Urinary neutrophil gelatinase-associated lipocalin may aid prediction of renal decline in patients with non-proteinuric Stages 3 and 4 chronic kidney disease (CKD)

Nephrology Dialysis Transplantation

Volumn 28, Issue 6, 2013, Pages 1569-1579

  Smith, Edward R ^a,b   Lee, Darren ^a   Cai, Michael M ^a   Tomlinson, Laurie A ^c   Ford, Martin L ^b   McMahon, Lawrence P ^a   Holt, Stephen G ^a,b  

^a MONASH UNIVERSITY   (Australia)

^b UK   (United Kingdom)

^c ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

CKD; NGAL; Renal decline; Risk prediction

Indexed keywords

CREATININE; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN;

AGED; ARTICLE; CARDIOVASCULAR RISK; CHRONIC KIDNEY DISEASE; DEATH; DETERIORATION; DISEASE COURSE; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; MORTALITY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEINURIA; RENAL REPLACEMENT THERAPY; RISK ASSESSMENT;

CKD; NGAL; RENAL DECLINE; RISK PREDICTION;

ACUTE-PHASE PROTEINS; AGED; BIOLOGICAL MARKERS; CREATININE; DISEASE PROGRESSION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW-UP STUDIES; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY FAILURE, CHRONIC; LIPOCALINS; MALE; PROGNOSIS; PROSPECTIVE STUDIES; PROTEINURIA; PROTO-ONCOGENE PROTEINS; RENAL INSUFFICIENCY, CHRONIC; RENAL REPLACEMENT THERAPY; RISK FACTORS; SURVIVAL RATE;

EID: 84879636449     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfs586     Document Type: Article

References (40)

1. The 34th Annual ANZDATA Report. Australia and New Zealand Dialysis and Transplant Registry. 2011
2. United States Renal Data System. USRDS 2011 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD. Am J Kidney Dis 2012; 59 (Suppl 1): e1-e420
3. Go AS, Chertow GM, Fan D et al. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. New Engl J Med 2004; 351: 1296-1305
4. Hunsicker LG, Adler S, Caggiula A et al. Predictors of the progression of renal disease in the modification of diet in renal disease study. Kidney Int 1997; 51: 1908-1919
5. Haroun MK, Jaar BG, Hoffman SC et al. Risk factors for chronic kidney disease: a prospective study of 23,534 men and women in Washington County, Maryland. J Am Soc Nephrol 2003; 14: 2934-2941
6. Ejerblad E, Fored CM, Lindblad P et al. Association between smoking and chronic renal failure in a nationwide populationbased case-control study. J Am Soc Nephrol 2004; 15: 2178-2185
7. Kurella M, Lo JC, Chertow GM. Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults. J Am Soc Nephrol 2005; 16: 2134-2140
8. Ruggenenti P, Perna A, Mosconi L et al. Urinary protein excretion rate is the best independent predictor of ESRF in nondiabetic proteinuric chronic nephropathies. 'Gruppo Italiano di Studi Epidemiologici in Nefrologia' (GISEN). Kidney Int 1998; 53: 1209-1216
9. Hemmelgarn BR, Manns BJ, Lloyd A et al. Relation between kidney function, proteinuria, and adverse outcomes. JAMA 2010; 303: 423-429
10. Tonelli M, Muntner P, Lloyd A et al. Using proteinuria and estimated glomerular filtration rate to classify risk in patients with chronic kidney disease: a cohort study. Ann Intern Med 2011; 154: 12-21
11. Clark WF, Macnab JJ, Sontrop JM et al. Dipstick proteinuria as a screening strategy to identify rapid renal decline. J Am Soc Nephrol 2011; 22: 1729-1736
12. Remuzzi G, Bertani T. Pathophysiology of progressive nephropathies. N Engl J Med 1998; 339: 1448-1456
13. D'Amico G, Bazzi C. Pathophysiology of proteinuria. Kidney Int 2003; 63: 809-825
14. Woo KT, Lau YK, Lee GS et al. Pattern of proteinuria in IgA nephritis by SDS-PAGE: clinical significance. Clin Nephrol 1991; 36: 6-11
15. Bazzi C, Petrini C, Rizza V et al. Characterization of proteinuria in primary glomerulonephritides. SDS-PAGE patterns: clinical significance and prognostic value of low molecular weight ('tubular') proteins. Am J Kidney Dis 1997; 29: 27-35
16. Reichert LJ, Koene RA, Wetzels JF. Urinary excretion of beta 2- microglobulin predicts renal outcome in patients with idiopathic membranous nephropathy. J Am Soc Nephrol 1995; 6: 1666-1669
17. Mastroianni Kirsztajn G, Nishida SK, Silva MS et al. Urinary retinol-binding protein as a prognostic marker in the treatment of nephrotic syndrome. Nephron 2000; 86: 109-114
18. Bazzi C, Petrini C, Rizza V et al. Urinary excretion of IgG and alpha(1)-microglobulin predicts clinical course better than extent of proteinuria in membranous nephropathy. Am J Kidney Dis 2001; 38: 240-248
19. Bazzi C, D'Amico G. The urinary excretion of IgG and alpha1- microglobulin predicts renal outcome and identifies patients deserving treatment in membranous nephropathy. Kidney Int 2002; 61: 2276
20. Mishra J, Dent C, Tarabishi R et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 2005; 365: 1231-1238
21. Hirsch R, Dent C, Pfriem H et al. NGAL is an early predictive biomarker of contrast-induced nephropathy in children. Pediatr Nephrol 2007; 22: 2089-2095
22. Wheeler DS, Devarajan P, Ma Q et al. Serum neutrophil gelatinase- associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock. Crit Care Med 2008; 36: 1297-1303
23. Bolignano D, Coppolino G, Lacquaniti A et al. Pathological and prognostic value of urinary neutrophil gelatinase-associated lipocalin in macroproteinuric patients with worsening renal function. Kidney Blood Press Res 2008; 31: 274-279
24. Bolignano D, Lacquaniti A, Coppolino G et al. Neutrophil gelatinase-associated lipocalin (NGAL) and progression of chronic kidney disease. Clin J Am Soc Nephrol 2009; 4: 337-344
25. Ford ML, Tomlinson LA, Chapman TP et al. Aortic stiffness is independently associated with rate of renal function decline in chronic kidney disease stages 3. Hypertension 2010; 55: 1110-1115
26. Levey AS, Stevens LA, Schmid CH et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009; 150: 604-612
27. Smith ER, Cai MM, McMahon LP et al. The value of simultaneous measurements of urinary albumin and total protein in proteinuric patients. Nephrol Dial Transplant 2012; 27: 1534-1541
28. Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury: section 2 AKI definition. Kidney Inter Suppl 2012; 2: 19-36
29. Steyerberg EW, Vickers AJ, Cook NR et al. Assessing the performance of prediction models: a framework for traditional and novel measures. Epidemiology 2010; 21: 128-138
30. Pencina MJ, D'Agostino RB, Sr, Steyerberg EW. Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers. Stat Med 2011; 30: 11-21
31. Damman K, Van Veldhuisen DJ, Navis G et al. Tubular damage in chronic systolic heart failure is associated with reduced survival independent of glomerular filtration rate. Heart 2010; 96: 1297-1302
32. Bolignano D, Basile G, Parisi P et al. Increased plasma neutrophil gelatinase-associated lipocalin levels predict mortality in elderly patients with chronic heart failure. Rejuvenation Res 2009; 12: 7-14
33. Parikh CR, Devarajan P, Zappitelli M et al. Postoperative biomarkers predict acute kidney injury and poor outcomes after pediatric cardiac surgery. J Am Soc Nephrol 2011; 22: 1737-1747
34. Gerstein HC, Mann JF, Yi Q et al. Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. JAMA 2001; 286: 421-426
35. Stehouwer CD, Nauta JJ, Zeldenrust GC et al. Urinary albumin excretion, cardiovascular disease, and endothelial dysfunction in non-insulin-dependent diabetes mellitus. Lancet 1992; 340: 319-323
36. Cai L, Rubin J, Han W et al. The origin of multiple molecular forms in urine of HNL/NGAL. Clin J Am Soc Nephrol 2010; 5: 2229-2235
37. Nickolas TL, Forster CS, Sise ME et al. NGAL (Lcn2) monomer is associated with tubulointerstitial damage in chronic kidney disease. Kidney Int 2012; 82: 718-722
38. Latouche C, El Moghrabi S, Messaoudi S et al. Neutrophil gelatinase- associated lipocalin is a novel mineralocorticoid target in the cardiovascular system. Hypertension 2012; 59: 966-972
39. Bhavsar NA, Kottgen A, Coresh J et al. Neutrophil gelatinaseassociated lipocalin (NGAL) and kidney injury molecule 1 (KIM- 1) as predictors of incident CKD stage 3: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis 2012; 60: 233-240
40. Peralta CA, Katz R, Bonventre JV et al. Associations of Urinary Levels of Kidney Injury Molecule 1 (KIM-1) and Neutrophil Gelatinase- Associated Lipocalin (NGAL) with kidney function decline in the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Kidney Dis 2012; 60: 904-911