Silencing of the ABCC4 gene by RNA interference reverses multidrug resistance in human gastric cancer

Oncology Reports

Volumn 33, Issue 3, 2015, Pages 1147-1154

  Zhang, Guangyu ^a   Wang, Zhenran ^a   Qian, Feng ^b   Zhao, Chen ^a   Sun, Chaowen ^a  

^a GUILIN MEDICAL UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

ABCC4 gene; Gastric cancer; Multidrug resistance; RNA interference

Indexed keywords

ADENOSINE TRIPHOSPHATE; FLUOROURACIL; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; RNA; ABCC4 PROTEIN, HUMAN; MULTIDRUG RESISTANCE PROTEIN;

ABCC4 GENE; APOPTOSIS; ARTICLE; CANCER CELL; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER SUSCEPTIBILITY; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG SENSITIVITY; GENE; GENE CASSETTE; GENE EXPRESSION; GENE SILENCING; GENETIC IDENTIFICATION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; MOUSE; MUCOSA CELL; MULTIDRUG RESISTANCE; NONHUMAN; PROTEIN EXPRESSION; RNA INTERFERENCE; STOMACH CANCER; TUMOR GROWTH; ANIMAL; DRUG RESISTANCE; GENETIC TRANSFECTION; GENETICS; NUDE MOUSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH TUMOR; TUMOR CELL LINE; WESTERN BLOTTING; XENOGRAFT;

ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HETEROGRAFTS; HUMANS; MICE; MICE, NUDE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; STOMACH NEOPLASMS; TRANSFECTION;

EID: 84921647982     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3702     Document Type: Article

References (30)

1. Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 55:74-108, 2005.
2. Sun J, Song Y, Wang Z, Chen X, Gao P, Xu Y, Zhou B and Xu H: Clinical significance of palliative gastrectomy on the survival of patients with incurable advanced gastric cancer: a systematic review and meta-analysis. BMC Cancer 13:577, 2013.
3. van de Ven R, de Groot J, Reurs AW, Wijnands PG, van de Wetering K, Schuetz JD, de Gruijl TD, Scheper RJ and Scheffer GL: Unimpaired immune functions in the absence of Mrp4 (Abcc4). Immunol Lett 124:81-87, 2009.
4. Russel FG, Koenderink JB and Masereeuw R: Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules. Trends Pharmacol Sci 29:200-207, 2008.
5. Keppler D: Multidrug resistance proteins (MRPs, ABCCs): importance for pathophysiology and drug therapy. Handb Exp Pharmacol 201:299-323, 2011.
6. Norris MD, Smith J, Tanabe K, Tobin P, Flemming C, Scheffer GL, Wielinga P, Cohn SL, London WB, Marshall GM, Allen JD and Haber M: Expression of multidrug transporter MRP4/ABCC4 is a marker of poor prognosis in neuroblastoma and confers resistance to irinotecan in vitro. Mol Cancer Ther 4:547-553, 2005.
7. Hendig D, Langmann T, Zarbock R, Schmitz G, Kleesiek K and Gotting C: Characterization of the ATP-binding cassette transporter gene expression profile in Y79: a retinoblastoma cell line. Mol Cell Biochem 328:85-92, 2009.
8. Heimerl S, Bosserhoff AK, Langmann T, Ecker J and Schmitz G: Mapping ATP-binding cassette transporter gene expression profiles in melanocytes and melanoma cells. Melanoma Res 17:265-273, 2007.
9. Holla VR, Backlund MG, Yang P, Newman RA and DuBois RN: Regulation of prostaglandin transporters in colorectal neoplasia. Cancer Prev Res 1:93-99, 2008.
10. Gillet JP, Efferth T, Steinbach D, Hamels J, de Longueville F, Bertholet V and Remacle J: Microarray-based detection of multidrug resistance in human tumor cells by expression profiling of ATP-binding cassette transporter genes. Cancer Res 64:8987-8993, 2004.
11. Beretta GL, Benedetti V, Cossa G, Assaraf YG, Bram E, Gatti L, Corna E, Carenini N, Colangelo D, Howell SB, Zunino F and Perego P: Increased levels and defective glycosylation of MRPs in ovarian carcinoma cells resistant to oxaliplatin. Biochem Pharmacol 79:1108-1117, 2010.
12. Gradilone A, Pulcinelli FM, Lotti LV, Trifiro E, Martino S, Gandini O, Gianni W, Frati L, Agliano AM and Gazzaniga P: Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy. Curr Cancer Drug Targets 8:414-420, 2008.
13. Lamba JK, Adachi M, Sun D, Tammur J, Schuetz EG, Allikmets R and Schuetz JD: Nonsense mediated decay downregulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons. Hum Mol Genet 12:99-109, 2003.
14. Ravna AW, Sylte I and Sager G: Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure. Theor Biol Med Model 6:20, 2009.
15. Adachi M, Sampath J, Lan LB, Sun D, Hargrove P, Flatley R, Tatum A, Edwards MZ, Wezeman M, Matherly L, Drake R and Schuetz J: Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing. J Biol Chem 277:38998-39004, 2002.
16. Dong Y, Zhang H, Gao AC, Marshall JR and Ip C: Androgen receptor signaling intensity is a key factor in determining the sensitivity of prostate cancer cells to selenium inhibition of growth and cancer-specific biomarkers. Mol Cancer Ther 4:1047-1055, 2005.
17. Cai C, Omwancha J, Hsieh CL and Shemshedini L: Androgen induces expression of the multidrug resistance protein gene MRP4 in prostate cancer cells. Prostate Cancer Prostatic Dis 10:39-45, 2007.
18. Ho LL, Kench JG, Handelsman DJ, Scheffer GL, Stricker PD, Grygiel JG, Sutherland RL, Henshall SM, Allen JD and Horvath LG: Androgen regulation of multidrug resistanceassociated protein 4 (MRP4/ABCC4) in prostate cancer. Prostate 68:1421-1429, 2008.
19. Hagmann W, Jesnowski R, Faissner R, Guo C and Lohr JM: ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology 9:136-144, 2009.
20. Bagnoli M, Beretta GL, Gatti L, Pilotti S, Alberti P, Tarantino E, Barbareschi M, Canevari S, Mezzanzanica D and Perego P: Clinicopathological impact of ABCC1/MRP1 and ABCC4/MRP4 in epithelial ovarian carcinoma. Biomed Res Int 2013:143202, 2013.
21. Dai ZJ, Gao J, Kang HF, Ma YG, Ma XB, Lu WF, Lin S, Ma HB, Wang XJ and Wu WY: Targeted inhibition of mammalian target of rapamycin (mTOR) enhances radiosensitivity in pancreatic carcinoma cells. Drug Des Devel Ther 7:149-159, 2013.
22. Nieminen AI, Partanen JI and Klefstrom J: c-Myc blazing a trail of death: coupling of the mitochondrial and death receptor apoptosis pathways by c-Myc. Cell Cycle 6:2464-2472, 2007.
23. Renault TT, Teijido O, Antonsson B, Dejean LM and Manon S: Regulation of Bax mitochondrial localization by Bcl-2 and Bcl-x (L): keep your friends close but your enemies closer. Int J Biochem Cell Biol 45:64-67, 2013.
24. Lindsay J, Esposti MD and Gilmore AP: Bcl-2 proteins and mitochondria - specificity in membrane targeting for death. Biochim Biophys Acta 1813:532-539, 2011.
25. Saito M, Korsmeyer SJ and Schlesinger PH: BAX-dependent transport of cytochrome c reconstituted in pure liposomes. Nat Cell Biol 2:553-555, 2000.
26. Yuan S and Akey CW: Apoptosome structure, assembly, and procaspase activation. Structure 21:501-515, 2013.
27. McIlwain DR, Berger T and Mak TW: Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol 5:a008656, 2013.
28. Zhu CY, Lv YP, Yan DF and Gao FL: Knockdown of MDR1 increases the sensitivity to adriamycin in drug resistant gastric cancer cells. Asian Pac J Cancer Prev 14:6757-6760, 2013.
29. Wang Y, Ma G, Wang Q, Wen M, Xu Y, He X, Zhang P, Wang Y, Yang T, Zhan P and Wei G: Involvement of CUL4A in regulation of multidrug resistance to P-gp substrate drugs in breast cancer cells. Molecules 19:159-176, 2013.
30. Tang B, Du J, Wang J, Tan G, Gao Z, Wang Z and Wang L: Alpinetin suppresses proliferation of human hepatoma cells by the activation of MKK7 and elevates sensitization to cis-diammined dichloridoplatium. Oncol Rep 27:1090-1096, 2012.