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Volumn 54, Issue 2, 2015, Pages 209-219

Population Pharmacokinetic Model of THC Integrates Oral, Intravenous, and Pulmonary Dosing and Characterizes Short- and Long-term Pharmacokinetics

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID DERIVATIVE; DELTA9 TETRAHYDROCANNOBINOL; UNCLASSIFIED DRUG; DRONABINOL; PSYCHOTROPIC DRUGS;

EID: 84921732859     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.1007/s40262-014-0195-5     Document Type: Article
Times cited : (64)

References (39)
  • 1
    • 0035138027 scopus 로고    scopus 로고
    • Pharmacology and effects of cannabis: a brief review
    • COI: 1:STN:280:DC%2BD3M3lvVKnsQ%3D%3D, PID: 11157422
    • Ashton CH. Pharmacology and effects of cannabis: a brief review. Br J Psychiatry. 2001;178:101–6.
    • (2001) Br J Psychiatry , vol.178 , pp. 101-106
    • Ashton, C.H.1
  • 2
    • 78249232046 scopus 로고    scopus 로고
    • Review on clinical studies with cannabis and cannabinoids 2005–2009
    • Hazekamp A, Grotenhermen F. Review on clinical studies with cannabis and cannabinoids 2005–2009. Cannabinoids. 2010;5:1–21.
    • (2010) Cannabinoids , vol.5 , pp. 1-21
    • Hazekamp, A.1    Grotenhermen, F.2
  • 3
    • 0034883101 scopus 로고    scopus 로고
    • Medicinal use of cannabis: history and current status
    • COI: 1:STN:280:DC%2BD387itVWgug%3D%3D, PID: 11854770
    • Kalant H. Medicinal use of cannabis: history and current status. Pain Res Manag. 2001;6:80–91.
    • (2001) Pain Res Manag , vol.6 , pp. 80-91
    • Kalant, H.1
  • 4
    • 0024263922 scopus 로고
    • Determination and characterization of a cannabinoid receptor in rat brain
    • COI: 1:CAS:528:DyaL1MXovVersQ%3D%3D, PID: 2848184
    • Devane WA, Dysarz FA III, Johnson MR, Melvin LS, Howlett AC. Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol. 1988;34:605–13.
    • (1988) Mol Pharmacol , vol.34 , pp. 605-613
    • Devane, W.A.1    Dysarz, F.A.2    Johnson, M.R.3    Melvin, L.S.4    Howlett, A.C.5
  • 5
    • 0032756226 scopus 로고    scopus 로고
    • Agonist selective regulation of G proteins by cannabinoid CB(1) and CB(2) receptors
    • COI: 1:CAS:528:DyaK1MXns1yhurg%3D, PID: 10570066
    • Glass M, Northup JK. Agonist selective regulation of G proteins by cannabinoid CB(1) and CB(2) receptors. Mol Pharmacol. 1999;56:1362–9.
    • (1999) Mol Pharmacol , vol.56 , pp. 1362-1369
    • Glass, M.1    Northup, J.K.2
  • 6
    • 84879483888 scopus 로고    scopus 로고
    • Surinabant, a selective cannabinoid receptor type 1 antagonist, inhibits delta 9-tetrahydrocannabinol-induced central nervous system and heart rate effects in humans
    • COI: 1:CAS:528:DC%2BC3sXpvFeks7g%3D, PID: 23278647
    • Klumpers LE, Roy C, Ferron G, Turpault S, Poitiers F, Pinquier JL, et al. Surinabant, a selective cannabinoid receptor type 1 antagonist, inhibits delta 9-tetrahydrocannabinol-induced central nervous system and heart rate effects in humans. Br J Clin Pharmacol. 2013;76:65–77.
    • (2013) Br J Clin Pharmacol , vol.76 , pp. 65-77
    • Klumpers, L.E.1    Roy, C.2    Ferron, G.3    Turpault, S.4    Poitiers, F.5    Pinquier, J.L.6
  • 7
    • 0037272302 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of cannabinoids
    • Grotenhermen F. Clinical pharmacokinetics of cannabinoids. J Cannabis Ther. 2003;3:3–51.
    • (2003) J Cannabis Ther , vol.3 , pp. 3-51
    • Grotenhermen, F.1
  • 8
    • 0019417069 scopus 로고
    • Clinical effects and plasma levels of delta 9-tetrahydrocannabinol (delta 9-THC) in heavy and light users of cannabis
    • COI: 1:CAS:528:DyaL3MXlt1Khs78%3D
    • Lindgren JE, Ohlsson A, Agurell S, Hollister L, Gillespie H. Clinical effects and plasma levels of delta 9-tetrahydrocannabinol (delta 9-THC) in heavy and light users of cannabis. Psychopharmacology (Berl). 1981;74:208–12.
    • (1981) Psychopharmacology (Berl) , vol.74 , pp. 208-212
    • Lindgren, J.E.1    Ohlsson, A.2    Agurell, S.3    Hollister, L.4    Gillespie, H.5
  • 9
    • 0018963804 scopus 로고
    • Plasma delta-9 tetrahydrocannabinol concentrations and clinical effects after oral and intravenous administration and smoking
    • COI: 1:CAS:528:DyaL3cXlvFOnu70%3D, PID: 6250760
    • Ohlsson A, Lindgren JE, Wahlen A, Agurell S, Hollister LE, Gillespie HK. Plasma delta-9 tetrahydrocannabinol concentrations and clinical effects after oral and intravenous administration and smoking. Clin Pharmacol Ther. 1980;28:409–16.
    • (1980) Clin Pharmacol Ther , vol.28 , pp. 409-416
    • Ohlsson, A.1    Lindgren, J.E.2    Wahlen, A.3    Agurell, S.4    Hollister, L.E.5    Gillespie, H.K.6
  • 10
    • 0029114516 scopus 로고
    • Involvement of CYP2C in the metabolism of cannabinoids by human hepatic microsomes from an old woman
    • COI: 1:CAS:528:DyaK2MXotlGnsbs%3D, PID: 8535411
    • Watanabe K, Matsunaga T, Yamamoto I, Funae Y, Yoshimura H. Involvement of CYP2C in the metabolism of cannabinoids by human hepatic microsomes from an old woman. Biol Pharm Bull. 1995;18:1138–41.
    • (1995) Biol Pharm Bull , vol.18 , pp. 1138-1141
    • Watanabe, K.1    Matsunaga, T.2    Yamamoto, I.3    Funae, Y.4    Yoshimura, H.5
  • 11
    • 33847633815 scopus 로고    scopus 로고
    • Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes
    • COI: 1:CAS:528:DC%2BD2sXislKgt7k%3D, PID: 17303175
    • Watanabe K, Yamaori S, Funahashi T, Kimura T, Yamamoto I. Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes. Life Sci. 2007;80:1415–9.
    • (2007) Life Sci , vol.80 , pp. 1415-1419
    • Watanabe, K.1    Yamaori, S.2    Funahashi, T.3    Kimura, T.4    Yamamoto, I.5
  • 12
    • 0015514995 scopus 로고
    • Intravenous injection in man of 9-tetrahydrocannabinol and 11-OH-9-tetrahydrocannabinol
    • COI: 1:CAS:528:DyaE38XltlGhu74%3D, PID: 4558903
    • Perez-Reyes M, Timmons MC, Lipton MA, Davis KH, Wall ME. Intravenous injection in man of 9-tetrahydrocannabinol and 11-OH-9-tetrahydrocannabinol. Science. 1972;177:633–5.
    • (1972) Science , vol.177 , pp. 633-635
    • Perez-Reyes, M.1    Timmons, M.C.2    Lipton, M.A.3    Davis, K.H.4    Wall, M.E.5
  • 13
    • 0016138682 scopus 로고
    • Physiochemical properties, solubility, and protein binding of delta 9-tetrahydrocannabinol
    • COI: 1:CAS:528:DyaE2MXhtFartg%3D%3D, PID: 4853640
    • Garrett ER, Hunt CA. Physiochemical properties, solubility, and protein binding of delta 9-tetrahydrocannabinol. J Pharm Sci. 1974;63:1056–64.
    • (1974) J Pharm Sci , vol.63 , pp. 1056-1064
    • Garrett, E.R.1    Hunt, C.A.2
  • 14
    • 0019292856 scopus 로고
    • Tolerance and disposition of tetrahydrocannabinol in man
    • COI: 1:CAS:528:DyaL3cXlsl2gsbs%3D, PID: 6256518
    • Hunt CA, Jones RT. Tolerance and disposition of tetrahydrocannabinol in man. J Pharmacol Exp Ther. 1980;215:35–44.
    • (1980) J Pharmacol Exp Ther , vol.215 , pp. 35-44
    • Hunt, C.A.1    Jones, R.T.2
  • 16
    • 0024575997 scopus 로고
    • Determination of delta 1-tetrahydrocannabinol in human fat biopsies from marihuana users by gas chromatography-mass spectrometry
    • COI: 1:CAS:528:DyaL1MXhtV2mt70%3D, PID: 2539872
    • Johansson E, Noren K, Sjovall J, Halldin MM. Determination of delta 1-tetrahydrocannabinol in human fat biopsies from marihuana users by gas chromatography-mass spectrometry. Biomed Chromatogr. 1989;3:35–8.
    • (1989) Biomed Chromatogr , vol.3 , pp. 35-38
    • Johansson, E.1    Noren, K.2    Sjovall, J.3    Halldin, M.M.4
  • 17
    • 0020031718 scopus 로고
    • Single dose kinetics of deuterium labelled delta 1-tetrahydrocannabinol in heavy and light cannabis users
    • COI: 1:CAS:528:DyaL38XhvFart70%3D, PID: 6277407
    • Ohlsson A, Lindgren JE, Wahlen A, Agurell S, Hollister LE, Gillespie HK. Single dose kinetics of deuterium labelled delta 1-tetrahydrocannabinol in heavy and light cannabis users. Biomed Mass Spectrom. 1982;9:6–10.
    • (1982) Biomed Mass Spectrom , vol.9 , pp. 6-10
    • Ohlsson, A.1    Lindgren, J.E.2    Wahlen, A.3    Agurell, S.4    Hollister, L.E.5    Gillespie, H.K.6
  • 18
    • 0022641356 scopus 로고
    • Pharmacokinetics of delta 9-tetrahydrocannabinol in rabbits following single or multiple intravenous doses
    • COI: 1:CAS:528:DyaL28Xhsl2ksr8%3D, PID: 2870899
    • Leuschner JT, Harvey DJ, Bullingham RE, Paton WD. Pharmacokinetics of delta 9-tetrahydrocannabinol in rabbits following single or multiple intravenous doses. Drug Metab Dispos. 1986;14:230–8.
    • (1986) Drug Metab Dispos , vol.14 , pp. 230-238
    • Leuschner, J.T.1    Harvey, D.J.2    Bullingham, R.E.3    Paton, W.D.4
  • 19
    • 0015208116 scopus 로고
    • Delta-9-tetrahydrocannabinol: metabolism and disposition in long-term marihuana smokers
    • COI: 1:CAS:528:DyaE3MXks1ajsb8%3D, PID: 5087483
    • Lemberger L, Tamarkin NR, Axelrod J, Kopin IJ. Delta-9-tetrahydrocannabinol: metabolism and disposition in long-term marihuana smokers. Science. 1971;173:72–4.
    • (1971) Science , vol.173 , pp. 72-74
    • Lemberger, L.1    Tamarkin, N.R.2    Axelrod, J.3    Kopin, I.J.4
  • 20
    • 0020565632 scopus 로고
    • Metabolism, disposition, and kinetics of delta-9-tetrahydrocannabinol in men and women
    • COI: 1:CAS:528:DyaL3sXlvVOjsbg%3D, PID: 6309462
    • Wall ME, Sadler BM, Brine D, Taylor H, Perez-Reyes M. Metabolism, disposition, and kinetics of delta-9-tetrahydrocannabinol in men and women. Clin Pharmacol Ther. 1983;34:352–63.
    • (1983) Clin Pharmacol Ther , vol.34 , pp. 352-363
    • Wall, M.E.1    Sadler, B.M.2    Brine, D.3    Taylor, H.4    Perez-Reyes, M.5
  • 21
    • 0021280299 scopus 로고
    • Marijuana effect and delta-9-tetrahydrocannabinol plasma level
    • COI: 1:CAS:528:DyaL2cXlt1aqtLw%3D, PID: 6086207
    • Chiang CW, Barnett G. Marijuana effect and delta-9-tetrahydrocannabinol plasma level. Clin Pharmacol Ther. 1984;36:234–8.
    • (1984) Clin Pharmacol Ther , vol.36 , pp. 234-238
    • Chiang, C.W.1    Barnett, G.2
  • 23
    • 0019855369 scopus 로고
    • Relationship between plasma delta-9-tetrahydrocannabinol concentration and pharmacologic effects in man
    • COI: 1:CAS:528:DyaL38XhsFWlsA%3D%3D
    • Cocchetto DM, Owens SM, Perez-Reyes M, DiGuiseppi S, Miller LL. Relationship between plasma delta-9-tetrahydrocannabinol concentration and pharmacologic effects in man. Psychopharmacology (Berl). 1981;75:158–64.
    • (1981) Psychopharmacology (Berl) , vol.75 , pp. 158-164
    • Cocchetto, D.M.1    Owens, S.M.2    Perez-Reyes, M.3    DiGuiseppi, S.4    Miller, L.L.5
  • 24
    • 0030902952 scopus 로고    scopus 로고
    • Concentration-effect relationship of delta-9-tetrahydrocannabiol and prediction of psychotropic effects after smoking marijuana
    • COI: 1:CAS:528:DyaK2sXisFSlsrw%3D, PID: 9112136
    • Harder S, Rietbrock S. Concentration-effect relationship of delta-9-tetrahydrocannabiol and prediction of psychotropic effects after smoking marijuana. Int J Clin Pharmacol Ther. 1997;35:155–9.
    • (1997) Int J Clin Pharmacol Ther , vol.35 , pp. 155-159
    • Harder, S.1    Rietbrock, S.2
  • 26
    • 50249134409 scopus 로고    scopus 로고
    • Modelling of the concentration-effect relationship of THC on central nervous system parameters and heart rate: insight into its mechanisms of action and a tool for clinical research and development of cannabinoids
    • COI: 1:CAS:528:DC%2BD1cXht1Kru7rL, PID: 18583433
    • Strougo A, Zuurman L, Roy C, Pinquier JL, van Gerven JM, Cohen AF, et al. Modelling of the concentration-effect relationship of THC on central nervous system parameters and heart rate: insight into its mechanisms of action and a tool for clinical research and development of cannabinoids. J Psychopharmacol. 2008;22:717–26.
    • (2008) J Psychopharmacol , vol.22 , pp. 717-726
    • Strougo, A.1    Zuurman, L.2    Roy, C.3    Pinquier, J.L.4    van Gerven, J.M.5    Cohen, A.F.6
  • 27
    • 84862132674 scopus 로고    scopus 로고
    • Novel delta(9)-tetrahydrocannabinol formulation Namisol(R) has beneficial pharmacokinetics and promising pharmacodynamic effects
    • Klumpers LE, Beumer TL, van Hasselt JG, Lipplaa A, Karger LB, Kleinloog HD, et al. Novel delta(9)-tetrahydrocannabinol formulation Namisol(R) has beneficial pharmacokinetics and promising pharmacodynamic effects. Br J Clin Pharmacol. 2011;74:42–53.
    • (2011) Br J Clin Pharmacol , vol.74 , pp. 42-53
    • Klumpers, L.E.1    Beumer, T.L.2    van Hasselt, J.G.3    Lipplaa, A.4    Karger, L.B.5    Kleinloog, H.D.6
  • 28
    • 84866285509 scopus 로고    scopus 로고
    • Manipulating brain connectivity with delta(9)-tetrahydrocannabinol: a pharmacological resting state FMRI study
    • COI: 1:CAS:528:DC%2BC38XhsFSlt7fJ, PID: 22885247
    • Klumpers LE, Cole DM, Khalili-Mahani N, Soeter RP, Te Beek ET, Rombouts SA, et al. Manipulating brain connectivity with delta(9)-tetrahydrocannabinol: a pharmacological resting state FMRI study. Neuroimage. 2012;63:1701–11.
    • (2012) Neuroimage , vol.63 , pp. 1701-1711
    • Klumpers, L.E.1    Cole, D.M.2    Khalili-Mahani, N.3    Soeter, R.P.4    Te Beek, E.T.5    Rombouts, S.A.6
  • 29
    • 84866246492 scopus 로고    scopus 로고
    • Does olanzapine inhibit the psychomimetic effects of delta(9)-tetrahydrocannabinol?
    • COI: 1:CAS:528:DC%2BC2cXhs1OksrfL, PID: 22596206
    • Kleinloog D, Liem-Moolenaar M, Jacobs G, Klaassen E, de Kam M, Hijman R, et al. Does olanzapine inhibit the psychomimetic effects of delta(9)-tetrahydrocannabinol? J Psychopharmacol. 2012;26:1307–16.
    • (2012) J Psychopharmacol , vol.26 , pp. 1307-1316
    • Kleinloog, D.1    Liem-Moolenaar, M.2    Jacobs, G.3    Klaassen, E.4    de Kam, M.5    Hijman, R.6
  • 30
    • 70449629796 scopus 로고    scopus 로고
    • The acute effects of synthetic intravenous delta 9-tetrahydrocannabinol on psychosis, mood and cognitive functioning
    • COI: 1:STN:280:DC%2BD1MnhtFKksA%3D%3D, PID: 19335936
    • Morrison PD, Zois V, McKeown DA, Lee TD, Holt DW, Powell JF, et al. The acute effects of synthetic intravenous delta 9-tetrahydrocannabinol on psychosis, mood and cognitive functioning. Psychol Med. 2009;39:1607–16.
    • (2009) Psychol Med , vol.39 , pp. 1607-1616
    • Morrison, P.D.1    Zois, V.2    McKeown, D.A.3    Lee, T.D.4    Holt, D.W.5    Powell, J.F.6
  • 31
    • 82955215765 scopus 로고    scopus 로고
    • Does intravenous delta 9-tetrahydrocannabinol increase dopamine release? A SPET study
    • COI: 1:CAS:528:DC%2BC38XmsFGgtA%3D%3D, PID: 20851843
    • Barkus E, Morrison PD, Vuletic D, Dickson JC, Ell PJ, Pilowsky LS, et al. Does intravenous delta 9-tetrahydrocannabinol increase dopamine release? A SPET study. J Psychopharmacol. 2011;25:1462–8.
    • (2011) J Psychopharmacol , vol.25 , pp. 1462-1468
    • Barkus, E.1    Morrison, P.D.2    Vuletic, D.3    Dickson, J.C.4    Ell, P.J.5    Pilowsky, L.S.6
  • 32
    • 79951515596 scopus 로고    scopus 로고
    • Disruption of frontal theta coherence by delta 9-tetrahydrocannabinol is associated with positive psychotic symptoms
    • COI: 1:CAS:528:DC%2BC3MXhs1ylurc%3D, PID: 21150914
    • Morrison PD, Nottage J, Stone JM, Bhattacharyya S, Tunstall N, Brenneisen R, et al. Disruption of frontal theta coherence by delta 9-tetrahydrocannabinol is associated with positive psychotic symptoms. Neuropsychopharmacology. 2011;36:827–36.
    • (2011) Neuropsychopharmacology , vol.36 , pp. 827-836
    • Morrison, P.D.1    Nottage, J.2    Stone, J.M.3    Bhattacharyya, S.4    Tunstall, N.5    Brenneisen, R.6
  • 33
    • 75749126485 scopus 로고    scopus 로고
    • Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology
    • COI: 1:CAS:528:DC%2BC3cXhtlCrur0%3D, PID: 19924114
    • Bhattacharyya S, Morrison PD, Fusar-Poli P, Martin-Santos R, Borgwardt S, Winton-Brown T, et al. Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology. Neuropsychopharmacology. 2010;35:764–74.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 764-774
    • Bhattacharyya, S.1    Morrison, P.D.2    Fusar-Poli, P.3    Martin-Santos, R.4    Borgwardt, S.5    Winton-Brown, T.6
  • 34
    • 0017688679 scopus 로고
    • Estimation of population characteristics of pharmacokinetic parameters from routine clinical data
    • COI: 1:CAS:528:DyaE1cXksVOiuw%3D%3D, PID: 925881
    • Sheiner LB, Rosenberg B, Marathe VV. Estimation of population characteristics of pharmacokinetic parameters from routine clinical data. J Pharmacokinet Biopharm. 1977;5:445–79.
    • (1977) J Pharmacokinet Biopharm , vol.5 , pp. 445-479
    • Sheiner, L.B.1    Rosenberg, B.2    Marathe, V.V.3
  • 35
    • 84921816254 scopus 로고    scopus 로고
    • Promasys 6.1 version. Leiden: Promasys BV; 2011
    • Promasys 6.1 version. Leiden: Promasys BV; 2011.
  • 37
    • 84872205293 scopus 로고    scopus 로고
    • R: a language and environment for statistical computing
    • R Development Core Team. R: a language and environment for statistical computing. RFfSCVA. 2011.
    • (2011) RFfSCVA
    • Development Core Team, R.1
  • 38
    • 23944435458 scopus 로고    scopus 로고
    • PsN-Toolkit: a collection of computer intensive statistical methods for non-linear mixed effect modeling using NONMEM
    • PID: 16023764
    • Lindbom L, Pihlgren P, Jonsson EN. PsN-Toolkit: a collection of computer intensive statistical methods for non-linear mixed effect modeling using NONMEM. Comput Methods Programs Biomed. 2005;79:241–57.
    • (2005) Comput Methods Programs Biomed , vol.79 , pp. 241-257
    • Lindbom, L.1    Pihlgren, P.2    Jonsson, E.N.3
  • 39
    • 0020282991 scopus 로고
    • Bioavailability of delta-9-tetrahydrocannabinol-derived radioactivity following intramuscular administration of delta-9-11-C-14-tetrahydrocannabinol to rabbits
    • COI: 1:CAS:528:DyaL3sXhtlahsb8%3D
    • Litterst CL, Flora KP, Cradock JC. Bioavailability of delta-9-tetrahydrocannabinol-derived radioactivity following intramuscular administration of delta-9-11-C-14-tetrahydrocannabinol to rabbits. Res Commun Subst Abuse. 1982;3:453–65.
    • (1982) Res Commun Subst Abuse , vol.3 , pp. 453-465
    • Litterst, C.L.1    Flora, K.P.2    Cradock, J.C.3


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