Differences in the transduction of canonical Wnt signals demarcate effector and memory CD8 T Cells with distinct recall proliferation capacity

Journal of Immunology

Volumn 193, Issue 6, 2014, Pages 2784-2791

  Boudousquié, Caroline ^a   Danilo, Maxime ^a   Pousse, Laurène ^a   Jeevan Raj, Beena ^a   Angelov, Georgi S ^a   Chennupati, Vijaykumar ^b   Zehn, Dietmar ^b   Held, Werner ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR 7; AXIN; AXIN2 PROTEIN, MOUSE; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HNF1A PROTEIN, MOUSE; IMMUNOGLOBULIN RECEPTOR; KLRG1 PROTEIN, MOUSE; WNT PROTEIN;

ANIMAL CELL; ARTICLE; AXIN2 GENE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL EXPANSION; CELL FATE; CELL FUNCTION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; EFFECTOR CELL; FEMALE; GENE; GENE EXPRESSION REGULATION; IMMUNE RESPONSE; LISTERIOSIS; LYMPHOCYTE COUNT; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MALE; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SHORT LIVED EFFECTOR CELL; VIRUS INFECTION; WNT SIGNALING PATHWAY; ADOPTIVE TRANSFER; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTIC CHORIOMENINGITIS; T LYMPHOCYTE SUBPOPULATION; TRANSPLANTATION; VACCINATION; VIROLOGY;

ADOPTIVE TRANSFER; ANIMALS; AXIN PROTEIN; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; DOWN-REGULATION; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; IMMUNOLOGIC MEMORY; LYMPHOCYTIC CHORIOMENINGITIS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, IMMUNOLOGIC; T-LYMPHOCYTE SUBSETS; VACCINATION; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84921633840     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1400465     Document Type: Article

References (21)

1. Kaech, S. M., and W. Cui. 2012. Transcriptional control of effector and memory CD8+ T cell differentiation. Nat. Rev. Immunol. 12: 749-761.
2. Jeannet, G., C. Boudousquié, N. Gardiol, J. Kang, J. Huelsken, and W. Held. 2010. Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory. Proc. Natl. Acad. Sci. USA 107: 9777-9782.
3. Zhou, X., S. Yu, D. M. Zhao, J. T. Harty, V. P. Badovinac, and H. H. Xue. 2010. Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1. Immunity 33: 229-240.
4. Zhou, X., and H. H. Xue. 2012. Cutting edge: generation of memory precursors and functional memory CD8+ T cells depends on T cell factor-1 and lymphoid enhancer-binding factor-1. J. Immunol. 189: 2722-2726.
5. Clevers, H., and R. Nusse. 2012. Wnt/b-catenin signaling and disease. Cell 149: 1192-1205.
6. Prlic, M., and M. J. Bevan. 2011. Cutting edge: b-catenin is dispensable for T cell effector differentiation, memory formation, and recall responses. J. Immunol. 187: 1542-1546.
7. Driessens, G., Y. Zheng, and T. F. Gajewski. 2010. Beta-catenin does not regulate memory T cell phenotype. Nat. Med. 16: 513-514, author reply 514-515.
8. Gattinoni, L., X. S. Zhong, D. C. Palmer, Y. Ji, C. S. Hinrichs, Z. Yu, C. Wrzesinski, A. Boni, L. Cassard, L. M. Garvin, et al. 2009. Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells. Nat. Med. 15: 808-813.
9. Verbeek, S., D. Izon, F. Hofhuis, E. Robanus-Maandag, H. te Riele, M. van de Wetering, M. Oosterwegel, A. Wilson, H. R. MacDonald, and H. Clevers. 1995. An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature 374: 70-74.
10. +) thymocyte survival. Nat. Immunol. 2: 691-697.
11. Pircher, H., K. Bürki, R. Lang, H. Hengartner, and R. M. Zinkernagel. 1989. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342: 559-561.
12. Hogquist, K. A., S. C. Jameson, W. R. Heath, J. L. Howard, M. J. Bevan, and F. R. Carbone. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76: 17-27.
13. Lustig, B., B. Jerchow, M. Sachs, S. Weiler, T. Pietsch, U. Karsten, M. van de Wetering, H. Clevers, P. M. Schlag, W. Birchmeier, and J. Behrens. 2002. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol. Cell. Biol. 22: 1184-1193.
14. Battegay, M., S. Cooper, A. Althage, J. Bänziger, H. Hengartner, and R. M. Zinkernagel. 1991. Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates. J. Virol. Methods 33: 191-198.
15. Subramanian, A., P. Tamayo, V. K. Mootha, S. Mukherjee, B. L. Ebert, M. A. Gillette, A. Paulovich, S. L. Pomeroy, T. R. Golub, E. S. Lander, and J. P. Mesirov. 2005. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 102: 15545-15550.
16. Jeannet, G., M. Scheller, L. Scarpellino, S. Duboux, N. Gardiol, J. Back, F. Kuttler, I. Malanchi, W. Birchmeier, A. Leutz, et al. 2008. Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin. Blood 111: 142-149.
17. Jung, Y. W., R. L. Rutishauser, N. S. Joshi, A. M. Haberman, and S. M. Kaech. 2010. Differential localization of effector and memory CD8 T cell subsets in lymphoid organs during acute viral infection. J. Immunol. 185: 5315-5325.
18. Joshi, N. S., W. Cui, A. Chandele, H. K. Lee, D. R. Urso, J. Hagman, L. Gapin, and S. M. Kaech. 2007. Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity 27: 281-295.
19. Sarkar, S., V. Kalia, W. N. Haining, B. T. Konieczny, S. Subramaniam, and R. Ahmed. 2008. Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates. J. Exp. Med. 205: 625-640.
20. Kaech, S. M., S. Hemby, E. Kersh, and R. Ahmed. 2002. Molecular and functional profiling of memory CD8 T cell differentiation. Cell 111: 837-851.
21. Latner, D. R., S. M. Kaech, and R. Ahmed. 2004. Enhanced expression of cell cycle regulatory genes in virus-specific memory CD8+ T cells. J. Virol. 78: 10953-10959.