메뉴 건너뛰기




Volumn 18, Issue 1, 2015, Pages 1-7

Maintaining mood stability in bipolar disorder: A clinical perspective on pharmacotherapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; NEUROLEPTIC AGENT; TRANQUILIZER;

EID: 84921732218     PISSN: 13620347     EISSN: None     Source Type: Journal    
DOI: 10.1136/eb-2014-101948     Document Type: Article
Times cited : (17)

References (47)
  • 1
    • 0034666204 scopus 로고    scopus 로고
    • Historical perspectives and natural history of bipolar disorder
    • Angst J, Sellaro R. Historical perspectives and natural history of bipolar disorder. Biol Psychiatry 2000;48:445–57.
    • (2000) Biol Psychiatry , vol.48 , pp. 445-457
    • Angst, J.1    Sellaro, R.2
  • 2
    • 85028151444 scopus 로고    scopus 로고
    • New York: Guildford Publications
    • Miklowitz DJ, Gitlin MJ. Clinician’s Guide to Bipolar Disorder: Integrating Pharmacology and Psychotherapy. New York: Guildford Publications, 2014:113–44.
    • (2014) Clinician’ , pp. 113-144
    • Miklowitz, D.J.1    Gitlin, M.J.2
  • 3
    • 84859851346 scopus 로고    scopus 로고
    • Maintenance therapies in bipolar disorders
    • Gitlin M, Frye MA. Maintenance therapies in bipolar disorders. Bipolar Disord 2012;14(Suppl 2):51–65.
    • (2012) Bipolar Disord , vol.14 , pp. 51-65
    • Gitlin, M.1    Frye, M.A.2
  • 4
    • 84859829264 scopus 로고    scopus 로고
    • Balanced efficacy, safety, and tolerability recommendations for the clinical management of bipolar disorder
    • Malhi GS, Bargh DM, McIntyre R, et al. Balanced efficacy, safety, and tolerability recommendations for the clinical management of bipolar disorder. Bipolar Disord 2012;14(Suppl 2):1–21.
    • (2012) Bipolar Disord , vol.14 , pp. 1-21
    • Malhi, G.S.1    Bargh, D.M.2    McIntyre, R.3
  • 5
    • 79953059572 scopus 로고    scopus 로고
    • A 15-year prospective follow-up of bipolar affective disorders: Comparisons with unipolar nonpsychotic depression
    • Goldberg JF, Harrow M. A 15-year prospective follow-up of bipolar affective disorders: comparisons with unipolar nonpsychotic depression. Bipolar Disord 2011;13:155–63.
    • (2011) Bipolar Disord , vol.13 , pp. 155-163
    • Goldberg, J.F.1    Harrow, M.2
  • 6
    • 84858155175 scopus 로고    scopus 로고
    • Polarity index of pharmacological agents used for maintenance treatment of bipolar disorder
    • Popovic D, Reinares M, Goikolea JM, et al. Polarity index of pharmacological agents used for maintenance treatment of bipolar disorder. Eur Neuropsychopharmacol 2012;22:339–46.
    • (2012) Eur Neuropsychopharmacol , vol.22 , pp. 339-346
    • Popovic, D.1    Reinares, M.2    Goikolea, J.M.3
  • 7
    • 64149126289 scopus 로고    scopus 로고
    • Clinical practice recommendations for bipolar disorder
    • Malhi GS, Adams D, Lampe L et al. Clinical practice recommendations for bipolar disorder. Acta Psychiatr Scand Suppl 2009;119:27–46.
    • (2009) Acta Psychiatr Scand Suppl , vol.119 , pp. 27-46
    • Malhi, G.S.1    Adams, D.2    Lampe, L.3
  • 8
    • 33645004244 scopus 로고    scopus 로고
    • Predictors of recurrence in bipolar disorder: Primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    • Perlis RH, Ostacher MJ, Patel JK, et al. Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Am J Psychiatry 2006;163:217–24.
    • (2006) Am J Psychiatry , vol.163 , pp. 217-224
    • Perlis, R.H.1    Ostacher, M.J.2    Patel, J.K.3
  • 9
    • 84857360430 scopus 로고    scopus 로고
    • Predictors of relapse or recurrence in bipolar I disorder
    • Degenhardt EK, Gatz JL, Jacob J, et al. Predictors of relapse or recurrence in bipolar I disorder. J Affect Disord 2012;136:733–9.
    • (2012) J Affect Disord , vol.136 , pp. 733-739
    • Degenhardt, E.K.1    Gatz, J.L.2    Jacob, J.3
  • 10
    • 80053032908 scopus 로고    scopus 로고
    • Maintenance treatment study designs in bipolar disorder: Do they demonstrate that atypical neuroleptics (antipsychotics) are mood stabilizers?
    • Goodwin FK, Whitham EA, Ghaemi SN. Maintenance treatment study designs in bipolar disorder: do they demonstrate that atypical neuroleptics (antipsychotics) are mood stabilizers? CNS Drugs 2011;25:819–27.
    • (2011) CNS Drugs , vol.25 , pp. 819-827
    • Goodwin, F.K.1    Whitham, E.A.2    Ghaemi, S.N.3
  • 11
    • 84898544482 scopus 로고    scopus 로고
    • Clinical and regulatory implications of active run-in phases in long-term studies for bipolar disorder
    • Cipriani A, Barbui C, Rendell J, et al. Clinical and regulatory implications of active run-in phases in long-term studies for bipolar disorder. Acta Psychiatr Scand 2014;129:328–42.
    • (2014) Acta Psychiatr Scand , vol.129 , pp. 328-342
    • Cipriani, A.1    Barbui, C.2    Rendell, J.3
  • 12
    • 84880534484 scopus 로고    scopus 로고
    • Pharmacological management of bipolar depression: Acute treatment, maintenance, and prophylaxis
    • Vieta E, Valentí M. Pharmacological management of bipolar depression: acute treatment, maintenance, and prophylaxis. CNS Drugs 2013;27:515–29.
    • (2013) CNS Drugs , vol.27 , pp. 515-529
    • Vieta, E.1    Valentí, M.2
  • 13
    • 80052979456 scopus 로고    scopus 로고
    • Effectiveness of psychotropic medications in the maintenance phase of bipolar disorder: A meta-analysis of randomized controlled trials
    • Vieta E, Günther O, Locklear J, et al. Effectiveness of psychotropic medications in the maintenance phase of bipolar disorder: a meta-analysis of randomized controlled trials. Int J Neuropsychopharmacol 2011;14:1029–49.
    • (2011) Int J Neuropsychopharmacol , vol.14 , pp. 1029-1049
    • Vieta, E.1    Günther, O.2    Locklear, J.3
  • 14
    • 84896752475 scopus 로고    scopus 로고
    • Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder (Review)
    • (accessed 23 Jul 2014)
    • Cipriani A, Reid K, Young AH, et al. Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder (review). Cochrane Database Syst Rev 2013;10:CD003196. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD003196/ pdf/standard (accessed 23 Jul 2014).
    • (2013) Cochrane Database , vol.10
    • Cipriani, A.1    Reid, K.2    Young, A.H.3
  • 15
    • 84863831234 scopus 로고    scopus 로고
    • The science and practice of lithium therapy
    • Malhi GS, Tanious M, Das P, et al. The science and practice of lithium therapy. Aust N Z J Psychiatry 2012;46:192–211.
    • (2012) Aust N Z J Psychiatry , vol.46 , pp. 192-211
    • Malhi, G.S.1    Tanious, M.2    Das, P.3
  • 16
    • 0002642621 scopus 로고    scopus 로고
    • Excellent lithium responders: People whose lives have been changed by lithium prophylaxis, Lithium: 50 Years of Psychopharmacology.
    • In: Birch N, Gallichio V, Becker R, eds., Cheshire,CT: Weidner Publishing Group
    • Grof P. Excellent lithium responders: people whose lives have been changed by lithium prophylaxis. In: Birch N, Gallichio V, Becker R, eds. Lithium: 50 years of psychopharmacology. New perspectives in biomedical and clinical research. Cheshire, CT: Weidner Publishing Group, 1999:36–51.
    • (1999) New Perspectives in Biomedical and Clinical Research , pp. 36-51
    • Grof, P.1
  • 17
    • 84876930720 scopus 로고    scopus 로고
    • Potential mechanisms of action of lithium in bipolar disorder. Current understanding
    • Malhi GS, Tanious M, Das P, et al. Potential mechanisms of action of lithium in bipolar disorder. Current understanding. CNS Drugs 2013;27:135–53.
    • (2013) CNS Drugs , vol.27 , pp. 135-153
    • Malhi, G.S.1    Tanious, M.2    Das, P.3
  • 18
    • 77957359472 scopus 로고    scopus 로고
    • Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): A randomised open-label trial
    • Geddes JR, Goodwin GM, Rendell J, et al. Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial. Lancet 2010;375:385–95.
    • (2010) Lancet , vol.375 , pp. 385-395
    • Geddes, J.R.1    Goodwin, G.M.2    Rendell, J.3
  • 19
    • 2342540409 scopus 로고    scopus 로고
    • A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder
    • Goodwin GM, Bowden CL, Calabrese JR, et al. A pooled analysis of 2 placebo-controlled 18-month trials of lamotrigine and lithium maintenance in bipolar I disorder. J Clin Psychiatry 2004;65:432–41.
    • (2004) J Clin Psychiatry , vol.65 , pp. 432-441
    • Goodwin, G.M.1    Bowden, C.L.2    Calabrese, J.R.3
  • 20
    • 77955672759 scopus 로고    scopus 로고
    • Lamotrigine versus lithium as maintenance treatment in bipolar I disorder: An open, randomized effectiveness study mimicking clinical practice. The 6th trial of the Danish University Antidepressant Group (DUAG-6)
    • Licht RW, Nielsen JN, Gram LF, et al. Lamotrigine versus lithium as maintenance treatment in bipolar I disorder: an open, randomized effectiveness study mimicking clinical practice. The 6th trial of the Danish University Antidepressant Group (DUAG-6). Bipolar Disord 2010;12:483–93.
    • (2010) Bipolar Disord , vol.12 , pp. 483-493
    • Licht, R.W.1    Nielsen, J.N.2    Gram, L.F.3
  • 21
    • 79951483393 scopus 로고    scopus 로고
    • Long-term outcome of bipolar depressed patients receiving lamotrigine as add-on to lithium with the possibility of the addition of paroxetine in nonresponders: A randomized, placebo-controlled trial with a novel design
    • van der Loos ML, Mulder P, Hartong EG, et al. Long-term outcome of bipolar depressed patients receiving lamotrigine as add-on to lithium with the possibility of the addition of paroxetine in nonresponders: a randomized, placebo-controlled trial with a novel design. Bipolar Disord 2011;13:111–17.
    • (2011) Bipolar Disord , vol.13 , pp. 111-117
    • Van Der Loos, M.L.1    Mulder, P.2    Hartong, E.G.3
  • 22
    • 84861333455 scopus 로고    scopus 로고
    • Carbamazepine treatment of bipolar disorder: A retrospective evaluation of naturalistic long-term outcomes
    • Chen CH, Lin SK. Carbamazepine treatment of bipolar disorder: a retrospective evaluation of naturalistic long-term outcomes. BMC Psychiatry 2012;12:47.
    • (2012) BMC Psychiatry , vol.12 , pp. 47
    • Chen, C.H.1    Lin, S.K.2
  • 23
    • 81755166023 scopus 로고    scopus 로고
    • Continuation of quetiapine versus switching to placebo or lithium for maintenance treatment of bipolar I disorder (Trial 144: A randomized controlled study)
    • Weisler RH, Nolen WA, Neijber A, et al. Continuation of quetiapine versus switching to placebo or lithium for maintenance treatment of bipolar I disorder (Trial 144: a randomized controlled study). J Clin Psychiatry 2011;72:1452–64.
    • (2011) J Clin Psychiatry , vol.72 , pp. 1452-1464
    • Weisler, R.H.1    Nolen, W.A.2    Neijber, A.3
  • 24
    • 0041977102 scopus 로고    scopus 로고
    • Olanzapine versus divalproex sodium for the treatment of acute mania and maintenance of remission: A 47-week study
    • Tohen M, Ketter TA, Zarate CA, et al. Olanzapine versus divalproex sodium for the treatment of acute mania and maintenance of remission: a 47-week study. Am J Psychiatry 2003;160:1263–71.
    • (2003) Am J Psychiatry , vol.160 , pp. 1263-1271
    • Tohen, M.1    Ketter, T.A.2    Zarate, C.A.3
  • 25
    • 67650768089 scopus 로고    scopus 로고
    • Olanzapine in long-term treatment for bipolar disorder (Review)
    • Cipriani A, Rendell JM, Geddes J. Olanzapine in long-term treatment for bipolar disorder (review). Cochrane Database Syst Rev 2009;(1):CD004367.
    • (2009) Cochrane Database , Issue.1
    • Cipriani, A.1    Rendell, J.M.2    Geddes, J.3
  • 26
    • 84879429715 scopus 로고    scopus 로고
    • The ARIQUELI study: Potentiation of quetiapine in bipolar I nonresponders with lithium versus aripiprazole
    • Missio G, Moreno DH, Fernandes F, et al. The ARIQUELI study: potentiation of quetiapine in bipolar I nonresponders with lithium versus aripiprazole. Trials 2013;14:190.
    • (2013) Trials , vol.14 , pp. 190
    • Missio, G.1    Moreno, D.H.2    Fernandes, F.3
  • 27
    • 78651238924 scopus 로고    scopus 로고
    • A clinical review of aripiprazole in bipolar depression and maintenance therapy of bipolar disorder
    • Suppl
    • Yatham LN. A clinical review of aripiprazole in bipolar depression and maintenance therapy of bipolar disorder. J Affect Disord 2011;128(Suppl):S21–8.
    • (2011) J Affect Disord , vol.128 , pp. S21-S28
    • Yatham, L.N.1
  • 28
    • 84875367915 scopus 로고    scopus 로고
    • Efficacy of aripiprazole versus placebo as adjuncts to lithium or valproate in relapse prevention of manic or mixed episodes in bipolar I patients stratified by index manic or mixed episode
    • Yatham LN, Fountoulakis KN, Rahman Z, et al. Efficacy of aripiprazole versus placebo as adjuncts to lithium or valproate in relapse prevention of manic or mixed episodes in bipolar I patients stratified by index manic or mixed episode. J Affect Disord 2013;147:365–72.
    • (2013) J Affect Disord , vol.147 , pp. 365-372
    • Yatham, L.N.1    Fountoulakis, K.N.2    Rahman, Z.3
  • 29
    • 84887436090 scopus 로고    scopus 로고
    • The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders
    • Pacchiarotti I, Bond DJ, Baldessarini RJ, et al. The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders. Am J Psychiatry 2013;170:1249–62.
    • (2013) Am J Psychiatry , vol.170 , pp. 1249-1262
    • Pacchiarotti, I.1    Bond, D.J.2    Baldessarini, R.J.3
  • 30
    • 84857693708 scopus 로고    scopus 로고
    • Risk factors for antidepressant-related switch to mania
    • Valentí M, Pacchiarotti I, Bonnín CM, et al. Risk factors for antidepressant-related switch to mania. J Clin Psychiatry 2012;73:e271–6.
    • (2012) J Clin Psychiatry , vol.73 , pp. e271-e276
    • Valentí, M.1    Pacchiarotti, I.2    Bonnín, C.M.3
  • 31
    • 19244367200 scopus 로고    scopus 로고
    • Lithium for maintenance treatment of mood disorders
    • Burgess S, Geddes J, Hawton K, et al. Lithium for maintenance treatment of mood disorders. Cochrane Database Syst Rev 2001;(3):CD003013.
    • (2001) Cochrane Database , Issue.3
    • Burgess, S.1    Geddes, J.2    Hawton, K.3
  • 32
    • 0030666691 scopus 로고    scopus 로고
    • Comparative prophylactic efficacy of lithium, carbamazepine, and the combination in bipolar disorder
    • Denicoff KD, Smith-Jackson EE, Disney ER, et al. Comparative prophylactic efficacy of lithium, carbamazepine, and the combination in bipolar disorder. J Clin Psychiatry 1997;58:470–8.
    • (1997) Jclinpsychiatry , vol.58 , pp. 470-478
    • Denicoff, K.D.1    Smith-Jackson, E.E.2    Disney, E.R.3
  • 33
    • 0141961508 scopus 로고    scopus 로고
    • Lamotrigine: A review of its use in bipolar disorder
    • Goldsmith DR, Wagstaff AJ, Ibbotson T, et al. Lamotrigine: a review of its use in bipolar disorder. Drugs 2003;63:2029–50.
    • (2003) Drugs , vol.63 , pp. 2029-2050
    • Goldsmith, D.R.1    Wagstaff, A.J.2    Ibbotson, T.3
  • 34
    • 0034013393 scopus 로고    scopus 로고
    • A randomized, placebo-controlled 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder. Divalproex Maintenance Study Group
    • Bowden CL, Calabrese JR, McElroy SL, et al. A randomized, placebo-controlled 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder. Divalproex Maintenance Study Group. Arch Gen Psychiatry 2000;57:481–9.
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 481-489
    • Bowden, C.L.1    Calabrese, J.R.2    McElroy, S.L.3
  • 35
    • 84857078860 scopus 로고    scopus 로고
    • Aripiprazole in the acute and maintenance phase of bipolar I disorder
    • Zupancic M, Gonzalez ML. Aripiprazole in the acute and maintenance phase of bipolar I disorder. Ther Clin Risk Manag 2012;8:1–6.
    • (2012) Ther Clin Risk Manag , vol.8 , pp. 1-6
    • Zupancic, M.1    Gonzalez, M.L.2
  • 36
    • 83055186626 scopus 로고    scopus 로고
    • Efficacy of extended release quetiapine fumarate monotherapy in patients with major depressive disorder: A pooled analysis of two 6-week, double-blind, placebo-controlled studies
    • Weisler RH, Montgomery SA, Earley WR, et al. Efficacy of extended release quetiapine fumarate monotherapy in patients with major depressive disorder: a pooled analysis of two 6-week, double-blind, placebo-controlled studies. Int Clin Psychopharmacol 2012;27:27–39.
    • (2012) Int Clin Psychopharmacol , vol.27 , pp. 27-39
    • Weisler, R.H.1    Montgomery, S.A.2    Earley, W.R.3
  • 37
    • 34249892844 scopus 로고    scopus 로고
    • Quetiapine monotherapy in the treatment of patients with bipolar I or II depression and a rapid-cycling disease course: A randomized, double-blind, placebo-controlled study
    • Vieta E, Calabrese JR, Goikolea JM, et al. Quetiapine monotherapy in the treatment of patients with bipolar I or II depression and a rapid-cycling disease course: a randomized, double-blind, placebo-controlled study. Bipolar Disord 2007;9:413–25.
    • (2007) Bipolar Disord , vol.9 , pp. 413-425
    • Vieta, E.1    Calabrese, J.R.2    Goikolea, J.M.3
  • 38
    • 84856477629 scopus 로고    scopus 로고
    • Quetiapine for bipolar depression: A systematic review and meta-analysis
    • Chiesa A, Chierzi F, De Ronchi D, et al. Quetiapine for bipolar depression: a systematic review and meta-analysis. Int Clin Psychopharmacol 2012;27:76–90.
    • (2012) Int Clin Psychopharmacol , vol.27 , pp. 76-90
    • Chiesa, A.1    Chierzi, F.2    De Ronchi, D.3
  • 39
    • 77953639281 scopus 로고    scopus 로고
    • Risperidone long-acting injectable monotherapy in the maintenance treatment of bipolar I disorder
    • Quiroz JA, Yatham LN, Palumbo JM, et al. Risperidone long-acting injectable monotherapy in the maintenance treatment of bipolar I disorder. Biol Psychiatry 2010;68:156–62.
    • (2010) Biol Psychiatry , vol.68 , pp. 156-162
    • Quiroz, J.A.1    Yatham, L.N.2    Palumbo, J.M.3
  • 40
    • 71049161777 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of maintenance treatment with adjunctive risperidone long-acting therapy in patients with bipolar I disorder who relapse frequently
    • Macfadden W, Alphs L, Haskins JT, et al. A randomized, double-blind, placebo-controlled study of maintenance treatment with adjunctive risperidone long-acting therapy in patients with bipolar I disorder who relapse frequently. Bipolar Disord 2009;11:827–39.
    • (2009) Bipolar Disord , vol.11 , pp. 827-839
    • Macfadden, W.1    Alphs, L.2    Haskins, J.T.3
  • 41
    • 77649083125 scopus 로고    scopus 로고
    • Ziprasidone plus a mood stabilizer in subjects with bipolar I disorder: A 6-month, randomized, placebo-controlled, double-blind trial
    • Bowden CL, Vieta E, Ice KS, et al. Ziprasidone plus a mood stabilizer in subjects with bipolar I disorder: a 6-month, randomized, placebo-controlled, double-blind trial. J Clin Psychiatry 2010;71:130–7.
    • (2010) J Clin Psychiatry , vol.71 , pp. 130-137
    • Bowden, C.L.1    Vieta, E.2    Ice, K.S.3
  • 42
    • 66649085756 scopus 로고    scopus 로고
    • Medicating mood with maintenance in mind: Bipolar depression pharmacotherapy
    • Malhi GS, Adams D, Berk M. Medicating mood with maintenance in mind: bipolar depression pharmacotherapy. Bipolar Disord 2009;11(Suppl 2):55–76.
    • (2009) Bipolar Disord , vol.11 , pp. 55-76
    • Malhi, G.S.1    Adams, D.2    Berk, M.3
  • 43
    • 59649129159 scopus 로고    scopus 로고
    • The functional impact of subsyndromal depressive symptoms in bipolar disorder: Data from STEP-BD
    • Marangell LB, Dennehy EB, Miyahara S, et al. The functional impact of subsyndromal depressive symptoms in bipolar disorder: data from STEP-BD. J Affect Disord 2009;114:58–67.
    • (2009) J Affect Disord , vol.114 , pp. 58-67
    • Marangell, L.B.1    Dennehy, E.B.2    Miyahara, S.3
  • 44
    • 33846267290 scopus 로고    scopus 로고
    • A meta-analysis of relapse rates with adjunctive psychological therapies compared to usual psychiatric treatment for bipolar disorders
    • Scott J, Colom F, Vieta E. A meta-analysis of relapse rates with adjunctive psychological therapies compared to usual psychiatric treatment for bipolar disorders. Int J Neuropsychopharmacol 2007;10:123–9.
    • (2007) Int J Neuropsychopharmacol , vol.10 , pp. 123-129
    • Scott, J.1    Colom, F.2    Vieta, E.3
  • 45
    • 84877709911 scopus 로고    scopus 로고
    • Treatment of bipolar disorder
    • Geddes JR, Miklowitz DJ. Treatment of bipolar disorder. Lancet 2013;381:1672–82.
    • (2013) Lancet , vol.381 , pp. 1672-1682
    • Geddes, J.R.1    Miklowitz, D.J.2
  • 46
    • 84859880563 scopus 로고    scopus 로고
    • The clinical management of bipolar disorder complexity using a stratified model
    • Malhi GS, Bargh DM, Cashman E, et al. The clinical management of bipolar disorder complexity using a stratified model. Bipolar Disord 2012;14(Suppl 2):66–89.
    • (2012) Bipolar Disord , vol.14 , pp. 66-89
    • Malhi, G.S.1    Bargh, D.M.2    Cashman, E.3
  • 47
    • 49749109893 scopus 로고    scopus 로고
    • N-acetyl cysteine for depressive symptoms in bipolar disorder—a double-blind randomized placebo-controlled trial
    • Berk M, Copolov DL, Dean O, et al. N-acetyl cysteine for depressive symptoms in bipolar disorder—a double-blind randomized placebo-controlled trial. Biol Psychiatry 2008;64:468–75.
    • (2008) Biol Psychiatry , vol.64 , pp. 468-475
    • Berk, M.1    Copolov, D.L.2    Dean, O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.