Effect of phylloquinone (vitamin K1) supplementation for 12 months on the indices of vitamin K status and bone health in adult patients with Crohn's disease

British Journal of Nutrition

Volumn 112, Issue 7, 2014, Pages 1163-1174

  O'Connor, Eibhlís M ^a,c   Grealy, Geraldine ^a   McCarthy, Jane ^a   Desmond, Alan ^a   Craig, Orla ^a   Shanahan, Fergus ^a,b   Cashman, Kevin D ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c UNIVERSITY OF LIMERICK   (Ireland)

Author keywords

Bone health indices; Crohn's disease; Intervention studies; Percentage of undercarboxylated osteocalcin; Phylloquinone (vitamin K1)

Indexed keywords

25 HYDROXYVITAMIN D; ADALIMUMAB; ALKALINE PHOSPHATASE; AMINO TERMINAL TELOPEPTIDE; AZATHIOPRINE; BUDESONIDE; CALCIUM; CARBOXY TERMINAL TELOPEPTIDE; COLECALCIFEROL; ENEMA; INFLIXIMAB; MERCAPTOPURINE; MESALAZINE; METRONIDAZOLE; OSTEOCALCIN; PARATHYROID HORMONE; PHYTOMENADIONE; PLACEBO; PREDNISOLONE; SALAZOSULFAPYRIDINE; VITAMIN K GROUP; VITAMIN;

ABDOMINAL CRAMP; ADULT; ARTICLE; BONE DENSITOMETRY; BONE GROWTH; BONE MASS; BONE MINERAL; BONE TURNOVER; CLINICAL ARTICLE; COLITIS; CONTROLLED STUDY; CROHN DISEASE; DISEASE EXACERBATION; DOUBLE BLIND PROCEDURE; DRUG DOSE REDUCTION; DUAL ENERGY X RAY ABSORPTIOMETRY; ENZYME IMMUNOASSAY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FEMUR; FOOD FREQUENCY QUESTIONNAIRE; HUMAN; INTENTION TO TREAT ANALYSIS; LUMBAR SPINE; MAINTENANCE THERAPY; MALE; OSTEOPENIA; OSTEOPOROSIS; PARATHYROID HORMONE BLOOD LEVEL; PATIENT COMPLIANCE; RADIUS; RANDOMIZED CONTROLLED TRIAL; REMISSION; VITAMIN K DEFICIENCY; VITAMIN SUPPLEMENTATION; ADOLESCENT; AGED; BONE DENSITY; BONE REMODELING; DIET SUPPLEMENTATION; MIDDLE AGED; NUTRITIONAL STATUS; PATHOPHYSIOLOGY;

ADOLESCENT; ADULT; AGED; BONE DENSITY; BONE REMODELING; CALCIUM; CHOLECALCIFEROL; CROHN DISEASE; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; NUTRITIONAL STATUS; PLACEBOS; VITAMIN K; VITAMIN K 1; VITAMINS;

EID: 84921763267     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114514001913     Document Type: Article

References (39)

1. Bernstein CN ; Leslie WD (2004) Review Article: osteoporosis and inflammatory bowel disease. Aliment Pharmacol Ther 19, 941-952.
2. Vestergaard P (2003) Bone loss associated with gastrointestinal disease: prevalence and pathogenesis. Eur J Gastroenterol Hepatol 15, 851-856.
3. van Staa TP, Cooper C, Brusse LS, et al. (2003) Inflammatory bowel disease and the risk of fracture. Gastroenterology 125, 1591-1597.
4. Bernstein CN, Seeger LL, Anton PA, et al. (1996) A randomized, placebo-controlled trial of calcium supplementation for decreased bone density in corticosteroid-using patients with inflammatory bowel disease: a pilot study. Aliment Pharmacol Ther 10, 777-786.
5. Silvennoinen J, Lamberg-Allardt C, Karkkainen M, et al. (1996) Dietary calcium intake and its relation to bone mineral density in patients with inflammatory bowel disease. J Intern Med 240, 285-292.
6. Scott EM, Gaywood I ; Scott BB (2000) Guidelines for osteoporosis in coeliac disease and inflammatory bowel disease. British Society of Gastroenterology. Gut 46, S1-S8.
7. Arnaud SB, Goldsmith RS, Lambert PW, et al. (1975) 25-Hydroxyvitamin D3: evidence of an enterohepatic circulation in man. Proc Soc Exp Biol Med 149, 570-572.
8. Haderslev KV, Jeppesen PB, Sorensen HA, et al. (2003) Vitamin D status and measurements of markers of bone metabolism in patients with small intestinal resection. Gut 52, 653-658.
9. McCarthy D, Duggan P, O'Brien M, et al. (2005) Seasonality of vitamin D status and bone turnover in patients with Crohn's disease. Aliment Pharmacol Ther 21, 1073-1083.
10. Krasinski SD, Russell RM, Furie BC, et al. (1985) The prevalence of vitamin K deficiency in chronic gastrointestinal disorders. Am J Clin Nutr 41, 639-643.
11. Sokoll LJ ; Sadowski JA (1996) Comparison of biochemical indexes for assessing vitamin K nutritional status in a healthy adult population. Am J Clin Nutr 63, 566-573.
12. Schoon EJ, Müller MCA, Vermeer C, et al. (2001) Low serum and bone vitamin K status in patients with longstanding Crohn's disease: another pathogenetic factor of osteoporosis in Crohn's disease? Gut 48, 473-477.
13. Duggan P, O'Brien M, Kiely M, et al. (2004) Vitamin K status in patients with Crohn's disease and relationship to bone turnover. Am J Gastroenterol 99, 2178-2185.
14. Gilman J, Shanahan F ; Cashman KD (2006) Altered levels of biochemical indices of bone turnover and bone-related vitamins in patients with Crohn's disease and ulcerative colitis. Aliment Pharmacol Ther 23, 1007-1016.
15. Kuwabara A, Tanaka K, Tsugawa N, et al. (2009) High prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel disease. Osteoporos Int 20, 935-942.
16. Lewis NR ; Scott BB (2007) Guidelines for Osteoporosis in Inflammatory Bowel Disease and Coeliac Disease. London: British Society of Gastroenterology. http://www.bsg.org.uk (accessed 4 September 2008).
17. Binkley NC, Krueger DC, Kawahara TN, et al. (2002) A high phylloquinone intake is required to achieve maximal osteocalcin gamma-carboxylation. Am J Clin Nutr 76, 1055-1060.
18. Harvey RF ; Bradshaw JM (1980) A simple index of Crohn'sdisease activity. Lancet 1, 514.
19. Collins A (2006) Development and validation of methods for the measurement of micronutrient intakes relevant to bone health. PhD Thesis, National University of Ireland
20. Anonymous (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser 843, 1-129.
21. Wang LY, Bates CJ, Yan L, et al. (2004) Determination of phylloquinone (vitamin K1;/inf;) in plasma and serum by HPLC with fluorescence detection. Clin Chim Acta 347, 199-207.
22. Pilkey RM, Morton AR, Boffa MB, et al. (2007) Subclinical vitamin K deficiency in hemodialysis patients. Am J Kidney Dis 49, 432-439.
23. O'Shaughnessy D, Allen C, Woodcock T, et al. (2003) Echis time, under-carboxylated prothrombin and vitamin K status in intensive care patients. Clin Lab Haematol 25, 397-404.
24. European Commission (1993) Vitamin K. In Nutrient and Energy Intakes of the European Community. Report of the Scientific Committee for Food (31st series), pp. 147-149. Luxembourg: European Commission.
25. Department of Health (1991) Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. Report on Health and Social Subjects, no. 41. London: HMSO.
26. Institute of Medicine (2001) Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academies Press.
27. Bolton-Smith C, McMurdo ME, Paterson CR, et al. (2007) Two-year randomized controlled trial of vitamin K1;/inf; (phylloquinone) and vitamin D3;/inf; plus calcium on the bone health of older women. J Bone Miner Res 22, 509-519.
28. Szulc P, Chapuy MC, Meunier PJ, et al. (1993) Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. J Clin Invest 91, 1769-1774.
29. Szulc P, Chapuy MC, Meunier PJ, et al. (1996) Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture: a three year follow-up study. Bone 18, 487-488.
30. Oshima T, Taira S, Nonaka M, et al. (2008) A study on bone mineral density in patients with Crohn's disease. Hepatogastroenterology 55, 2116-2120.
31. Braam LA, Knapen MH, Geusens P, et al. (2003) Vitamin K1;/inf; supplementation retards bone loss in postmenopausal women between 50 and 60 years of age. Calcif Tissue Int 73, 21-26.
32. Kanellakis S, Moschonis G, Tenta R, et al. (2012) Changes in parameters of bone metabolism in postmenopausal women following a 12-month intervention period using dairy products enriched with calcium, vitamin D, and phylloquinone (vitamin K(1)) or menaquinone-7 (vitamin K (2)): the Postmenopausal Health Study II. Calcif Tissue Int 90, 251-262.
33. Booth SL, Dallal G, Shea MK, et al. (2008) Effect of vitamin K supplementation on bone loss in elderly men and women. J Clin Endocrinol Metab 93, 1217-1223.
34. Cheung AM, Tile L, Lee Y, et al. (2008) Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial. PLoS Med 5, e196.
35. Institute of Medicine (1997) Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. Washington, DC: The National Academies Press.
36. Institute of Medicine (2011) Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: The National Academies Press.
37. Knapen MH, Drummen NE, Smit E, et al. (2013) Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int 24, 2499-2507.
38. Gundberg CM, Nieman SD, Abrams S, et al. (1998) Vitamin K status and bone health: an analysis of methods for determination of undercarboxylated osteocalcin. J Clin Endocrinol Metab 83, 3258-3266.
39. Cashman KD ; O'Connor E (2008) Does high vitamin K1;/inf; intake protect against bone loss in later life? Nutr Rev 66, 532-538.