The short-term impact of vitamin D-based hip fracture prevention in older adults in the United Kingdom

Journal of Endocrinological Investigation

Volumn 37, Issue 9, 2014, Pages 811-817

  Poole, Chris D ^a   Smith, Jamie C ^b   Davies, J Stephen ^c  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b TORBAY HOSPITAL   (United Kingdom)

^c UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

Author keywords

Colecalciferol; Elderly care; Health economics; Hip fracture; Mortality; Vitamin D

Indexed keywords

CALCIUM; COLECALCIFEROL; PLACEBO; BONE DENSITY CONSERVATION AGENT;

AGED; ARTICLE; CALCIUM INTAKE; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CONTROLLED STUDY; COST CONTROL; DEATH; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ECONOMIC EVALUATION; FEMALE; FRACTURE REDUCTION; HEALTH CARE COST; HIP FRACTURE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; META ANALYSIS (TOPIC); MORTALITY; POPULATION; PRESCRIPTION; RANDOMIZED CONTROLLED TRIAL; SOCIAL CARE; UNITED KINGDOM; VITAMIN SUPPLEMENTATION; ECONOMICS; HEALTH INSURANCE; HIP FRACTURES; STANDARDS; STATISTICS AND NUMERICAL DATA; TIME; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BONE DENSITY CONSERVATION AGENTS; CHOLECALCIFEROL; FEMALE; GREAT BRITAIN; HEALTH CARE COSTS; HIP FRACTURES; HUMANS; MALE; MANAGED CARE PROGRAMS; TIME FACTORS;

EID: 84921515671     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.1007/s40618-014-0109-2     Document Type: Article

References (40)

1. Mellanby E (1976) Nutrition Classics. The Lancet 1:407-12, 1919. An experimental investigation of rickets. Edward Mellanby. Nutr Rev 34:338-340
2. Norman AW (2008) From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr 88:491S-499S
3. Darling AL, Hart KH, Macdonald HM et al (2013) Vitamin D deficiency in UK South Asian Women of childbearing age: a comparative longitudinal investigation with UK Caucasian women. Osteoporos Int 24:477-488
4. Hyppönen E, Power C (2007) Hypovitaminosis D in British adults at age 45 year: nationwide cohort study of dietary and lifestyle predictors. Am J Clin Nutr 85:860-868
5. Schöttker B, Haug U, Schomburg L et al (2013) Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study. Am J Clin Nutr 25:782-793
6. Pearce SH, Cheetham TD (2010) Diagnosis and management of vitamin D deficiency. BMJ 340:b5664
7. Lee HJ, Gong HS, Song CH et al (2013) Evaluation of vitamin D level and grip strength recovery in women with a distal radius fracture. J Hand Surg Am 38:519-525
8. Diamond T, Wong YK, Golombick T (2013) Effect of oral cholecalciferol 2, 000 versus 5, 000 IU on serum vitamin D, PTH, bone and muscle strength in patients with vitamin D deficiency. Osteoporos Int 24:1101-1105
9. Dhesi JK, Jackson SHD, Bearne LM et al (2004) Vitamin D supplementation improves neuromuscular function in older people who fall. Age Ageing 33:589-595
10. Muir SW, Montero-Odasso M (2011) Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: a systematic review and meta-analysis. J Am Geriatr Soc 59:2291-2300
11. Murad MH, Elamin KB, Abu Elnour NO et al (2011) Clinical review: The effect of vitamin D on falls: a systematic review and meta-analysis. J Clin Endocrinol Metab 96:2997-3006
12. Cameron ID, Gillespie LD, Robertson MC et al (2012) Interventions for preventing falls in older people in care facilities and hospitals. Cochrane Database Syst Rev 12: CD005465
13. Bischoff-Ferrari HA, Willett WC, Orav EJ et al (2012) A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med 367:40-49
14. Davies SC, Jewell T, McBride M, et al. VITAMIN D-ADVICE ON SUPPLEMENTS FOR AT RISK GROUPS. London: Department of Health 2012. https://www.gov. uk/government publications/vitamin-d-advice-on-supplements-for-at-risk-groups
15. Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB et al (2009) Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ 339:b3692
16. Office for National Statistics (2011) Mortality figures for United Kingdom. http://www.statistics.gov. uk/hub/population/deaths mortality-rates. (Accessed 14 Apr. 2013)
17. NHSBSA Prescription Services. Electronic Drug Tariff. http:/www.ppa.org.uk/ppa/edt-intro.htm. (Accessed 14 Apr. 2014)
18. Collins GS, Mallett S, Altman DG (2011) Predicting risk of osteoporotic and hip fracture in the United Kingdom: prospective independent and external validation of Q fracture scores. BMJ 342:d3651
19. Baker NL, Cook MN, Arrighi HM et al (2011) Hip fracture risk and subsequent mortality among Alzheimer's disease patients in the United Kingdom, 1988-2007. Age Ageing 40:49-54
20. Parrott S. The Economic Cost of Hip Fracture in the UK. York: 00. http://webarchive.nationalarchives.gov. uk/?/http://www.berr. gov. uk/files/file21463.pdf
21. HM Treasury (2012) 2012 GDP deflators. http://www.hm-treas ury.gov. uk/data-gdp-index.htm. (Accessed 29 Mar. 2013)
22. Nikitovic M, Wodchis WP, Krahn MD et al (2013) Direct healthcare costs attributed to hip fractures among seniors: a matched cohort study. Osteoporos Int 24:659-669
23. XE.com (2013) XE currency conversion. http://www.xe.com/ucc convert/?Amount=37575&From=CAD&To=GBP. (Accessed 14 Apr. 2013)
24. Kanis JA, Oden A, Johnell O et al (2003) The components of excess mortality after hip fracture. Bone 32:468-473
25. Office for National Statistics (2012) Death Registrations Summary Tables-England and Wales, 2011 (Final). http://www.ons. gov. uk/ons/rel/vsob1/death-reg-sum-tables/2011-final-/index.html. (Accessed 14 May 2013)
26. Woolf AD, Akesson K (2003) Preventing fractures in elderly people. BMJ 327:89-95
27. MHRA. Off-label or unlicensed use of medicines: prescribers' responsibilities. http://www.mhra.gov. uk/Safetyinformation DrugSafetyUpdate/CON087990. (Accessed 14 Apr. 2013)
28. Leblanc ES, Perrin N, Johnson JD et al (2013) Over-the-counter and compounded vitamin D: is potency what we expect? JAMA Intern Med 173:585-586
29. Garg S, Sabri D, Kanji J et al (2013) Evaluation of vitamin D medicines and dietary supplements and the physicochemical analysis of selected formulations. J Nutr Health Aging 17:158-161
30. British Orthopaedic Association (2007) The care of patients with fragility fracture. http://www.bgs.org.uk/pdf-cms/pubs/Blue% 20Book%20on%20fragility%20fracture%20care.pdf. Accessed 14 Apr. 2014
31. Bebbington A, Darton R, Netten A. Elderly people admitted to residential and nursing homes: 42 months on 2000. http://www.pssru.ac.uk/pdf/p051.pdf
32. Gutiérrez L, Roskell N, Castellsague J et al (2012) Clinical burden and incremental cost of fractures in postmenopausal women in the United Kingdom. Bone 51:324-331
33. Holt G, Smith R, Duncan K et al (2008) Epidemiology and outcome after hip fracture in the under 65 s-evidence from the Scottish hip fracture audit. Injury 39:1175-1181
34. Gunasekera N, Boulton C, Morris C et al (2010) Hip fracture audit: the Nottingham experience. Osteoporos Int 21:S647-S653
35. Autier P, Gandini S (2007) Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch Intern Med 167:1730-1737
36. Bjelakovic G, Gluud LL, Nikolova D et al (2011) Vitamin D supplementation for prevention of mortality in adults. Cochrane Database Syst Rev 7: CD007470
37. Grey A, Bolland M, Reid I (2012) Vitamin D dose requirements for fracture prevention. N Engl J Med 367:1367-1370
38. Gibson S (2001) Dietary sugars and micronutrient dilution in normal adults aged 65 years and over. Public Health Nutr 4:1235-1244
39. Bolland MJ, Grey A, Avenell A et al (2011) Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ 342:d2040
40. British Medical Association, Royal Pharmaceutical Society (2013) British National Formulary. 65th edn. BMJ Publishing & Pharmaceutical Press 2013. http://www.bnf.org