The relationship between catechol-O-methyltransferase gene Val158Met (COMT) polymorphism and premorbid cannabis use in Turkish male patients with schizophrenia

In Vivo

Volumn 29, Issue 1, 2015, Pages 129-132

  Ermis, Aysegul ^a   Erkiran, Murat ^b   Dasdemir, Selcuk ^c   Turkcan, Ayse Solmaz ^b   Ceylan, Mehmet Emin ^d   Bireller, Elif Sinem ^e   Cakmakoglu, Bedia ^c  

^a Esenyurt State Hospital   (Turkey)

^b Research Hospital   (Turkey)

^c ISTANBUL UNIVERSITY   (Turkey)

^d USKUDAR UNIVERSITY   (Turkey)

^e NONE

Author keywords

Cannabis; COMT; Schizophrenia; Val158Met

Indexed keywords

CANNABIS; CATECHOL METHYLTRANSFERASE;

ADULT; ALLELE; ARTICLE; CANNABIS USE; CANNABIS-INDUCED PSYCHOSIS; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA POLYMORPHISM; DRUG EXPOSURE; ENZYME ACTIVITY; GENETIC PREDISPOSITION; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MAJOR CLINICAL STUDY; MALE; POSITIVE AND NEGATIVE SYNDROME SCALE; SCHIZOPHRENIA; TURK (PEOPLE); ADOLESCENT; AGED; CANNABIS ADDICTION; COMPLICATION; DISEASE PREDISPOSITION; GENETIC POLYMORPHISM; GENETICS; MIDDLE AGED; RISK FACTOR; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ALLELES; CATECHOL O-METHYLTRANSFERASE; DISEASE SUSCEPTIBILITY; GENOTYPE; HUMANS; MALE; MARIJUANA ABUSE; MIDDLE AGED; POLYMORPHISM, GENETIC; RISK FACTORS; SCHIZOPHRENIA; YOUNG ADULT;

EID: 84921662036     PISSN: 0258851X     EISSN: 17917549     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. De Sousa KR, Tiwari AK, Giuffra DE, Mackenzie B, Zai CC and Kennedy JL: Age at onset of schizophrenia: cannabis, COMT gene, and their interactions. Schizophr Res 151(1-3): 289-290, 2013.
2. Radhakrishnan R, Wilkinson ST and D'Souza DC: Gone to Pot - A Review of the Association between Cannabis and Psychosis. Front Psychiatry 22(5): 54, 2014.
3. Arseneault L, Cannon M, Witton J and Murray RM: Causal association between cannabis and psychosis examination of the evidence. Br J Psychiatry 184: 110-117, 2004.
4. Caspi A, Moffitt TE, Cannon M, McClay J, Murray R, Harrington H, Taylor A, Arseneault L, Williams B, Braithwaite A, Poulton R and Craig IW: Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction. Biol Psychiatry 57(10): 1117-1127, 2005.
5. Henquet C, Di Forti M, Morrison P, Kuepper R and Murray RM: Gene-environment interplay between cannabis and psychosis. Schizophr Bull 34(6): 1111-1121, 2008.
6. Chen J, Lipska BK, Halim N, Ma QD, Matsumoto M, Melhem S, Kolachana BS, Hyde TM, Herman MM, Apud J, Egan MF, Kleinman JE and Weinberger DR: Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet 75(5): 807-821, 2004.
7. Meyer-Lindenberg A, Kohn PD, Kolachana B, Kippenhan S, McInerney-Leo A, Nussbaum R, Weinberger DR and Berman KF: Midbrain dopamine and prefrontal function in humans: interaction and modulation by COMT genotype. Nat Neurosci 8(5): 594-596, 2005.
8. Henquet C, Rosa A, Krabbendam L, Papiol S, Fananás L, Drukker M, Ramaekers JG and van Os J: An experimental study of catechol-o-methyltransferase Val158Met moderation of delta-9-tetrahydrocannabinol-induced effects on psychosis and cognition. Neuropsychopharmacology 31(12): 2748-2757, 2006.
9. Henquet C, Rosa A, Delespaul P, Papiol S, Fananás L, van Os J and Myin-Germeys I: COMT ValMet moderation of cannabis-induced psychosis: a momentary assessment study of 'switching on' hallucinations in the flow of daily life. Acta Psychiatr Scand 119(2): 156-160, 2009.
10. Kantrowitz JT, Nolan KA, Sen S, Simen AA, Lachman HM and Bowers MB Jr.: Adolescent cannabis use, psychosis and catechol-O-methyltransferase genotype in African Americans and Caucasians. Psychiatr Q 80(4): 213-218, 2009.
11. Zammit S, Spurlock G, Williams H, Norton N, Williams N, O'Donovan MC and Owen MJ: Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use. Br J Psychiatry 191: 402-407, 2007.
12. Pelayo-Terán JM, Pérez-Iglesias R, Mata I, Carrasco-Marín E, Vázquez-Barquero JL and Crespo-Facorro B: Catechol-OMethyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affective psychosis: clinical-onset implications. Psychiatry Res 179(3): 291-296, 2010.
13. Veling W, Mackenbach JP, van Os J and Hoek HW: Cannabis use and genetic predisposition for schizophrenia: a case-control study. Psychol Med 38(9): 1251-1256, 2008.
14. Kay SR, Fiszbein A and Opler LA: The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13(2): 261-276, 1987.
15. Lajin B, Alachkar A, Hamzeh AR, Michati R and Alhaj H: No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population. N Am J Med Sci 3(4): 176-178, 2011.
16. Bertolino A, Caforio G, Blasi G, De Candia M, Latorre V, Petruzzella V, Altamura M, Nappi G, Papa S, Callicott JH, Mattay VS, Bellomo A, Scarabino T, Weinberger DR and Nardini M: Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia. Am J Psychiatry 161(10): 1798-1805, 2004.
17. Costas J, Sanjuán J, Ramos-Ríos R, Paz E, Agra S, Tolosa A, Páramo M, Brenlla J and Arrojo M: Interaction between COMT haplotypes and cannabis in schizophrenia: a case-only study in two samples from Spain. Schizophr Res 127(1-3): 22-27, 2011.
18. Van der Knaap LJ, Schaefer JM, Franken IH, Verhulst FC, van Oort FV and Riese H: Catechol-O-methyltransferase gene methylation and substance use in adolescents: the TRAILS study. Genes Brain Behav 13(7): 618-25, 2014.
19. Zammit S, Owen MJ, Evans J, Heron J and Lewis G: Cannabis, COMT and psychotic experiences. Br J Psychiatry 199(5): 380-385, 2011.
20. Estrada G, Fatjó-Vilas M, Muñoz MJ, Pulido G, Miñano MJ, Toledo E, Illa JM, Martín M, Miralles ML, Miret S, Campanera S, Bernabeu C, Navarro ME and Fañanás L: Cannabis use and age at onset of psychosis: further evidence of interaction with COMT Val158Met polymorphism. Acta Psychiatr Scand 123(6): 485-492, 2011.