TLR4 and NALP3 inflammasome in the development of endothelial dysfunction in uraemia

European Journal of Clinical Investigation

Volumn 45, Issue 2, 2015, Pages 160-169

  Martin Rodriguez, Susana ^a   Caballo, Carolina ^a   Gutierrez, Gabriela ^a   Vera, Manel ^a   Cruzado, Josep M ^b   Cases, Aleix ^a   Escolar, Gines ^a   Diaz Ricart, Maribel ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b Diaverum Institut Hemodiálisis   (Spain)

Author keywords

Chronic kidney disease; Endothelial dysfunction; Innate immunity; NALP3; TLR4; Uraemia

Indexed keywords

CRYOPYRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 4; CARRIER PROTEIN; INFLAMMASOME; NLRP3 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

ADULT; ARTICLE; CELL STRESS; CELL SURFACE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; FEMALE; HEMODIALYSIS; HUMAN; HUMAN CELL; MALE; PERITONEAL DIALYSIS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SURFACE PROPERTY; UREMIA; ANTAGONISTS AND INHIBITORS; CARDIOVASCULAR DISEASE; CELL CULTURE; CHRONIC KIDNEY FAILURE; INNATE IMMUNITY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM;

ADULT; CARDIOVASCULAR DISEASES; CARRIER PROTEINS; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; IMMUNITY, INNATE; INFLAMMASOMES; INTERCELLULAR ADHESION MOLECULE-1; MALE; REACTIVE OXYGEN SPECIES; RENAL INSUFFICIENCY, CHRONIC; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; UREMIA;

EID: 84921490974     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/eci.12392     Document Type: Article

References (34)

1. Ringoir S. An update on uremic toxins. Kidney Int Suppl 1997;62:S2-4.
2. Vanholder R, Van Laecke S, Glorieux G. What is new in uremic toxicity?. Pediatr Nephrol 2008;23:1211-21.
3. Zemel D, Krediet RT. Cytokine patterns in the effluent of continuous ambulatory peritoneal dialysis: relationship to peritoneal permeability. Blood Purif 1996;14:198-216.
4. Herbelin A, Urena P, Nguyen AT, Zingraff J, Descamps-Latscha B. Elevated circulating levels of interleukin-6 in patients with chronic renal failure. Kidney Int 1991;39:954-60.
5. Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 2010;11:373-84.
6. Carbo C, Arderiu G, Escolar G, Fuste B, Cases A, Carrascal M, et al. Differential expression of proteins from cultured endothelial cells exposed to uremic vs. normal serum. Am J Kidney Dis 2008;51:603-12.
7. Erlandsson HH, Andersson U. Mini-review: the nuclear protein HMGB1 as a proinflammatory mediator. Eur J Immunol 2004;34:1503-12.
8. Sutton TA, Dagher PC. Fueling the fire in acute kidney injury: endothelial cells collect their Toll. Kidney Int 2001;79:267-9.
9. Schroder K, Tschopp J. The inflammasomes. Cell 2010;140:821-32.
10. Strowig T, Henao-Mejia J, Elinav E, Flavell R. Inflammasomes in health and disease. Nature 2012;481:278-86.
11. Schroder K, Zhou R, Tschopp J. The NLRP3 inflammasome: a sensor for metabolic danger? Science 2010;327:296-300.
12. Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol 2010;11:136-40.
13. Kasza A. IL-1 and EGF regulate expression of genes important in inflammation and cancer. Cytokine 2013;62:22-33.
14. Caballo C, Palomo M, Cases A, Galan AM, Molina P, Vera M, et al. NFkappaB in the development of endothelial activation and damage in uremia: an in vitro approach. PLoS ONE 2012;7:e43374.
15. Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 1973;52:2745-56.
16. Serradell M, Diaz-Ricart M, Cases A, Petriz J, Ordinas A, Escolar G. Uraemic medium accelerates proliferation but does not induce apoptosis of endothelial cells in culture. Nephrol Dial Transplant 2003;18:1079-85.
17. Serradell M, Diaz-Ricart M, Cases A, Zurbano MJ, Lopez-Pedret J, Arranz O, et al. Uremic medium causes expression, redistribution and shedding of adhesion molecules in cultured endothelial cells. Haematologica 2002;87:1053-61.
18. Aznar-Salatti J, Escolar G, Cases A, Gomez-Ortiz G, Anton P, Castillo R, et al. Uraemic medium causes endothelial cell dysfunction characterized by an alteration of the properties of its subendothelial matrix. Nephrol Dial Transplant 1995;10:2199-204.
19. Serradell M, Diaz-Ricart M, Cases A, Zurbano MJ, Aznar-Salatti J, Lopez-Pedret J, et al. Uremic medium disturbs the hemostatic balance of cultured human endothelial cells. Thromb Haemost 2001;86:1099-105.
20. Sung B, Ahn KS, Aggarwal BB. Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to chemotherapeutic agents and cytokines by modulating the NF-kappaB signaling pathway. Cancer Res 2010;70:3259-68.
21. Xiang M, Shi X, Li Y, Xu J, Yin L, Xiao G, et al. Hemorrhagic shock activation of NLRP3 inflammasome in lung endothelial cells. J Immunol 2011;187:4809-17.
22. Piccinini AM, Midwood KS. DAMPening inflammation by modulating TLR signalling. Mediators Inflamm 2010; 672395. Epub ahead of print doi: 10.1155/2010/672395.
23. Lee KM, Seong SY. Partial role of TLR4 as a receptor responding to damage-associated molecular pattern. Immunol Lett 2009;125:31-9.
24. Jounai N, Kobiyama K, Takeshita F, Ishii KJ. Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination. Front Cell Infect Microbiol 2012;2:168.
25. Kawai T, Akira S. Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med 2007;13:460-9.
26. Lee HS, Kwon SH, Ham JE, Lee JY, Kim DH, Shin KH, et al. Zaprinast activates MAPKs, NFkappaB, and Akt and induces the expressions of inflammatory genes in microglia. Int Immunopharmacol 2012;13:232-41.
27. Howe LR, Subbaramaiah K, Hudis CA, Dannenberg AJ. Molecular pathways: adipose inflammation as a mediator of obesity-associated cancer. Clin Cancer Res 2013;19:6074-83.
28. Zhu P, Xie L, Ding HS, Gong Q, Yang J, Yang L. High mobility group box 1 and kidney diseases (Review). Int J Mol Med 2013;31:763-8.
29. Himmelfarb J, Stenvinkel P, Ikizler TA, Hakim RM. The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia. Kidney Int 2002;62:1524-38.
30. Tschopp J, Schroder K. NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? Nat Rev Immunol 2010;10:210-5.
31. Ogura Y, Sutterwala FS, Flavell R. The inflammasome: first line of the immune response to cell stress. Cell 2010;126:659-62.
32. USRDS 2011 Annual Data Report (2011) Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States: Morbidity & mortality.
33. Konings CJ, Kooman JP, Schonck M, Dammers R, Cheriex E, Palmans Meulemans AP, et al. Fluid status, blood pressure, and cardiovascular abnormalities in patients on peritoneal dialysis. Perit Dial Int 2002;22:477-87.
34. Cheng LT, Gao YL, Qin C, Tian JP, Gu Y, Bi SH, et al. Volume overhydration is related to endothelial dysfunction in continuous ambulatory peritoneal dialysis patients. Perit Dial Int 2008;28:397-402.