Single-dose azithromycin versus penicillin G benzathine for the treatment of early syphilis

New England Journal of Medicine

Volumn 353, Issue 12, 2005, Pages 1236-1244

  Riedner, Gabriele ^a,h   Rusizoka, Mary ^b   Todd, Jim ^a   Maboko, Leonard ^c   Hoelscher, Michael ^d   Mmbando, Donan ^b   Samky, Eleuter ^e   Lyamuya, Eligius ^f   Mabey, David ^a   Grosskurth, Heiner ^g   Hayes, Richard ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b Regional Medical Office   (Tanzania)

^c Mbeya Medical Research Programme   (Tanzania)

^d UNIVERSITY OF MUNICH   (Germany)

^e Mbeya Consultant Hospital Tanzania   (Tanzania)

^f MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^g UGANDA VIRUS RESEARCH INSTITUTE   (Uganda)

^h WHO Regional Office for the Eastern Mediterranean   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; AZITHROMYCIN; BENZATHINE PENICILLIN; MACROLIDE; PENICILLIN DERIVATIVE; ANTIINFECTIVE AGENT;

ADOLESCENT; ADULT; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL VIRULENCE; CLINICAL TRIAL; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE REGIMEN; DRUG EFFECT; DRUG EFFICACY; EPITHELIZATION; FEMALE; GENITAL ULCER; HUMAN; INFECTION PREVENTION; INFECTION RISK; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SCREENING TEST; SEROLOGY; SYPHILIS; TANZANIA; TITRIMETRY; TREPONEMA PALLIDUM; DEVELOPING COUNTRY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTRAMUSCULAR DRUG ADMINISTRATION; ORAL DRUG ADMINISTRATION; PROPORTIONAL HAZARDS MODEL;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; DEVELOPING COUNTRIES; FEMALE; HIV SEROPOSITIVITY; HUMANS; INJECTIONS, INTRAMUSCULAR; MALE; PENICILLIN G, BENZATHINE; PROPORTIONAL HAZARDS MODELS; SYPHILIS;

EID: 25144523570     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMoa044284     Document Type: Article

References (13)

1. Parkes R, Renton A, Meheus A, Laukamm-Josten U. Review of current evidence and comparison of guidelines for effective syphilis treatment in Europe. Int J STD AIDS 2004;15:73-88.
2. Martin DH, Mroczkowski TF, Dalu ZA, et al. A controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis. N Engl J Med 1992;327:921-5.
3. Handsfield HH, Dalu ZA, Martin DH, Douglas JM Jr, McCarty JM, Schlossberg D. Multicenter trial of single-dose azithromycin vs. ceftriaxone in the treatment of uncomplicated gonorrhea. Sex Transm Dis 1994;21:107-11.
4. Martin DH, Sargent SJ, Wendel GD Jr, McCormack WM, Spier NA, Johnson RB. Comparison of azithromycin and ceftriaxone for the treatment of chancroid. Clin Infect Dis 1995;21:409-14.
5. Hook EW III, Stephens J, Ennis DM. Azithromycin compared with penicillin G benzathine for treatment of incubating syphilis. Ann Intern Med 1999;131:434-7.
6. Hook EW III, Martin DH, Stephens J, Smith BS, Smith K. A randomized, comparative pilot study of azithromycin versus penicillin G benzathine for treatment of early syphilis. Sex Transm Dis 2002;29:486-90.
7. Orle KA, Gates CA, Martin DH, Body BA, Weiss JB. Simultaneous PCR detection of Haemophilus ducreyi, Treponema pallidum, and herpes simplex virus types 1 and 2 from genital ulcers. J Clin Microbiol 1996;34:49-54.
8. Azithromycin treatment failures in syphilis infections - San Francisco, California, 2002-2003. MMWR Morb Mortal Wkly Rep 2004;53:197-8.
9. Lukehart SA, Godornes C, Molini BJ, et al. Macrolide resistance in Treponema pallidum in the United States and Ireland. N Engl J Med 2004;351:154-8.
10. Hopkins S. Clinical toleration and safety of azithromycin. Am J Med 1991;91:40S-45S.
11. Rolfs RT, Joesoef MR, Hendershot EF, et al. A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. N Engl J Med 1997;337:307-14.
12. Musher DM, Hamill RJ, Baughn RE. Effect of human immunodeficiency virus (HIV) infection on the course of syphilis and on the response to treatment. Ann Intern Med 1990;113:872-81.
13. Hart G. Syphilis tests in diagnostic and therapeutic decision making. Ann Intern Med 1986;104:368-76.