Novel helper factors influencing recombinant protein production in Pichia pastoris based on proteomic analysis under simulated microgravity

Applied Microbiology and Biotechnology

Volumn 99, Issue 2, 2015, Pages 653-665

  Huangfu, Jie ^a   Qi, Feng ^a,c   Liu, Hongwei ^b   Zou, Hanfa ^b   Ahmed, Muhammad Saad ^a   Li, Chun ^a  

^a BEIJING INSTITUTE OF TECHNOLOGY   (China)

^b DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^c FUJIAN NORMAL UNIVERSITY   (China)

Author keywords

Pichia pastoris; Proteomics analysis; Recombinant protein; Simulate microgravity (SMG); Strengthen production

Indexed keywords

FERMENTATION; METHANOL; MICROGRAVITY; MICROGRAVITY PROCESSING; PROTEOMICS; TRANSCRIPTION; YEAST;

EUKARYOTIC EXPRESSION; OXIDATIVE STRESS RESPONSE; PICHIA PASTORIS; RECOMBINANT PROTEIN PRODUCTIONS; SIMULATE MICROGRAVITY (SMG); SIMULATED MICROGRAVITY; TRANSCRIPTION PROFILING; TRANSCRIPTIONAL LEVELS;

RECOMBINANT PROTEINS;

ENDO BETA 1,4 XYLANASE; FUNGAL ENZYME; HELPER FACTOR; RECOMBINANT BETA GLUCURONIDASE; RECOMBINANT ENZYME; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; FUNGAL DNA; FUNGAL PROTEIN;

ENZYME ACTIVITY; FERMENTATION; GENE EXPRESSION; PROTEIN; PROTEOMICS; RECOMBINATION; YEAST;

AKR E GENE; ARTICLE; CELL DENSITY; CONTROLLED STUDY; ENO GENE; FBA GENE; FUNGAL GENE; FUNGAL STRAIN; GENE EXPRESSION; KOMAGATAELLA PASTORIS; MICROGRAVITY; NONHUMAN; OXIDATIVE STRESS; PGAM GENE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FOLDING; REPORTER GENE; RNA EXTRACTION; SBA1 GENE; SIMULATED MICROGRAVITY; TPX GENE; YEAST CELL; BIOSYNTHESIS; DOWN REGULATION; FERMENTATION; FUNGAL GENOME; GENE EXPRESSION PROFILING; GENETIC DATABASE; GENETICS; METABOLISM; PICHIA; PROCEDURES; PROTEOMICS; UPREGULATION; WEIGHTLESSNESS;

EUKARYOTA; PICHIA PASTORIS; PROKARYOTA; XENOX;

DATABASES, GENETIC; DNA, FUNGAL; DOWN-REGULATION; FERMENTATION; FUNGAL PROTEINS; GENE EXPRESSION PROFILING; GENES, REPORTER; GENOME, FUNGAL; OXIDATIVE STRESS; PICHIA; PROTEIN FOLDING; PROTEOMICS; RECOMBINANT PROTEINS; UP-REGULATION; WEIGHTLESSNESS SIMULATION;

EID: 84921763362     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-014-6175-8     Document Type: Article

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