Co-culture of bone marrow-derived mesenchymal stem cells overexpressing lipocalin 2 with HK-2 and HEK293 cells protects the kidney cells against cisplatin-induced injury

Cell Biology International

Volumn 39, Issue 2, 2015, Pages 152-163

  Halabian, Raheleh ^a   Roudkenar, Mehryar Habibi ^b   Jahanian Najafabadi, Ali ^c   Hosseini, Kamran Mousavi ^b   Tehrani, Hossein Abdul ^a  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b HIGH INSTITUTE FOR RESEARCH AND EDUCATION IN TRANSFUSION MEDICINE   (Iran)

^c ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Cisplatin; HEK293; HK 2; Lcn2; Mesenchymal stem cells

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; GROWTH FACTOR; HEME OXYGENASE 1; METALLOTHIONEIN I; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; ACUTE PHASE PROTEIN; ANTIOXIDANT; CISPLATIN; CYTOKINE; LCN2 PROTEIN, HUMAN; LIPOCALIN; ONCOPROTEIN; SIGNAL PEPTIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CELL DAMAGE; CELL PROLIFERATION; CELL PROTECTION; COCULTURE; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; HEK293 CELL LINE; HUMAN; HUMAN CELL; KIDNEY CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; BONE MARROW CELL; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM;

ACUTE-PHASE PROTEINS; ANTIOXIDANTS; APOPTOSIS; BONE MARROW CELLS; CELL PROLIFERATION; CELLS, CULTURED; CISPLATIN; COCULTURE TECHNIQUES; CYTOKINES; HEK293 CELLS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOCALINS; MESENCHYMAL STROMAL CELLS; PROTO-ONCOGENE PROTEINS;

EID: 84921609424     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1002/cbin.10344     Document Type: Article

References (43)

1. Brooke G, Cooka M, Blair C, Han R, Heazlewood C, Jones B, Kambouris M, Kollar K, McTaggart S, Pelekanos R, Rice A, Rossetti T, Atkinson K (2007) Therapeutic applications of mesenchymal stromal cells. Semin Cell Dev Biol 18: 846-58.
2. Bussolati B, Hauser PV, Carvalhosa R, Camussi G (2009) Contribution of stem cells to kidney repair. Curr Stem Cell Res Ther 4: 2-8.
3. Challen GA, Martinez G, Davis MJ, Taylor DF, Crowe M, Teasdale RD, Grimmond SM, Little MH (2004) Identifying the molecular phenotype of renal progenitor cells. J Am Soc Nephrol 15: 2344-57.
4. Cowland JB, Borregaard N (1997) Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinaseassociated lipocalin from humans. Genomics 45: 17-23.
5. Cui LY, Yang S, Zhang J (2011) Protective effects of neutrophil gelatinase-associated lipocalin on hypoxia/reoxygenation injury of HK-2 cells. Transplant Proc 43: 3622-7.
6. Flower DR (2000) Experimentally determined lipocalin structures. Biochim Biophys Acta 1482: 46-5.
7. Friedl A, Stoesz SP, Buckley P, Gould MN (1999) Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression. Histochem J 31: 433-41.
8. Fukasawa H, Furuya R, Yasuda H, Yamamoto T, Hishida A, Kitagawa M (2014) Anti-cancer agent-induced nephrotoxicity. Anticancer Agents Med Chem. DOI: 10.2174/1871520614666140127105809, Jan 26. [Epub ahead of print].
9. Halabian R, Tehrani HA, Jahanian-Najafabadi A, Habibi Roudkenar M (2013) Lipocalin-2-mediated upregulation of various antioxidants and growth factors protects bone marrowderived mesenchymal stem cells against unfavorable microenvironments. Cell Stress Chaperones 18: 785-800.
10. Han X, Chesney RW (2009) Mechanism of TauT in protecting against cisplatin-induced kidney injury (AKI). Adv Exp Med Biol 643: 105-12.
11. Herrera MB, Bussolati B, Bruno S, Fonsato V, Romanazzi GM, Camussi G (2004) Mesenchymal stem cells contribute to the renal repair of acute tubular epithelial injury. Int J Mol Med 14: 1035-41.
12. Hopkins C, Li J, Rae F, Little MH (2009) Stem cell options for kidney disease. J Pathol 217: 265-81.
13. Kale S, Karihaloo A, Clark PR, Kashgarian M, Krause DS, Cantley LG (2003) Bone marrow stem cells contribute to repair of the ischemically injured renal tubule. J Clin Invest 112: 42-9.
14. Kamarainen M, Seppala M, Virtanen I, Andersson LC (1997) Expression of glycodelin in MCF-7 breast cancer cells induces differentiation into organized acinar epithelium. Lab Invest 77: 565-73.
15. Kanki M, Moriguchi A, Sasaki D, Mitori H, Yamada A, Unami A, Miyamae Y (2014) Identification of urinary miRNA biomarkers for detecting cisplatin-induced proximal tubular injury in rats. Toxicology pii: S0300-483X(14)00098-5. doi: 10.1016/j. tox.2014.05.004. [Epub ahead of print].
16. Kehrer JP (2009) Lipocalin-2: pro- or anti-apoptotic? Cell Biol Toxicol 26: 83-9.
17. Kjeldsent L, Johnsen AH, SengelAv H, Borregaard N (1993) Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem 268: 10425.
18. Kolossov E, Bostani T, Roell W, Breitbach M, Pillekamp F, Nygren JM, Sasse P, Rubenchik O, Fries JW, Wenzel D, Geisen C, Xia Y, Lu Z, Duan Y, Kettenhofen R, Jovinge S, Bloch W, Bohlen H, Welz A, Hescheler J, Jacobsen SE, Fleischmann BK (2006) Engraftment of engineered ES cellâ derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium. J Exp Med 203: 2315-27.
19. Kratchmarova I, Kalume DE, Blagoev B, Scherer PE, Podtelejnikov AV, Molina H, Bickel PE, Andersen JS, Fernandez MM, Bunkenborg J, Roepstorff P, Kristiansen K, Lodish HF, Mann M, Pandey A (2002) A proteomic approach for identification of 3T3-L1 preadipocytes to adipocytes. Mol Cell Proteomics 1: 213.
20. Lange C, Togel F, Ittrich H, Clayton F, Nolte-Ernsting C, Zander AR, Westenfelder C (2005) Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion-induced acute renal failure in rats. Kidney Int 68: 1613-7.
21. Liu Q, Nilsen-Hamilton M (1995) Identification of a new acute phase protein. J Biol Chem 270: 22565-70.
22. McGinley L, McMahon J, Strappe P, Barry F, Murphy M, O'Toole D, O'Brien T (2011) Lentiviral vector mediated modification of mesenchymal stem cells&enhanced survival in an in vitro model of ischaemia. Stem Cell Res 2: 12-8.
23. Meheus LA, Fransen LM, Raymackers JG, Meheus LA, Fransen LM, Raymackers JG, Blockx HA, Van Beeumen JJ, Van Bun SM, Van de Voorde A (1993) Identification by microsequencing of lipopolysaccharide-induced proteins secreted by mouse macrophages. J Immunol 151: 1535-42.
24. Miller RP, Tadagavadi RK, Ramesh G, Reeves WB (2010) Mechanisms of cisplatin nephrotoxicity. Toxins (Basel) 2(11): 2490-518.
25. Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, Yang J, Barasch J, Devarajan P (2003) Identification of neutrophil gelatinase associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 14: 2534-43.
26. Mishra J, Mori K, Ma Q, Kelly C, Yang J, Mitsnefes M, Barasch J, Devarajan P (2004) Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol 15(12): 3073-82.
27. Mori K, Lee HT, Rapoport D, Drexler IR, Foster K, Yang J, Schmidt-Ott KM, Chen X, Li JY, Weiss S, Mishra J, Cheema FH, Markowitz G, Suganami T, Sawai K, Mukoyama M, Kunis C, D'Agati V, Devarajan P, Barasch J (2005) Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J Clin Invest 115: 610-21.
28. Morigi M, Imberti B, Zoja C, Corna D, Tomasoni S, Abbate M, Rottoli D, Angioletti S, Benigni A, Perico N, Alison M, Remuzzi G (2004) Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure. J Am Soc Nephrol 15: 1794-80.
29. Nandoe RDS, Hurtado A, Levi ADO, Grotenhuis A, Oudega M (2006) Bone marrow stromal cells for repair of the spinal cord: towards clinical application. Cell Transplant 15: 563-77.
30. Oh GS, Kim HJ, Choi JH, Shen A, Choe SK, Karna A, Lee SH, Jo HJ, Yang SH, Kwak TH, Lee CH, Park R, So HS (2014) Pharmacological activation of NQO1 increases NAD+ levels and attenuates cisplatin-mediated acute kidney injury in mice. Kidney Int 85(3): 547-60.
31. Owen HC, Roberts SJ, Ahmed SF, Farquharson C (2008) Dexamethasone-induced expression of the glucocorticoid response gene lipocalin 2 in chondrocytes. Am J Physiol Endocrinol Metab 294: 1023-34.
32. Qian H, Yang H, Xu W, Yan Y, Chen Q, Zhu W, Cao H, Yin Q, Zhou H, Mao F, Chen Y (2008) Bone marrow mesenchymal stem cells ameliorate rat acute renal failure by differentiation into renal tubular epithelial-like cells. Int J Mol Med 22: 325-32.
33. Roudkenar MH, Ghasemipour Z, Halabian R, Roushandeh AM, Yaghmai P, Gharehbaghian A (2008a) Lipocalin 2 acts as a cytoprotective factor against cisplatin toxicity, an in vitro study. Daru 16: 106-11.
34. Roudkenar MH, Halabian R, Ghasemipour Z, Roushandeh AM, Rouhbakhsh M, Nekogoftar M, Kuwahara Y, Fukumoto M, Shokrgozar MA (2008b) Neutrophil gelatinase-associated lipocalin acts as a protective factor against H(2)O(2) toxicity. Arch Med Res 39: 560-6.
35. Roudkenar MH, Halabian R, Roushandeh AM, Nourani MR, Masroori N, Ebrahimi M, Nikogoftar M, Rouhbakhsh M, Bahmani P, Najafabadi AJ, Shokrgozar MA (2009) Lipocalin 2 regulation by thermal stresses: protective role of Lcn2/NGAL against cold and heat stresses. Exp Cell Res 315(18): 3140-51.
36. Roudkenar MH, Halabian R, Bahmani P, Roushandeh AM, Kuwahara Y, Fukumoto M (2011) Neutrophil gelatinaseassociated lipocalin: a new antioxidant that exerts its cytoprotective effect independent on Heme Oxygenase-1. Free Radic Res 45: 810-9.
37. Schmidt-Ott KM, Mori K, Kalandadze A, Li JY, Paragas N, Nicholas T, Devarajan P, Barasch J (2006) Neutrophil gelatinaseassociated lipocalin-mediated iron traffic in kidney epithelia. Curr Opin Nephrol Hypertens 15: 442-9.
38. Sotiropoulou P, Perez S, Salagianni M (2006) Characterization of the optimal culture conditions for clinical scale production of human mesenchymal stemcells. Stem Cells 24: 462-71.
39. Togel F, Weiss K, Yang Y, Hu Z, Zhang P, Westenfelder C (2007) Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury. Am J Physiol Renal Physiol 295: 1626-35.
40. Valina C, Pinkernell K, Song YH, Bai X, Sadat S, Campeau RJ, Le Jemtel TH, Alt E (2007) Intracoronary administration of autologous adipose tissue-derived stem cells improves left ventricular function, perfusion, and remodelling after acute myocardial infarction. Eur Heart J 28: 2667-7.
41. Yang J, Goetz D, Li JY, Wang W, Mori K, Setlik D, Du T, Erdjument-Bromage H, Tempst P, Strong R, Barasch J (2002) An iron delivery pathway mediated by a lipocalin. Mol Cell 10: 1045-56.
42. Yuan L, Wu MJ, Sun HY, Xiong J, Zhang Y, Liu CY, Fu LL, Liu DM, Liu HQ, Mei CL (2011) VEGF-modified human embryonic mesenchymal stem cell implantation enhances protection against cisplatin-induced acute kidney injury. Am J Physiol Renal Physiol 300(1): 207-18.
43. Zhu W, Chen J, Cong X, Hu S, Chen X (2006) Hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells. Stem Cells 24: 416-25.