Interference of fisetin with targets of the nuclear factor-ϰB signal transduction pathway activated by epstein-barr virus encoded latent membrane protein 1

Asian Pacific Journal of Cancer Prevention

Volumn 15, Issue 22, 2014, Pages 9835-9839

  Li, Rong ^a   Liang, Hong Ying ^a   Li, Ming Yong ^a   Lin, Chun Yan ^a   Shi, Meng Jie ^a   Zhang, Xiu Juan ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

Fisetin; Latent membrane protein 1; Nasopharyngeal carcinoma; NF script B

Indexed keywords

EBV-ASSOCIATED MEMBRANE ANTIGEN, EPSTEIN-BARR VIRUS; FISETIN; FLAVONOIDS; NF-KAPPA B; VIRAL MATRIX PROTEINS;

APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; DRUG EFFECTS; FLUORESCENT ANTIBODY TECHNIQUE; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 4, HUMAN; HUMANS; METABOLISM; NASOPHARYNGEAL NEOPLASMS; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; VIROLOGY;

APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; FLAVONOIDS; FLUORESCENT ANTIBODY TECHNIQUE; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 4, HUMAN; HUMANS; NASOPHARYNGEAL NEOPLASMS; NF-KAPPA B; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; VIRAL MATRIX PROTEINS;

EID: 84921510572     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2014.15.22.9835     Document Type: Article

References (17)

1. Adham M, Kurniawan AN, Muhtadi AI, et al (2012). Nasopharyngeal carcinoma in Indonesia: epidemiology, incidence, signs, and symptoms at presentation. Chin J Cancer, 31, 185-96.
2. Bambang H, Sunarto S, Sofia M, et al (2010). LMP1 and LMP2 may be prognostic factors for outcome of therapy in nasopharyngeal cancers in Indonesia. Asian Pac J Cancer Prev, 11, 763-6.
3. Chen Y, Chen XY (2002). Effect of epstein-barr virus latent membrane protein 1 (LMP1) on apoptosis of nasopharyngeal carcinoma cell line CNE1. Ai Zheng, 21, 498-503 (in Chinese).
4. Eliopoulos AG, Young LS (2001). LMP1 structure and signal transduction. Semin Cancer Bio, 111, 435-44.
5. Guo L, Tang M, Yang L, et al (2012). Epstein-Barr virus oncoprotein LMP1 mediates survivin upregulation by p53 contributing to G1/S cell cycle progression in nasopharyngeal carcinoma. Int J Mol Med, 29, 574-80.
6. Kim KR, Yoshizake T, Miyamori H, et al (2000). Transformation of Madin darby canine kidney (MDCK) epithelial cell by Epstein-Barr virus latent membra ne protein 1 (LMP1) induces expression of Ets1 and invasi ve growth. Oncogene, 19, 1764-77.
7. Li R, Li XB, Cai KR, et al (2010). Effects of fisetin on HepG2 cells proliferation, growth cycle and apoptosis. Shi Zhen Guo Yi GuoYao, 21, 3206-8 (in Chinese).
8. Li R, Li XB, Jing M, et al (2011). Effect of fisetin on epithelial-mesenchymal transition in hepatocellular carcinoma cell line HepG2. Chinese Pharmacologival Bulletin, 27, 91-4 (in Chinese).
9. Li R, Li XB, Cai KR, et al (2011). Effect of p53 on fisetin induced apoptosis in hepatocellular carcinoma cell line HepG2. Guangdong Med J, 32, 688-90 (In Chinese).
10. Ramdass B, Maliekal TT, Lakshmi S, et al (2007). Coexpression of Notch1 and NF-kappaB signaling pathway components in human cervical cancer progression. Gynecol Oncol, 104,352-61.
11. Vermeulen L, De Wilde G, Van Damme P, et al (2003). Transcriptional activation of the NF-κB p65 subunit by mitogen-and stress-activated protein kinase-1 (MSK1). EMBO J, 22, 1313-24.
12. Xu TP, Shen H, Liu LX, et al (2012). Plumbagin from plumbago zeylanica L induces apoptosis in human non-small cell lung cancer cell lines through NF-κB inactivation. Asian Pac J Cancer Prev, 14, 2325-31.
13. Yang XS, Liu SHA, Liu JW, et al (2012). Fucosyltransferase IV enhances expression of MMP-12 stimulated by EGF via the ERK1/2, p38 and NF-κB pathways in A431cells. Asian Pacific J Cancer Prev, 13, 1657-62.
14. Yoshizaki T (2002). Promotion of metastasis in nasopharyngeal carcinom a by Epstein-Barr virus latent membrane protein-1.Histol Histopathol, 17, 845-50.
15. Zheng H, Li LL, Hu DS, et al (2007). Role of Epstein-Barr virus encoded latent membrane protein 1 in the carcinogenesis of nasopharyngeal carcinoma. Cell Mol Immuno, 14, 185-96.
16. Zuercher E, Butticaz C, Wyniger J, et al (2012). Swiss HIV cohort study.genetic diversity of EBV-encoded LMP1 in the swiss HIV cohort study and implication for NF-κB activation. PLoS One, 7, 32168.
17. Zuo QP, Liu SK, Li ZJ, et al (2011). NF-kappaB p65 modulates the telomerase reverse transcriptase in the HepG hepatoma cell line. Eur J Pharmacol, 672, 113-201.