Antibiotics for syphilis diagnosed during pregnancy

Cochrane Database of Systematic Reviews

Volumn 2010, Issue 2, 2001, Pages

  Walker, Godfrey JA ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; PENICILLIN DERIVATIVE;

CONGENITAL SYPHILIS; DISEASE TRANSMISSION; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PREGNANCY; PREGNANCY COMPLICATION; REVIEW; SYPHILIS;

ANTI-BACTERIAL AGENTS; DISEASE TRANSMISSION, VERTICAL; FEMALE; HIV INFECTIONS; HUMANS; PENICILLINS; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; SYPHILIS; SYPHILIS, CONGENITAL;

EID: 84921537426     PISSN: 14651858     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD001143     Document Type: Article

References (213)

1. Akorbian AA, Iaroshetskaia NA. Comparative assessment of the treatment of syphilis with bacillin-3-4 +6. Vestnik Dermatologii i Venerologii 1969;43:45-8.
2. Alexander JM, Sheffield JS, Sanchez PJ, Mayfield J, Wendel GD. Efficacy of treatment for syphilis in pregnancy. Obstetrics & Gynecology 1999;93(1):5-8.
3. Aron HCS, Barton RL, Bauer TJ. Prenatal syphilis. Archives of Dermatology and Syphilology 1947;56:349-56.
4. Bundesen HN, Rodriquez J, Aron HCS, Korman BF. Outcome of pregnancies of women treated with aqueous penicillin for early infectious syphilis. Archives of Dermatology and Syphilology 1950;62:230-6.
5. Cole HN, Ayres S, Barr JH, Genatios T, Held B, Murphy WW, et al. Use of penicillin in the treatment of syphilis in pregnancy. Archives of Dermatology and Syphilology 1946;54(3):255-64.
6. Cole HN, Plotke F, Thomas EW, Jenkins KH. Penicillin in the treatment of syphilis in pregnancy. Journal of Venereal Disease Information 1949;29(1):95-100.
7. Cole HN, Plotke F, Thomas EW, Jenkins KH. Effectiveness of penicillin in preventing congenital syphilis when administered prior to pregnancy. Journal of Venereal Disease Information 1950;31:201-3.
8. Cross JB, McCain JR, Heyman A. The use of crystalline G in the treatment of syphilis in pregnancy. American Journal of Obstetrics and Gynecology 1949;57(3):461-5.
9. Donders GG, Desmyter J, Hooft P, Dewet GH. Apparent failure of one injection of benzathine penicillin G for syphilis during pregnancy in human immunodeficiency virus-seronegative African women. Sexually Transmitted Diseases 1997;24(2):94-101.
10. Goodwin MS, Moore JE. Penicillin in prevention of prenatal syphilis. JAMA 1946;130(11):688-94.
11. Haagsma FM. Control of congenital syphilis by treating syphilitics during pregnancy [Bestrijding van congenitale syfilis door behandeling van de syfilitische zwangeren]. Nederlands Tijdschrift voor Geneeskunde 1956;100:3068-77.
12. Ingraham NR, Stokes JH, Beerman H, Lentz JW. Penicillin treatment of the syphilitic pregnant woman. JAMA 1946;130(11):683-7.
13. Ingraham NR, Rose EK, Beerman H, Wammock VS, Stokes JH, Gyorgy P. Treatment of the syphilitic woman with penicillin in oil-beeswax. A comparison with results obtained using aqueous sodium penicillin. Journal of Venereal Disease Information 1947;28:155-61.
14. Ingraham NR. The value of penicillin alone in the prevention and treatment of congenital syphilis. Acta Dermato Venereologica Supplementum 1951;31(Suppl 24):60-88.
15. Jackson FR, Vanderstoep EM, Knox JM, Desmond MM, Moore MB. Use of aqueous benzathine penicillin G in the treatment of syphilis in pregnant women. American Journal of Obstetrics and Gynecology 1962;83(10):1389-92.
16. Kampmeier RH, Sweeney A, Quinn RW, Lefkowitz LB, Dupont WD. A survey of 251 patients with acute syphilis treated in the collaborative penicillin study of 1943-1950. Sexually Transmitted Diseases 1981;8(4):266-79.
17. Lentz JW, Ingraham NR, Beerman H, Stokes JH. Penicillin in the prevention and treatment of congenital syphilis. JAMA 1944;126(7):408-13.
18. Mashkilleison AL. Azithromycin in the treatment of syphilis. Antibiotiki i Khimioterapiia 1994;39:36-8.
19. Mashkilleyson AL, Gomberg MA, Mashkilleyson N, Kutin SA. Treatment of syphilis with azithromycin. International Journal of STD and AIDS 1996;7(Suppl 1):13-5.
20. Moore JE, Mahoney JF, Scwartz W, Sternberg T, Wood WB. The treatment of early syphilis with penicillin. JAMA 1944;126(2):67-73.
21. Nelson NA, Struve VR. Prevention of congenital syphilis by treatment of syphilis in pregnancy. JAMA 1956;161(9):869-72.
22. Olansky S, Beck R. Rapid treatment of prenatal syphilis. American Journal of Syphilis, Gonorrhoea and Venereal Diseases 1947;31:51-6.
23. Phaosavasdi S, Snidvongs W, Thasanapradit P, Ungthavorn P, Bhongsvej S, Jongpiputvanich S, et al. Effectiveness of benzathine penicillin regimen in the treatment of syphilis in pregnancy. Journal of the Medical Association of Thailand 1989;72(2):101-8.
24. Robinson HM, Robinsin HM Jr. Antibiotics in early syphilis and in syphilis complicated by pregnancy. A.M.A. Archives of Dermatology and Syphilology 1951;63:687-701.
25. Shafer JK, Smith CA. Treatment of early infectious syphilis with N,N-dibenzylethylenediamine dipenicillin G. Bulletin of the World Health Organization 1954;10:627-90.
26. Speiser M, Flaum G, Moon-Adams D, Thomas EW. Penicillin therapy for syphilis in pregnancy. Journal of Venereal Disease Information 1947;28:108-20.
27. Tucker HA. Penicillin syphiliotherapy administered prior to pregnancy. American Journal of Syphilis, Gonorrhoea and Venereal Diseases 1949;33(1):1-7.
28. Tucker HA. Penicillin syphilotherapy administered during pregnancy: a study of 149 pregnancies during which penicillin was given for early maternal syphilis. American Journal of Medical Science 1949;217:157-61.
29. Wammock VS, Carrozzino OM, Ingraham NR, Clair NE. Penicillin therapy of the syphilitic pregnant woman: its practical application to a large urban obstetrical service. American Journal of Obstetrics and Gynecology 1950;59(4):806-17.
30. Zhou P, Gu Z, Xu J, Wang X, Liao K. A study evaluating ceftriaxone as a treatment agent for primary and secondary syphilis in pregnancy. Sexually Transmitted Diseases 2005;32(8):495-8.
31. Adler MW. ABC of Sexually Transmitted Diseases. 3rd Edition. London: BMJ Publishing Group, 1995.
32. Adler MW, Cowan F, French P, Mitchell H, Richens J. ABC of Sexually Transmitted Infections. Fifth. London: BMJ Books, 2004.
33. Association for Genitourinary Medicine (AGUM), Medical Society for the Study of Venereal Disease (MSSVD). 2002 national guidelines on the management of early syphilis. London: Association for Genitourinary Medicine (AGUM), Medical Society for the Study of Venereal Disease (MSSVD), 2002.
34. ZG, Yang KH, Liu YL, Tian JH, Ma B, Mi DH, et al. Azithromycin vs. benzathine penicillin G for early syphilis: a meta-analysis of randomized clinical trials. International Journal of STD and AIDS 2008;19(4):217-21.
35. Bai ZG, Yang KH, Tian JH, Ma B, Liu YL, Jiang L, et al. Azithromycin versus penicillin G Benzathine for early syphilis. Cochrane Database of Systematic Reviews 2008, Issue 3. [DOI: 10.1002/14651858.CD007270]
36. Ballard RC, Berman SM, Fenton KA. Azithromycin versus penicillin for early syphilis. New England Journal of Medicine 2006;354:203.
37. Bastos dos Santos R, Folgosa E, Fransen L. Reproductive tract infections in Mozambique: a case study of integrated services. In: Germain A, Holmes KK, Piot P, Wasserheit JN editor(s). Reproductive tract infections. Global impact and priorities for women's health. New York and London: Plenum Press, 1992.
38. Bateman DA, Phibbs CS, Joyce T, Heagarty MC. The hospital cost of congenital syphilis. Journal of Pediatrics 1997;130(5):752-8.
39. Beerman H, Ingraham NR. Recent advances in the management of the syphilitic pregnant woman. Medical Clinics of North America 1945;29:1463-76.
40. Beltrami J, Berman S. Congenital syphilis: a persisting sentinel public health event. Sexually Transmitted Diseases 2006;33(11):675-6.
41. Blandford JM, Gift TL, Vasaikar S, Mwesigwa-Kayongo D, Dlali P, Bronzan RN. Cost-effectiveness of on-site antenatal screening to prevent congenital syphilis in rural eastern Cape Province, Republic of South Africa. Sexually Transmitted Diseases 2007;34(7 Suppl):S61-S66.
42. Brocklehurst P. Update on the treatment of sexually transmitted infections in pregnancy. International Journal of STD and AIDS 1999;10:571-81.
43. Centers for Disease Control and Prevention (CDC). 1993 Sexually transmitted diseases treatment guidelines. Morbidity and Mortality Weekly Report 1993;42(RR-14):1-102.
44. Centers for Disease Control and Prevention (CDC). 1998 Guidelines for treatment of sexually transmitted diseases. Morbidity and Mortality Weekly Report 1998;47(RR-1):1-111.
45. Centers for Disease Control and Prevention (CDC). Epidemic of congenital syphilis - Baltimore, 1996-1997. Morbidity and Mortality Weekly Report 1998;47(42):904-7.
46. Centers for Disease Control and Prevention (CDC). Congenital syphilis - United States, 1998. Morbidity and Mortality Weekly Report 1999;48(34):757-61.
47. Centers for Disease Control and Prevention (CDC). Primary and secondary syphilis - United States, 1998. Morbidity and Mortality Weekly Report 1999;48(39):873-8.
48. Ceners for Disease Control and Prevention, Division of STD Prevention. The national plan to eliminate syphilis from the United States. Atlanta: National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, 1999.
49. Ceners for Disease Control and Prevention, Division of STD Prevention. Sexually transmitted disease surveillance, 1999. Atlanta: Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), 2000.
50. Centers for Disease Control and Prevention (CDC). Sexually transmitted diseases treatment guidelines 2002. Morbidity and Mortality Weekly Report 2002;51(RR-6):1-80.
51. Centers for Disease Control and Prevention (CDC). Sexually Transmitted Diseases Treatment Guidelines 2006. Morbidity and Mortality Weekly Report 2006;55(RR-11):1-100.
52. Centers for Disease Control and Prevention. Sexually transmitted disease surveillance 2007. Syphilis. http://www.cdc.gov/std/stats07/syphilis.htm#a15 (accessed 8 December 2009).
53. Centers for Disease Control and Prtevention (CDC). Sexually transmitted disease surveillance 2007 Supplement. Syphilis surveillance report. Atlanta, GA: CDC, March 2009.
54. STD Section, PHLS Communicable Disease Surveillance Centre. Report to the National Screening Committee, antenatal syphilis screening in the UK: a systematic review and national options appraisal with recommendations. London: Public Health Laboratory Service, 1998.
55. CDSC. Sexually transmitted diseases quarterly report: syphilis - national and international epidemiology. Communicable Disease Report 1999;9(5):38-9.
56. Chakraborty R, Luck S. Syphilis is on the increase: the implications for child health. Archives of Disease in Childhood 2008;93(2):105-9.
57. Chattopadhyay B. Prevention of congenital syphilis. British Journal of Hospital Medicine 1988;22:68-70.
58. Chen ZQ, Zhang GC, Gong XD, Lin C, Gao X, Liang GJ, et al. Syphilis in China: results of a national surveillance programme. Lancet 2007;369(9556):132-8.
59. Cheng JQ, Zhou H, Hong FC, Zhang D, Zhang YJ, Pan P, et al. Syphilis screening and intervention in 500,000 pregnant women in Shenzhen, the People's Republic of China. Sexually Transmitted Infections 2007;83(5):347-50.
60. Chesson H, Owusu-Edusei K Jr. Examining the impact of federally-funded syphilis elimination activities in the US. Social Science and Medicine 2008;67(12):2069-62.
61. Connor N, Roberts J, Nicoll A. Strategic options for antenatal screening for syphilis in the United Kingdom: a cost effectiveness analysis. Journal of Medical Screening 2000;7:7-13.
62. Conover CS, Rend CA, Miller-GB Jr, Schmid GP. Congenital syphilis after treatment of maternal syphilis with a penicillin regimen exceeding CDC guidelines. Infectious Diseases in Obstetrics and Gynecology 1998;6(3):134-7.
63. Conway JH. Recognizing and reducing the global burden of congenital syphilis: the time is now. Sexually Transmitted Diseases 2007;34(7 Suppl):S2-S4.
64. Crowe G, Theodore C, Forster GE, Goh BT. Acceptability and compliance with daily injections of procaine penicillin in the outpatient treatment of syphilis - treponemal infection. Sexually Transmitted Diseases 1997;24:127-30.
65. Currie AE, Winter AJ, Nandwani. The re-emergence of syphilis in Scotland. Scottish Medical Journal 2008;53(2):25-9.
66. Deayton J, French P. Incidence of early syphilis acquired in former Soviet Union is increasing. BMJ 1997;315:1018-9.
67. Desperthes BD, Meheus A, O'Reilly K, Broutet N. Maternal and congenital syphilis programmes: case studies in Bolivia, Kenya and South Africa. Bulletin of the World Health Organization 2004;82(6):410-6.
68. Doherty L, Fenton KA, Jones J, Paine TC, Higgins SP, Williams D, et al. Syphilis: old problem, new strategy. British Medical Journal 2002;325:153-6.
69. Doroshenko A, Sherrard J, Pollard AJ. Syphilis in pregnancy and the neonatal period. International Journal of STD and AIDS 2006;17(4):221-7.
70. Dunn RA, Webster LA, Nakashima AK, Sylvester GC. Surveillance for geographic and secular trends in congenital syphilis - United States, 1983-1991. Morbidity and Mortality Weekly Report 1993;42:59-71.
71. Eccleston K, Collins L, Higgins SP. Primary syphilis. International Journal of STD and AIDS 2008;19(3):145-51.
72. Eurosurveillance. Syphilis cases increasing in Denmark, 2000-01. Eurosurveillance (http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=1869) (accessed 2009) 2002.
73. Anonymous. Syphilis in Europe. Eurosurveillance 2004;9(10-12):3-27.
74. Faundes A, Tanaka AC. Reproductive tract infections in Brazil: solutions in a difficult economic climate. In: Germain A, Holmes KK, Piot P, Wasserheit JN editor(s). Reproductive tract infections. Global impact and priorities for women's health. New York and London: Plenum Press, 1992.
75. Fenton LJ, Light IJ. Congenital syphilis after maternal treatment with erythromycin. Obstetrics & Gynecology 1976;47(4):492-4.
76. Fenton KA. Sexual health and HIV positive individuals: emerging lessons from recent outbreaks of infectious syphilis in England. Communicable Disease and Public Health 2002;5:4-6.
77. Fenton KA, Breban R, Vardavas R, Okano JT, Martin T, Aral S, et al. Infectious syphilis in high-income settings in the 21st century. Lancet Infectious Diseases 2008;8(4):344-53.
78. Fiumara NJ. Treatment of early latent syphilis of less than one years' duration: an evaluation of 275 cases. Sexually Transmitted Diseases 1978;5(3):85-8.
79. French P, Gomberg M, Janier M, Schmidt B, van Voorst Vader P, Young H. IUSTI: 2008 European Guidelines on the Management of Syphilis. International Journal of STD and AIDS 2009;20(5):300-9.
80. Galan HL, Montalvo JF, Deaver J. Retrospective analysis of the serologic response to the treatment of syphilis during pregnancy. Infectious Diseases in Obstetrics and Gynecology 1997;5(1):23-8.
81. Garnett GP, Aral SO, Hoyle DV, Cates W, Anderson RM. The natural history of syphilis. Implications for the transmission dynamics and control of infection. Sexually Transmitted Diseases 1997;24:185-98.
82. Genc M, Ledger WJ. Syphilis in pregnancy. Sexually Transmitted Infections 2000;76:73-9.
83. Ghanem KG, Erbelding EJ, Cheng WW, Rompalo AM. Doxycycline compared with benzathine penicillin for the treatment of early syphilis. Clinical Infectious Diseases 2006;42(6):e45-e49.
84. Gichangi P, Renterghem LV, Karanja J, Bwayo J, Kiragu D, Temmerman M. Congenital syphilis in a Nairobi maternity hospital. East African Medical Journal 2004;81(11):589-93.
85. Giles AJH, Lawrence AG. Treatment failure with penicillin in early syphilis. British Journal of Venereal Diseases 1979;55:62-4.
86. Gloyd S, Chai S, Mercer MA. Antenatal syphilis in sub-Saharan Africa: missed opportunities for mortality reduction. Health Policy Plan 2001;16(1):29-34.
87. Gloyd S, Montoya P, Floriano F, Chadreque MC, Pfeiffer J, Gimbel-Sherr K. Scaling up antenatal syphilis screening in Mozambique: transforming policy to action. Sexually Transmitted Diseases 2007;34(7 Suppl):S31-S36.
88. Goh BT. Syphilis in adults. Sexually Transmitted Infections 2005;81:448-52.
89. Gonzalez-Ochoa A, Moreno JB. The treatment of early syphilis with cephaloridine. Postgraduate Medical Journal 1967;43:134-5.
90. Goodwin MS. Status of treatment of syphilitic pregnant women and children who have congenital syphilis. Journal of Venereal Disease Information 1950;31:178-84.
91. Hardy JB, Hardy PH, Oppenheimer EH, Ryan SJ, Sheff RN. Failure of penicillin in a newborn with congenital syphilis. JAMA 1970;212(8):1345-9.
92. Hartmann JF, Lescoeur B, Mercier JC, Delepine N, Bompard Y, Beaufils F. Neonatal syphilis despite erythromycin treatment of the mother [Syphilis neo-natale malagre le traitement de la mere par l'erythromycine]. Presse Médicale 1984;13(35):2133-5.
93. Hashisaki P, Wertzberger GG, Conrad GL, Nichols CR. Erythromycin failure in the treatment of syphilis in a pregnant woman. Sexually Transmitted Diseases 1983;10(1):36-8.
94. Hay PE, Taylor-Robinson D, Waldron S, Goldmeyer D. Amoxycillin, syphilis, and HIV infection. Lancet 1990;335:474-5.
95. Higgins JPT, Green S, editors. Highly sensitive search strategies for identifying reports of randomized controlled trials in MEDLINE. Cochrane Handbook for Systematic Reviews of Interventions 4.2.5 [updated May 2005]; APPENDIX 5b. http://www.cochrane.org/resources/handbook/hbook.htm (accessed 31st March 2006).
96. Holder WR, Knox JM. Syphilis in pregnancy. Medical Clinics of North America 1972;56(5):1151-60.
97. Hollier LM, Cox SM. Syphilis. Seminars in Perinatology 1998;22:323-31.
98. Holmes KK. Azithromycin versus penicillin G benzathine for early syphilis. New England Journal of Medicine 2005;353:1291-3.
99. Hook EW 3rd, Roddy RE, Handsfield HH. Ceftriaxone therapy for incubating and early syphilis. Journal of Infectious Diseases 1988;158:881-4.
100. Hook EW 3rd. Treatment of syphilis: current recommendations, alternatives, and continuing problems. Reviews of Infectious Diseases 1989;11(Suppl 6):S1511-S1517.
101. Hook EW 3rd, Marra CM. Acquired syphilis in adults. New England Journal of Medicine 1992;326:1060-9.
102. Hook EW 3rd. Is elimination of endemic syphilis transmission a realistic goal for the USA?. Lancet 1998;351(Suppl 3):19-21.
103. Hook EW 3rd, Stephens J, Ennis DM. Azithromycin compared with penicillin G benzathine for treatment of incubating syphilis. Annals of Internal Medicine 1999;131(6):434-7.
104. Hossain M, Broutet N, Hawkes S. The elimination of congenital syphilis: a comparison of the proposed World Health Organization action plan for the elimination of congenital syphilis with existing national maternal and congenital syphilis policies. Sexually Transmitted Diseases 2007;34(7 Suppl):S22-S30.
105. Health Protection Agency (HPA). Syphilis and lymphogranuloma venereum: resurgent sexually transmitted infections in the UK. London: HPA, 2009.
106. Health Protection Agency (HPA) & UK National Screening Committee. Infectious Diseases in Pregnancy Screening Programme. 2007/08 Annual Report and 2005-2007 Surveillance Data. London: HPA, 2009.
107. Hurtig AK, Nicoll A, Carne C, Lissauer T, Connor N, Webster JP, et al. Syphilis in pregnant women and their children in the United Kingdom: results from national clinician reporting surveys 1994-7. BMJ 1998;317:1617-9.
108. Hutchinson CM, Hook EW 3rd. Syphilis in adults. Medical Clinics of North America 1990;74:1389-416.
109. Idsoe O, Guthe T, Willcox RR. Penicillin in the treatment of syphilis: the experience of three decades. Bulletin of World Health Organization 1972;47 Suppl:S1-S68.
110. Ingraham NR. Prevention and treatment of prenatal syphilis. American Journal of Medicine 1948;5:693-701.
111. Ingraham NR. Prenatal management of syphilis with special reference to penicillin therapy. Medical Clinics of North America 1948;32:1647-58.
112. Jefferiss FJG, Willcox RR. Treatment of early syphilis with penicillin alone. British Journal of Venereal Diseases 1963;39:143-8.
113. Kampmeier RH. The introduction of penicillin for the treatment of syphilis. Sexually Transmitted Diseases 1981;8(4):260-5.
114. Karumudi UR, Augenbraun M. Syphilis and HIV: a dangerous duo. Expert Review of Anti-infective Therapy 2005;3:825-31.
115. Katsambas A, Adoniou C, Katsarou A, Kerkidou A, Stratigos J. Comparative study of ceftriaxone and benzathine G in the treatment of primary and secondary syphilis. Chemiotherapia 1987;6:549-50.
116. Katz KA, Klausner JD. Azithromycin resistance Treponema pallidum. Current Opinion in Infectious Diseases 2008;21(1):83-91.
117. Kingston M, French P, Goh B, Goold P, Higgins S, Sukthankar A, et al. Syphilis Guidelines Revision Group 2008, Clinical Effectiveness Group. UK national guidelines on the management of syphilis 2008. International Journal of STD and AIDS 2008;19(11):729-40.
118. Klausner JD, Kohn RP, Kent CK. Azithromycin versus penicillin for early syphilis. New England Journal of Medicine 2006;354(2):204.
119. Klein VR, Cox SM, Mitchell MD, Wendel GD Jr. The Jarisch-Herxheimer reaction complicating syphilotherapy in pregnancy. Obstetrics & Gynecology 1990;75(3):375-80.
120. Lee V, Kinghorn G. Syphilis: an update. Clinical Medicine 2008;8(3):330-3.
121. Levin CE, Steele M, Atherly D, García SG, Tinajeros F, Revollo R, et al. Analysis of the operational costs of using rapid syphilis tests for the detection of maternal syphilis in Bolivia and Mozambique. Sexually Transmitted Diseases 2007;34(7):S47-S54.
122. Linglof T. Rapid increase of syphilis and gonorrhoea in parts of the former USSR. Sexually Transmitted Diseases 1995;22:160-1.
123. Lucas JB, Price EV. Co-operative evaluation of treatment for early syphilis. Preliminary report with special reference to spectinomycin sulphate (actinospectacin). British Journal of Venereal Diseases 1967;43:244-8.
124. Lukehart SA. Biology of treponemes. In: Holmes KK, Sparling PF, Stamm WE, Piot P, Wasserheit JN, Corey L, Cohen MS, Watts DH editor(s). Sexually transmitted diseases. Fourth. New York: McGraw Hill Medical, 2008.
125. Luthra UK, Mehta S, Bhargava NC, Ramachandran P, Murthy NS, Sehgal A, et al. Reproductive tract infections in India: the need for comprehensive reproductive health policy and programs. In: Germain A, Holmes KK, Piot P, Wasserheit JN editor(s). Reproductive tract infections. Global impact and priorities for women's health. New York and London: Plenum Press, 1992.
126. Macfarlane A, Mugford M. Birth counts. London: Her Majesty's Stationery Office, 1984.
127. Maggwa ABN, Ngugi EN. Reproductive tract infections in Kenya: insights for action and research. In: Germain A, Holmes KK, Piot P, Wasserheit JN editor(s). Reproductive tract infections. Global impact and priorities for women's health. New York and London: Plenum Press, 1992.
128. Marcus U, Hamouda O. Syphilis in Germany, 2004: diagnoses increasing, particularly in smaller cities and rural areas. Eurosurveillance 2005;10(30):2759.
129. Markovitz DM, Beutner KR, Maggio RP, Reichman RC. Failure of recommended treatment for secondary syphilis. JAMA 1986;255(13):1767-8.
130. Mascola L, Pelosi R, Alexander CE. Inadequate treatment of syphilis in pregnancy. American Journal of Obstetrics and Gynecology 1984;150(8):945-7.
131. Mascola L, Pelosi R, Blount JH, Alexander CE, Cates W Jr. Congenital syphilis revisited. American Journal of Diseases of Children 1985;139:575-80.
132. Mbopi Keou F-X, Mbu R, Mauclere P, Andela A, Tetanye E, Leke R, et al. Antenatal HIV prevalence in Yaounde, Cameroon. International Journal of STD and AIDS 1998;9(7):400-2.
133. McCraken GH, Kaplan JM. Penicillin treatment for congenital syphilis. A critical reappraisal. JAMA 1974;228:855-8.
134. McFarlin BL, Bottoms SF, Dock BS, Isada NB. Epidemic syphilis: maternal factors associated with congenital infection. American Journal of Obstetrics and Gynecology 1994;150(2):535-40.
135. Mitchell SJ, Engelman J, Kent CK, Lukehart SA, Godornes C, Klausner JD. Azithromycin-resistant syphilis infection: San Francisco, California, 2000-2004. Clinical Infectious Diseases 2006;42(3):337-45.
136. Monif GRG. Is current therapy for maternal syphilis inadequate for established fetal infection?. American Journal of Obstetrics and Gynecology 1994;170(2):705.
137. Montgomery CH, Knox JM. Antibiotics other than penicillin in the treatment of syphilis. New England Journal of Medicine 1959;261(6):277-80.
138. Montgomery CH, Knox JM, Sciple GW, Vander Stoep EM. Erythromycin in treatment of early syphilis. Archives of Internal Medicine 1961;107:164-7.
139. Musher DM. How much penicillin cures early syphilis?. Annals of Internal Medicine 1988;109(11):849-51.
140. Myles TD, Elam G, Park-Hwang E, Nguyen T. The Jarisch-Herxheimer reaction and fetal monitoring changes in pregnant women treated for syphilis. Obstetrics & Gynecology 1998;92(5):859-64.
141. Nathan L, Bawdon RE, Sidawi JE, Stettler RW, McIntire DM, Wendel GD. Penicillin levels following the administration of benzathine penicillin G in pregnancy. Obstetrics & Gynecology 1993;82(3):338-42.
142. Nicolay N, Gallay A, Michel A, Nicolau J, Desenclos JC, Semaille C. Reported cases of congenital syphilis in the French national hospital database. Eurosurveillance (http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19062) (accessed 2009) 2008.
143. Nicoll A, Moisley C. Antenatal screening for syphilis should continue - at least until the results of new surveillance studies are known. BMJ 1994;308:1253-4.
144. UK National Screening Committee. Second report of the UK National Screening Committee. London: Department of Health, 2000.
145. O'Connor M, Kleinman S, Goff M. Syphilis in pregnancy. Journal of Midwifery and Womens Health 2008;53(3):e17-e21.
146. Oller LZ. Cephaloridine in gonorrhoea and syphilis. British Journal of Venereal Diseases 1967;43:39-47.
147. Paley SS. Syphilis in pregnancy. New York State Journal of Medicine 1937;37(6):585-90.
148. Peeling RW, Ye H. Diagnostic tools for preventing and managing maternal and congenital syphilis: an overview. Bulletin of the World Health Organization 2004;82(6):439-46.
149. Polnikorn N, Witoonpanich R, Vorachit M, Vejjajiva S, Vejjajiva A. Penicillin concentrations in cerebrospinal fluid after different treatment regimens for syphilis. British Journal of Venereal Diseases 1980;56:363-7.
150. Public Health Agency of Canada. Expert Working Group on the Canadian Sexually Transmitted Infections (STI) Guidelines – revised version 2006 edition. Ottawa: Centre for Communicable Diseases and Infection Control, Public Health Agency of Canada, 2006.
151. Qolahle DC, Hoosen AA, Moodley J, Smith AN, Nlisana KP. Serological screening for sexually transmitted infections in pregnancy: is there any value in re-screening for HIV and syphilis at the time of delivery?. Genitourinary Medicine 1995;71:65-7.
152. Rawstron SA, Bromberg K. Failure of recommended maternal therapy to prevent congenital syphilis. Sexually Transmitted Diseases 1991;18:102-6.
153. Ray JG. Lues-lues: maternal and fetal considerations of syphilis. Obstetrical and Gynecological Survey 1995;50(12):845-50.
154. Richardson MP, Palfreeman A, Nielsen PB, Fenton KA. Congenital syphilis following negative antenatal screening. Communicable Disease and Public Health 2002;5(1):72-3.
155. Richens J, Mabey CW. Sexually transmitted infections (excluding HIV). In: Cook G, Zumla A editor(s). Manson's tropical diseases. 22nd Edition. London: Saunders Elsevier, 2008.
156. Riedner G, Rusizoka M, Todd J, Maboko L, Hoelscher M, Mmbando D, et al. Single-dose azithromycin versus penicillin G benzathine for the treatment of early syphilis. New England Journal of Medicine 2005;353:1236-44.
157. Riedner G, Grosskurth H, Hayes R. Azithromycin versus penicillin for early syphilis. New England Journal of Medicine 2006;354(2):204-5.
158. Rodrigues CS, Guimarães MD, César CC. Missed opportunities for congenital syphilis and HIV perinatal transmission prevention. Revista de Saude Publica 2008;42(6):851-8.
159. Rolfs RT. Treatment of syphilis, 1993. Clinical Infectious Diseases 1995;20 Suppl 1:S23-S38.
160. Rolfs RT, Joesoef MR, Hendershot EF, Rompalo AM, Augenbraun MH, Chiu M, et al. A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. New England Journal of Medicine 1997;337(5):307-14.
161. Rudnicka I, Majewski S. Sexually transmitted infections situation is a cause for concern in Poland. Eurosurveillance (http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=2706) (accessed 2009) 2005.
162. Rydzak CE, Goldie SJ. Cost-effectiveness of rapid point-of-care prenatal syphilis screening in sub-Saharan Africa. Sexually Transmitted Diseases 2008;35(9):775-84.
163. Sanchez PJ, Wendel GD. Syphilis in pregnancy. Infections in Perinatology 1997;24(1):71-89.
164. Schmid GP. Serologic screening for syphilis. Rationale, cost, and realpolitik. Sexually Transmitted Diseases 1996;23(1):45-50.
165. Schmid GP, Stoner BP, Hawkes S, Broutet N. The need and plan for global elimination of congenital syphilis. Sexually Transmitted Diseases 2007;34(7 Suppl):S5-S10.
166. Schofer H, Vogt HJ, Milbradt R. Ceftriaxone for the treatment of primary and secondary syphilis. Chemotherapy 1989;35:140-5.
167. Schulz KF, Scholte JM, Berman SM. Maternal health and child survival: opportunities to protect both women and children from adverse consequences of reproductive tract infections. Reproductive tract Infections. Global impact and priorities for women's health. New York and London: Plenum Press, 1992.
168. Senanayake S. Congenital syphilis in China. Lancet 2007;369(9568):1165.
169. Shafii T, Radolf JD, Sanchez PJ, Schulz KF, Murphy FK. Congenital syphilis. In: Holmes KK, Sparling PF, Stamm WE, Piot P, Wasserheit JN, Corey L, Cohen MS, Watts DH editor(s). Sexually transmitted diseases. Fourth. New York: McGraw Hill Medical, 2008.
170. Sheffield JS, Wendel GD Jr. Syphilis in pregnancy. Clinical Obstetrics and Gynecology 1999;42(1):97-106.
171. Sheffield JS, Sanchez PJ, Morris G, Maberry M, Zeray F, McIntire DD, et al. Congenital syphilis after maternal treatment for syphilis during pregnancy. American Journal of Obstetrics and Gynecology 2002;186(3):569-73.
172. Simms I, Ward H. Congenital syphilis in the United Kingdom. Are we prepared?. Sexually Transmitted Infections 2006;82(1):1.
173. Smith CA, Kamp M, Olansky S, Price EV. Benzathine penicillin G in the treatment of syphilis. Bulletin of the World Health Organization 1956;15:1087-96.
174. South MA, Short DH, Knox JM. Failure of erythromycin estolate therapy in utero syphilis. JAMA 1964;190(1):70-1.
175. Sparling PF. Diagnosis and treatment of syphilis. New England Journal of Medicine 1971;284(12):642-53.
176. Sparling PF, Swartz MN, Musher DM, Healy BP. Clinical manifestations of syphilis. In: Holmes KK, Sparling PF, Stamm WE, Piot P, Wasserheit JN, Corey L, Cohen MS, Watts DH editor(s). Sexually Transmitted Diseases. Fourth. New York: McGraw Hill Medical, 2008.
177. St Louis ME, Farley TA, Aral SO. Untangling the persistence of syphilis in the south. Sexually Transmitted Diseases 1996;23:4.
178. Stokes JH, Beerman H, Ingraham NR. The present status of penicillin in the treatment of syphilis in pregnancy and infantile congenital syphilis. American Journal of Medical Science 1950;219:433-42.
179. Stoner BP. Rapid tests for maternal syphilis screening: effective and cost-effective. Sexually Transmitted Diseases 2008;35(9):785-6.
180. Stray-Pedersen B. Economic evaluation of maternal screening to prevent congenital syphilis. Sexually Transmitted Diseases 1983;10(4):167-72.
181. Sweeney J, Forster G, Goh BT. Antenatal screening for syphilis should continue. BMJ 1994;309:194.
182. Thomas EW. Rapid treatment of syphilis with penicillin. II Penicillin in prenatal and infantile syphilis. Bulletin of the World Health Organization 1949;2:249-55.
183. Thompson SE, Wiesner PJ, Sanford JP. Why review syphilis therapy now?. Journal of the American Venereal Disease Association 1976;3(3):98.
184. Thompson SE. Treatment of syphilis in pregnancy. Journal of the American Venereal Disease Association 1976;3(2):159-67.
185. Tikhonova L, Salakhov E, Southwick K, Shakarishvili A, Ryan C, Hillis S. Congenital syphilis in the Russian Federation: magnitude, determinants, and consequences. Sexually Transmitted Infections 2003;79:106-10.
186. Tourneux P, Boussemart T, Lackmy-Port-Lis M, Azi M, Dufillot D. Congenital syphilis still exists. Presse Médicale 2001;30(34):1683-5.
187. U.S. Preventive Services Task Force. Screening for syphilis infection in pregnancy: U.S. Preventive Services Task Force reaffirmation recommendation statement. Annals of Internal Medicine 2009;150(10):705-9.
188. Van Eijk RVW, Wolters EC, Tutuarima JA, Hische EAH, Bos JD, van Trotsenburg L, de Koning GA, van der Helm HJ. Effect of early and late syphilis on central nervous system: cerebrospinal fluid changes and neurological deficit. Genitourinary Medicine 1987;63:77-82.
189. Velicko I, Arneborn M, Blaxhult A. Syphilis epidemiology in Sweden: re-emergence since 2000 primarily due to spread among men who have sex with men. Eurosurveillance (http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19063) (accessed 2009) 2008.
190. Venereology Society of Victoria. National Management Guidelines for Sexually Transmissible Diseases and Genital Infections. Carlton, Australia: Venereology Society of Victoria in conjunction with the Australasian College of Sexual Health Physicians, 2002.
191. Walker DG, Walker GJA. Forgotten but not gone: the continuing scourge of congenital syphilis. Lancet Infectious Diseases 2002;2:432-6.
192. Walker GJ, Walker DG. Congenital syphilis: a continuing but neglected problem. Seminars in Fetal and Neonatal Medicine 2007;12(3):198-206.
193. Welch J. Antenatal screeing for syphilis. Still important in preventing disease. BMJ 1998;317:1605-6.
194. Wendel GD, Stark BJ, Jamison RB, Molina RD, Sullivan TJ. Penicillin allergy and desensitization in serious infections during pregnancy. New England Journal of Medicine 1985;312(19):1229-32.
195. Wendel GD, Sheffield JS, Hollier LM, Hill JB, Ramsey S, Sanchez PJ. Treatment of syphilis in pregnancy and prevention of congenital syphilis. Clinical Infectious Diseases 2002;35(Suppl 2):S200-S209.
196. World Health Organization. Global prevalence and incidence of selected curable sexually transmitted infections overview and estimates. WHO/HIV_AIDS/2001.02 and WHO/CDS/CSR/EDC/2001.10. Geneva: WHO, 2001.
197. World Health Organization. Guidelines for the management of sexually transmitted infections. Geneva: WHO, 2003.
198. WHO. The use of Rapid Syphilis Tests. TDR/SDI/06.1. The use of Rapid Syphilis Tests. TDR/SDI/06.1. Geneva: WHO, 2006.
199. World Health Organization Europe. Review of current evidence and comparison of guidelines for effective syphilis treatment in Europe. Copenhagen: WHO, 2003.
200. Wilkinson D, Sach M. Improved treatment of syphilis among pregnant women through on-site testing: an intervention study in rural South Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene 1998;92(3):348.
201. Willcox RR. Treatment of early venereal syphilis with antibiotics. British Journal of Venereal Diseases 1962;38:109-25.
202. Willcox RR. Treatment of syphilis. Bulletin of the World Health Organization 1981;59(5):655-63.
203. Williams K. Screening for syphilis in pregnancy: an assessment of the costs and benefits. Community Medicine 1985;7:37-42.
204. Wolff T, Shelton E, Sessions C, Miller T. Screening for syphilis infection in pregnant women: evidence for the U.S. Preventive Services Task Force reaffirmation recommendation statement. Annals of Internal Medicine 2009;150(10):710-6.
205. Woltz JHE, Wiley MM. The transmission of penicillin to the previable fetus. JAMA 1946;131(12):969-70.
206. Wong T, Singh AE, De P. Primary syphilis: serological treatment response to doxycycline/tetracycline versus benzathine penicillin. American Journal of Medicine 2008;121(10):903-8.
207. Woods CR. Syphilis in children: congenital and acquired. Seminars in Pediatric Infectious Diseases 2005;16(4):245-57.
208. Woods CR. Congenital Syphilis? Persisting Pestilence. Pediatric Infectious Disease Journal 2009;28(6):536-537.
209. Zenker PN, Rolfs RT. Treatment of syphilis, 1989. Reviews of Infectious Diseases 1990;12 Suppl 6:S590-S609.
210. Zetola NM, Klausner JD. Syphilis and HIV infection: an update. Clinical Infectious Diseases 2007;44(9):1222-8.
211. Zhou H, Chen XS, Hong FC, Pan P, Yang F, Cai YM, et al. Risk factors for syphilis infection among pregnant women: results of a case-control study in Shenzhen, China. Sexually Transmitted Infections 2007;83(6):476-80.
212. Ziaya PR, Hankins GD, Gilstrap LC 3rd, Halsey AB. Intravenous penicillin desensitization and treatment during pregnancy. JAMA 1986;256(18):2561-2.
213. Zákoucká H, Polanecký V, Kastánková V. Syphilis and gonorrhoea in the Czech Republic. Eurosurveillance (http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=496) (accessed 2009) 2004.