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Volumn 33, Issue 39, 2014, Pages 4722-4723

Combined PKC and MEK inhibition for treating metastatic uveal melanoma

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN D1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN BCL XL; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; SURVIVIN; X LINKED INHIBITOR OF APOPTOSIS; GNA11 PROTEIN, HUMAN; GNAQ PROTEIN, HUMAN; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT;

EID: 84921735637     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.555     Document Type: Review
Times cited : (28)

References (13)
  • 1
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    • Genomic, prognostic, and cell-signaling advances in uveal melanoma
    • Harbour JW. Genomic, prognostic, and cell-signaling advances in uveal melanoma. Am Soc Clin Oncol Educ Book 2013;2013:388-391.
    • (2013) Am Soc Clin Oncol Educ Book , vol.2013 , pp. 388-391
    • Harbour, J.W.1
  • 2
    • 21244489514 scopus 로고    scopus 로고
    • Activation of the MAPK pathway is a common event in uveal melanomas although it rarely occurs through mutation of BRAF or RAS
    • Zuidervaart W, Van Nieuwpoort F, Stark M, Dijkman R, Packer L, Borgstein AM et al. Activation of the MAPK pathway is a common event in uveal melanomas although it rarely occurs through mutation of BRAF or RAS. Br J Cancer 2005;92:2032-2038.
    • (2005) Br J Cancer , vol.92 , pp. 2032-2038
    • Zuidervaart, W.1    Van Nieuwpoort, F.2    Stark, M.3    Dijkman, R.4    Packer, L.5    Borgstein, A.M.6
  • 8
    • 84881030814 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3
    • Martin M, Masshofer L, Temming P, Rahmann S, Metz C, Bornfeld N et al. Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3. Nat Genet 2013;45:933-936.
    • (2013) Nat Genet , vol.45 , pp. 933-936
    • Martin, M.1    Masshofer, L.2    Temming, P.3    Rahmann, S.4    Metz, C.5    Bornfeld, N.6
  • 10
    • 84908316203 scopus 로고    scopus 로고
    • Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations
    • Chen X, Wu Q, Tan L, Porter D, Jager MJ, Emery C et al. Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations. Oncogene 2013;33:4724-4734.
    • (2013) Oncogene , vol.33 , pp. 4724-4734
    • Chen, X.1    Wu, Q.2    Tan, L.3    Porter, D.4    Jager, M.J.5    Emery, C.6
  • 11
    • 84855782488 scopus 로고    scopus 로고
    • The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma
    • Wu X, Zhu M, Fletcher JA, Giobbie-Hurder A, Hodi FS. The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma. PLoS One 2012;7:e29622.
    • (2012) PLoS One , vol.7 , pp. e29622
    • Wu, X.1    Zhu, M.2    Fletcher, J.A.3    Giobbie-Hurder, A.4    Hodi, F.S.5
  • 12
    • 84865096605 scopus 로고    scopus 로고
    • Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner
    • Khalili JS, Yu X, Wang J, Hayes BC, Davies MA, Lizee G et al. Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res 2012;18:4345-4355.
    • (2012) Clin Cancer Res , vol.18 , pp. 4345-4355
    • Khalili, J.S.1    Yu, X.2    Wang, J.3    Hayes, B.C.4    Davies, M.A.5    Lizee, G.6
  • 13


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.