Urine neutrophil gelatinase-associated lipocalin and risk of cardiovascular disease and death in CKD: Results from the chronic renal insufficiency cohort (CRIC) study

American Journal of Kidney Diseases

Volumn 65, Issue 2, 2015, Pages 267-274

  Liu, Kathleen D ^a   Yang, Wei ^b   Go, Alan S ^c   Anderson, Amanda H ^b   Feldman, Harold I ^b   Fischer, Michael J ^d   He, Jiang ^e   Kallem, Radhakrishna R ^b   Kusek, John W ^f   Master, Stephen R ^b   Miller, Edgar R ^g   Rosas, Sylvia E ^h   Steigerwalt, Susan ⁱ   Tao, Kaixiang ^b   Weir, Matthew R ^j   Hsu, Chi Yuan ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c DIVISION OF RESEARCH   (United States)

^d UNIVERSITY OF ILLINOIS HOSPITAL AND HEALTH SCIENCES SYSTEM   (United States)

^e TULANE UNIVERSITY   (United States)

^f NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^g JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h HARVARD MEDICAL SCHOOL   (United States)

ⁱ ST JOHN HOSPITAL AND MEDICAL CENTER   (United States)

^j UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

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Author keywords

(CKD); (NGAL) renal tubular; atherosclerotic event; chronic kidney disease; Chronic Renal; dysfunction biomarker; Index Words; injury renal tubular; Insufficiency Cohort (CRIC); ischemic; Neutrophil gelatinase associated lipocalin; Study cardiovascular disease

Indexed keywords

NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; ACUTE PHASE PROTEIN; BIOLOGICAL MARKER; LCN2 PROTEIN, HUMAN; LIPOCALIN; ONCOPROTEIN;

ADULT; AGED; ALBUMINURIA; ARTICLE; BRAIN ISCHEMIA; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHEMILUMINESCENT MICROPARTICLE IMMUNOASSAY; CHRONIC KIDNEY DISEASE; CHRONIC KIDNEY FAILURE; COHORT ANALYSIS; DEATH; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; GENERAL ASPECTS OF DISEASE; GLOMERULUS FILTRATION RATE; HEART FAILURE; HEART INFARCTION; HUMAN; IMMUNOASSAY; MAJOR CLINICAL STUDY; MALE; PERIPHERAL OCCLUSIVE ARTERY DISEASE; RISK ASSESSMENT; URINALYSIS; URINE LEVEL; YOUNG ADULT; CARDIOVASCULAR DISEASES; CLINICAL TRIAL; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; RENAL INSUFFICIENCY, CHRONIC; RISK FACTOR; TRENDS; URINE;

ACUTE-PHASE PROTEINS; ADULT; AGED; BIOMARKERS; CARDIOVASCULAR DISEASES; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; LIPOCALINS; MALE; MIDDLE AGED; MORTALITY; PROTO-ONCOGENE PROTEINS; RENAL INSUFFICIENCY, CHRONIC; RISK FACTORS;

EID: 84921516363     PISSN: 02726386     EISSN: 15236838     Source Type: Journal    
DOI: 10.1053/j.ajkd.2014.07.025     Document Type: Article

References (41)

1. J. Coresh, E. Selvin, and L.A. Stevens Prevalence of chronic kidney disease in the United States JAMA 298 17 2007 2038 2047
2. A.S. Go, G.M. Chertow, D. Fan, C.E. McCulloch, and C.Y. Hsu Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization N Engl J Med 351 13 2004 1296 1305
3. B.R. Hemmelgarn, B.J. Manns, and A. Lloyd Relation between kidney function, proteinuria, and adverse outcomes JAMA 303 5 2010 423 429
4. K. Matsushita, M. van der Velde, and B.C. Astor Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis Lancet 375 9731 2010 2073 2081
5. A.K. Israni, and B.L. Kasiske Laboratory assessment of kidney disease: glomerular filtration rate, urinalysis, and proteinuria M.W. Taal, G.M. Chertow, P.A. Marsden, K. Skorecki, A.S.L. Yu, B.M. Brenner, Brenner and Rector's The Kidney 9th ed. 2012 Elsevier Saunders Philadelphia, PA 868 869
6. K.D. Liu, W. Yang, and A.H. Anderson Urine neutrophil gelatinase-associated lipocalin levels do not improve risk prediction of progressive chronic kidney disease Kidney Int 83 5 2013 909 914
7. D. Bolignano, V. Donato, and G. Coppolino Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage Am J Kidney Dis 52 3 2008 595 605
8. R.G. Fassett, S.K. Venuthurupalli, G.C. Gobe, J.S. Coombes, M.A. Cooper, and W.E. Hoy Biomarkers in chronic kidney disease: a review Kidney Int 80 8 2011 806 821
9. C.A. Peralta, R. Katz, and J.V. Bonventre Associations of urinary levels of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) with kidney function decline in the Multi-Ethnic Study of Atherosclerosis (MESA) Am J Kidney Dis 60 6 2012 904 911
10. N.A. Bhavsar, A. Kottgen, J. Coresh, and B.C. Astor Neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) as predictors of incident CKD stage 3: the Atherosclerosis Risk in Communities (ARIC) Study Am J Kidney Dis 60 2 2012 233 240
11. E.R. Smith, D. Lee, and M.M. Cai Urinary neutrophil gelatinase-associated lipocalin may aid prediction of renal decline in patients with non-proteinuric stages 3 and 4 chronic kidney disease (CKD) Nephrol Dial Transplant 28 6 2013 1569 1579
12. N. Paragas, A. Qiu, and Q. Zhang The Ngal reporter mouse detects the response of the kidney to injury in real time Nat Med 17 2 2011 216 222
13. J. Mishra, C. Dent, and R. Tarabishi Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery Lancet 365 9466 2005 1231 1238
14. D. Bolignano, G. Coppolino, A. Lacquaniti, and M. Buemi From kidney to cardiovascular diseases: NGAL as a biomarker beyond the confines of nephrology Eur J Clin Invest 40 3 2010 273 276
15. D.N. Cruz, S. Gaiao, A. Maisel, C. Ronco, and P. Devarajan Neutrophil gelatinase-associated lipocalin as a biomarker of cardiovascular disease: a systematic review Clin Chem Lab Med 50 9 2012 1533 1545
16. G.J. Ko, D.N. Grigoryev, and D. Linfert Transcriptional analysis of kidneys during repair from AKI reveals possible roles for NGAL and KIM-1 as biomarkers of AKI-to-CKD transition Am J Physiol Renal Physiol 298 6 2010 F1472 F1483
17. K. Damman, S. Masson, and H.L. Hillege Clinical outcome of renal tubular damage in chronic heart failure Eur Heart J 32 21 2011 2705 2712
18. H.I. Feldman, L.J. Appel, and G.M. Chertow The Chronic Renal Insufficiency Cohort (CRIC) Study: design and methods J Am Soc Nephrol 14 7 suppl 2 2003 S148 S153
19. J.P. Lash, A.S. Go, and L.J. Appel Chronic Renal Insufficiency Cohort (CRIC) Study: baseline characteristics and associations with kidney function Clin J Am Soc Nephrol 4 8 2009 1302 1311
20. M. Joffe, C.Y. Hsu, and H.I. Feldman Variability of creatinine measurements in clinical laboratories: results from the CRIC Study Am J Nephrol 31 5 2010 426 434
21. A.S. Levey, J. Coresh, and T. Greene Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine values Clin Chem 53 4 2007 766 772
22. A.H. Anderson, W. Yang, and C.Y. Hsu Estimating GFR among participants in the Chronic Renal Insufficiency Cohort (CRIC) Study Am J Kidney Dis 60 2 2012 250 261
23. R.R. Townsend, A.H. Anderson, and J. Chen Metabolic syndrome, components, and cardiovascular disease prevalence in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) Study Am J Nephrol 33 6 2011 477 484
24. P.A. McKee, W.P. Castelli, P.M. McNamara, and W.B. Kannel The natural history of congestive heart failure: the Framingham Study N Engl J Med 285 26 1971 1441 1446
25. P.T. Einhorn, B.R. Davis, and B.M. Massie The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Heart Failure Validation Study: diagnosis and prognosis Am Heart J 153 1 2007 42 53
26. K. Thygesen, J.S. Alpert, and H.D. White Universal definition of myocardial infarction Circulation 116 22 2007 2634 2653
27. W.D. Rosamond, A.R. Folsom, and L.E. Chambless Stroke incidence and survival among middle-aged adults: 9-year follow-up of the Atherosclerosis Risk in Communities (ARIC) cohort Stroke 30 4 1999 736 743
28. M.J. Sarnak, A.S. Levey, and A.C. Schoolwerth Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention Circulation 108 17 2003 2154 2169
29. G. Leoncini, M. Mussap, and F. Viazzi Combined use of urinary neutrophil gelatinase-associated lipocalin (uNGAL) and albumin as markers of early cardiac damage in primary hypertension Clin Chim Acta 412 21-22 2011 1951 1956
30. T. Isakova, H. Xie, and W. Yang Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease JAMA 305 23 2011 2432 2439
31. C. Faul, A.P. Amaral, and B. Oskouei FGF23 induces left ventricular hypertrophy J Clin Invest 121 11 2011 4393 4408
32. J.R. Dominguez, M.G. Shlipak, M.A. Whooley, and J.H. Ix Fractional excretion of phosphorus modifies the association between fibroblast growth factor-23 and outcomes J Am Soc Nephrol 24 4 2013 647 654
33. A.C. Carlsson, A. Larsson, and J. Helmersson-Karlqvist Urinary kidney injury molecule 1 and incidence of heart failure in elderly men Eur J Heart Fail 15 4 2013 441 446
34. L.B. Daniels, E. Barrett-Connor, P. Clopton, G.A. Laughlin, J.H. Ix, and A.S. Maisel Plasma neutrophil gelatinase-associated lipocalin is independently associated with cardiovascular disease and mortality in community-dwelling older adults: the Rancho Bernardo Study J Am Coll Cardiol 59 12 2012 1101 1109
35. T.L. Nickolas, C.S. Forster, and M.E. Sise NGAL (Lcn2) monomer is associated with tubulointerstitial damage in chronic kidney disease Kidney Int 82 6 2012 718 722
36. T.L. Nickolas, K.M. Schmidt-Ott, and P. Canetta Diagnostic and prognostic stratification in the emergency department using urinary biomarkers of nephron damage: a multicenter prospective cohort study J Am Coll Cardiol 59 3 2012 246 255
37. L. Cai, J. Rubin, W. Han, P. Venge, and S. Xu The origin of multiple molecular forms in urine of HNL/NGAL Clin J Am Soc Nephrol 5 12 2010 2229 2235
38. J. Martensson, S. Xu, M. Bell, C.R. Martling, and P. Venge Immunoassays distinguishing between HNL/NGAL released in urine from kidney epithelial cells and neutrophils Clin Chim Acta 413 19-20 2012 1661 1667
39. N.J. Glassford, A.G. Schneider, and S.Y. Xu The nature and discriminatory value of urinary neutrophil gelatinase-associated lipocalin in critically ill patients at risk of acute kidney injury Intensive Care Med 39 10 2013 1714 1724
40. J. Helmersson-Karlqvist, A. Larsson, and A.C. Carlsson Urinary neutrophil gelatinase-associated lipocalin (NGAL) is associated with mortality in a community-based cohort of older Swedish men Atherosclerosis 227 2 2013 408 413
41. C.A. Peralta, R. Scherzer, and C. Grunfeld Urinary biomarkers of kidney injury are associated with all-cause mortality in the Women's Interagency HIV Study (WIHS) HIV Med 15 5 2014 291 300