Decreased functional expression of Grp78 and Grp94 inhibits proliferation and attenuates apoptosis in a human gastric cancer cell line in vitro

Oncology Letters

Volumn 9, Issue 3, 2015, Pages 1181-1186

  Zhang, Xinchen ^a   Zhang, Liying ^a   Wang, Shu ^a   Wu, Dequan ^a   Yang, Weiliang ^a  

^a THE SECOND AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cell proliferation; Grp78; Grp94; RNA interference

Indexed keywords

GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH CANCER; TRANSCRIPTION REGULATION;

EID: 84921739967     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2014.2831     Document Type: Article

References (28)

1. Lee AS: The glucose-regulated proteins: stress induction and clinical applications. Trends Biochem Sci 26: 504-510, 2001.
2. Lee AS: The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress. Methods 35: 373-381, 2005.
3. Li J and Lee AS: Stress induction of GRP78/BiP and its role in cancer. Curr Mol Med 6: 45-54, 2006.
4. Strbo N and Podack ER: Secreted heat shock protein gp96-Ig: an innovative vaccine approach. Am J Reprod Immunol 59: 407-416, 2008.
5. Langer R, Ott K, Specht K, et al: Protein expression profiling in esophageal adenocarcinoma patients indicates association of heat-shock protein 27 expression and chemotherapy response. Clin Cancer Res 14: 8279-8287, 2008.
6. Langer R, Feith M, Siewert JR, Wester HJ and Hoefler H: Expression and clinical significance of glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus. BMC Cancer 8: 70, 2008.
7. Chen X, Ding Y, Liu CG, Mikhail S and Yang CS: Overexpression of glucose-regulated protein 94 (Grp94) in esophageal adenocarcinomas of a rat surgical model and humans. Carcinogenesis 23: 123-130, 2002.
8. Wang Q, He Z, Zhang J, et al: Overexpression of endoplasmic reticulum molecular chaperone GRP94 and GRP78 in human lung cancer tissues and its significance. Cancer Detect Prev 29: 544-551, 2005.
9. Ying-Yan W, Tao W, Xin L, Hong-Wei G, Bing-Cheng L and Qi W: The analysis of chemotherapy resistance in human lung cancer cell line with microchip-based system. Biomed Microdevices 10: 429-435, 2008.
10. Zhang L, Wang S, Wangtao, et al: Upregulation of GRP78 and GRP94 and its function in chemotherapy resistance to VP-16 in human lung cancer cell line SK-MES-1. Cancer Invest 27: 453-458, 2009.
11. Kubota H, Suzuki T, Lu J, et al: Increased expression of GRP94 protein is associated with decreased sensitivity to X-rays in cervical cancer cell lines. Int J Radiat Biol 81: 701-709, 2005.
12. Zhang LY, Zhang XC, et al: Increased expression of GRP94 protein is associated with decreased sensitivity to adriamycin in ovarian carcinoma cell lines. Clin Exp Obstet Gynecol 35: 257-263, 2008.
13. Gazit G, Lu J and Lee AS: De-regulation of GRP stress protein expression in human breast cancer cell lines. Breast Cancer Res Treat 54: 135-146, 1999.
14. Wang XP, Qiu FR, Liu GZ and Chen RF: Correlation between clinicopathology and expression of heat shock protein 70 and glucose-regulated protein 94 in human colonic adenocarcinoma. World J Gastroenterol 11: 1056-1059, 2005.
15. Lim SO, Park SG, Yoo JH, et al: Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules. World J Gastroenterol 11: 2072-2079, 2005.
16. Daneshmand S, Quek ML, Lin E, et al: Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival. Hum Pathol 38: 1547-1552, 2007.
17. Zhang XC, Yang WL, Xu HF, Wu DQ and Yang BF: Inhibitory effects of siRNA on expression of Grp94 in human gastric cell line. Chinese Journal of Experimental Surgery 24: 543-545, 2007.
18. Zhang XC, Yang WL, Xu HF, Wu DQ and Yang BF: Repressive effects of small interfering RNA on expression of glucose-regulated protein Grp78 in human gastric cell line. World Chinese Journal of Digestology 15: 447-452, 2007.
19. Fu Y and Lee AS: Glucose regulated proteins in cancer progression, drug resistance and immunotherapy. Cancer Biol Ther 5: 741-744, 2006.
20. Roy B and Lee AS: The mammalian endoplasmic reticulum stress response element consists of an evolutionarily conserved tripartite structure and interacts with a novel stress-inducible complex. Nucleic Acids Res 27: 1437-1443, 1999.
21. Zhang K and Kaufman RJ: Protein folding in the endoplasmic reticulum and the unfolded protein response. Handb Exp Pharmacol: 69-91, 2006.
22. Aridor M and Balch WE: Integration of endoplasmic reticulum signaling in health and disease. Nat Med 5: 745-751, 1999.
23. Urano F, Bertolotti A and Ron D: IRE1 and efferent signaling from the endoplasmic reticulum. J Cell Sci 113: 3697-3702, 2000.
24. Kaufman RJ: Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev 13: 1211-1233, 1999.
25. Mori K: Tripartite management of unfolded proteins in the endoplasmic reticulum. Cell 101: 451-454, 2000.
26. Foti DM, Welihinda A, Kaufman RJ and Lee AS: Conservation and divergence of the yeast and mammalian unfolded protein response. Activation of specific mammalian endoplasmic reticulum stress element of the grp78/BiP promoter by yeast Hac1. J Biol Chem 274: 30402-30409, 1999.
27. Zhang J, Jiang Y, Jia Z, et al: Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer. Clin Exp Metastasis 23: 401-410, 2006.
28. Zheng HC, Takahashi H, Li XH, et al: Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas. Hum Pathol 39: 1042-1049, 2008.