Polyacrylate-based delivery system for self-adjuvanting anticancer peptide vaccine

Journal of Medicinal Chemistry

Volumn 58, Issue 2, 2015, Pages 888-896

  Liu, Tzu Yu ^a   Hussein, Waleed M ^a   Giddam, Ashwini Kumar ^a   Jia, Zhongfan ^a   Reiman, Jennifer M ^b   Zaman, Mehfuz ^a   McMillan, Nigel A J ^b   Good, Michael F ^b   Monteiro, Michael J ^a   Toth, Istvan ^a   Skwarczynski, Mariusz ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b GRIFFITH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; MONTANIDE ISA 51; PEPTIDE VACCINE; POLYACRYLIC ACID; POLYMER; PROTEIN E7; ACRYLIC ACID RESIN; CANCER VACCINE; CARBOPOL 940; ONCOGENE PROTEIN E7, HUMAN PAPILLOMAVIRUS TYPE 16; SUBUNIT VACCINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; ATOM TRANSFER RADICAL POLYMERIZATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONJUGATE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; DRUG DELIVERY SYSTEM; DRUG EFFICACY; FEMALE; HUMAN PAPILLOMAVIRUS TYPE 16; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; MACROPHAGE; MOUSE; NONHUMAN; PARTICLE SIZE; PEPTIDE SYNTHESIS; SURVIVAL RATE; T LYMPHOCYTE ACTIVATION; TREATMENT RESPONSE; TUMOR GROWTH; TUMOR VOLUME; WART VIRUS; ANIMAL; C57BL MOUSE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; NEOPLASMS, EXPERIMENTAL; T LYMPHOCYTE; VIROLOGY;

ACRYLIC RESINS; ANIMALS; CANCER VACCINES; DENDRITIC CELLS; DRUG DELIVERY SYSTEMS; FEMALE; LYMPHOCYTE ACTIVATION; MACROPHAGES; MICE; MICE, INBRED C57BL; NEOPLASMS, EXPERIMENTAL; PAPILLOMAVIRUS E7 PROTEINS; T-LYMPHOCYTES; VACCINES, SUBUNIT;

EID: 84921512451     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501514h     Document Type: Article

References (38)

1. Oka, Y.; Tsuboi, A.; Fujiki, F.; Shirakata, T.; Nishida, S.; Hosen, N.; Nakajima, H.; Li, Z.; Kawase, I.; Oji, Y.; Sugiyama, H. "Cancer antigen WT1 protein-derived peptide"-based treatment of cancer -toward the further development Curr. Med. Chem. 2008, 15, 3052-3061
2. zur Hausen, H. Papillomaviruses and cancer: from basic studies to clinical application Nat. Rev. Cancer 2002, 2, 342-350
3. Khallouf, H.; Grabowska, A.; Riemer, A. Therapeutic vaccine strategies against human papillomavirus Vaccines 2014, 2, 422-462
4. Liu, T. Y.; Hussein, W. M.; Toth, I.; Skwarczynski, M. Advances in peptide-based human papillomavirus therapeutic vaccines Curr. Top. Med. Chem. 2012, 12, 1581-1592
5. Reed, S. G.; Bertholet, S.; Coler, R. N.; Friede, M. New horizons in adjuvants for vaccine development Trends Immunol. 2009, 30, 23-32
6. Brewer, J. M. (How) do aluminium adjuvants work? Immunol. Lett. 2006, 102, 10-15
7. Skwarczynski, M.; Zaman, M.; Urbani, C. N.; Lin, I. C.; Jia, Z.; Batzloff, M. R.; Good, M. F.; Monteiro, M. J.; Toth, I. Polyacrylate dendrimer nanoparticles: a self-adjuvanting vaccine delivery system Angew. Chem., Int. Ed. 2010, 49, 5742-5745
8. Zaman, M.; Skwarczynski, M.; Malcolm, J. M.; Urbani, C. N.; Jia, Z. F.; Batzloff, M. R.; Good, M. F.; Monteiro, M. J.; Toth, I. Self-adjuvanting polyacrylic nanoparticulate delivery system for group A streptococcus (GAS) vaccine Nanomedicine 2011, 7, 168-173
9. Ahmad Fuaad, A. A.; Jia, Z.; Zaman, M.; Hartas, J.; Ziora, Z. M.; Lin, I. C.; Moyle, P. M.; Batzloff, M. R.; Good, M. F.; Monteiro, M. J.; Skwarczynski, M.; Toth, I. Polymer-peptide hybrids as a highly immunogenic single-dose nanovaccine Nanomedicine 2014, 9, 35-43
10. Palena, C.; Schlom, J. Vaccines against human carcinomas: strategies to improve antitumor immune responses J. Biomed. Biotechnol. 2010, 2010, 380697
11. Liu, T. Y.; Ahmad Fuaad, A. A.; Toth, I.; Skwarczynski, M. Self-assembled peptide-polymer conjugates as vaccines Chim. Oggi 2014, 32, 18-22
12. Liu, T. Y.; Hussein, W. M.; Jia, Z.; Ziora, Z. M.; McMillan, N. A.; Monteiro, M. J.; Toth, I.; Skwarczynski, M. Self-adjuvanting polymer-peptide conjugates as therapeutic vaccine candidates against cervical cancer Biomacromolecules 2013, 14, 2798-2806
13. Tindle, R. W.; Croft, S.; Herd, K.; Malcolm, K.; Geczy, A. F.; Stewart, T.; Fernando, G. J. A vaccine conjugate of ISCAR immunocarrier and peptide epitopes of the E7 cervical cancer-associated protein of human papillomavirus type 16 elicits specific Th1- and Th2-type responses in immunized mice in the absence of oil-based adjuvants Clin. Exp. Immunol. 1995, 101, 265-271
14. Frazer, I. H.; Leggatt, G. R.; Mattarollo, S. R. Prevention and treatment of papillomavirus-related cancers through immunization Annu. Rev. Immunol. 2011, 29, 111-138
15. Hussein, W. M.; Liu, T. Y.; Toth, I.; Skwarczynski, M. Microwave-assisted synthesis of difficult sequence-containing peptides using the isopeptide method Org. Biomol. Chem. 2013, 11, 2370-2376
16. Ahmad Fuaad, A. A.; Azmi, F.; Skwarczynski, M.; Toth, I. Peptide conjugation via CuAAC click chemistry Molecules 2013, 18, 13148-13174
17. Macdonald, J. E.; Kelly, J. A.; Veinot, J. G. Iron/iron oxide nanoparticle sequestration of catalytic metal impurities from aqueous media and organic reaction products Langmuir 2007, 23, 9543-9545
18. Wu, C. Y.; Monie, A.; Pang, X.; Hung, C. F.; Wu, T. C. Improving therapeutic HPV peptide-based vaccine potency by enhancing CD4+ T help and dendritic cell activation J. Biomed. Sci. 2010, 17, 88
19. Tang, J.; Yin, R.; Tian, Y.; Huang, Z.; Shi, J.; Fu, X.; Wang, L.; Wu, Y.; Hao, F.; Ni, B. A novel self-assembled nanoparticle vaccine with HIV-1 Tat/HPV16 E7 fusion peptide and GM-CSF DNA elicits potent and prolonged CD8 T cell-dependent anti-tumor immunity in mice Vaccine 2012, 30, 1071-1082
20. Butler, N. S.; Moebius, J.; Pewe, L. L.; Traore, B.; Doumbo, O. K.; Tygrett, L. T.; Waldschmidt, T. J.; Crompton, P. D.; Harty, J. T. Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection Nat. Immunol. 2012, 13, 188-195
21. Good, M. F.; Reiman, J. M.; Rodriguez, I. B.; Ito, K.; Yanow, S. K.; El-Deeb, I. M.; Batzloff, M. R.; Stanisic, D. I.; Engwerda, C.; Spithill, T.; Hoffman, S. L.; Lee, M.; McPhun, V. Cross-species malaria immunity induced by chemically attenuated parasites J. Clin. Invest. 2013, 123, 3353-3362
22. Reed, S. G.; Orr, M. T.; Fox, C. B. Key roles of adjuvants in modern vaccines Nat. Med. 2013, 19, 1597-1608
23. Skwarczynski, M.; Toth, I. Peptide-based subunit nanovaccines Curr. Drug Delivery 2011, 8, 282-289
24. Zaman, M.; Simerska, P.; Toth, I. Synthetic polyacrylate polymers as particulate intranasal vaccine delivery systems for the induction of mucosal immune response Curr. Drug Delivery 2010, 7, 118-124
25. Greenhalgh, K.; Turos, E. In vivo studies of polyacrylate nanoparticle emulsions for topical and systemic applications Nanomedicine 2009, 5, 46-54
26. Liu, T. Y.; Giddam, A. K.; Hussein, W. M.; Jia, Z.; McMillan, N. A.; Monteiro, M. J.; Toth, I.; Skwarczynski, M. Self-Adjuvanting therapeutic peptide-based vaccine induce CD8+ cytotoxic T lymphocyte responses in a murine human papillomavirus tumor model Curr. Drug Delivery 2014, 10.2174/1567201811666141001155729
27. Whittaker, M. R.; Urbani, C. N.; Monteiro, M. J. Synthesis of linear and 4-arm star block copolymers of poly(methyl acrylate-b-solketal acrylate) by SET-LRP at 25 degrees C J. Polym. Sci., Part A: Polym. Chem. 2008, 46, 6346-6357
28. Xiang, S. D.; Scholzen, A.; Minigo, G.; David, C.; Apostolopoulos, V.; Mottram, P. L.; Plebanski, M. Pathogen recognition and development of particulate vaccines: does size matter? Methods 2006, 40, 1-9
29. Bachmann, M. F.; Jennings, G. T. Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns Nat. Rev. Immunol. 2010, 10, 787-796
30. Oyewumi, M. O.; Kumar, A.; Cui, Z. Nano-microparticles as immune adjuvants: correlating particle sizes and the resultant immune responses Expert Rev. Vaccines 2010, 9, 1095-1107
31. Manolova, V.; Flace, A.; Bauer, M.; Schwarz, K.; Saudan, P.; Bachmann, M. F. Nanoparticles target distinct dendritic cell populations according to their size Eur. J. Immunol. 2008, 38, 1404-1413
32. Jia, Z.; Bell, C. A.; Monteiro, M. J. Rapid and highly efficient functionalization of polymer bromide end-groups by SET-NRC Macromolecules 2011, 44, 1747-1751
33. da Fonseca, L. S.; Silveira, R. P.; Deboni, A. M.; Benvenutti, E. V.; Costa, T. M.; Guterres, S. S.; Pohlmann, A. R. Nanocapsule@xerogel microparticles containing sodium diclofenac: a new strategy to control the release of drugs Int. J. Pharm. 2008, 358, 292-295
34. Lin, K. Y.; Guarnieri, F. G.; Staveley-OCarroll, K. F.; Levitsky, H. I.; August, J. T.; Pardoll, D. M.; Wu, T. C. Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen Cancer Res. 1996, 56, 21-26
35. Hung, C. F.; Cheng, W. F.; Chai, C. Y.; Hsu, K. F.; He, L.; Ling, M.; Wu, T. C. Improving vaccine potency through intercellular spreading and enhanced MHC class I presentation of antigen J. Immunol. 2001, 166, 5733-5740
36. Zeng, Q.; Peng, S.; Monie, A.; Yang, M.; Pang, X.; Hung, C. F.; Wu, T. C. Control of cervicovaginal HPV-16 E7-expressing tumors by the combination of therapeutic HPV vaccination and vascular disrupting agents Hum. Gene Ther. 2011, 22, 809-819
37. White, K. L.; Rades, T.; Furneaux, R. H.; Tyler, P. C.; Hook, S. Mannosylated liposomes as antigen delivery vehicles for targeting to dendritic cells J. Pharm. Pharmacol. 2006, 58, 729-737
38. Kim, H. J.; Yang, J. S.; Woo, S. S.; Kim, S. K.; Yun, C. H.; Kim, K. K.; Han, S. H. Lipoteichoic acid and muramyl dipeptide synergistically induce maturation of human dendritic cells and concurrent expression of proinflammatory cytokines J. Leukocyte Biol. 2007, 81, 983-989