Acute and chronic toxicity of six anticancer drugs on rotifers and crustaceans

Chemosphere

Volumn 115, Issue 1, 2014, Pages 59-66

  Parrella, Alfredo ^a   Lavorgna, Margherita ^a   Criscuolo, Emma ^a   Russo, Chiara ^a   Fiumano, Vittorio ^a   Isidori, Marina ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

Acute toxicity; Anticancer drugs; Chronic toxicity; Crustacea; Cytostatics; Rotifers

Indexed keywords

AQUATIC ORGANISMS; CELL PROLIFERATION; TOXICITY;

ACUTE TOXICITY; ANTICANCER DRUG; CHRONIC TOXICITY; CRUSTACEA; CYTOSTATICS; ROTIFERS;

ENVIRONMENTAL IMPACT;

ANTINEOPLASTIC AGENT; CAPECITABINE; CISPLATIN; CYTOSTATIC AGENT; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; IMATINIB; WATER POLLUTANT;

ANATOMY; AQUATIC ORGANISM; CONCENTRATION (COMPOSITION); CRUSTACEAN; DRUG; ENVIRONMENTAL IMPACT; INHIBITION; ORGANIC COMPOUND; POLLUTION EFFECT; REPRODUCTION; TOXICITY;

ACUTE TOXICITY; ANIMAL EXPERIMENT; AQUATIC SPECIES; ARTICLE; BRACHIONUS CALYCIFLORUS; CERIODAPHNIA DUBIA; CHRONIC TOXICITY; CONTROLLED STUDY; CRUSTACEA; DAPHNIA MAGNA; ECOTOXICOLOGY; EFFLUENT; ENVIRONMENTAL IMPACT; LONG TERM EXPOSURE; NONHUMAN; REPRODUCTION; RISK ASSESSMENT; ROTIFERA; THAMNOCEPHALUS PLATYURUS; TOXICITY TESTING; WASTE WATER; WATER POLLUTANT; ANIMAL; DRUG EFFECTS; PHYSIOLOGY; TOXICITY;

BRACHIONUS CALYCIFLORUS; CERIODAPHNIA DUBIA; CRUSTACEA; DAPHNIA MAGNA; ROTIFERA; THAMNOCEPHALUS PLATYURUS;

ANIMALS; ANTINEOPLASTIC AGENTS; CRUSTACEA; ROTIFERA; TOXICITY TESTS, ACUTE; WATER POLLUTANTS, CHEMICAL;

EID: 84921627666     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2014.01.013     Document Type: Article

References (46)

1. ASTM E 1440-91, 2004. Standard guide for acute toxicity with the rotifer Brachionus. American Society for Testing and Materials. Philadelphia PA, USA, reapproved.
2. Baek I.H., Chae J.W., Chae H.J., Kwon K.I. Development and Validation of a Robust LC-MS/MS Method for the Simultaneous Quantification of Doxifluridine and its Two Metabolites in Beagle Dog Plasma. Bull. Korean Chem. Soc. 2010, 31(8):2235-2241.
3. Besse J.P., Latour J.F., Garric J. Anticancer drugs in surface waters: what can we say about the occurrence and environmental significance of cytotoxic, cytostatic and endocrine therapy drugs?. Environ. Int. 2012, 39:73-86.
4. Brausch J.M., Connors K.A., Brooks B.W., Rand G.M. Human pharmaceuticals in the aquatic environment: a review of recent toxicological studies and considerations for toxicity testing. Rev. Environ. Contam. Toxicol. 2012, 218:1-99.
5. Blume-Jensen P., Hunter T. Oncogenic kinase signaling. Nature 2001, 411:355-365.
6. Catastini C., Mullot J.-U., Boukari S., Mazellier P., Levi Y., Cervantes P., Ormsby J.-N. Assessment of antineoplastic drugs in effluents of two hospitals | [Identification de molecules anticancéreuses dans les effluents hospitaliers]. J. Eur. Hydrol. 2008, 39(2):171-180.
7. Constantine L.A., Huggett D.B. A comparison of the chronic effects of human pharmaceuticals on two cladocerans, Daphnia magna and Ceriodaphnia dubia. Chemosphere 2010, 80:1069-1074.
8. Crane M., Watts C., Boucard T. Chronic aquatic environmental risks from exposure to human pharmaceuticals. Sci. Total. Environ. 2006, 367:23-41.
9. Fox D.R. NECs, NOECs and the ECx, Australas. J. Ecotoxicol. 2008, 14:7-9.
10. Hartmann A., Alder A.C., Koller T., Widmer R.M. Identification of fluoroquinolone antibiotics as the main source of umuC genotoxicity in native hospital wastewater. Environ. Toxicol. Chem. 1998, 17:377-382.
11. International Agency on the Research on Cancer. Agents classified by the IARC monographs. (accessed 10.04.13). http://monographs.iarc.fr/ENG/Classification/.
12. ISO 6341, 1996. Water quality-determination of the inhibition of the mobility of Daphnia magna Straus (Cladocera, Crustacea)-Acute toxicity test. International Organization for Standardization, Geneva, Switzerland.
13. ISO 10706, 2000. Water quality-determination of long term toxicity of substances to Daphnia magna Straus (Cladocera, Crustacea). International Organization for Standardization, Geneva, Switzerland.
14. ISO 14380, 2011. Water quality-Determination of the acute toxicity to Thamnocephalus platyurus (Crustacea, Anostraca). International Organization for Standardization, Geneva, Switzerland.
15. ISO 20665, 2008. Water quality-determination of chronic toxicity to Ceriodaphnia dubia in 7 days-population growth inhibition test. International Organization for Standardization, Geneva, Switzerland.
16. ISO 20666, 2008. Water quality-determination of chronic toxicity to Brachionus calyciflorus in 48h-population growth inhibition test.: International Organization for Standardization, Geneva, Switzerland.
17. Johnson A.C., Jürgens M.D., Williams R.J., Kümmerer K., Kortenkamp A., Sumpter J.P. Do cytotoxic chemotheraphy drugs discharged into rivers pose a risk to the environment and human health? An overview and UK case study. J. Hydrol. 2008, 348:167-175.
18. Kartalou M., Essigmann J.M. Recognition of cisplatin adducts by cellular proteins. Mutat. Res. 2001, 478:1-21.
19. Kosjek T., Heath E. Occurrence, fate and determination of cytostatic pharmaceuticals in the environment. Trends Anal. Chem. 2011, 30(7):1065-1087.
20. Kosjek T., Perko S., Žigon D., Heath E. Fluorouracil in the environment: analysis, occurrence, degradation and transformation. J. Chromatogr. A. 2013, 1290:62-72.
21. Kovalova L., McArdell C.S., Hollender J. Challenge of high polarity and low concentrations in analysis of cytostatics and metabolites in wastewater by hydrophilic interaction chromatography/tandem mass spectrometry. J. Chromatogr. A 2009, 1216:1100-1108.
22. Lenz K., Mahnik S.N., Weissenbacher N., Mader R.M., Krenn P., Hann S., Koellensperger G., Uhl M., Knasmueller S., Ferk F., Bursh W., Fuerhacker M. Monitoring, removal and risk assessment of cytostatic drugs in hospital wastewater. Water Sci. Technol. 2007, 56(12):141-149.
23. Mahnik S.N., Lenz K., Weissenbacher N., Mader R.M., Fuerhacker M. Fate of 5-fluorouracil, doxorubicin, epirubicin, and daunorubicin in hospital wastewater and their elimination by activated sludge and treatment in a membrane-bio-reactor system. Chemosphere 2007, 65(1):30-37.
24. Mahnik S.N., Rizovski B., Fürhacker M., Mader R.M. Determination of 5-fluorouracil in hospital effluents. Anal. Bioanal. Chem. 2004, 380:31-35.
25. Mahnik S.N., Rizovski B., Fuerhacker M., Mader R.M. Development of an analytical method for the determination of anthracyclines in hospital effluents. Chemosphere 2006, 65(8):1419-1425.
26. Martin J., Camacho-Munoz D., Santos J.L., Aparicio I., Alonso E. Simultaneous determination of a selected group of cytostatic drugs in water using high-performance liquid chromatography-triple-quadrupole mass spectrometry. J. Sep. Sci. 2011, 34:3166-3177.
27. Miller S.E., House D.A. The hydrolysis products of cis-diamminedichloroplatinum(II).I. The kinetics of formation and anation of the cis-diammine(aqua)chloroplatinum(II) cation in acidic aqueous solution. Inorganica Chim Acta. 1989, 161:131-137.
28. Miller S.E., House D.A. The hydrolysis products of cis-dichlodiammineplatinum(II).2. The kinetics of formation and anation of the cis-diammine(aqua)chloroplatinum(II) cation. Inorganica Chim Acta. 1989, 166:189-197.
29. Miller S.E., House D.A. The hydrolysis products of cis-dichlorodiammineplatinum(II).3. Hydrolysis kinetics at physiological pH. Inorganica Chim Acta. 1990, 173:53-60.
30. Minotti G., Menna P., Salvatorelli E., Cairo G., Gianni L. Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol. Rev. 2004, 56(2):185-229.
31. Mompelat S., Le Bot B., Thomas O. Occurrence and fate of pharmaceutical products and by-products, from resource to drinking water. Environ. Int. 2009, 35:803-814.
32. Nawara K., Krysinski P., Blanchard G.J. Photoinduced reactivity of doxorubicin: catalysis and degradation. J. Phys. Chem. A. 2012, 116(17):4330-4337.
33. Negreira N., Mastroianni N., López de Alda M., Barceló D. Multianalyte determination of 24 cytostatics and metabolites by liquid chromatography-electrospray-tandem mass spectrometry and study of their stability and optimum storage conditions in aqueous solution. Talanta 2013, 116:290-299.
34. OECD 202, 2004. Daphnia sp., acute immobilization test. Organization for Economic Co-operation and Development, Paris.
35. OECD 211, 2008. Daphnia magna reproduction test. Organization for Economic Co-operation and Development, Paris.
36. Shi S., Yao W., Xu J., Long J., Liu C., Yu X. Combinational therapy: new hope for pancreatic cancer?. Cancer Lett. 2012, 317(2):127-135.
37. Straub J.O. Combined environmental risk assessment for 5-fluorouracil and capecitabine in Europe. Integr. Environ. Assess. Manage. 2009, 6(1):540-566.
38. Suhail N., Bilal N., Khan H.Y., Hasan S., Sharma S., Khan F., Mansoor T., Banu N. Effect of vitamins C and E on antioxidant status of breast-cancer patients undergoing chemotherapy. J. Clin. Pharm. Ther. 2012, 37:22-26.
39. Tarczynska M., Nalecz-Jawecki G., Romanowska-Duda Z., Sawicki J., Beattie K., Codd G., Zalewski M. Tests for the toxicity assessment of cyanobacterial bloom samples. Environ. Toxicol. 2001, 16:383-390.
40. Tauxe-Wuersch A., De Alencastro L.F., Grandjean D., Tarradellas J. Trace determination of tamoxifen and 5-fluorouracil in hospital and urban wastwaters. Int. J. Environ. Anal. Chem. 2006, 86:473-485.
41. US EPA, 1993. Methods for measuring the acute toxicity of effluents and receiving waters to freshwater and marine organisms, fourth ed. EPA-600-4-90. Washington DC: US Environmental Protection Agency.
42. Xie, H., 2012. Occurrence, ecotoxicology, and treatment of anticancer agents as water contaminants. J. Environ. Anal. Toxicol., S:2.
43. Yin J., Shao B., Zhang J., Li K. A preliminary study on the occurrence of cytostatic drugs in hospital effluents in Beijing. China. Bull. Environ. Contam. Toxicol. 2010, 84(1):39-45.
44. Zaltauskaite J., Brazaityte V. Assessment of the effect of sulfonylureas herbicide amidosulforum application on target and non-target organisms. Fresenius Environ. Bull. 2013, 22(7a):1977-1982.
45. Zounkova R., Kovalova L., Blaha L., Dott W. Ecotoxicity and genotoxicity assessment of cytotoxic antineoplastic drugs and their metabolites. Chemosphere 2010, 81:253-260.
46. Zounkova R., Odráška P., Doležalová L., Hilscherová K., Maršálek B., Bláha L. Ecotoxicity and genotoxicity assessment of cytostatic pharmaceuticals. Environ. Toxicol. Chem. 2007, 26(10):2208-2214.