Preliminary experience with combined inhaled milrinone and prostacyclin in cardiac surgical patients with pulmonary hypertension

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 29, Issue 1, 2015, Pages 38-45

  Laflamme, Maxime ^a   Perrault, Louis P ^a   Carrier, Michel ^a   Elmi Sarabi, Mahsa ^a   Fortier, Annik ^b   Denault, André Y ^a  

^a MONTREAL HEART INSTITUTE   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

cardiac surgery; cardiopulmonary bypass; epoprostenol; milrinone; prostacyclin; pulmonary hypertension

Indexed keywords

MILRINONE; PROSTACYCLIN; ANTIHYPERTENSIVE AGENT; VASODILATOR AGENT;

ADULT; ANTIHYPERTENSIVE THERAPY; ARTERIAL PRESSURE; ARTICLE; CARDIOPULMONARY BYPASS; CENTRAL VENOUS PRESSURE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HEART INDEX; HEART LEFT VENTRICLE EJECTION FRACTION; HEART RATE; HEART RIGHT VENTRICLE PRESSURE; HIGH RISK PATIENT; HUMAN; LENGTH OF STAY; LUNG ARTERY PRESSURE; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; MITRAL VALVE; NEW YORK HEART ASSOCIATION CLASS; PRIORITY JOURNAL; PULMONARY HYPERTENSION; REOPERATION; RETROSPECTIVE STUDY; TRICUSPID VALVE REPLACEMENT; AGED; CASE CONTROL STUDY; DRUG COMBINATION; HEART SURGERY; HYPERTENSION, PULMONARY; INHALATIONAL DRUG ADMINISTRATION; MIDDLE AGED; PROCEDURES;

ADMINISTRATION, INHALATION; AGED; ANTIHYPERTENSIVE AGENTS; CARDIAC SURGICAL PROCEDURES; CASE-CONTROL STUDIES; DRUG THERAPY, COMBINATION; EPOPROSTENOL; FEMALE; HUMANS; HYPERTENSION, PULMONARY; MALE; MIDDLE AGED; MILRINONE; RETROSPECTIVE STUDIES; VASODILATOR AGENTS;

EID: 84921505798     PISSN: 10530770     EISSN: 15328422     Source Type: Journal    
DOI: 10.1053/j.jvca.2014.06.012     Document Type: Article

References (41)

1. A.D. Bernstein, and V. Parsonnet Bedside estimation of risk as an aid for decision-making in cardiac surgery Ann Thorac Surg 69 2000 823 828
2. S.A. Nashef, F. Roques, and B.G. Hammill Validation of European System for Cardiac Operative Risk Evaluation (EuroSCORE) in North American cardiac surgery Eur J Cardiothorac Surg 22 2002 101 105
3. C.L. Reichert, C.A. Visser, and R.B. van den Brink Prognostic value of biventricular function in hypotensive patients after cardiac surgery as assessed by transesophageal echocardiography J Cardiothorac Vasc Anesth 6 1992 429 432
4. V.G. Davila-Roman, A.D. Waggoner, and W.E. Hopkins Right ventricular dysfunction in low output syndrome after cardiac operations: assessment by transesophageal echocardiography Ann Thorac Surg 60 1995 1081 1086
5. A.Y. Denault, R.G. Pearl, and R.E. Michler Tezosentan and Right Ventricular Failure in Patients with Pulmonary Hypertension Undergoing Cardiac Surgery: The TACTICS Trial J Cardiothorac Vasc Anesth 27 2013 1212 1217
6. A. Denault, A. Deschamps, and J.C. Tardif Pulmonary hypertension in cardiac surgery Curr Cardiol Rev 6 2010 1 14
7. A.P. Goldman, R.E. Delius, and J.E. Deanfield Nitric oxide is superior to prostacyclin for pulmonary hypertension after cardiac operations Ann Thorac Surg 60 1995 300 305
8. P. Radermacher, B. Santak, and H.J. Wust Prostacyclin for the treatment of pulmonary hypertension in the adult respiratory distress syndrome: effects on pulmonary capillary pressure and ventilation-perfusion distributions Anesthesiology 72 1990 238 244
9. A. Haraldsson, N. Kieler-Jensen, and U. Nathorst-Westfelt Comparison of inhaled nitric oxide and inhaled aerosolized prostacyclin in the evaluation of heart transplant candidates with elevated pulmonary vascular resistance Chest 114 1998 780 786
10. N. Hegazy Comparison of hemodynamic effects of inhaled milrinone and inhaled prostacyclin after adult cardiac surgery J Applied Sci Res 6 2010 38 44
11. R.T. Schermuly, E. Krupnik, and H. Tenor Coaerosolization of phosphodiesterase inhibitors markedly enhances the pulmonary vasodilatory response to inhaled iloprost in experimental pulmonary hypertension. Maintenance of lung selectivity Am J Respir Crit Care Med 164 2001 1694 1700
12. A. Haraldsson, N. Kieler-Jensen, and S.E. Ricksten The additive pulmonary vasodilatory effects of inhaled prostacyclin and inhaled milrinone in postcardiac surgical patients with pulmonary hypertension Anesth Analg 93 2001 1439 1445
13. S. Ricksten The pulmonary vasodilatory effect of inhaled prostacyclin and milrinone in heart [article in Spanish] Rev Esp Anestesiol Reanim 48 2001 460 461
14. V.H. Kumar, D.D. Swartz, and N. Rashid Prostacyclin and milrinone by aerosolization improve pulmonary hemodynamics in newborn lambs with experimental pulmonary hypertension J Appl Physiol 109 2010 677 684
15. J. Huang, M.J. Bouvette, and J. Zhou Simultaneous delivery of inhaled prostacyclin and milrinone through a double nebulizer system J Cardiothorac Vasc Anesth 25 2011 590 591
16. S. Fortier, R.G. DeMaria, and Y. Lamarche Inhaled prostacyclin reduces cardiopulmonary bypass-induced pulmonary endothelial dysfunction via increased cyclic adenosine monophosphate levels J Thorac Cardiovasc Surg 128 2004 109 116
17. Y. Lamarche, O. Malo, and E. Thorin Inhaled but not intravenous milrinone prevents pulmonary endothelial dysfunction after cardiopulmonary bypass J Thorac Cardiovasc Surg 130 2005 83 92
18. Y. Lamarche, L.P. Perrault, and S. Maltais Preliminary experience with inhaled milrinone in cardiac surgery Eur J Cardiothorac Surg 31 2007 1081 1087
19. A.Y. Denault, J. Gorcsan III, and M.R. Pinsky Dynamic effects of positive-pressure ventilation on canine left ventricular pressure-volume relations J Appl Physiol 91 2001 298 308
20. A.Y. Denault, F. Haddad, and E. Jacobsohn Perioperative right ventricular dysfunction Curr Opin Anaesthesiol 26 2013 71 81
21. A.Y. Denault, M. Chaput, and P. Couture Dynamic right ventricular outflow tract obstruction in cardiac surgery J Thorac Cardiovasc Surg 132 2006 43 49
22. P. St-Pierre, A. Deschamps, and R. Cartier Inhaled milrinone and epoprostenol in a patient with severe pulmonary hypertension, right ventricular failure and reduced baseline brain saturation value from a left atrial myxoma J Cardiothorac Vasc Anesth 28 2014 723 729
23. F. Haddad, P. Couture, and C. Tousignant The right ventricle in cardiac surgery, a perioperative perspective: I. Anatomy, physiology, and assessment Anesth Analg 108 2009 407 421
24. J.W. Kinch, and T.J. Ryan Right ventricular infarction N Engl J Med 330 1994 1211 1217
25. L.G. Rudski, W.W. Lai, and J. Afilalo Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography Endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography J Am Soc Echocardiogr 23 2010 685 713
26. M. Carricart, A.Y. Denault, and P. Couture Incidence and significance of abnormal hepatic venous Doppler flow velocities before cardiac surgery J Cardiothorac Vasc Anesth 19 2005 751 758
27. A. Deschamps, J. Lambert, and P. Couture Reversal of Decreases in Cerebral Saturation in High-risk Cardiac Surgery J Cardiothorac Vasc Anesth 27 2013 1260 1266
28. M. Hache, A. Denault, and S. Belisle Inhaled epoprostenol (prostacyclin) and pulmonary hypertension before cardiac surgery J Thorac Cardiovasc Surg 125 2003 642 649
29. M. Hache, A.Y. Denault, and S. Belisle Inhaled prostacyclin (PGI2) is an effective addition to the treatment of pulmonary hypertension and hypoxia in the operating room and intensive care unit Can J Anaesth 48 2001 924 929
30. A.Y. Denault, F. Haddad, and Y. Lamarche Pilot randomized controlled trial of inhaled milrinone in high-risk cardiac surgical patients Surgery Curr Res 4 2014 1 8
31. A.Q. Nguyen, Y. Theoret, and C. Chen High performance liquid chromatography using UV detection for the quantification of milrinone in plasma: improved sensitivity for inhalation J Chromatogr B Analyt Technol Biomed Life Sci 877 2009 657 660
32. A.Y. Denault, J.C. Tardif, and C.D. Mazer Difficult and complex separation from cardiopulmonary bypass in high-risk cardiac surgical patients: a multicenter study J Cardiothorac Vasc Anesth 26 2012 608 616
33. C. Paquet, A. Deschamps, and A.Y. Denault Baseline regional cerebral oxygen saturation correlates with left ventricular systolic and diastolic function J Cardiothorac Vasc Anesth 22 2008 840 846
34. M. Heringlake, C. Garbers, and J.H. Kabler Preoperative cerebral oxygen saturation and clinical outcomes in cardiac surgery Anesthesiology 114 2011 58 69
35. J. Zhang, F. Chen, and X. Zhao Nebulized phosphodiesterase III inhibitor during warm ischemia attenuates pulmonary ischemia-reperfusion injury J Heart Lung Transplant 28 2009 79 84
36. A.D. Maslow, M.M. Regan, and P. Panzica Precardiopulmonary bypass right ventricular function is associated with poor outcome after coronary artery bypass grafting in patients with severe left ventricular systolic dysfunction Anesth Analg 95 2002 1507 1518
37. F. Haddad, P. Fisher, and M. Pham Right ventricular dysfunction predicts poor outcome following hemodynamically compromising rejection J Heart Lung Transplant 28 2009 312 319
38. N. Ad, S.D. Barnett, and A.M. Speir The performance of the EuroSCORE and the Society of Thoracic Surgeons mortality risk score: the gender factor Interact Cardiovasc Thorac Surg 6 2007 192 195
39. H.J. Geissler, P. Holzl, and S. Marohl Risk stratification in heart surgery: comparison of six score systems Eur J Cardiothorac Surg 17 2000 400 406
40. A. Robitaille, A.Y. Denault, and P. Couture Importance of relative pulmonary hypertension in cardiac surgery: the mean systemic-to-pulmonary artery pressure ratio J Cardiothorac Vasc Anesth 20 2006 331 339
41. F. Haddad, J. Guihaire, and M. Skhiri Septal curvature is marker of hemodynamic, anatomical, and electromechanical ventricular interdependence in patients with pulmonary arterial hypertension Echocardiography 31 2014 699 707