Daily chlorhexidine bathing for critically ill patients: A note of caution

JAMA - Journal of the American Medical Association

Volumn 313, Issue 4, 2015, Pages 365-366

  Pittet, Didier ^a   Angus, Derek C ^b  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORHEXIDINE; PSEUDOMONIC ACID; DISINFECTANT AGENT;

ANTIBIOTIC RESISTANCE; BLOOD CULTURE; CHLORHEXIDINE BATHING; CRITICALLY ILL PATIENT; DISINFECTION; EDITORIAL; HAND WASHING; HEALTH CARE; HEALTHCARE ASSOCIATED INFECTION; HUMAN; INFECTION CONTROL; INFECTION RATE; INTENSIVE CARE UNIT; LOW DRUG DOSE; MULTIDRUG RESISTANCE; NONHUMAN; RANDOMIZED CONTROLLED TRIAL (TOPIC); TREATMENT OUTCOME; BATH; CROSS INFECTION; FEMALE; MALE;

BATHS; CHLORHEXIDINE; CROSS INFECTION; DISINFECTANTS; FEMALE; HUMANS; MALE;

EID: 84921726904     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2014.18482     Document Type: Editorial

References (12)

1. NotoMJ, Domenico HJ, Byrne DW, et al. Chlorhexidine bathing and health care-associated infections: a randomized clinical trial. JAMA. doi:10.1001/jama.2014.18400.
2. ClimoMW, Yokoe DS,WarrenDK, et al. Effect of daily chlorhexidine bathing on hospital-acquired infection. N Engl J Med. 2013;368(6):533-542.
3. Huang SS, Septimus E, Kleinman K, et al; CDC Prevention Epicenters Program; AHRQ DECIDE Network and Healthcare-Associated Infections Program. Targeted versus universal decolonization to prevent ICU infection. N Engl J Med. 2013;368 (24):2255-2265.
4. Harbarth S, Tuan Soh S, Horner C, Wilcox MH. Is reduced susceptibility to disinfectants and antiseptics a risk in healthcare settings? a point/counterpoint review. J Hosp Infect. 2014;87 (4):194-202.
5. Edmond MB,Wenzel RP. Screening inpatients for MRSA-case closed. N Engl J Med. 2013;368(24): 2314-2315.
6. Patel JB, Gorwitz RJ, Jernigan JA. Mupirocin resistance. Clin Infect Dis. 2009;49(6):935-941.
7. Mayer S, Boos M, Beyer A, Fluit AC, Schmitz FJ. Distribution of the antiseptic resistance genes qacA, qacB and qacC in 497 methicillin-resistant and-susceptible European isolates of Staphylococcus aureus. J Antimicrob Chemother. 2001;47(6):896-897.
8. Lee AS, Macedo-Vinas M, François P, et al. Impact of combined low-level mupirocin and genotypic chlorhexidine resistance on persistent methicillin-resistant Staphylococcus aureus carriage after decolonization therapy: a case-control study. Clin Infect Dis. 2011;52(12):1422-1430.
9. Allegranzi B, Pittet D. Role of hand hygiene in healthcare-associated infection prevention. J Hosp Infect. 2009;73(4):305-315.
10. Derde LP, Cooper BS, Goossens H, et al; MOSAR WP3 Study Team. Interventions to reduce colonisation and transmission of antimicrobial-resistant bacteria in intensive care units: an interrupted time series study and cluster randomised trial. Lancet Infect Dis. 2014;14(1):31-39.
11. Calfee DP, Salgado CD,Milstone AM, et al. Strategies to prevent methicillin-resistant Staphylococcus aureus transmission and infection in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol. 2014;35(7):772-796.
12. Price R, MacLennan G, Glen J; SuDDICU Collaboration. Selective digestive or oropharyngeal decontamination and topical oropharyngeal chlorhexidine for prevention of death in general intensive care: systematic review and network meta-analysis. BMJ. 2014;348:g2197.