Combined determination of circulating miR-196a and miR-196b levels produces high sensitivity and specificity for early detection of oral cancer

Clinical Biochemistry

Volumn 48, Issue 3, 2015, Pages 115-121

  Lu, Ya Ching ^a   Chang, Joseph Tung Chieh ^a   Huang, Yu Chen ^b   Huang, Chi Che ^b   Chen, Wen Ho ^b   Lee, Li Yu ^a   Huang, Bing Shen ^a   Chen, Yin Ju ^a   Li, Hsiao Fang ^a   Cheng, Ann Joy ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Circulating miRNA; Early detection; MiR 196a; MiR 196b; Oral cancer

Indexed keywords

MICRORNA; MICRORNA 196A; MICRORNA 196B; UNCLASSIFIED DRUG; MIRN196 MICRORNA, HUMAN; TUMOR MARKER;

ADULT; ARTICLE; BLOOD SAMPLING; CANCER DIAGNOSIS; CANCER PATIENT; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MOUTH CANCER; PRECANCER; PRIORITY JOURNAL; RNA STABILITY; SENSITIVITY AND SPECIFICITY; AGED; BLOOD; COLD; EARLY DIAGNOSIS; GENE EXPRESSION REGULATION; GENETICS; MOUTH TUMOR; PATHOLOGY; PRESERVATION; RECEIVER OPERATING CHARACTERISTIC; STATISTICAL MODEL; YOUNG ADULT;

ADULT; AGED; COLD TEMPERATURE; EARLY DETECTION OF CANCER; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LOGISTIC MODELS; MALE; MICRORNAS; MIDDLE AGED; MOUTH NEOPLASMS; PRECANCEROUS CONDITIONS; PRESERVATION, BIOLOGICAL; RNA STABILITY; ROC CURVE; SENSITIVITY AND SPECIFICITY; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84921715825     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2014.11.020     Document Type: Article

References (33)

1. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 2009, 45:309-316.
2. Saman D.M. A review of the epidemiology of oral and pharyngeal carcinoma: Update. Head Neck Oncol 2012, 4:1.
3. Chen Y.J., Chang J.T., Liao C.T., Wang H.M., Yen T.C., Chiu C.C., et al. Head and neck cancer in the betel quid chewing area: Recent advances in molecular carcinogenesis. Cancer Sci 2008, 99:1507-1514.
4. Secretan B., Straif K., Baan R., Grosse Y., El Ghissassi F., Bouvard V., et al. A review of human carcinogens-part e: Tobacco, areca nut, alcohol, coal smoke, and salted fish. Lancet Oncol 2009, 10:1033-1034.
5. Lian Ie B., Tseng Y.T., Su C.C., Tsai K.Y. Progression of precancerous lesions to oral cancer: Results based on the taiwan national health insurance database. Oral Oncol 2013, 49:427-430.
6. Johnson N.W., Warnakulasuriya S., Gupta P.C., Dimba E., Chindia M., Otoh E.C., et al. Global oral health inequalities in incidence and outcomes for oral cancer: Causes and solutions. Adv Dent Res 2011, 23:237-246.
7. Iorio M.V., Croce C.M. Microrna dysregulation in cancer: Diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med 2012, 4:143-159.
8. Jansson M.D., Lund A.H. Microrna and cancer. Mol Oncol 2012, 6:590-610.
9. Li M., Li J., Ding X., He M., Cheng S.Y. Microrna and cancer. AAPS J 2010, 12:309-317.
10. Hui A.B., Lenarduzzi M., Krushel T., Waldron L., Pintilie M., Shi W., et al. Comprehensive microrna profiling for head and neck squamous cell carcinomas. Clin Cancer Res 2010, 16:1129-1139.
11. Ramdas L., Giri U., Ashorn C.L., Coombes K.R., El-Naggar A., Ang K.K., et al. Mirna expression profiles in head and neck squamous cell carcinoma and adjacent normal tissue. Head Neck 2009, 31:642-654.
12. Schwarzenbach H., Nishida N., Calin G.A., Pantel K. Clinical relevance of circulating cell-free micrornas in cancer. Nat Rev Clin Oncol 2014, 11:145-156.
13. Kang K., Peng X., Luo J., Gou D. Identification of circulating mirna biomarkers based on global quantitative real-time pcr profiling. J Anim Sci Biotechnol 2012, 3:4.
14. Wang J., Zhang K.Y., Liu S.M., Sen S. Tumor-associated circulating micrornas as biomarkers of cancer. Molecules 2014, 19:1912-1938.
15. Toiyama Y., Takahashi M., Hur K., Nagasaka T., Tanaka K., Inoue Y., et al. Serum mir-21 as a diagnostic and prognostic biomarker in colorectal cancer. J Natl Cancer Inst 2013, 105:849-859.
16. Lu Y.C., Chen Y.J., Wang H.M., Tsai C.Y., Chen W.H., Huang Y.C., et al. Oncogenic function and early detection potential of mirna-10b in oral cancer as identified by microrna profiling. Cancer Prev Res 2012, 5:665-674.
17. Chen C., Zhang Y., Zhang L., Weakley S.M., Yao Q. Microrna-196: Critical roles and clinical applications in development and cancer. J Cell Mol Med 2011, 15:14-23.
18. Schimanski C.C., Frerichs K., Rahman F., Berger M., Lang H., Galle P.R., et al. High mir-196a levels promote the oncogenic phenotype of colorectal cancer cells. World J Gastroenterol 2009, 15:2089-2096.
19. Ma R., Yan W., Zhang G., Lv H., Liu Z., Fang F., et al. Upregulation of mir-196b confers a poor prognosis in glioblastoma patients via inducing a proliferative phenotype. PLoS One 2012, 7:e38096.
20. Sun M., Liu X.H., Li J.H., Yang J.S., Zhang E.B., Yin D.D., et al. Mir-196a is upregulated in gastric cancer and promotes cell proliferation by downregulating p27(kip1). Mol Cancer Ther 2012, 11:842-852.
21. Li Y., Zhang M., Chen H., Dong Z., Ganapathy V., Thangaraju M., et al. Ratio of mir-196s to hoxc8 messenger rna correlates with breast cancer cell migration and metastasis. Cancer Res 2010, 70:7894-7904.
22. Huang F., Tang J., Zhuang X., Zhuang Y., Cheng W., Chen W., et al. Mir-196a promotes pancreatic cancer progression by targeting nuclear factor kappa-b-inhibitor alpha. PLoS One 2014, 9:e87897.
23. Liu C.J., Tsai M.M., Tu H.F., Lui M.T., Cheng H.W., Lin S.C. Mir-196a overexpression and mir-196a2 gene polymorphism are prognostic predictors of oral carcinomas. Ann Surg Oncol 2013, 20(Suppl. 3):S406-S414.
24. Ruopp M.D., Perkins N.J., Whitcomb B.W., Schisterman E.F. Youden index and optimal cut-point estimated from observations affected by a lower limit of detection. Biom J 2008, 50:419-430.
25. Goebel G., Zitt M., Muller H.M. Circulating nucleic acids in plasma or serum (cnaps) as prognostic and predictive markers in patients with solid neoplasias. Dis Markers 2005, 21:105-120.
26. Mitchell P.S., Parkin R.K., Kroh E.M., Fritz B.R., Wyman S.K., Pogosova-Agadjanyan E.L., et al. Circulating micrornas as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A 2008, 105:10513-10518.
27. Cortez M.A., Bueso-Ramos C., Ferdin J., Lopez-Berestein G., Sood A.K., Calin G.A. Micrornas in body fluids-the mix of hormones and biomarkers. Nat Rev Clin Oncol 2011, 8:467-477.
28. Patnaik S.K., Mallick R., Yendamuri S. Detection of micrornas in dried serum blots. Anal Biochem 2010, 407:147-149.
29. Turchinovich A., Weiz L., Langheinz A., Burwinkel B. Characterization of extracellular circulating microrna. Nucleic Acids Res 2011, 39:7223-7233.
30. Mathivanan S., Ji H., Simpson R.J. Exosomes: Extracellular organelles important in intercellular communication. J Proteomics 2010, 73:1907-1920.
31. Valadi H., Ekstrom K., Bossios A., Sjostrand M., Lee J.J., Lotvall J.O. Exosome-mediated transfer of mrnas and micrornas is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007, 9:654-659.
32. Pegtel D.M., Cosmopoulos K., Thorley-Lawson D.A., van Eijndhoven M.A., Hopmans E.S., Lindenberg J.L., et al. Functional delivery of viral mirnas via exosomes. Proc Natl Acad Sci U S A 2010, 107:6328-6333.
33. Creemers E.E., Tijsen A.J., Pinto Y.M. Circulating micrornas: Novel biomarkers and extracellular communicators in cardiovascular disease?. Circ Res 2012, 110:483-495.