic activation and enhanced cardiac sympathetic afferent reflex in renovascular hypertensive rats. Exp Physiol 2011;96:94-103
    • (2011) Exp Physiol , vol.96 , pp. 94-103
    • Chen, A.D.1    Zhang, S.J.2    Yuan, N.3    Xu, Y.4    De, W.5    Gao, X.Y.6    Zhu, G.Q.7
  • 36
    • 84863324606 scopus 로고    scopus 로고
    • Involvement of enhanced cardiac sympathetic afferent reflex in sympathetic activation in early stage of diabetes
    • Zhang L, Xiong XQ, Fan ZD, Gan XB, Gao XY, Zhu GQ. Involvement of enhanced cardiac sympathetic afferent reflex in sympathetic activation in early stage of diabetes. J Appl Physiol 2012;113:47-55
    • (2012) J Appl Physiol , vol.113 , pp. 47-55
    • Zhang, L.1    Xiong, X.Q.2    Fan, Z.D.3    Gan, X.B.4    Gao, X.Y.5    Zhu, G.Q.6
  • 37
    • 3142782136 scopus 로고    scopus 로고
    • Reduced nitric oxide in the rostral ventrolateral medulla enhances cardiac sympathetic afferent reflex in rats with chronic heart failure
    • Zhu GQ, Gao XY, Zhang F, Wang W. Reduced nitric oxide in the rostral ventrolateral medulla enhances cardiac sympathetic afferent reflex in rats with chronic heart failure. Sheng Li Xue Bao 2004;56:47-53
    • (2004) Sheng Li Xue Bao , vol.56 , pp. 47-53
    • Zhu, G.Q.1    Gao, X.Y.2    Zhang, F.3    Wang, W.4
  • 38
    • 84892948187 scopus 로고    scopus 로고
    • Intermedin in paraventricular nucleus attenuates sympathetic activity and blood pressure via nitric oxide in hypertensive rats
    • Zhou YB, Sun HJ, Chen D, Liu TY, Han Y, Wang JJ, Tang CS, Kang YM, Zhu GQ. Intermedin in paraventricular nucleus attenuates sympathetic activity and blood pressure via nitric oxide in hypertensive rats. Hypertension 2014;63:330-7
    • (2014) Hypertension , vol.63 , pp. 330-337
    • Zhou, Y.B.1    Sun, H.J.2    Chen, D.3    Liu, T.Y.4    Han, Y.5    Wang, J.J.6    Tang, C.S.7    Kang, Y.M.8    Zhu, G.Q.9
  • 40
    • 19444381493 scopus 로고    scopus 로고
    • Stress hormone secretion is altered by central administration of intermedin/adrenomedullin-2
    • Taylor MM, Samson WK. Stress hormone secretion is altered by central administration of intermedin/adrenomedullin-2. Brain Res 2005;1045:199-205
    • (2005) Brain Res , vol.1045 , pp. 199-205
    • Taylor, M.M.1    Samson, W.K.2
  • 41
    • 84858427547 scopus 로고    scopus 로고
    • Cardiovascular effects of the intracerebroventricular injection of adrenomedullin: Roles of the peripheral vasopressin and central cholinergic systems
    • Cam-Etoz B, Isbil-Buyukcoskun N, Ozluk K. Cardiovascular effects of the intracerebroventricular injection of adrenomedullin: roles of the peripheral vasopressin and central cholinergic systems. Braz J Med Biol Res 2012;45:250-5
    • (2012) Braz J Med Biol Res , vol.45 , pp. 250-255
    • Cam-Etoz, B.1    Isbil-Buyukcoskun, N.2    Ozluk, K.3
  • 42
    • 40349100269 scopus 로고    scopus 로고
    • Intermedin (adrenomedullin-2): A novel counterregulatory peptide in the cardiovascular and renal systems
    • Bell D, McDermott BJ. Intermedin (adrenomedullin-2): a novel counterregulatory peptide in the cardiovascular and renal systems. Br J Pharmacol 2008;153(Suppl 1): S247-62
    • (2008) Br J Pharmacol , vol.153 , pp. S247-S262
    • Bell, D.1    McDermott, B.J.2
  • 43
    • 79955988456 scopus 로고    scopus 로고
    • Protein kinase A-dependent neuronal nitric oxide synthase activation mediates the enhancement of baroreflex response by adrenomedullin in the nucleus tractus solitarii of rats
    • Yen DH, Chen LC, Shen YC, Chiu YC, Ho IC, Lou YJ, Chen IC, Yen JC. Protein kinase A-dependent neuronal nitric oxide synthase activation mediates the enhancement of baroreflex response by adrenomedullin in the nucleus tractus solitarii of rats. J Biomed Sci 2011;18:32
    • (2011) J Biomed Sci , vol.18 , pp. 32
    • Yen, D.H.1    Chen, L.C.2    Shen, Y.C.3    Chiu, Y.C.4    Ho, I.C.5    Lou, Y.J.6    Chen, I.C.7    Yen, J.C.8
  • 44
    • 84885118129 scopus 로고    scopus 로고
    • Intermedin enhances sympathetic outflow via receptor-mediated cAMP/PKA signaling pathway in nucleus tractus solitarii of rats
    • Li P, Sun HJ, Han Y, Wang JJ, Zhang F, Tang CS, Zhou YB. Intermedin enhances sympathetic outflow via receptor-mediated cAMP/PKA signaling pathway in nucleus tractus solitarii of rats. Peptides 2013;47:1-6
    • (2013) Peptides , vol.47 , pp. 1-6
    • Li, P.1    Sun, H.J.2    Han, Y.3    Wang, J.J.4    Zhang, F.5    Tang, C.S.6    Zhou, Y.B.7
  • 45
    • 33646487461 scopus 로고    scopus 로고
    • Angiotensin-mediated increase in enal sympathetic nerve dischargewithin the PVN: Role of nitric oxide
    • Li YF, Wang W, Mayhan WG, Patel KP. Angiotensin-mediated increase in enal sympathetic nerve dischargewithin the PVN: role of nitric oxide. Am J Physiol Regul Integr Comp Physiol 2006;290:R1035-43
    • (2006) Am J Physiol Regul Integr Comp Physiol , vol.290 , pp. R1035-R1043
    • Li, Y.F.1    Wang, W.2    Mayhan, W.G.3    Patel, K.P.4
  • 46
    • 0036889025 scopus 로고    scopus 로고
    • Adrenomedullin influences magnocellular and parvocellular neurons of paraventricular nucleus via separate mechanisms
    • Follwell MJ, Ferguson AV. Adrenomedullin influences magnocellular and parvocellular neurons of paraventricular nucleus via separate mechanisms. Am J Physiol Regul Integr Comp Physiol 2002;283:R1293-302
    • (2002) Am J Physiol Regul Integr Comp Physiol , vol.283 , pp. R1293-R1302
    • Follwell, M.J.1    Ferguson, A.V.2
  • 47
    • 81355148589 scopus 로고    scopus 로고
    • Chronic treadmill running in normotensive rats resets the resting blood pressure to lower levels by upregulating the hypothalamic GABAergic system
    • Hsu YC, Chen HI, Kuo YM, Yu L, Huang TY, Chen SJ, Chuang JI,Wu FS, Jen CJ. Chronic treadmill running in normotensive rats resets the resting blood pressure to lower levels by upregulating the hypothalamic GABAergic system. J Hypertens 2011;29:2339-48
    • (2011) J Hypertens , vol.29 , pp. 2339-2348
    • Hsu, Y.C.1    Chen, H.I.2    Kuo, Y.M.3    Yu, L.4    Huang, T.Y.5    Chen, S.J.6    Chuang, J.I.7    Wu, F.S.8    Jen, C.J.9
  • 48
    • 0036847889 scopus 로고    scopus 로고
    • Nitric oxide inhibits spinally projecting paraventricular neurons through potentiation of presynaptic GABA release
    • Li DP, Chen SR, Pan HL. Nitric oxide inhibits spinally projecting paraventricular neurons through potentiation of presynaptic GABA release. J Neurophysiol 2002;88:2664-74
    • (2002) J Neurophysiol , vol.88 , pp. 2664-2674
    • Li, D.P.1    Chen, S.R.2    Pan, H.L.3
  • 49
    • 0031708593 scopus 로고    scopus 로고
    • Effect of nitric oxide within the paraventricular nucleus on renal sympathetic nerve discharge: Role of GABA
    • Zhang K, Patel KP. Effect of nitric oxide within the paraventricular nucleus on renal sympathetic nerve discharge: role of GABA. Am J Physiol 1998;275:R728-34
    • (1998) Am J Physiol , vol.275 , pp. R728-R734
    • Zhang, K.1    Patel, K.P.2


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